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Research Article

Randomized phase II trial comparing two dose levels of thymoglobulin in patients undergoing unrelated donor hematopoietic cell transplant

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Pages 915-919 | Received 24 Mar 2011, Accepted 12 Oct 2011, Published online: 05 Dec 2011

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Anand Tandra, Fahrettin Covut, Brenda Cooper, Richard Creger, Lauren Brister, Bernadette McQuigg, Paolo Caimi, Ehsan Malek, Ben Tomlinson, Hillard M. Lazarus, Folashade Otegbeye, Merle Kolk, Marcos de Lima & Leland Metheny. (2018) Low dose anti-thymocyte globulin reduces chronic graft-versus-host disease incidence rates after matched unrelated donor transplantation. Leukemia & Lymphoma 59:7, pages 1644-1651.
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Geothy Chakupurakal, Paul Freudenberger, Nicole Skoetz, Hans Ahr & Sebastian Theurich. (2023) Polyclonal anti-thymocyte globulins for the prophylaxis of graft-versus-host disease after allogeneic stem cell or bone marrow transplantation in adults. Cochrane Database of Systematic Reviews 2023:6.
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Joice Zuckermann, Bruno Mateus de Castro, Thiago Almirante Cunha, Alessandra Paz & Leila Beltrami Moreira. (2023) Systematic review and meta-analysis of anti-thymocyte globulin dosage as a component of graft-versus-host disease prophylaxis. PLOS ONE 18:4, pages e0284476.
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David Merrell, Thevaa Chandereng & Yeonhee Park. (2023) A Markov decision process for response-adaptive randomization in clinical trials. Computational Statistics & Data Analysis 178, pages 107599.
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Souichi Shiratori, Junichi Sugita, Shigeo Fuji, Jun Aoki, Masashi Sawa, Yukiyasu Ozawa, Daigo Hashimoto, Ken-ichi Matsuoka, Kazunori Imada, Noriko Doki, Takashi Ashida, Yasunori Ueda, Masatsugu Tanaka, Yasushi Sawayama, Tatsuo Ichinohe, Seitaro Terakura, Satoko Morishima, Yoshiko Atsuta, Takahiro Fukuda & Takanori Teshima. (2021) Low-dose antithymocyte globulin inhibits chronic graft-versus-host disease in peripheral blood stem cell transplantation from unrelated donors. Bone Marrow Transplantation 56:9, pages 2231-2240.
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Souichi Shiratori, Junichi Sugita, Shuichi Ota, Senji Kasahara, Jun Ishikawa, Takayoshi Tachibana, Yoshiki Hayashi, Goichi Yoshimoto, Tetsuya Eto, Hiromi Iwasaki, Mine Harada, Keitaro Matsuo, Takanori Teshima, Masahiro Imamura, Shuichi Taniguchi, Chihiro Shimazaki, Shinji Nakao, Mitsune Tanimoto, Kenji Imajo, Koichi Akashi, Takanori Teshima, Takashi Okamura, Koji Nagafuji, Toshihiro Miyamoto, Yuju Ohno, Takahiro Fukuda, Tetsuya Eto, Morio Matsumoto, Hirokazu Okumura, Tohru Murayama, Kazutaka Sunami, Naoki Kobayashi, Naoyuki Uchida, Yoshinobu Kanda, Hideki Tsujimura, Koji Kato, Yasushi Takamatsu, Junichi Sugita, Michihiro Hidaka, Yuichiro Nawa & Mine Harada. (2020) Low-dose anti-thymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplantation 56:1, pages 129-136.
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Joshua Pecoraro & Hillard M. Lazarus. 2021. Blood and Marrow Transplant Handbook. Blood and Marrow Transplant Handbook 153 186 .
Xin Lv, Jiaqian Qi, Meng Zhou, Bingyu Shi, Chengsen Cai, Yaqiong Tang, Tingting Pan & Yue Han. (2020) Comparative efficacy of 20 graft-versus-host disease prophylaxis therapies for patients after hematopoietic stem-cell transplantation: A multiple-treatments network meta-analysis. Critical Reviews in Oncology/Hematology 150, pages 102944.
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Ling Zhou, Zhi-yong Gao & Dao-pei Lu. (2020) Comparison of ATG-thymoglobulin with ATG-Fresenius for Epstein-Barr virus infections and graft-versus-host-disease in patients with hematological malignances after haploidentical hematopoietic stem cell transplantation: a single-center experience. Annals of Hematology 99:6, pages 1389-1400.
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Hassan Issa, Nidhi Sharma, Qiuhong Zhao, Amy S. Ruppert, Patrick Elder, Don M. Benson, Sam Penza, Sumithira Vasu, Basem William, Samantha Jaglowski, Steven M. Devine & Yvonne A. Efebera. (2019) Comparison of Two Doses of Antithymocyte Globulin in Reduced-Intensity Conditioning Allogeneic Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 25:10, pages 1993-2001.
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Lisa V. E. Oostenbrink, Cornelia M. Jol-van der Zijde, Katrine Kielsen, Anja M. Jansen-Hoogendijk, Marianne Ifversen, Klaus G. Müller, Arjan C. Lankester, Astrid G. S. van Halteren, Robbert G. M. Bredius, Marco W. Schilham & Maarten J. D. van Tol. (2019) Differential Elimination of Anti-Thymocyte Globulin of Fresenius and Genzyme Impacts T-Cell Reconstitution After Hematopoietic Stem Cell Transplantation. Frontiers in Immunology 10.
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Lily Yan & Alison Gulbis. 2019. Hematopoietic Cell Transplantation for Malignant Conditions. Hematopoietic Cell Transplantation for Malignant Conditions 37 57 .
Michela Montagna, Giorgio La Nasa, Maria E. Bernardo, Eugenia Piras, Maria A. Avanzini, Mario Regazzi & Franco Locatelli. (2017) A New Enzyme-Linked Immunosorbent Assay for a Total Anti-T Lymphocyte Globulin Determination: Development, Analytical Validation, and Clinical Applications. Therapeutic Drug Monitoring 39:3, pages 282-289.
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Rick Admiraal, Stefan Nierkens, Moniek A de Witte, Eefke J Petersen, Ger-jan Fleurke, Luka Verrest, Svetlana V Belitser, Robbert G M Bredius, Reinier A P Raymakers, Catherijne A J Knibbe, Monique C Minnema, Charlotte van Kesteren, Jurgen Kuball & Jaap J Boelens. (2017) Association between anti-thymocyte globulin exposure and survival outcomes in adult unrelated haemopoietic cell transplantation: a retrospective, pharmacodynamic cohort analysis. The Lancet Haematology 4:4, pages e183-e191.
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Andrea Bacigalupo. (2017) ATG in allogeneic stem cell transplantation: standard of care in 2017? Point. Blood Advances 1:9, pages 569-572.
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R Reshef & D L Porter. (2015) Reduced-intensity conditioned allogeneic SCT in adults with AML. Bone Marrow Transplantation 50:6, pages 759-769.
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Rick Admiraal, Charlotte van Kesteren, Cornelia M Jol-van der Zijde, Arjan C Lankester, Marc B Bierings, Toine C G Egberts, Maarten J D van Tol, Catherijne A J Knibbe, Robbert G M Bredius & Jaap J Boelens. (2015) Association between anti-thymocyte globulin exposure and CD4+ immune reconstitution in paediatric haemopoietic cell transplantation: a multicentre, retrospective pharmacodynamic cohort analysis. The Lancet Haematology 2:5, pages e194-e203.
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Rick Admiraal, Charlotte van Kesteren, Cornelia M. Jol-van der Zijde, Maarten J. D. van Tol, Imke H. Bartelink, Robbert G. M. Bredius, Jaap Jan Boelens & Catherijne A. J. Knibbe. (2014) Population Pharmacokinetic Modeling of Thymoglobulin® in Children Receiving Allogeneic-Hematopoietic Cell Transplantation: Towards Improved Survival Through Individualized Dosing. Clinical Pharmacokinetics 54:4, pages 435-446.
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V Ratanatharathorn, A Deol, L Ayash, S Cronin, D Bhutani, L G Lum, M Abidi, M Ventimiglia, K Mellert & J P Uberti. (2014) Low-dose antithymocyte globulin enhanced the efficacy of tacrolimus and mycophenolate for GVHD prophylaxis in recipients of unrelated SCT. Bone Marrow Transplantation 50:1, pages 106-112.
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Mohamad Mohty, Andrea Bacigalupo, Faouzi Saliba, Andreas Zuckermann, Emmanuel Morelon & Yvon Lebranchu. (2014) New Directions for Rabbit Antithymocyte Globulin (Thymoglobulin®) in Solid Organ Transplants, Stem Cell Transplants and Autoimmunity. Drugs 74:14, pages 1605-1634.
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Roberto Crocchiolo, Benjamin Esterni, Luca Castagna, Sabine Fürst, Jean El-Cheikh, Raynier Devillier, Angela Granata, Claire Oudin, Boris Calmels, Christian Chabannon, Réda Bouabdallah, Norbert Vey & Didier Blaise. (2013) Two days of antithymocyte globulin are associated with a reduced incidence of acute and chronic graft-versus-host disease in reduced-intensity conditioning transplantation for hematologic diseases. Cancer 119:5, pages 986-992.
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Steven Z. Pavletic & Daniel H. Fowler. (2012) Are we making progress in GVHD prophylaxis and treatment?. Hematology 2012:1, pages 251-264.
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Tanya Siddiqi & Didier Blaise. (2012) Does antithymocyte globulin have a place in reduced-intensity conditioning for allogeneic hematopoietic stem cell transplantation?. Hematology 2012:1, pages 246-250.
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Yoshihisa Morishita & Yoshihiro Inamoto. (2012) Management of Chronic Graft-versus-Host Disease 2012. Journal of Hematopoietic Cell Transplantation 1:2, pages 37-51.
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