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Original Articles: Research

Complement dependent cytotoxicity in chronic lymphocytic leukemia: ofatumumab enhances alemtuzumab complement dependent cytotoxicity and reveals cells resistant to activated complement

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Pages 2218-2227 | Received 21 Jan 2012, Accepted 26 Mar 2012, Published online: 21 May 2012

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Yu Fan, Juan Liao, Yu Wang, Zhu Wang, Hong Zheng & Yanping Wang. (2023) miR-132-3p regulates antibody-mediated complement-dependent cytotoxicity in colon cancer cells by directly targeting CD55. Clinical and Experimental Immunology 211:1, pages 57-67.
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Manh-Hung Do, Hien Duong Thanh, Phuong Kim To, Min Soo Kim, Changjong Moon & Chaeyong Jung. (2022) CD46 protects the bladder cancer cells from cetuximab-mediated cytotoxicity. Scientific Reports 12:1.
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Yoonyoung Kim, Yu Seok Youn, Kyung Taek Oh, Dongin Kim & Eun Seong Lee. (2020) Tumor-Targeting Liposomes with Transient Holes Allowing Intact Rituximab Internally. Biomacromolecules 22:2, pages 723-731.
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Clive S. Zent, Jonathan J. Pinney, Charles C. Chu & Michael R. Elliott. (2020) Complement Activation in the Treatment of B-Cell Malignancies. Antibodies 9:4, pages 68.
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Clive S. Zent. (2018) Monoclonal antibody therapy in chronic lymphocytic leukemia. Oncology Signaling 1:1, pages 11-13.
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Erika A.K. Fletcher, Mohamed Eltahir, Frida Lindqvist, Jonas Rieth, Gunilla Törnqvist, Justyna Leja-Jarblad & Sara M. Mangsbo. (2018) Extracorporeal human whole blood in motion, as a tool to predict first-infusion reactions and mechanism-of-action of immunotherapeutics. International Immunopharmacology 54, pages 1-11.
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Ronald P. Taylor & Margaret A. Lindorfer. (2016) Cytotoxic mechanisms of immunotherapy: Harnessing complement in the action of anti-tumor monoclonal antibodies. Seminars in Immunology 28:3, pages 309-316.
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Grzegorz Stasiłojć, Anders Österborg, Anna M. Blom & Marcin Okrój. (2016) New perspectives on complement mediated immunotherapy. Cancer Treatment Reviews 45, pages 68-75.
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Emyr Bakker, Malak Qattan, Luciano Mutti, Constantinos Demonacos & Marija Krstic-Demonacos. (2016) The role of microenvironment and immunity in drug response in leukemia. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:3, pages 414-426.
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A K Church, K R VanDerMeid, N A Baig, A M Baran, T E Witzig, G S Nowakowski & C S Zent. (2016) Anti-CD20 monoclonal antibody-dependent phagocytosis of chronic lymphocytic leukaemia cells by autologous macrophages. Clinical and Experimental Immunology 183:1, pages 90-101.
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Margaret A. Lindorfer, Joost M. Bakker, Paul W.H.I. Parren & Ronald P. Taylor. 2014. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 1733 1774 .
Laura M. Rogers, Suresh Veeramani & George J. Weiner. (2014) Complement in monoclonal antibody therapy of cancer. Immunologic Research 59:1-3, pages 203-210.
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Clive S. Zent, Ronald P. Taylor, Margaret A. Lindorfer, Paul V. Beum, Betsy LaPlant, Wenting Wu, Timothy G. Call, Deborah A. Bowen, Michael J. Conte, Lori A. Frederick, Brian K. Link, Sue E. Blackwell, Suresh Veeramani, Nisar A. Baig, David S. Viswanatha, George J. Weiner & Thomas E. Witzig. (2014) Chemoimmunotherapy for relapsed/refractory and progressive 17p13-deleted chronic lymphocytic leukemia (CLL) combining pentostatin, alemtuzumab, and low-dose rituximab is effective and tolerable and limits loss of CD20 expression by circulating CLL cells. American Journal of Hematology 89:7, pages 757-765.
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Nisar A. Baig, Ronald P. Taylor, Margaret A. Lindorfer, Amy K. Church, Betsy R. LaPlant, Adam M. Pettinger, Tait D. Shanafelt, Grzegorz S. Nowakowski & Clive S. Zent. (2014) Induced Resistance to Ofatumumab-Mediated Cell Clearance Mechanisms, Including Complement-Dependent Cytotoxicity, in Chronic Lymphocytic Leukemia. The Journal of Immunology 192:4, pages 1620-1629.
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Ronald P. Taylor & Margaret A. Lindorfer. (2014) The role of complement in mAb-based therapies of cancer. Methods 65:1, pages 18-27.
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Giuseppe TridenteGiuseppe Tridente. 2014. Adverse Events with Biomedicines. Adverse Events with Biomedicines 281 289 .
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Shundong Cang, Nikhil Mukhi, Kemeng Wang & Delong Liu. (2012) Novel CD20 monoclonal antibodies for lymphoma therapy. Journal of Hematology & Oncology 5:1.
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