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Research Article

JAK2V617F allele burden is associated with transformation to myelofibrosis

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Pages 2210-2213 | Received 04 Nov 2011, Accepted 30 Mar 2012, Published online: 21 May 2012

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Jaspal Kaeda, Martin Bonamino, Jackline Ayres-Silva, Cristiana Solza, Frauke Ringel, Olga Blau, Ademo Daumas, Christian Oberender, Bernd Dörken, Philipp le Coutre & Ilana Zalcberg. (2014) JAK2 V617F allele burden quantified by real time quantitative polymerase chain reaction and competitive polymerase chain reaction in patients with chronic myeloproliferative neoplasia. Leukemia & Lymphoma 55:1, pages 128-135.
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Emina Babarović, Blažen Marijić, Luka Vranić, Josipa Ban, Toni Valković & Ita Hadžisejdić. (2023) A Comparison of Bone Marrow Morphology and Peripheral Blood Findings in Low and High Level JAK2 V617F Allele Burden. Diagnostics 13:12, pages 2086.
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Wenjing Gu, Yuhui Zhang, Ting Sun, Mankai Ju, Xiaofan Liu, Feng Xue, Yunfei Chen, Wei Liu, Huiyuan Li, Wentian Wang, Ying Chi, Renchi Yang, Rongfeng Fu, Jie Bai & Lei Zhang. (2023) Prediction of thrombosis in polycythemia vera: Development and validation of a multiple factor-based prognostic score system. Research and Practice in Thrombosis and Haemostasis 7:3, pages 100132.
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Kunihito Arai, Masahiro Sakaguchi, Shunsuke Yui, Tomoaki Kitano, Miho Miyata, Mayumi Yogosawa, Kazutaka Nakayama, Kenji Tajika, Kensuke Usuki, Junya Kuroda, Nobuhiko Uoshima, Yutaka Kobayashi, Hitoji Uchiyama, Yasushi Kubota, Shinya Kimura, Shinichiro Mori, Mitsuharu Hirai, Satoshi Wakita & Hiroki Yamaguchi. (2022) Simultaneous detection of JAK2 , CALR , and MPL mutations and quantitation of JAK2 V617F allele burden in myeloproliferative neoplasms using the quenching probe‐Tm method in i‐densy IS ‐5320 . International Journal of Laboratory Hematology 44:6, pages 1102-1110.
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Jaskamal Padda, Khizer Khalid, Jayant Yadav, Abdulelah H Almanie, Krutagni Adwait Mehta, Hussam Al Hennawi, Nymisha L Boddeti, Victor Yosef Melt Campos & Gutteridge Jean-Charles. (2021) JAK2 and TET2 Mutation in Polycythemia Vera. Cureus.
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Francesco La Rocca, Vitina Grieco, Vitalba Ruggieri, Emanuela Zifarone, Oreste Villani, Pietro Zoppoli, Sabino Russi, Simona Laurino, Geppino Falco, Giovanni Calice, Anna Marinaccio, Maria Iole Natalicchio, Francesco Albano & Pellegrino Musto. (2020) Superiority of Droplet Digital PCR Over Real-Time Quantitative PCR for JAK2 V617F Allele Mutational Burden Assessment in Myeloproliferative Neoplasms: A Retrospective Study. Diagnostics 10:3, pages 143.
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Giuseppe A. Palumbo, Stefania Stella, Maria Stella Pennisi, Cristina Pirosa, Elisa Fermo, Sonia Fabris, Daniele Cattaneo & Alessandra Iurlo. (2019) The Role of New Technologies in Myeloproliferative Neoplasms. Frontiers in Oncology 9.
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Dorota Link-Lenczowska, Niels Pallisgaard, Sabrina Cordua, Magdalena Zawada, Sylwia Czekalska, Dorota Krochmalczyk, Zuzanna Kanduła & Tomasz Sacha. (2018) A comparison of qPCR and ddPCR used for quantification of the JAK2 V617F allele burden in Ph negative MPNs. Annals of Hematology 97:12, pages 2299-2308.
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Yen-Chien Lee, Chung-Cheng Hsieh, Yen-Ling Lee & Chung-Yi Li. (2018) Molecular Markers and Prognosis of Myelofibrosis in the Genomic Era: A Meta-analysis. Clinical Lymphoma Myeloma and Leukemia 18:9, pages 558-568.
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Eunyoung Lee, Kyoung Joo Lee, Hyein Park, Jin Young Chung, Mi-Na Lee, Myung Hee Chang, Jongha Yoo, Hyewon Lee, Sun-Young Kong & Hyeon-Seok Eom. (2018) Clinical Implications of Quantitative JAK2 V617F Analysis using Droplet Digital PCR in Myeloproliferative Neoplasms . Annals of Laboratory Medicine 38:2, pages 147-154.
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Elena Kinz & Axel Muendlein. 2018. Digital PCR. Digital PCR 257 273 .
Hua Wang, Xinju zhang, Xiao Xu, Qunfeng Zhang, Hengliang Wang, Dong Li, Zhihua Kang, Zhiyuan Wu, Yigui Tang, Zhenhua An & Ming Guan. (2017) A portable microfluidic platform for rapid molecular diagnostic testing of patients with myeloproliferative neoplasms. Scientific Reports 7:1.
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G. Fontanelli, C. Baratè, E. Ciabatti, F. Guerrini, S. Grassi, M. Del Re, R. Morganti, I. Petrini, R. Arici, S. Barsotti, M. R. Metelli, R. Danesi & S. Galimberti. (2015) Real-Time PCR and Droplet Digital PCR: two techniques for detection of the JAK2 V617F mutation in Philadelphia-negative chronic myeloproliferative neoplasms . International Journal of Laboratory Hematology 37:6, pages 766-773.
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Brady L. SteinStephen T. OhDmitriy BerenzonGabriela S. HobbsMarina KremyanskayaRaajit K. RampalCamille N. AbboudKenneth AdlerMark L. HeaneyElias J. JabbourRami S. KomrokjiAlison R. MoliternoEllen K. RitchieLawrence RiceJohn MascarenhasRonald Hoffman. (2015) Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F . Journal of Clinical Oncology 33:33, pages 3953-3960.
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E. Kinz, A. Leiherer, A. H. Lang, H. Drexel & A. Muendlein. (2015) Accurate quantitation of JAK2 V617F allele burden by array-based digital PCR. International Journal of Laboratory Hematology 37:2, pages 217-224.
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Shuichi Shirane, Marito Araki, Soji Morishita, Yoko Edahiro, Yoshitaka Sunami, Yumi Hironaka, Masaaki Noguchi, Michiaki Koike, Eriko Sato, Akimichi Ohsaka & Norio Komatsu. (2014) Consequences of the JAK2V617F allele burden for the prediction of transformation into myelofibrosis from polycythemia vera and essential thrombocythemia. International Journal of Hematology 101:2, pages 148-153.
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Axel Muendlein, Klaus Gasser, Elena Kinz, Nicole Stark, Andreas Leiherer, Philipp Rein, Christoph H. Saely, Harald Grallert, Annette Peters, Heinz Drexel & Alois H. Lang. (2014) Evaluation of the prevalence and prospective clinical impact of the JAK2 V617F mutation in coronary patients . American Journal of Hematology 89:3, pages 295-301.
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