Advanced search
Publication Cover
Leukemia & Lymphoma Volume 53, 2012 - Issue 12
Submit an article Journal homepage
234
Views
41
CrossRef citations to date
0
Altmetric
Research Article

Novel function of scutellarin in inhibiting cell proliferation and inducing cell apoptosis of human Burkitt lymphoma Namalwa cells

Yizhong FengCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China;The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Shasha ZhangCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Jian TuCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Zhifei CaoCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Yanyan PanCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Bingxue ShangCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Ruifang LiuCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Meimei BaoCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
,
Pengda GuoCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China
&
Quansheng ZhouCyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, China;Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Soochow University, Suzhou, Jiangsu, ChinaCorrespondence[email protected]
 show all
Pages 2456-2464 | Received 02 Jan 2012, Accepted 08 May 2012, Published online: 07 Jun 2012

Citations (41)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Xinran Wang, Cai Zhang, Ning Han, Juyuan Luo, Shuofeng Zhang, Chunguo Wang, Zhanhong Jia & Shouying Du. (2021) Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism. Drug Delivery 28:1, pages 1664-1672.
Read now
Shi-lei Tang, Yuan-lin Gao & Wen-zhong Hu. (2019) Scutellarin inhibits the metastasis and cisplatin resistance in glioma cells. OncoTargets and Therapy 12, pages 587-598.
Read now

Articles from other publishers (39)

Shadi Vesaghhamedani, Seyedeh Shabnam Mazloumi Kiapey, Arezoo Gowhari Shabgah, Sedigheh Amiresmaili, Abbas Jahanara, Maziar Oveisee, Aliakbar Shekarchi, Seyed Mohammad Gheibihayat, Farhad Jadidi-Niaragh & Jamshid Gholizadeh Navashenaq. (2023) From traditional medicine to modern oncology: Scutellarin, a promising natural compound in cancer treatment. Progress in Biophysics and Molecular Biology 180-181, pages 19-27.
Crossref
Natalie Vivien Gunter & Siau Hui Mah. 2023. Handbook of Dietary Flavonoids. Handbook of Dietary Flavonoids 1 73 .
Minhua Teng, Xiao Yuan, Dashan Wang, Hui Gao, Kaiyue Zhang, Wenxue Wang & Baodong Zhao. (2022) Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats. Stem Cells International 2022, pages 1-10.
Crossref
Tong Han, Chunyu Jiang, Xing Wei, Meilin Sheng, Qin Xie, Jiqiang Zhang, Yongyi Zhang & Chenghao Jin. (2022) Design, synthesis of amide derivatives of scutellarin and their antileukemia and neuroprotective activities. Medicinal Chemistry Research 31:6, pages 905-915.
Crossref
Markandan Birundadevi, Rangasamy Sivashankar & Sivagnanam Mathukumar. (2022) Scutellarein apoptosis mediated by mitochondria in oral squamous cell carcinomas. Biomedical and Biotechnology Research Journal (BBRJ) 6:1, pages 60.
Crossref
Rui-Ze Niu, Liu-Lin Xiong, Hao-Li Zhou, Lu-Lu Xue, Qing-Jie Xia, Zheng Ma, Yuan Jin, Li Chen, Ya Jiang, Ting-Hua Wang & Jia Liu. (2021) Scutellarin ameliorates neonatal hypoxic-ischemic encephalopathy associated with GAP43-dependent signaling pathway. Chinese Medicine 16:1.
Crossref
Hua Fan, Peng Lin, Qiang Kang, Zhi-Long Zhao, Ji Wang & Jia-Yi Cheng. (2021) Metabolism and Pharmacological Mechanisms of Active Ingredients in Erigeron breviscapus. Current Drug Metabolism 22:1, pages 24-39.
Crossref
怡萍 李. (2021) Research Progress on the Anti-Tumor Mechanism of Scutellarin. Traditional Chinese Medicine 10:01, pages 101-106.
Crossref
Liu-Lin Xiong, Ya-Xin Tan, Ruo-Lan Du, Yuan Peng, Lu-Lu Xue, Jia Liu, Mohammed Al-Hawwas, Larisa Bobrovskaya, Dong-Hui Liu, Li Chen, Ting-Hua Wang & Xin-Fu Zhou. (2021) Effect of Sutellarin on Neurogenesis in Neonatal Hypoxia–Ischemia Rat Model: Potential Mechanisms of Action. The American Journal of Chinese Medicine 49:03, pages 677-703.
Crossref
Yiyu Wang, Xiaoming Fan, Biao Fan, Kerong Jiang, Haoxin Zhang, Feng Kang, Hui Su, Danshan Gu, Shude Li & Shaofang Lin. (2020) Scutellarin Reduce the Homocysteine Level and Alleviate Liver Injury in Type 2 Diabetes Model. Frontiers in Pharmacology 11.
Crossref
Liu-Lin Xiong, Ruo-Lan Du, Lu-Lu Xue, Ya Jiang, Jin Huang, Li Chen, Jia Liu & Ting-Hua Wang. (2020) Anti-colorectal cancer effects of scutellarin revealed by genomic and proteomic analysis. Chinese Medicine 15:1.
Crossref
Jiwei Ye, Mingquan Gao, Xinwu Guo, Henan Zhang & Fuchun Jiang. (2020) Breviscapine suppresses the growth and metastasis of prostate cancer through regulating PAQR4-mediated PI3K/Akt pathway. Biomedicine & Pharmacotherapy 127, pages 110223.
Crossref
Lingchong Wang, Dapeng Zhang, Ning Wang, Sha Li, Hor-Yue Tan & Yibin Feng. (2019) Polyphenols of Chinese skullcap roots: from chemical profiles to anticancer effects. RSC Advances 9:44, pages 25518-25532.
Crossref
Pikun Cao, Bin Liu, Feng Du, Dong Li, Yongzheng Wang, Xiaoyan Yan, Xiao Li & Yuliang Li. (2019) Scutellarin suppresses proliferation and promotes apoptosis in A549 lung adenocarcinoma cells via AKT/mTOR/4EBP1 and STAT3 pathways. Thoracic Cancer 10:3, pages 492-500.
Crossref
Xiu-Ying He, Liu-Lin Xiong, Qing-Jie Xia, Yang-Yang Wang, Xiao-Ming Zhao, Ruo-Lan Du, Jin Huang, Xiao-Qiong He, Jia-Liu & Ting-Hua Wang. (2019) C 18 H 17 NO 6 and Its Combination with Scutellarin Suppress the Proliferation and Induce the Apoptosis of Human Glioma Cells via Upregulation of Fas-Associated Factor 1 Expression . BioMed Research International 2019, pages 1-20.
Crossref
Wenting Deng, Wei Han, Tao Fan, Xiaoku Wang, Zhao Cheng, Bo Wan & Jinlian Chen. (2018) Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomedicine & Pharmacotherapy 107, pages 1505-1513.
Crossref
Liping Wang & Qiang Ma. (2018) Clinical benefits and pharmacology of scutellarin: A comprehensive review. Pharmacology & Therapeutics 190, pages 105-127.
Crossref
Tong Han, Yan Wang, Mingying Wang, Xu Li, Keguang Cheng, Xiang Gao, Zhanlin Li, Jiao Bai, Huiming Hua & Dahong Li. (2018) Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway. European Journal of Medicinal Chemistry 158, pages 493-501.
Crossref
Juan Nie, Hong-Mei Yang, Chao-Yue Sun, Yan-Lu Liu, Jian-Yi Zhuo, Zhen-Biao Zhang, Xiao-Ping Lai, Zi-Ren Su & Yu-Cui Li. (2018) Scutellarin Enhances Antitumor Effects and Attenuates the Toxicity of Bleomycin in H22 Ascites Tumor-Bearing Mice. Frontiers in Pharmacology 9.
Crossref
Sebastian Chledzik, Jakub Strawa, Katarzyna Matuszek & Jolanta Nazaruk. (2018) Pharmacological Effects of Scutellarin, An Active Component of Genus Scutellaria and Erigeron : A Systematic Review . The American Journal of Chinese Medicine 46:02, pages 319-337.
Crossref
Lin You, Hong Zhu, Chun Wang, Fang Wang, Yongjun Li, Yan Li, Yonglin Wang & Bin He. (2017) Scutellarin inhibits Hela cell growth and glycolysis by inhibiting the activity of pyruvate kinase M2. Bioorganic & Medicinal Chemistry Letters 27:24, pages 5404-5408.
Crossref
Ping Yang, Fulu Dong & Quansheng Zhou. (2017) Triptonide acts as a novel potent anti-lymphoma agent with low toxicity mainly through inhibition of proto-oncogene Lyn transcription and suppression of Lyn signal pathway. Toxicology Letters 278, pages 9-17.
Crossref
Tong Han, Jia Li, Jingjing Xue, He Li, Fanxing Xu, Keguang Cheng, Dahong Li, Zhanlin Li, Ming Gao & Huiming Hua. (2017) Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation. European Journal of Medicinal Chemistry 135, pages 270-281.
Crossref
Yang Ke, Tianhao Bao, Xuesong Wu, Haoran Tang, Yan Wang, Jiayun Ge, Bimang Fu, Xu Meng, Li Chen, Cheng Zhang, Yuqi Tan, Haotian Chen, Zhitang Guo, Fan Ni, Xuefen Lei, Zhitian Shi, Dong Wei & Lin Wang. (2017) Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity. Biochemical and Biophysical Research Communications 483:1, pages 509-515.
Crossref
Ning Yang, Yuying Zhao, Zhipeng Wang, Yu Liu & Yanqiao Zhang. (2016) Scutellarin suppresses growth and causes apoptosis of human colorectal cancer cells by regulating the p53 pathway. Molecular Medicine Reports.
Crossref
Yun Yuan, Ming Fang, Chun-Yun Wu & Eng-Ang Ling. (2016) Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. NeuroMolecular Medicine 18:3, pages 264-273.
Crossref
Nana Zheng, Zihe Huo, Bin Zhang, Mei Meng, Zhifei Cao, Zhiwei Wang & Quansheng Zhou. (2016) Thrombomodulin reduces tumorigenic and metastatic potential of lung cancer cells by up-regulation of E-cadherin and down-regulation of N-cadherin expression. Biochemical and Biophysical Research Communications 476:4, pages 252-259.
Crossref
Yinghui Huang, Jie Zhou, Yan Huang, Jintao He, Yuting Wang, Chaohui Yang, Dongbo Liu, Li Zhang & Fengtian He. (2016) SARI , a novel target gene of glucocorticoid receptor, plays an important role in dexamethasone-mediated killing of B lymphoma cells. Cancer Letters 373:1, pages 57-66.
Crossref
Jun He, Longsheng Du, Meimei Bao, Bin Zhang, Haixin Qian, Quansheng Zhou & Zhifei Cao. (2016) Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence. Anti-Cancer Drugs 27:3, pages 204-215.
Crossref
Ping Yang, Shilong Fu, Zhifei Cao, Huaidong Liao, Zihe Huo, Yanyan Pan, Gaochuan Zhang, Aidi Gao & Quansheng Zhou. (2015) Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicology and Applied Pharmacology 288:2, pages 269-279.
Crossref
Katrin Sak & Hele Everaus. (2015) Multi-Target Cytotoxic Actions of Flavonoids in Blood Cancer Cells. Asian Pacific Journal of Cancer Prevention 16:12, pages 4843-4847.
Crossref
Chengwei Niu, Yuchen Sheng, Rui Yang, Bin Lu, Qingyun Bai, Lili Ji & Zhengtao Wang. (2015) Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. Journal of Ethnopharmacology 164, pages 301-308.
Crossref
Xiaohua Du, Chen Chen, Min Zhang, Donghua Cai, Jiaqi Sun, Jian Yang, Na Hu, Congji Ma, Liyan Zhang, Jun Zhang & Weimin Yang. (2015) Scutellarin Reduces Endothelium Dysfunction through the PKG-I Pathway. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-12.
Crossref
Yong-Long Han, Dan Li, Quan-Jun Yang, Zhi-Yong Zhou, Li-Ya Liu, Bin Li, Jin Lu & Cheng Guo. (2014) In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein. Molecules 19:5, pages 5748-5760.
Crossref
Di Yu, Shilong Fu, Zhifei Cao, Meimei Bao, Gaochuan Zhang, Yanyan Pan, Wenming Liu & Quansheng Zhou. (2014) Unraveling the novel anti-osteosarcoma function of coptisine and its mechanisms. Toxicology Letters 226:3, pages 328-336.
Crossref
Ruifang Liu, Zhifei Cao, Yanyan Pan, Gaochuan Zhang, Ping Yang, Pengda Guo & Quansheng Zhou. (2013) Jatrorrhizine hydrochloride inhibits the proliferation and neovascularization of C8161 metastatic melanoma cells. Anti-Cancer Drugs 24:7, pages 667-676.
Crossref
Zhifei Cao, Di Yu, Shilong Fu, Gaochuan Zhang, Yanyan Pan, Meimei Bao, Jian Tu, Bingxue Shang, Pengda Guo, Ping Yang & Quansheng Zhou. (2013) Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology Letters 218:2, pages 174-185.
Crossref
Jinhua Zheng. (2013) Scutellarin inhibits the growth and invasion of human tongue squamous carcinoma through the inhibition of matrix metalloproteinase-2 and -9 and αvβ6 integrin. International Journal of Oncology.
Crossref
Meimei Bao, Zhifei Cao, Di Yu, Shilong Fu, Gaochuan Zhang, Ping Yang, Yanyan Pan, Bo Yang, Hongyan Han & Quansheng Zhou. (2012) Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity. Toxicology Letters 215:3, pages 174-180.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.