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Review Article

Targeting the B cell receptor pathway in chronic lymphocytic leukemia

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Pages 2362-2370 | Received 11 Apr 2012, Accepted 16 May 2012, Published online: 23 May 2012

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Jessica A. Gasser, Hiroyuki Inuzuka, Alan W. Lau, Wenyi Wei, Rameen Beroukhim & Alex Toker. (2014) SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer. Molecular Cell 56:4, pages 595-607.
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Amin Aalipour & Ranjana H. Advani. (2014) Bruton’s tyrosine kinase inhibitors and their clinical potential in the treatment of B-cell malignancies: focus on ibrutinib. Therapeutic Advances in Hematology 5:4, pages 121-133.
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Freda K. Stevenson, Francesco Forconi & Graham Packham. (2014) The Meaning and Relevance of B-Cell Receptor Structure and Function in Chronic Lymphocytic Leukemia. Seminars in Hematology 51:3, pages 158-167.
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Matthew S. Davids. (2014) Boldly Targeting Kinases without mutations. Blood 123:8, pages 1119-1121.
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Jennifer R Brown. (2014) A new era of treatment for chronic lymphocytic leukaemia?. The Lancet Oncology 15:1, pages 3-5.
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Carsten U. Niemann & Adrian Wiestner. (2013) B-cell receptor signaling as a driver of lymphoma development and evolution. Seminars in Cancer Biology 23:6, pages 410-421.
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Amin Aalipour & Ranjana H. Advani. (2013) Bruton tyrosine kinase inhibitors: a promising novel targeted treatment for B cell lymphomas. British Journal of Haematology 163:4, pages 436-443.
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P Oppezzo & G Dighiero. (2013) “Role of the B-cell receptor and the microenvironment in chronic lymphocytic leukemia’’. Blood Cancer Journal 3:9, pages e149-e149.
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Antonino Carbone & Anas YounesPiers EM PattenCharles C ChuNicholas Chiorazzi. 2013. Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies. Non-Hodgkin Lymphomas: Advanced Diagnostics & Personalized Therapies 196 214 .
Yair Herishanu, Ben-Zion Katz, Andrew Lipsky & Adrian Wiestner. (2013) Biology of Chronic Lymphocytic Leukemia in Different Microenvironments. Hematology/Oncology Clinics of North America 27:2, pages 173-206.
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Jennifer R. Brown. (2013) Ibrutinib (PCI-32765), the First BTK (Bruton’s Tyrosine Kinase) Inhibitor in Clinical Trials. Current Hematologic Malignancy Reports 8:1, pages 1-6.
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Dan A Landau & Catherine J Wu. (2013) Chronic lymphocytic leukemia: molecular heterogeneity revealed by high-throughput genomics. Genome Medicine 5:5, pages 47.
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Valentina Audrito, Tiziana Vaisitti, Sara Serra, Cinzia Bologna, Davide Brusa, Fabio Malavasi & Silvia Deaglio. (2013) Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options. Cancer Letters 328:1, pages 27-35.
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Rita Shaknovich. 2013. Advances in Chronic Lymphocytic Leukemia. Advances in Chronic Lymphocytic Leukemia 133 150 .
Carsten U. Niemann, Jade Jones & Adrian Wiestner. 2013. Advances in Chronic Lymphocytic Leukemia. Advances in Chronic Lymphocytic Leukemia 259 291 .

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