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Research Article

Hypoxia-inducible factor-1α expression indicates poor prognosis in myelodysplastic syndromes

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Pages 2412-2418 | Received 17 Mar 2012, Accepted 20 May 2012, Published online: 18 Jun 2012

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Kevin Rouault-Pierre, Ashley Hamilton & Dominique Bonnet. (2016) Effect of hypoxia-inducible factors in normal and leukemic stem cell regulation and their potential therapeutic impact. Expert Opinion on Biological Therapy 16:4, pages 463-476.
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Harold Elias & Amit Verma. (2012) Activation of hypoxia signaling is marker of poor prognosis in myelodysplasia. Leukemia & Lymphoma 53:12, pages 2337-2338.
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Beibei Qu, Xiuhua Han, Lan Zhao, Feifei Zhang & Qingmei Gao. (2022) Relationship of HIF‑1α expression with apoptosis and cell cycle in bone marrow mesenchymal stem cells from patients with myelodysplastic syndrome. Molecular Medicine Reports 26:1.
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Paige Dausinas Ni, Christopher Basile, Chase Junge, Melissa Hartman & Heather A. O’Leary. (2022) Hypoxia and Hematopoiesis. Current Stem Cell Reports 8:1, pages 24-34.
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Di Zhan & Christopher Y. Park. (2021) Stem Cells in the Myelodysplastic Syndromes. Frontiers in Aging 2.
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Jiaxin Hu, Fanqiao Meng, Xian Hu, Lei Huang, Hui Liu, Zhaoyun Liu & Lijuanli Li. (2020) Iron overload regulate the cytokine of mesenchymal stromal cells through ROS/HIF-1α pathway in Myelodysplastic syndromes. Leukemia Research 93, pages 106354.
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Hai‐wei Liang, Bin Luo, Li‐hua Du, Rong‐quan He, Gang Chen, Zhi‐gang Peng & Jie Ma. (2019) Expression significance and potential mechanism of hypoxia‐inducible factor 1 alpha in patients with myelodysplastic syndromes. Cancer Medicine 8:13, pages 6021-6035.
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Paolo Alberto Lorenzini, Resilind Su Ern Chew, Cheryl Weiqi Tan, Jing Yen Yong, Fan Zhang, Jie Zheng & Xavier Roca. (2019) Human PRPF40B regulates hundreds of alternative splicing targets and represses a hypoxia expression signature. RNA 25:8, pages 905-920.
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Zhaoyun Liu, Mengyue Tian, Kai Ding, Hui Liu, Yangyang Wang & Rong Fu. (2019) High expression of PIM2 induces HSC proliferation in myelodysplastic syndromes via the IDH1/HIF1‑α signaling pathway. Oncology Letters.
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Niraj Shenoy, Mythri Mudireddy, Rangit Vallapureddy, Nelson Leung, Lance Pagliaro, Thomas Witzig, Fang-Shu Ou, Tamas Ordog, John Cheville, Mrinal Patnaik, R. Houston Thompson, Ayalew Tefferi & Kebede Begna. (2018) Association Between Renal Cell Carcinoma and Myelodysplastic Syndromes: Epigenetic Underpinning?. Clinical Genitourinary Cancer 16:6, pages e1117-e1122.
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L Schito, S Rey & M Konopleva. (2017) Integration of hypoxic HIF-α signaling in blood cancers. Oncogene 36:38, pages 5331-5340.
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Qing-qing Zheng, You-shan Zhao, Juan Guo, Si-da Zhao, Lu-xi Song, Cheng-ming Fei, Zheng Zhang, Xiao Li & Chun-kang Chang. (2017) Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome. Leukemia Research 58, pages 55-62.
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Christos K. Kontos, Sotirios G. Papageorgiou, Marios A. Diamantopoulos, Andreas Scorilas, Efthimia Bazani, Diamantina Vasilatou, Konstantinos Gkontopoulos, Eirini Glezou, Georgia Stavroulaki, George Dimitriadis & Vasiliki Pappa. (2017) mRNA overexpression of the hypoxia inducible factor 1 alpha subunit gene (HIF1A): An independent predictor of poor overall survival in chronic lymphocytic leukemia. Leukemia Research 53, pages 65-73.
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Na Wang, Fei Wang, Ningning Shan, Xiaohui Sui & Hongzhi Xu. (2017) IDH1 Mutation Is an Independent Inferior Prognostic Indicator for Patients with Myelodysplastic Syndromes. Acta Haematologica 138:3, pages 143-151.
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Laura Guerenne, Stéphanie Beurlet, Mohamed Said, Petra Gorombei, Carole Le Pogam, Fabien Guidez, Pierre de la Grange, Nader Omidvar, Valérie Vanneaux, Ken Mills, Ghulam J Mufti, Laure Sarda-Mantel, Maria Elena Noguera, Marika Pla, Pierre Fenaux, Rose Ann Padua, Christine Chomienne & Patricia Krief. (2016) GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways. Journal of Hematology & Oncology 9:1.
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Margaux Deynoux, Nicola Sunter, Olivier Hérault & Frédéric Mazurier. (2016) Hypoxia and Hypoxia-Inducible Factors in Leukemias. Frontiers in Oncology 6.
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Ali N. Chamseddine, Elias Jabbour, Hagop M. Kantarjian, Zachary S. Bohannan & Guillermo Garcia-Manero. (2015) Unraveling Myelodysplastic Syndromes: Current Knowledge and Future Directions. Current Oncology Reports 18:1.
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Erinn B. Rankin, Anupama Narla, Joseph K. Park, Shuo Lin & Kathleen M. Sakamoto. (2015) Biology of the bone marrow microenvironment and myelodysplastic syndromes. Molecular Genetics and Metabolism 116:1-2, pages 24-28.
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Jose F. Falantes, Pablo Trujillo, Jose I. Piruat, Cristina Calder?n, Francisco J. M?rquez-Malaver, Beatriz Mart?n-Antonio, Africa Mill?n, Marina G?mez, Jose Gonz?lez, Maria L. Martino, Isabel Montero, Roc?o Parody, Ildefonso Espigado, Alvaro Urbano-Ispizua & Jose A. P?rez-Sim?n. (2015) Overexpression of GYS1, MIF, and MYC Is Associated With Adverse Outcome and Poor Response to Azacitidine in Myelodysplastic Syndromes and Acute Myeloid Leukemia. Clinical Lymphoma Myeloma and Leukemia 15:4, pages 236-244.
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Jie Jin, Chao Hu, Mengxia Yu, Feifei Chen, Li Ye, Xiufeng Yin, Zhengping Zhuang & Hongyan Tong. (2014) Prognostic Value of Isocitrate Dehydrogenase Mutations in Myelodysplastic Syndromes: A Retrospective Cohort Study and Meta-Analysis. PLoS ONE 9:6, pages e100206.
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Deniz Gezer, Milica Vukovic, Tomoyoshi Soga, Patrick J. Pollard & Kamil R. Kranc. (2014) Concise Review: Genetic Dissection of Hypoxia Signaling Pathways in Normal and Leukemic Stem Cells. Stem Cells 32:6, pages 1390-1397.
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Sergio Manzetti & Oergis Tzamneti. (2013) Hypoxia-induced signaling and its relevance in discovering biomarkers for cancer research. Biomarkers and Genomic Medicine 5:4, pages 135-141.
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