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Leukemia & Lymphoma Volume 53, 2012 - Issue 11
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Research Article

Heat shock protein-90 inhibitor, NVP-AUY922, is effective in combination with fludarabine against chronic lymphocytic leukemia cells cultured on CD40L-stromal layer and inhibits their activated/proliferative phenotype

O. Giles BestNorthern Blood Research Centre, Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia;CLL Australian Research ConsortiumCorrespondence[email protected]
&
Stephen P. MulliganNorthern Blood Research Centre, Kolling Institute, Royal North Shore Hospital, St Leonards, Sydney, NSW, Australia;CLL Australian Research Consortium
Pages 2314-2320 | Received 14 May 2012, Accepted 19 May 2012, Published online: 09 Jul 2012

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Claire E Bocchini, Moses M Kasembeli, Soung-Hun Roh & David J Tweardy. (2014) Contribution of chaperones to STAT pathway signaling. JAK-STAT 3:3.
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Chun-Xia He, You Lv, Meng Guo, Huan Zhou, Wei Qin, Dong Zhao, Hui-Jin Li, Lu Xing, Xin Zhou, Peng-Quan Li, Feng Yu, Jian-Hua He & Hui-Ling Cao. (2022) Complex Crystal Structure Determination of Hsp90N-NVP-AUY922 and In Vitro Anti-NSCLC Activity of NVP-AUY922. Frontiers in Oncology 12.
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Zarema Albakova, Yana Mangasarova & Alexander Sapozhnikov. (2021) Heat Shock Proteins in Lymphoma Immunotherapy. Frontiers in Immunology 12.
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Thu-Huyen Pham, Hyo-Min Park, Jinju Kim, Jin Tae Hong & Do-Young Yoon. (2020) STAT3 and p53: Dual Target for Cancer Therapy. Biomedicines 8:12, pages 637.
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Timothy L. Chen, Nikhil Gupta, Amy Lehman, Amy S. Ruppert, Lianbo Yu, Christopher C. Oakes, Rainer Claus, Christoph Plass, Kami J. Maddocks, Leslie Andritsos, Jeffery A. Jones, David M. Lucas, Amy J. Johnson, John C. Byrd & Erin Hertlein. (2016) Hsp90 inhibition increases SOCS3 transcript and regulates migration and cell death in chronic lymphocytic leukemia. Oncotarget 7:19, pages 28684-28696.
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Torunn Wendel, Yan Zhen, Zenhe Suo, Skjalg Bruheim & Antoni Wiedlocha. (2016) The novel HSP90 inhibitor NVP-AUY922 shows synergistic anti-leukemic activity with cytarabine in vivo. Experimental Cell Research 340:2, pages 220-226.
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Ana E Rodríguez-Vicente, Dalia Quwaider, Rocío Benito, Irena Misiewicz-Krzeminska, María Hernández-Sánchez, Alfonso García de Coca, Rosa Fisac, José-María Alonso, Carolina Zato, Juan Francisco de Paz, Juan Luis García, Ma Eugenia Sarasquete, José Ángel Hernández, Juan M Corchado, Marcos González, Norma C Gutiérrez & Jesús-María Hernández-Rivas. (2015) MicroRNA-223 is a novel negative regulator of HSP90B1 in CLL. BMC Cancer 15:1.
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Zuzana Sol�rov�, J�n Mojžiš & Peter Sol�r. (2014) Hsp90 inhibitor as a sensitizer of cancer cells to different therapies (Review). International Journal of Oncology.
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Si-Meng Chen, Chen-Liang Guo, Jia-Jie Shi, Yi-Chao Xu, Yi Chen, Yan-Yan Shen, Yi Su, Jian Ding & Ling-Hua Meng. (2014) HSP90 inhibitor AUY922 abrogates up-regulation of RTKs by mTOR inhibitor AZD8055 and potentiates its antiproliferative activity in human breast cancer. International Journal of Cancer 135:10, pages 2462-2474.
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Martin Trbusek & Jitka Malcikova. 2013. Advances in Chronic Lymphocytic Leukemia. Advances in Chronic Lymphocytic Leukemia 109 131 .

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