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Leukemia & Lymphoma Volume 54, 2013 - Issue 4
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Research Article

Mechanism of the antitumoral activity of deferasirox, an iron chelation agent, on mantle cell lymphoma

Liat Vazana-BaradDepartment of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
,
Galit GranotFelsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Israel
,
Rahav Mor-TzuntzFelsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Israel
,
Itai LeviInstitute of Hematology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
,
Martin DreylingDepartment of Internal Medicine III, Klinikum der Universität München, Campus Grosshadern, Germany
,
Ilana NathanDepartment of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel;Institute of Hematology, Soroka University Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
&
Ofer ShpilbergFelsenstein Medical Research Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, Israel;Institute of Hematology, Davidoff Cancer Center, Beilinson Hospital, Sackler School of Medicine, Tel Aviv University, IsraelCorrespondence[email protected]
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Pages 851-859 | Received 12 Jun 2012, Accepted 23 Sep 2012, Published online: 02 Jan 2013

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Louise Kostos, Khai Li Chai, Constantine S. Tam & Ali Bazargan. (2017) The positive effect of deferasirox on erythropoiesis in a patient with a dual diagnosis of myelofibrosis and diffuse large B-cell lymphoma. Leukemia & Lymphoma 58:11, pages 2720-2723.
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Joy Benadiba, Celia Rosilio, Marielle Nebout, Vera Heimeroth, Zouhour Neffati, Alexandra Popa, Didier Mary, Emmanuel Griessinger, Véronique Imbert, Nicolas Sirvent & Jean-François Peyron. (2017) Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia/lymphoma. Leukemia & Lymphoma 58:6, pages 1433-1445.
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Articles from other publishers (18)

Yasushi Nakai, Yoshihiro Tatsumi, Shunta Hori, Yosuke Morizawa, Kota Iida, Kenta Onishi, Makito Miyake, Yuki Oda, Takuya Owari, Tomomi Fujii, Sayuri Onishi, Nobumichi Tanaka & Kiyohide Fujimoto. (2022) 5‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis. Oncology Reports 48:4.
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Julie Devin, Tatiana Cañeque, Yea-Lih Lin, Lucie Mondoulet, Jean-Luc Veyrune, Matthieu Abouladze, Elvira Garcia De Paco, Ouissem Karmous Gadacha, Guillaume Cartron, Philippe Pasero, Caroline Bret, Raphaël Rodriguez & Jerome Moreaux. (2022) Targeting Cellular Iron Homeostasis with Ironomycin in Diffuse Large B-cell Lymphoma. Cancer Research 82:6, pages 998-1012.
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Mahmood Barani, Saman Sargazi, Mohammad Reza Hajinezhad, Abbas Rahdar, Fakhara Sabir, Abbas Pardakhty, Farshid Zargari, Md. Khalid Anwer & M. Ali Aboudzadeh. (2021) Preparation of pH-Responsive Vesicular Deferasirox: Evidence from In Silico , In Vitro , and In Vivo Evaluations . ACS Omega 6:37, pages 24218-24232.
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Aladin Samara, Saar Shapira, Ido Lubin, Ofer Shpilberg, Smadar Avigad, Galit Granot & Pia Raanani. (2021) Deferasirox induces cyclin D1 degradation and apoptosis in mantle cell lymphoma in a reactive oxygen species‐ and GSK3β‐dependent mechanism. British Journal of Haematology 192:4, pages 747-760.
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Azmi Khan, Pratika Singh & Amrita Srivastava. (2020) Iron: Key player in cancer and cell cycle?. Journal of Trace Elements in Medicine and Biology 62, pages 126582.
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Paul Seligman & Gamini Siriwardana. 2020. Heavy Metal Toxicity in Public Health. Heavy Metal Toxicity in Public Health.
Olga Babosova, Katarina Kapralova, Leona Raskova Kafkova, Vladimir Korinek, Vladimir Divoky, Josef T. Prchal & Lucie Lanikova. (2019) Iron chelation and 2‐oxoglutarate‐dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1. Journal of Cellular and Molecular Medicine 23:11, pages 7785-7795.
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Saar Shapira, Pia Raanani, Aladin Samara, Arnon Nagler, Ido Lubin, Nadir Arber & Galit Granot. (2019) Deferasirox selectively induces cell death in the clinically relevant population of leukemic CD34+CD38– cells through iron chelation, induction of ROS, and inhibition of HIF1α expression. Experimental Hematology 70, pages 55-69.e4.
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Man Theerasilp, Punlop Chalermpanapun, Kanyawan Ponlamuangdee, Dusita Sukvanitvichai & Norased Nasongkla. (2017) Imidazole-modified deferasirox encapsulated polymeric micelles as pH-responsive iron-chelating nanocarrier for cancer chemotherapy. RSC Advances 7:18, pages 11158-11169.
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Claire Legendre, Sylvie Avril, Catherine Guillet & Emmanuel Garcion. (2016) Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells. BMC Cancer 16:1.
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Yusuke Kamihara, Kohichi Takada, Tsutomu Sato, Yutaka Kawano, Kazuyuki Murase, Yohei Arihara, Shohei Kikuchi, Naotaka Hayasaka, Makoto Usami, Satoshi Iyama, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune & Junji Kato. (2016) The iron chelator deferasirox induces apoptosis by targeting oncogenic Pyk2/β-catenin signaling in human multiple myeloma. Oncotarget 7:39, pages 64330-64341.
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Samie Salehi, Amir Sh. Saljooghi & Ali Shiri. (2016) Synthesis, characterization and in vitro anticancer evaluations of two novel derivatives of deferasirox iron chelator. European Journal of Pharmacology 781, pages 209-217.
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Goldie Y.L. Lui, Zaklina Kovacevic, Vera Richardson, Angelica M. Merlot, Danuta S. Kalinowski & Des R. Richardson. (2015) Targeting cancer by binding iron: Dissecting cellular signaling pathways. Oncotarget 6:22, pages 18748-18779.
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Sol-Rim JeonJae-Wook LeePil-Sang JangNack-Gyun ChungBin ChoDae-Chul Jeong. (2015) Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines. Blood Research 50:1, pages 33.
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Galit Granot. 2017. Encyclopedia of Cancer. Encyclopedia of Cancer 1319 1325 .
Galit Granot. 2016. Encyclopedia of Cancer. Encyclopedia of Cancer 1 6 .
Jessica L. Heath, Joshua M. Weiss, Catherine P. Lavau & Daniel S. Wechsler. (2014) Effects of iron depletion on CALM-AF10 leukemias. Experimental Hematology 42:12, pages 1022-1030.e1.
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Jessica Heath, Joshua Weiss, Catherine Lavau & Daniel Wechsler. (2013) Iron Deprivation in Cancer––Potential Therapeutic Implications. Nutrients 5:8, pages 2836-2859.
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