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Letter

HMGA1 overexpression correlates with relapse in childhood B-lineage acute lymphoblastic leukemia

, , , , , , , , & show all
Pages 2565-2567 | Received 31 Jan 2013, Accepted 01 Mar 2013, Published online: 30 Apr 2013

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Amy Belton, Lingling Xian, Tait Huso, Michael Koo, Li Z. Luo, James Turkson, Brent D. G. Page, Patrick T. Gunning, Guosheng Liu, David L. Huso & Linda M. S. Resar. (2016) STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)–STAT3 pathway. Leukemia & Lymphoma 57:11, pages 2681-2684.
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Joelle Hillion, Amy M. Belton, Sandeep N. Shah, James Turkson, Naijie Jing, David J. Tweardy, Francescopaolo di Cello, David L. Huso & Linda M. S. Resar. (2014) Nanoparticle delivery of inhibitory signal transducer and activator of transcription 3 G-quartet oligonucleotides blocks tumor growth in HMGA1 transgenic model of T-cell leukemia. Leukemia & Lymphoma 55:5, pages 1194-1197.
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Tait H Huso & Linda MS Resar. (2014) The high mobility group A1 molecular switch: turning on cancer – can we turn it off?. Expert Opinion on Therapeutic Targets 18:5, pages 541-553.
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Articles from other publishers (19)

Lionel Chia, Bowen Wang, Jung-Hyun Kim, Li Z. Luo, Shuai Shuai, Iliana Herrera, Sophia Y. Chen, Liping Li, Lingling Xian, Tait Huso, Mohammad Heydarian, Karen Reddy, Woo Jung Sung, Shun Ishiyama, Gongbo Guo, Elizabeth Jaffee, Lei Zheng, Leslie M. Cope, Kathy Gabrielson, Laura Wood & Linda Resar. (2023) HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation. Journal of Clinical Investigation 133:6.
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Liping Li, Jung-Hyun Kim, Wenyan Lu, Donna M. Williams, Joseph Kim, Leslie CopeRaajit K. RampalRichard P. KocheLingling Xian, Li Z. Luo, Marija Vasiljevic, Daniel R. Matson, Zhizhuang Joe ZhaoOphelia Rogers, Matthew C. Stubbs, Karen ReddyAntonio-Rodriguez Romero, Bethan Psaila, Jerry L. SpivakAlison R. Moliterno & Linda M. S. Resar. (2022) HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression. Blood 139:18, pages 2797-2815.
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Marco De Martino, Francesco Esposito & Alfredo Fusco. (2021) Critical role of the high mobility group A proteins in hematological malignancies. Hematological Oncology 40:1, pages 3-11.
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Vasiliki Symeonidou, Hélène Jakobczyk, Salem Bashanfer, Camille Malouf, Foteini Fotopoulou, Rishi S. Kotecha, Richard A. Anderson, Andrew J. Finch & Katrin Ottersbach. (2021) Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements. Cell Reports 37:4, pages 109900.
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Mireia Pujals, Linda Resar & Josep Villanueva. (2021) HMGA1, Moonlighting Protein Function, and Cellular Real Estate: Location, Location, Location!. Biomolecules 11:9, pages 1334.
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Guo‐Bing Qiao, Ren‐Tao Wang, Shu‐Nan Wang, Shao‐Lin Tao, Qun‐You Tan & Hua Jin. (2021) GRP75 ‐mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK / c‐JUN signaling . Thoracic Cancer 12:10, pages 1558-1569.
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Zilu Tian, Zhiyi Liu, Xiaokang Fang, Kuan Cao, Bin Zhang, Rui Wu, Xin Wen, Quan Wen, Hengliang Shi & Renhao Wang. (2021) ANP32A promotes the proliferation, migration and invasion of hepatocellular carcinoma by modulating the HMGA1/STAT3 pathway. Carcinogenesis 42:3, pages 493-506.
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Angela Minervini, Nicoletta Coccaro, Luisa Anelli, Antonella Zagaria, Giorgina Specchia & Francesco Albano. (2020) HMGA Proteins in Hematological Malignancies. Cancers 12:6, pages 1456.
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Marco De Martino, Davide De Biase, Floriana Forzati, Sara Carmela Credendino, Giuseppe Palma, Antonio Barbieri, Claudio Arra, Orlando Paciello, Eugenio Gaudio, Maurilio Ponzoni, Gabriella De Vita, Paolo Chieffi, Francesco Bertoni, Alfredo Fusco & Francesco Esposito. (2020) HMGA1-pseudogene7 transgenic mice develop B cell lymphomas. Scientific Reports 10:1.
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Mikhail Gorbounov, Neil M. Carleton, Rebecca J. Asch-Kendrick, Lingling Xian, Lisa Rooper, Lionel Chia, Ashley Cimino-Mathews, Leslie Cope, Alan Meeker, Vered Stearns, Robert W. Veltri, Young Kyung Bae & Linda M. S. Resar. (2019) High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer. Breast Cancer Research and Treatment 179:1, pages 25-35.
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Marco De Martino, Alfredo Fusco & Francesco Esposito. (2019) HMGA and Cancer: A Review on Patent Literatures. Recent Patents on Anti-Cancer Drug Discovery 14:3, pages 258-267.
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Linda Resar, Lionel Chia & Lingling Xian. (2018) Lessons from the Crypt: HMGA1—Amping up Wnt for Stem Cells and Tumor Progression. Cancer Research 78:8, pages 1890-1897.
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Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L. Huso, Andrew J. Ewald & Linda M. S. Resar. (2017) HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche. Nature Communications 8:1.
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Ling-Ling Zhai, Jiao Zhou, Jing Zhang, Xi Tang, Ling-Yu Zhou, Jia-Yu Yin, Minse-Evola Deniz Vanessa, Wen Peng, Jiang Lin & Zhao-Qun Deng. (2017) Down-regulation of pseudogene Vimentin 2p is associated with poor outcome in de novo acute myeloid leukemia. Cancer Biomarkers 18:3, pages 305-312.
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Michael D. Williams, Lingling Xian, Tait Huso, Jeong-Jin Park, David Huso, Leslie M. Cope, David R. Gang, William F. Siems, Linda Resar, Raymond Reeves & Herbert H. HillJr.Jr.. (2016) Fecal Metabolome in Hmga1 Transgenic Mice with Polyposis: Evidence for Potential Screen for Early Detection of Precursor Lesions in Colorectal Cancer . Journal of Proteome Research 15:12, pages 4176-4187.
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Xiuxia Han, Yanhua Cao, Kun Wang & Guiping Zhu. (2016) HMGA1 facilitates tumor progression through regulating Wnt/β-catenin pathway in endometrial cancer. Biomedicine & Pharmacotherapy 82, pages 312-318.
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Joelle Hillion, Sujayita Roy, Mohammad Heydarian, Leslie Cope, Lingling Xian, Michael Koo, Li Z. Luo, Kathleen Kellyn, Brigitte M. Ronnett, Tait Huso, Deborah Armstrong, Karen Reddy, David L. Huso & L.M.S. Resar. (2016) The High Mobility Group A1 ( HMGA1 ) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 ( MMP-2 ) in a subset of tumors. Gynecologic Oncology 141:3, pages 580-587.
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Marco De Martino, Floriana Forzati, Claudio Arra, Alfredo Fusco & Francesco Esposito. (2016) HMGA1 -pseudogenes and cancer . Oncotarget 7:19, pages 28724-28735.
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Michael D. Williams, Xing Zhang, Jeong-Jin Park, William F. Siems, David R. Gang, Linda M. S. Resar, Raymond Reeves & Herbert H. HillJrJr. (2015) Characterizing metabolic changes in human colorectal cancer. Analytical and Bioanalytical Chemistry 407:16, pages 4581-4595.
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