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Research Article

CD68 tumor-associated macrophage marker is not prognostic of clinical outcome in classical Hodgkin lymphoma

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Pages 1031-1037 | Received 08 Apr 2013, Accepted 06 Jul 2013, Published online: 10 Mar 2014

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Oscar Silva, Vivek Charu, Mark D. Ewalt, Ryan A. Metcalf, Shuchun Zhao, E. Mauricio Castellanos, Elizabeth Orellana, Yasodha Natkunam & Sandra Luna-Fineman. (2021) Classic Hodgkin lymphoma in Guatemalan children of age less than six years: analysis of immune regulatory pathways and the tumor microenvironment. Leukemia & Lymphoma 62:7, pages 1609-1618.
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Martin S. Staege, Stefanie Kewitz, Toralf Bernig, Caspar Kühnöl & Christine Mauz-Körholz. (2015) Prognostic Biomarkers for Hodgkin Lymphoma. Pediatric Hematology and Oncology 32:7, pages 433-454.
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Ariel Agur, Gail Amir, Ora Paltiel, Martine Klein, Eldad J. Dann, Hanoch Goldschmidt & Neta Goldschmidt. (2015) CD68 staining correlates with the size of residual mass but not with survival in classical Hodgkin lymphoma. Leukemia & Lymphoma 56:5, pages 1315-1319.
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Articles from other publishers (28)

Ahmad Zargari, Katherine D. Cummins, Patrick Hosking, Alan Pham, Eliza Hawkes & Stephen B. Ting. (2023) Increased STAT expression in Reed–Sternberg cells as a potential positive prognostication biomarker in Hodgkin lymphoma. Pathology 55:5, pages 650-655.
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Vasileios Georgoulis, Alexandra Papoudou-Bai, Alexandros Makis, Panagiotis Kanavaros & Eleftheria Hatzimichael. (2023) Unraveling the Immune Microenvironment in Classic Hodgkin Lymphoma: Prognostic and Therapeutic Implications. Biology 12:6, pages 862.
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Isacco Ferrarini, Andrea Bernardelli, Ester Lovato, Alberto Schena, Mauro Krampera & Carlo Visco. (2023) An updated portrait of monocyte-macrophages in classical Hodgkin lymphoma. Frontiers in Oncology 13.
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Imen Zawati, Olfa Adouni, Maroua Manai, Majdi Nagara, Moisis Tacam, Carolina Reduzzi, Amor Gamoudi & Mohamed Manai. (2022) FOXP3+/CD68+ ratio within the tumor microenvironment may serve as a potential prognostic factor in classical Hodgkin lymphoma. Human Immunology 83:12, pages 843-856.
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Yutong Xie, Huan Yang, Chao Yang, Liren He, Xi Zhang, Li Peng, Hongbin Zhu & Lei Gao. (2022) Role and Mechanisms of Tumor-Associated Macrophages in Hematological Malignancies. Frontiers in Oncology 12.
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Kristiina Karihtala, Suvi-Katri Leivonen, Marja-Liisa Karjalainen-LindsbergFong Chun Chan, Christian Steidl, Teijo Pellinen & Sirpa Leppä. (2022) Checkpoint protein expression in the tumor microenvironment defines the outcome of classical Hodgkin lymphoma patients. Blood Advances 6:6, pages 1919-1931.
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Giuseppe Ingravallo, Roberto Tamma, Giuseppina Opinto, Tiziana Annese, Francesco Gaudio, Giorgina Specchia, Tommasina Perrone, Pellegrino Musto, Gerardo Cazzato, Emilio Bellitti, Saverio Capodiferro, Eugenio Maiorano & Domenico Ribatti. (2022) The Effect of the Tumor Microenvironment on Lymphoid Neoplasms Derived from B Cells. Diagnostics 12:3, pages 573.
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Giuseppina Opinto, Claudio Agostinelli, Sabino Ciavarella, Attilio Guarini, Eugenio Maiorano & Giuseppe Ingravallo. (2021) Hodgkin Lymphoma: A Special Microenvironment. Journal of Clinical Medicine 10:20, pages 4665.
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Katherine Antel, D. Chetty, J. Oosthuizen, Z. Mohamed, L. Van der Vyver & E. Verburgh. (2021) CD68-positive tumour associated macrophages, PD-L1 expression, and EBV latent infection in a high HIV-prevalent South African cohort of Hodgkin lymphoma patients. Pathology 53:5, pages 628-634.
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Emanuele Cencini, Alberto Fabbri, Anna Sicuranza, Alessandro Gozzetti & Monica Bocchia. (2021) The Role of Tumor-Associated Macrophages in Hematologic Malignancies. Cancers 13:14, pages 3597.
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Jennifer E. Agrusa, Brooks P. Scull, Harshal A. Abhyankar, Howard Lin, Nmazuo W. Ozuah, Rikhia Chakraborty, Olive S. Eckstein, Nitya Gulati, Elmoataz Abdel Fattah, Nader K. El-Mallawany, Rayne H. Rouce, ZoAnn E. Dreyer, Julienne Brackett, Judith F. Margolin, Joseph Lubega, Terzah M. Horton, Catherine M. Bollard, M. Monica Gramatges, Kala Y. Kamdar, Kenneth L. McClain, Tsz-Kwong Man & Carl E. Allen. (2020) Defining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma. Cancers 12:12, pages 3603.
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Amira Osman, Miharu Oze, Said M. Afify, Ghmkin Hassan, Samah EL-Ghlban, Hend M. Nawara, Xiaoying Fu, Maram Hussein Zahra, Akimasa Seno, Ira Winer, David S. Salomon & Masaharu Seno. (2020) Tumor-associated macrophages derived from cancer stem cells. Acta Histochemica 122:8, pages 151628.
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Kristiina Karihtala, Suvi-Katri Leivonen, Oscar Brück, Marja-Liisa Karjalainen-Lindsberg, Satu Mustjoki, Teijo Pellinen & Sirpa Leppä. (2020) Prognostic Impact of Tumor-Associated Macrophages on Survival Is Checkpoint Dependent in Classical Hodgkin Lymphoma. Cancers 12:4, pages 877.
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Lan V. Pham, Elizabeth Pogue & Richard J. Ford. (2018) The Role of Macrophage/B-Cell Interactions in the Pathophysiology of B-Cell Lymphomas. Frontiers in Oncology 8.
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Peter Hollander, Klaus Rostgaard, Karin E. Smedby, Daniel Molin, Angelica Loskog, Peter de Nully Brown, Gunilla Enblad, Rose-Marie Amini, Henrik Hjalgrim & Ingrid Glimelius. (2018) An anergic immune signature in the tumor microenvironment of classical Hodgkin lymphoma is associated with inferior outcome. European Journal of Haematology 100:1, pages 88-97.
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Manuel Gotti, Marta Nicola, Marco Lucioni, Valeria Fiaccadori, Virginia Ferretti, Roberta Sciarra, Mariangela Costanza, Elisa Bono, Silvana Molo, Aldo Maffi, Giorgio A. Croci, Marzia Varettoni, Marco Frigeni, Cristiana Pascutto, Luca Arcaini, Maurizio Bonfichi, Marco Paulli & Mario Cazzola. (2017) Independent prognostic impact of tumour-infiltrating macrophages in early-stage Hodgkin's lymphoma. Hematological Oncology 35:3, pages 296-302.
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Peter Hollander, Peter KamperKarin Ekstrom SmedbyGunilla EnbladMaja LudvigsenJulie MortensenRose-Marie Amini, Stephen Hamilton-Dutoit, Francesco d’AmoreDaniel Molin & Ingrid Glimelius. (2017) High proportions of PD-1+ and PD-L1+ leukocytes in classical Hodgkin lymphoma microenvironment are associated with inferior outcome. Blood Advances 1:18, pages 1427-1439.
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Emanuele Cencini, Alberto Fabbri, Luigi Rigacci, Stefano Lazzi, Guido Gini, Maria Christina Cox, Salvatrice Mancuso, Elisabetta Abruzzese, Sofia Kovalchuk, Gaia Goteri, Arianna Di Napoli, Roberto Bono, Stefano Fratoni, Simonetta Di Lollo, Alberto Bosi, Lorenzo Leoncini & Monica Bocchia. (2017) Evaluation of the prognostic role of tumour-associated macrophages in newly diagnosed classical Hodgkin lymphoma and correlation with early FDG-PET assessment. Hematological Oncology 35:1, pages 69-78.
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Baoping Guo, Hong Cen, Xiaohong Tan & Qing Ke. (2016) Meta-analysis of the prognostic and clinical value of tumor-associated macrophages in adult classical Hodgkin lymphoma. BMC Medicine 14:1.
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Annika Englund, Daniel Molin, Gunilla Enblad, Jonas Karlén, Ingrid Glimelius, Gustaf Ljungman & Rose‐Marie Amini. (2016) The role of tumour‐infiltrating eosinophils, mast cells and macrophages in Classical and Nodular Lymphocyte Predominant Hodgkin Lymphoma in children. European Journal of Haematology 97:5, pages 430-438.
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Jinfeng Liao, Wenli Feng, Rong Wang, Shihui Ma, Lina Wang, Xiao Yang, Feifei Yang, Yongmin Lin, Qian Ren & Guoguang Zheng. (2015) Diverse in vivo effects of soluble and membrane-bound M-CSF on tumor-associated macrophages in lymphoma xenograft model . Oncotarget 7:2, pages 1354-1366.
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Jian-Qiang Lu, Benjamin Adam, Andrew S. Jack, Anna Lam, Robert W. Broad & Constance L. Chik. (2015) Immune Cell Infiltrates in Pituitary Adenomas: More Macrophages in Larger Adenomas and More T Cells in Growth Hormone Adenomas. Endocrine Pathology 26:3, pages 263-272.
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Yoshihiro Komohara, Daisuke Niino, Koji Ohnishi, Koichi Ohshima & Motohiro Takeya. (2015) Role of tumor-associated macrophages in hematological malignancies. Pathology International 65:4, pages 170-176.
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Sha-Yan Chen, Xiao Yang, Wen-Li Feng, Jin-Feng Liao, Li-Na Wang, Li Feng, Yong-Min Lin, Qian Ren & Guo-Guang Zheng. (2015) Organ-Specific Microenvironment Modifies Diverse Functional and Phenotypic Characteristics of Leukemia-Associated Macrophages in Mouse T Cell Acute Lymphoblastic Leukemia. The Journal of Immunology 194:6, pages 2919-2929.
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Joseph M. Connors. (2015) Risk assessment in the management of newly diagnosed classical Hodgkin lymphoma. Blood 125:11, pages 1693-1702.
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David W. Scott & Christian Steidl. (2014) The classical Hodgkin lymphoma tumor microenvironment: macrophages and gene expression-based modeling. Hematology 2014:1, pages 144-150.
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Alberto Mantovani. (2014) Macrophages, Neutrophils, and Cancer: A Double Edged Sword. New Journal of Science 2014, pages 1-14.
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Christian Marinaccio, Beatrice Nico, Eugenio Maiorano, Giorgina Specchia & Domenico Ribatti. (2014) Insights in Hodgkin Lymphoma angiogenesis. Leukemia Research 38:8, pages 857-861.
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