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Research Article

Myeloma skews regulatory T and pro-inflammatory T helper 17 cell balance in favor of a suppressive state

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Pages 1090-1098 | Received 06 May 2013, Accepted 12 Jul 2013, Published online: 28 Aug 2013

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Deepesh Lad, Qing Huang, Romy Hoeppli, Rosa Garcia, Lixin Xu, Megan Levings, Kevin Song & Raewyn Broady. (2019) Evaluating the role of Tregs in the progression of multiple myeloma. Leukemia & Lymphoma 60:9, pages 2134-2142.
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Crossref
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Crossref
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Crossref
Douglas Joshua, Hayley Suen, Ross Brown, Christian Bryant, P. Joy Ho, Derek Hart & John Gibson. (2016) The T Cell in Myeloma. Clinical Lymphoma Myeloma and Leukemia 16:10, pages 537-542.
Crossref
H Suen, R Brown, S Yang, C Weatherburn, P J Ho, N Woodland, N Nassif, P Barbaro, C Bryant, D Hart, J Gibson & D Joshua. (2016) Multiple myeloma causes clonal T-cell immunosenescence: identification of potential novel targets for promoting tumour immunity and implications for checkpoint blockade. Leukemia 30:8, pages 1716-1724.
Crossref
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Crossref
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Crossref
Eszter Persa, Andrea Balogh, Géza Sáfrány & Katalin Lumniczky. (2015) The effect of ionizing radiation on regulatory T cells in health and disease. Cancer Letters 368:2, pages 252-261.
Crossref
Giada Bianchi & Kenneth C. Anderson. 2015. Targeted Therapy in Translational Cancer Research. Targeted Therapy in Translational Cancer Research 145 156 .
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Crossref
Giada Bianchi & Nikhil C. Munshi. (2015) Pathogenesis beyond the cancer clone(s) in multiple myeloma. Blood 125:20, pages 3049-3058.
Crossref
Lei Wang, Nan Jin, Anita Schmitt, Jochen Greiner, Georg Malcherek, Michael Hundemer, Jiju Mani, Dirk Hose, Marc S Raab, Anthony D. Ho, Bao-an Chen, Hartmut Goldschmidt & Michael Schmitt. (2015) T cell-based targeted immunotherapies for patients with multiple myeloma. International Journal of Cancer 136:8, pages 1751-1768.
Crossref
T Dosani, M Carlsten, I Maric & O Landgren. (2015) The cellular immune system in myelomagenesis: NK cells and T cells in the development of MM and their uses in immunotherapies. Blood Cancer Journal 5:4, pages e306-e306.
Crossref
Thibaud André, Mehdi Najar, Basile Stamatopoulos, Karlien Pieters, Olivier Pradier, Dominique Bron, Nathalie Meuleman & Laurence Lagneaux. (2014) Immune impairments in multiple myeloma bone marrow mesenchymal stromal cells. Cancer Immunology, Immunotherapy 64:2, pages 213-224.
Crossref

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