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The role of ATM mutations and 11q deletions in disease progression in chronic lymphocytic leukemia

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Pages 1227-1239 | Received 01 Jun 2013, Accepted 24 Jul 2013, Published online: 12 Sep 2013

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Rashmi Kanagal-Shamanna, Haiyan Bao, Hutton Kearney, Stephanie Smoley, Zhenya Tang, Rajyalakshmi Luthra, Hui Yang, Shanshan Zhang, Pei Lin, Depei Wu, L. Jeffrey Medeiros & Xinyan Lu. (2022) Molecular characterization of Novel ATM fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia. Leukemia & Lymphoma 63:4, pages 865-875.
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Mónica Villa-Álvarez, Seila Lorenzo-Herrero, Ana P. Gonzalez-Rodriguez, Alejandro López-Soto, Angel R. Payer, Esther Gonzalez-Garcia, Leticia Huergo-Zapico & Segundo Gonzalez. (2017) Ig-like transcript 2 (ILT2) suppresses T cell function in chronic lymphocytic leukemia. OncoImmunology 6:10.
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Carol Lozano-Santos, José A. García-Vela, Nuria Pérez-Sanz, Sara Nova-Gurumeta, Belen Fernandez-Cuevas, Natalia Gomez-Lozano, Margarita Sánchez-Beato, Pedro Sanchez-Godoy, José Luis Bueno & José A. Garcia-Marco. (2017) Biallelic ATM alterations detected at diagnosis identify a subset of treatment-naïve chronic lymphocytic leukemia patients with reduced overall survival similar to patients with p53 deletion. Leukemia & Lymphoma 58:4, pages 859-865.
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Jan Verner, Martin Trbusek, Jana Chovancova, Zuzana Jaskova, Mojmir Moulis, Frantisek Folber, Roman Halouzka, Jiri Mayer, Sarka Pospisilova & Michael Doubek. (2015) NOD/SCID IL2Rγ-null mouse xenograft model of human p53-mutated chronic lymphocytic leukemia and ATM-mutated mantle cell lymphoma using permanent cell lines. Leukemia & Lymphoma 56:11, pages 3198-3206.
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Johannes Winkler, Kay Hofmann & Shuhua Chen. (2014) Novel targets for ATM-deficient malignancies. Molecular & Cellular Oncology 1:1.
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Crossref
V. Bakthavatchalu & S. Muthupalani. 2018. Comprehensive Toxicology. Comprehensive Toxicology 363 395 .
Nicholas J. Davies, Marwan Kwok, Clive Gould, Ceri E. Oldreive, Jingwen Mao, Helen Parry, Edward Smith, Angelo Agathanggelou, Guy Pratt, Alexander Malcolm R. Taylor, Paul Moss, Mike Griffiths & Tatjana Stankovic. (2017) Dynamic changes in clonal cytogenetic architecture during progression of chronic lymphocytic leukemia in patients and patient-derived murine xenografts. Oncotarget 8:27, pages 44749-44760.
Crossref
Jennifer Goy, Tanya L. Gillan, Helene Bruyere, Steven J.T. Huang, Monica Hrynchak, Aly Karsan, Khaled Ramadan, Joseph Connors, Cynthia L. Toze & Alina S. Gerrie. (2017) Chronic Lymphocytic Leukemia Patients With Deletion 11q Have a Short Time to Requirement of First-Line Therapy, But Long Overall Survival: Results of a Population-Based Cohort in British Columbia, Canada. Clinical Lymphoma Myeloma and Leukemia 17:6, pages 382-389.
Crossref
Barry D. Hock, Sean A. MacPherson & Judith L. McKenzie. (2017) Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells. PLOS ONE 12:3, pages e0172858.
Crossref
Massoud Marcel. (2017) Chronic Lymphocytic Leukemia (CLL): Upfront Treatment Options in 2017. Hematology & Transfusion International Journal 4:2.
Crossref
Sotirios G. Papageorgiou, Christos K. Kontos, Marios A. Diamantopoulos, Anthi Bouchla, Eirini Glezou, Efthymia Bazani, Vasiliki Pappa & Andreas Scorilas. (2017) MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis. Disease Markers 2017, pages 1-10.
Crossref
Helen ParkerJonathan C. Strefford. (2016) The mutational signature of chronic lymphocytic leukemia. Biochemical Journal 473:21, pages 3725-3740.
Crossref
Y Jiang, H-C Chen, X Su, P A Thompson, X Liu, K-A Do, W Wierda, M J Keating & W Plunkett. (2016) ATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2). Blood Cancer Journal 6:9, pages e465-e465.
Crossref
Andrea Tomasella, Raffaella Picco, Sonia Ciotti, Andrea Sgorbissa, Elisa Bianchi, Rossella Manfredini, Fabio Benedetti, Valentina Trimarco, Federica Frezzato, Livio Trentin, Gianpietro Semenzato, Domenico Delia & Claudio Brancolini. (2016) The isopeptidase inhibitor 2cPE triggers proteotoxic stress and ATM activation in chronic lymphocytic leukemia cells. Oncotarget 7:29, pages 45429-45443.
Crossref
Katrien Van Roosbroeck & George A. Calin. (2016) MicroRNAs in chronic lymphocytic leukemia: miRacle or miRage for prognosis and targeted therapies?. Seminars in Oncology 43:2, pages 209-214.
Crossref
Giulia Fabbri & Riccardo Dalla-Favera. (2016) The molecular pathogenesis of chronic lymphocytic leukaemia. Nature Reviews Cancer 16:3, pages 145-162.
Crossref
Gera D. te Raa & Arnon P. Kater. (2016) TP53 dysfunction in CLL: Implications for prognosis and treatment. Best Practice & Research Clinical Haematology 29:1, pages 90-99.
Crossref
Marwan KwokNicholas DaviesAngelo AgathanggelouEdward SmithCeri OldreiveEva PetermannGrant StewartJeff BrownAlan LauGuy Pratt, Helen ParryMalcolm TaylorPaul MossPeter Hillmen & Tatjana Stankovic. (2016) ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells. Blood 127:5, pages 582-595.
Crossref
Lesley-Ann Sutton & Richard Rosenquist. (2015) The complex interplay between cell-intrinsic and cell-extrinsic factors driving the evolution of chronic lymphocytic leukemia. Seminars in Cancer Biology 34, pages 22-35.
Crossref
G D te Raa, P D Moerland, A C Leeksma, I A Derks, H Yigittop, N Laddach, M Loden-van Straaten, V Navrkalova, M Trbusek, D M Luijks, T Zenz, A Skowronska, M Hoogendoorn, T Stankovic, M H van Oers, E Eldering & A P Kater. (2015) Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification. Cell Death & Disease 6:8, pages e1852-e1852.
Crossref
Júlia L.F. Abrantes, Thaís F. Tornatore, Karin J. Pelizzaro-Rocha, Marcelo B. de Jesus, Rodrigo T. Cartaxo, Renato Milani & Carmen V. Ferreira-Halder. (2014) Crosstalk between kinases, phosphatases and miRNAs in cancer. Biochimie 107, pages 167-187.
Crossref
Jitka Malcikova, Sarka Pavlova, Katerina Stano Kozubik & Sarka Pospisilova. (2014) TP53 Mutation Analysis in Clinical Practice: Lessons From Chronic Lymphocytic Leukemia. Human Mutation 35:6, pages 663-671.
Crossref

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