568
Views
48
CrossRef citations to date
0
Altmetric
Research Article

Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance of FLT3 mutations and complex karyotype

, , , , , , , , , , , , , , & show all
Pages 1523-1532 | Received 06 Jun 2013, Accepted 01 Sep 2013, Published online: 04 Feb 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Yu-hua Song, Peng Peng, Chun Qiao, Jian-yong Li, Qi-qiang Long & Hua Lu. (2021) Potential Effects of the FLT3-ITD Mutation on Chemotherapy Response and Prognosis of Acute Promyelocytic Leukemia. Cancer Management and Research 13, pages 2371-2378.
Read now
Jorge Labrador, Elisa Luño, Edo Vellenga, Salut Brunet, José González-Campos, Maria C. Chillón, Aleksandra Holowiecka, Jordi Esteve, Juan Bergua, José D González-Sanmiguel, Cristina Gil, Mar Tormo, Olga Salamero, Felix Manso, Isolda Fernández, Javier de laSerna, María-José Moreno, Manuel Pérez-Encinas, Isabel Krsnik, Josep-Maria Ribera, Jose Cervera, María J. Calasanz, Blanca Boluda, Marta Sobas, Bob Lowenberg, Miguel A. Sanz & Pau Montesinos. (2019) Clinical significance of complex karyotype at diagnosis in pediatric and adult patients with de novo acute promyelocytic leukemia treated with ATRA and chemotherapy. Leukemia & Lymphoma 60:5, pages 1146-1155.
Read now
Yingchao Fan, Yanan Cao, Xiaosong Bai & Wenfang Zhuang. (2018) The clinical significance of FLT3 ITD mutation on the prognosis of adult acute promyelocytic leukemia. Hematology 23:7, pages 379-384.
Read now
Li-Na Wang, Yan-Lai Tang, Yin-Chuan Zhang, Zu-Han Zhang, Xiao-Jian Liu, Zhi-Yong Ke, Yu Li, Hui-Zhen Tan, Li-Bin Huang & Xue-Qun Luo. (2017) Arsenic trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways. Leukemia & Lymphoma 58:10, pages 2426-2438.
Read now
Richard Dillon & David Grimwade. (2014) Prognostic significance of additional cytogenetic abnormalities and FLT3 mutations in acute promyelocytic leukemia. Leukemia & Lymphoma 55:7, pages 1444-1446.
Read now

Articles from other publishers (43)

Hui Zeng, Hai‐Bo Dong, Qi‐Guo Zhang, Min Zhou, Qian Zhang, Lan‐Xin Chen, Cui‐Ying Yuan, Ru‐Ru Jiang, Jin‐Wen Liu, Jian Ou‐Yang, Jie He & Bing Chen. (2023) Additional cytogenetic abnormalities in patients with newly diagnosed acute promyelocytic leukemia predict inferior event‐free survival. Cancer Medicine.
Crossref
Harry J. Iland, Nigel Russell, Richard Dillon, Andre C. Schuh, Aditya Tedjaseputra, Andrew Wei, Asim Khwaja, Steven Knapper, Steven W. Lane, John Reynolds, Mary Frances McMullin, Annalise Martin, Peter Tan, David C. Taussig, Anny Wong, John Taper, Christina Fraga, Richard Kelly, Kiran Tawana, Priyanka Mehta, Alain Mina, Jessica K. Altman, Ingolf Mølle, Sudhir Tauro & Eleni Tholouli. (2023) Characteristics and outcomes of patients with acute promyelocytic leukemia and extreme hyperleukocytosis at presentation. Blood Advances 7:11, pages 2580-2585.
Crossref
Xiaodong Liu, Wanting Li, Jian Xiao, Huixiu Zhong & Kun Yang. (2023) Case Report: Co-existence of a novel EXOC4‐TRHDE gene fusion with PML-RARA in acute promyelocytic leukemia. Frontiers in Oncology 13.
Crossref
Xian Zhang, Shulan Wu, Junfang Yang, Gailing Zhang, Yunchao Su, Min Zhang, Jiujiang He, Yanze Shi, Wenqian Li, Peihua Lu & Daopei Lu. (2022) Long-term retrospective study of retinoic acid combined with arsenic and chemotherapy for acute promyelocytic leukemia. International Journal of Hematology 117:4, pages 530-537.
Crossref
Minh Phuong Vu, Cuc Nhung Nguyen, Hoang Vu, Tuyet Mai Nguyen, Tuan Tung Nguyen & Phuong Thao Pham. (2022) Association between FLT3-ITD and additional chromosomal abnormalities in the prognosis of acute promyelocytic leukemia . Journal of International Medical Research 50:12, pages 030006052211384.
Crossref
Leonardo Mejía-Buriticá, Manuela Ocampo-Medina, Sigifredo Ospina-Ospina, Carlos Andrés Regino-Agamez, Gonzalo Vásquez-Palacio & José Domingo Torres-Hernández. (2022) Caracterización clínica y citogenética de una cohorte de pacientes con leucemia promielocítica aguda atendidos en un Hospital Universitario en Medellín, Colombia. Medicina y Laboratorio 26:3, pages 273-286.
Crossref
Zachary D. Epstein-Peterson, Andriy Derkach, Susan Geyer, Krzysztof Mrózek, Jessica Kohlschmidt, Jae H. Park, Sridevi Rajeeve, Eytan M. Stein, Yanming Zhang, Harry Iland, Lynda J. Campbell, Richard A. Larson, Xavier Poiré, Bayard L. Powell, Wendy Stock, Richard M. Stone & Martin S. Tallman. (2022) Effect of additional cytogenetic abnormalities on survival in arsenic trioxide-treated acute promyelocytic leukemia. Blood Advances 6:11, pages 3433-3439.
Crossref
F. Nguyen-Khac, A. Bidet, A. Daudignon, M. Lafage-Pochitaloff, G. Ameye, C. Bilhou-Nabéra, E. Chapiro, M. A. Collonge-Rame, W. Cuccuini, N. Douet-Guilbert, V. Eclache, I. Luquet, L. Michaux, N. Nadal, D. Penther, B. Quilichini, C. Terre, C. Lefebvre, M.-B. Troadec & L. Véronèse. (2022) The complex karyotype in hematological malignancies: a comprehensive overview by the Francophone Group of Hematological Cytogenetics (GFCH). Leukemia 36:6, pages 1451-1466.
Crossref
Darren King, Charles E. Foucar, Vincent Ma, Lydia Benitez, Anthony J. Perissinotti, Bernard L. Marini, Dan Robinson, Rupali Roy Bhave & Dale Bixby. (2021) Identification of variant APL translocations PRKAR1A-RARα and ZBTB16-RARα (PLZF-RARα) through the MI-ONCOSEQ platform. Cancer Genetics 258-259, pages 57-60.
Crossref
Minh Phuong Vu, Cuc Nhung Nguyen & Hoang Vu. (2021) Cytogenetic influence on prognosis in acute promyelocytic leukaemia: a cohort study in Vietnam. Hematology/Oncology and Stem Cell Therapy.
Crossref
Julie Quessada, Wendy Cuccuini, Paul Saultier, Marie Loosveld, Christine J. Harrison & Marina Lafage-Pochitaloff. (2021) Cytogenetics of Pediatric Acute Myeloid Leukemia: A Review of the Current Knowledge. Genes 12:6, pages 924.
Crossref
Lin-wei Xu, Yong-zhong Su & Hong-fang Tao. (2021) All-trans Retinoic Acid, Arsenic Trioxide, and Anthracycline-based Chemotherapy Improves Outcome in Newly Diagnosed Acute Promyelocytic Leukemia Regardless of FLT3-ITD Mutation Status. Current Medical Science 41:3, pages 491-497.
Crossref
Sabine Kayser, Richard F. Schlenk, Delphine Lebon, Martin Carre, Katharina S. Götze, Friedrich Stölzel, Ana Berceanu, Kerstin Schäfer-Eckart, Pierre Peterlin, Yosr Hicheri, Ramy Rahme, Emmanuel Raffoux, Fatiha Chermat, Stefan W. Krause, Walter E. Aulitzky, Sophie Rigaudeau, Richard Noppeney, Celine Berthon, Martin Görner, Edgar Jost, Philippe Carassou, Ulrich Keller, Corentin Orvain, Thorsten Braun, Colombe Saillard, Ali Arar, Volker Kunzmann, Mathieu Wemeau, Maike De Wit, Dirk Niemann, Caroline Bonmati, Carsten Schwänen, Julie Abraham, Ahmad Aljijakli, Stephanie Haiat, Alwin Krämer, Albrecht Reichle, Martina Gnadler, Christophe Willekens, Karsten Spiekermann, Wolfgang Hiddemann, Carsten Müller-Tidow, Christian Thiede, Christoph Röllig, Hubert Serve, Martin Bornhäuser, Claudia D. Baldus, Eva Lengfelder, Pierre Fenaux, Uwe Platzbecker & Lionel Adès. (2021) Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study. Haematologica 106:12, pages 3100-3106.
Crossref
Sabine Kayser, Ramy Rahmé, David Martínez-Cuadrón, Gabriel Ghiaur, Xavier Thomas, Marta Sobas, Agnes Guerci-Bresler, Ana Garrido, Arnaud Pigneux, Cristina Gil, Emmanuel Raffoux, Mar Tormo, Norbert Vey, Javier de la Serna, Olga Salamero, Eva Lengfelder, Mark J. Levis, Pierre Fenaux, Miguel A. Sanz, Uwe Platzbecker, Richard F. Schlenk, Lionel Adès & Pau Montesinos. (2020) Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative Study. Leukemia 34:9, pages 2333-2341.
Crossref
Harinder S. Gill, Rita Yim, Cyrus R. Kumana, Eric Tse & Yok‐Lam Kwong. (2020) Oral arsenic trioxide, all‐ trans retinoic acid, and ascorbic acid maintenance after first complete remission in acute promyelocytic leukemia: Long‐term results and unique prognostic indicators . Cancer 126:14, pages 3244-3254.
Crossref
Marie-Claude Geoffroy & Hugues de Thé. (2020) Classic and Variants APLs, as Viewed from a Therapy Response. Cancers 12:4, pages 967.
Crossref
Mengyuan Lyu, Hongyan Liao, Xiao Shuai, Yongmei Jin, Jun Su & Qin Zheng. (2020) The prognosis predictive value of FMS-like tyrosine kinase 3-internal tandem duplications mutant allelic ratio (FLT3-ITD MR) in patients with acute myeloid leukemia detected by GeneScan. Gene 726, pages 144195.
Crossref
Gledson L. Picharski, Diancarlos P. Andrade, Ana Luiza M. R. Fabro, Luana Lenzi, Fernanda S. Tonin, Raul C. Ribeiro & Bonald C. Figueiredo. (2019) The Impact of Flt3 Gene Mutations in Acute Promyelocytic Leukemia: A Meta-Analysis. Cancers 11:9, pages 1311.
Crossref
Xavier Thomas. (2019) Acute Promyelocytic Leukemia: A History over 60 Years—From the Most Malignant to the most Curable Form of Acute Leukemia. Oncology and Therapy 7:1, pages 33-65.
Crossref
Sabine Kayser & Mark J. Levis. (2018) Clinical implications of molecular markers in acute myeloid leukemia. European Journal of Haematology 102:1, pages 20-35.
Crossref
Lili Lv, Longfei Yang, Honghua Cui & Tonghui Ma. (2018) A complex translocation (1;17;15) with spliced short‑type PML‑RARA fusion transcripts in acute promyelocytic leukemia: A case report. Experimental and Therapeutic Medicine.
Crossref
Rui Wang, Ying Li, Ping Gong, Janice Gabrilove, Samuel Waxman & Yongkui Jing. (2018) Arsenic Trioxide and Sorafenib Induce Synthetic Lethality of FLT3-ITD Acute Myeloid Leukemia Cells. Molecular Cancer Therapeutics 17:9, pages 1871-1880.
Crossref
Zeba N. Singh, Vu H. Duong, Rima Koka, Ying Zou, Sameer Sawhney, Li Tang, Maria R. Baer, Nicholas Ambulos, Firas El Chaer & Ashkan Emadi. (2018) High-risk acute promyelocytic leukemia with unusual T/myeloid immunophenotype successfully treated with ATRA and arsenic trioxide-based regimen. Journal of Hematopathology 11:3, pages 67-74.
Crossref
Can Chen, Xilian Huang, Kaile Wang, Kuang Chen, Danquan Gao & Shenxian Qian. (2018) Early mortality in acute promyelocytic leukemia: Potential predictors (Review). Oncology Letters.
Crossref
Chiara Martinelli. 2018. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs. Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs 233 262 .
Elisabeth Paietta. 2018. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood 237 279 .
Javier de la Serna, Pau Montesinos & Miguel A. Sanz. 2018. Acute Promyelocytic Leukemia. Acute Promyelocytic Leukemia 87 98 .
Anna Hecht, Seraphina Doll, Heidi Altmann, Daniel Nowak, Eva Lengfelder, Christoph Röllig, Gerhard Ehninger, Karsten Spiekermann, Wolfgang Hiddemann, Christel Weiß, Wolf-Karsten Hofmann, Florian Nolte & Uwe Platzbecker. (2017) Validation of a Molecular Risk Score for Prognosis of Patients With Acute Promyelocytic Leukemia Treated With All-trans Retinoic Acid and Chemotherapy-containing Regimens. Clinical Lymphoma Myeloma and Leukemia 17:12, pages 889-896.e5.
Crossref
S Kayser, J Krzykalla, M A Elliott, K Norsworthy, P Gonzales, R K Hills, M R Baer, Z Ráčil, J Mayer, J Novak, P Žák, T Szotkowski, D Grimwade, N H Russell, R B Walter, E H Estey, J Westermann, M Görner, A Benner, A Krämer, B D Smith, A K Burnett, C Thiede, C Röllig, A D Ho, G Ehninger, R F Schlenk, M S Tallman, M J Levis & U Platzbecker. (2017) Characteristics and outcome of patients with therapy-related acute promyelocytic leukemia front-line treated with or without arsenic trioxide. Leukemia 31:11, pages 2347-2354.
Crossref
Barbara J. Bain. 2017. Leukaemia Diagnosis. Leukaemia Diagnosis 135 248 .
Chin-Hin Ng & Wee-Joo Chng. (2017) Recent advances in acute promyelocytic leukaemia. F1000Research 6, pages 1273.
Crossref
L Cicconi, M Divona, C Ciardi, T Ottone, A Ferrantini, S Lavorgna, V Alfonso, F Paoloni, A Piciocchi, G Avvisati, F Ferrara, E Di Bona, F Albano, M Breccia, E Cerqui, M Sborgia, M G Kropp, A Santoro, A Levis, S Sica, S Amadori, M T Voso, F Mandelli & F Lo-Coco. (2016) PML–RARα kinetics and impact of FLT3–ITD mutations in newly diagnosed acute promyelocytic leukaemia treated with ATRA and ATO or ATRA and chemotherapy. Leukemia 30:10, pages 1987-1992.
Crossref
Tilmann Bochtler, Stefan Fröhling, Wilko Weichert, Volker Endris, Christian Thiede, Barbara Hutter, Michael Hundemer, Anthony D. Ho & Alwin Krämer. (2016) Evolution of a FLT3 -TKD mutated subclone at meningeal relapse in acute promyelocytic leukemia . Molecular Case Studies 2:5, pages a001123.
Crossref
Hayley S. Ma, Sarah M. Greenblatt, Courtney M. Shirley, Amy S. DuffieldJ. Kyle Bruner, Li Li, Bao Nguyen, Eric JungPeter D. Aplan, Gabriel Ghiaur, Richard J. Jones & Donald Small. (2016) All-trans retinoic acid synergizes with FLT3 inhibition to eliminate FLT3/ITD+ leukemia stem cells in vitro and in vivo. Blood 127:23, pages 2867-2878.
Crossref
Yanli He, Ping Wang, Kaiwei Liang, Xiangjun Chen, Wen Du, Juan Li, Yanjie Hu, Yan Bai, Wei Liu, Xiaoqing Li, Runming Jin, Min Zhang & Jine Zheng. (2015) A Pediatric Acute Promyelocytic Leukemia With a Rare Karyotype of ider(17)(q10)t(15;17) and Favorable Outcome. Medicine 94:41, pages e1778.
Crossref
Yinjun Lou, Yafang Ma, Shanshan Suo, Wanmao Ni, Yungui Wang, Hanzhang Pan, Hongyan Tong, Wenbin Qian, Haitao Meng, Wenyuan Mai, Jian Huang, Wenjuan Yu, Juyin Wei, Liping Mao & Jie Jin. (2015) Prognostic factors of patients with newly diagnosed acute promyelocytic leukemia treated with arsenic trioxide-based frontline therapy. Leukemia Research 39:9, pages 938-944.
Crossref
Harry J Iland, Marnie Collins, Ken Bradstock, Shane G Supple, Alberto Catalano, Mark Hertzberg, Peter Browett, Andrew Grigg, Frank Firkin, Lynda J Campbell, Amanda Hugman, John Reynolds, Juliana Di Iulio, Campbell Tiley, Kerry Taylor, Robin Filshie, Michael Seldon, John Taper, Jeff Szer, John Moore, John Bashford & John F Seymour. (2015) Use of arsenic trioxide in remission induction and consolidation therapy for acute promyelocytic leukaemia in the Australasian Leukaemia and Lymphoma Group (ALLG) APML4 study: a non-randomised phase 2 trial. The Lancet Haematology 2:9, pages e357-e366.
Crossref
Matteo Molica & Massimo Breccia. (2015) FLT3-ITD in acute promyelocytic leukemia: Clinical distinct profile but still controversial prognosis. Leukemia Research 39:4, pages 397-399.
Crossref
Alessandra di Masi, Loris Leboffe, Elisabetta De Marinis, Francesca Pagano, Laura Cicconi, Cécile Rochette-Egly, Francesco Lo-Coco, Paolo Ascenzi & Clara Nervi. (2015) Retinoic acid receptors: From molecular mechanisms to cancer therapy. Molecular Aspects of Medicine 41, pages 1-115.
Crossref
Carolina Pereira Souza Melo, Catharina Brant Campos, Álvaro Pimenta Dutra, Joaquim Caetano Aguirre Neto, Alexandre José Silva Fenelon, Abrahão Hallack Neto, Edna Kakitani Carbone, Mara Albonei Dudeque Pianovski, Alessandro Clayton de Souza Ferreira & Juliana Godoy Assumpcão. (2015) Correlation between FLT3–ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias. Leukemia Research 39:2, pages 131-137.
Crossref
Krzysztof Mrózek & Clara D. Bloomfield. 2015. Chromosomal Translocations and Genome Rearrangements in Cancer. Chromosomal Translocations and Genome Rearrangements in Cancer 275 317 .
Peter H. Wiernik. (2014) Inching toward cure of acute myeloid leukemia: a summary of the progress made in the last 50 years. Medical Oncology 31:8.
Crossref
Xiaojing Hu, Gongwen Ai, Xiuqin Meng, Jun Hou, Rong Wei, Yi Tao, Qianqiao Zhang, Ying Han & Jumei Shi. (2014) An ider(17)(q10)t(15;17) with spliced long-type PML-RARA fusion transcripts in a case of acute promyelocytic leukemia. Cancer Genetics 207:6, pages 253-257.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.