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Leukemia & Lymphoma Volume 55, 2014 - Issue 7
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Letter

Successful treatment of l-asparaginase-induced severe acute hepatotoxicity using mitochondrial cofactors

Chadi Al-NawakilUnité Fonctionnelle d’Hématologie;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France
,
Lise WillemsUnité Fonctionnelle d’Hématologie;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France
,
Cedric MauprivezCentre régional de Pharmacovigilance
,
Benjamin LaffyUnité Fonctionnelle d’Hématologie;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France
,
Mona Benm’radUniversité Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Service de Médecine Interne
,
Jerome TamburiniUnité Fonctionnelle d’Hématologie;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France
,
Helene FontaineUniversité Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Service d’Hépatologie
,
Philippe SogniUniversité Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Service d’Hépatologie
,
Benoit TerrisUniversité Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Service d’Anatomopathologie, Hôpital Cochin, AP-HP, Paris, France
,
Didier BouscaryUnité Fonctionnelle d’Hématologie;Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France
&
Laurence MoachonUniversité Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, Paris, France;Centre régional de PharmacovigilanceCorrespondence[email protected]
 show all
Pages 1670-1674 | Received 02 Aug 2013, Accepted 12 Sep 2013, Published online: 14 Nov 2013

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Krishna R Juluri, Chloe Siu & Ryan D Cassaday. (2022) Asparaginase in the Treatment of Acute Lymphoblastic Leukemia in Adults: Current Evidence and Place in Therapy. Blood and Lymphatic Cancer: Targets and Therapy 12, pages 55-79.
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Gözde Nur Yurttaş, Zeynep Canan Özdemir, Cihan Tanrıkut, Ezgi Kar, Zeynep Küskü Kiraz, Özkan Alataş, Dilek Burukoğlu Dönmez & Özcan Bör. (2022) The effects of N-acetylcysteine on experimentally created l-asparaginase-induced liver and pancreatic damage in rats. Leukemia & Lymphoma 63:6, pages 1445-1454.
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Elena Trang, Dat Ngo, Jason Chen, Ibrahim Aldoss, Amandeep Salhotra & Vinod Pullarkat. (2020) Levocarnitine for pegasparaginase-induced hepatotoxicity in acute lymphoblastic leukemia. Leukemia & Lymphoma 61:13, pages 3161-3164.
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Jessica L. Sea, Etan Orgel, Ting Chen, Rebecca L. Paszkiewicz, Abigail S. Krall, Matthew J. Oberley, Linsey Stiles & Steven D. Mittelman. (2020) Levocarnitine does not impair chemotherapy cytotoxicity against acute lymphoblastic leukemia. Leukemia & Lymphoma 61:2, pages 420-428.
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Yiwei Liu, Laura J. Janke, Lie Li & Mary V. Relling. (2019) L-carnitine does not ameliorate asparaginase-associated hepatotoxicity in a C57BL6 mouse model. Leukemia & Lymphoma 60:8, pages 2088-2090.
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Rachael R. Schulte, Manasi V. Madiwale, Allyson Flower, Jessica Hochberg, Michael J. Burke, Jennifer L. McNeer, Adam DuVall & Archie Bleyer. (2018) Levocarnitine for asparaginase-induced hepatic injury: a multi-institutional case series and review of the literature. Leukemia & Lymphoma 59:10, pages 2360-2368.
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Caitlin R. Rausch, Bernard L. Marini, Lydia L. Benitez, Allison Elias, Patrick W. Burke, Dale Bixby & Anthony J. Perissinotti. (2018) PEGging down risk factors for peg-asparaginase hepatotoxicity in patients with acute lymphoblastic leukemia. Leukemia & Lymphoma 59:3, pages 617-624.
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Gary Lu, Vinit Karur, Jon D. Herrington & Mary G. Walker. (2016) Successful Treatment of Pegaspargase-Induced Acute Hepatotoxicity with Vitamin B Complex and L-Carnitine. Baylor University Medical Center Proceedings 29:1, pages 46-47.
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Calogero Vetro, Andrea Duminuco, Lucia Gozzo, Cinzia Maugeri, Marina Parisi, Serena Brancati, Laura Longo, Daniela Cristina Vitale, Giovanni Luca Romano, Roberto Ciuni, Elisa Mauro, Paolo Fabio Fiumara, Giuseppe Alberto Maria Palumbo, Filippo Drago & Francesco Di Raimondo. (2022) Pegylated Asparaginase‐Induced Liver Injury: A Case‐Based Review and Data From Pharmacovigilance. The Journal of Clinical Pharmacology 62:9, pages 1142-1150.
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Gundala Venkata Naveen Kumar, Keito Hoshitsuki, Sanjay Rathod, Manda J. Ramsey, Lauren Kokai, Erin E. Kershaw, Wen Xie & Christian A. Fernandez. (2021) Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice. Acta Pharmaceutica Sinica B 11:12, pages 3779-3790.
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Kjeld Schmiegelow, Cecilie Utke Rank, Wendy Stock, Emily Dworkin & Inge van der Sluis. (2021) SOHO State of the Art Updates and Next Questions: Management of Asparaginase Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia. Clinical Lymphoma Myeloma and Leukemia 21:11, pages 725-733.
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Rachael Schulte, Ashley Hinson, Van Huynh, Erin H. Breese, Joanna Pierro, Seth Rotz, Benjamin A. Mixon, Jennifer L. McNeer, Michael J. Burke & Etan Orgel. (2021) Levocarnitine for pegaspargase‐induced hepatotoxicity in older children and young adults with acute lymphoblastic leukemia. Cancer Medicine 10:21, pages 7551-7560.
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Christina Lee, Thomas M Leventhal & Chimaobi M Anugwom. (2021) L-Asparaginase-Induced Hepatotoxicity Treated Successfully With L-Carnitine and Vitamin B Infusion. Cureus.
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Ibrahim Aldoss & Dan Douer. (2020) How I Treat the Toxicities of Pegasparaginase in Adults with Acute Lymphoblastic Leukemia. Blood.
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Najeebah A Bade, Crystal Lu, Ciera L Patzke, Maria R Baer, Vu H Duong, Jennie Y Law, Seung T Lee, Edward A Sausville, Ann B Zimrin, Alison P Duffy, Justin Lawson & Ashkan Emadi. (2019) Optimizing pegylated asparaginase use: An institutional guideline for dosing, monitoring, and management. Journal of Oncology Pharmacy Practice 26:1, pages 74-92.
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Bernard Fromenty. (2019) Inhibition of mitochondrial fatty acid oxidation in drug-induced hepatic steatosis. Liver Research 3:3-4, pages 157-169.
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Natasha Kamal, Christopher Koh, Niharika Samala, Robert J. Fontana, Andrew Stolz, Francisco Durazo, Paul H. Hayashi, Elizabeth Phillips, Tongrong Wang & Jay H. Hoofnagle. (2019) Asparaginase-induced hepatotoxicity: rapid development of cholestasis and hepatic steatosis. Hepatology International 13:5, pages 641-648.
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Sumant Arora, Jagpal Klair, Andrew M. Bellizzi & Tomohiro Tanaka. (2019) L-carnitine and Vitamin B Complex for PEG-L-asparaginase-Induced Hepatotoxicity. ACG Case Reports Journal 6:8, pages e00194.
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Alison Blackman, Alyssa Boutin, Alexei Shimanovsky, William J Baker & Nicholas Forcello. (2017) Levocarnitine and vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: A case report and review of the literature. Journal of Oncology Pharmacy Practice 24:5, pages 393-397.
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Caitlin R. Rausch, Shilpa Paul, Kayleigh R. Marx, Elias Jabbour, Naveen Pemmaraju, Alessandra Ferrajoli & Hagop Kantarjian. (2018) L-carnitine and Vitamin B Complex for the Treatment of Pegasparaginase-induced Hyperbilirubinemia. Clinical Lymphoma Myeloma and Leukemia 18:5, pages e191-e195.
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Bernard L. Marini, Anthony J. Perissinotti, Dale L. Bixby, Julia Brown & Patrick W. Burke. (2017) Catalyzing improvements in ALL therapy with asparaginase. Blood Reviews 31:5, pages 328-338.
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. (2017) Hepatology Clinical. Journal of Gastroenterology and Hepatology 32:S2, pages 87-115.
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Robert S. Bresalier, H. Franklin Herlong & Boris Blechacz. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 16 .
Zeynep Canan ÖzdemirAyşe Bozkurt TurhanMakbule ErenÖzcan Bor. (2017) Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity?. Blood Research 52:1, pages 69.
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Ruham Alshiekh-Nasany & Dan Douer. (2016) <smlcap>L</smlcap>-Carnitine for Treatment of Pegasparaginase-Induced Hepatotoxicity. Acta Haematologica 135:4, pages 208-210.
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Elizabeth Emma Palmer, Jaclyn Hayner, Rani Sachdev, Michael Cardamone, Tejaswi Kandula, Paula Morris, Kerith-Rae Dias, Jiang Tao, David Miller, Ying Zhu, Rebecca Macintosh, Marcel E. Dinger, Mark J. Cowley, Michael F. Buckley, Tony Roscioli, Ann Bye, Michael S. Kilberg & Edwin P. Kirk. (2015) Asparagine Synthetase Deficiency causes reduced proliferation of cells under conditions of limited asparagine. Molecular Genetics and Metabolism 116:3, pages 178-186.
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. (2014) Asparaginase. Reactions Weekly 1511:1, pages 8-8.
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