Advanced search
Publication Cover
Leukemia & Lymphoma Volume 55, 2014 - Issue 7
Submit an article Journal homepage
254
Views
16
CrossRef citations to date
0
Altmetric
Research Article

Medium-sized FLT3 internal tandem duplications confer worse prognosis than short and long duplications in a non-elderly acute myeloid leukemia cohort

Magdalena KoszarskaLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, HungaryCorrespondence[email protected]
,
Nora MeggyesiLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
,
Andras BorsLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
,
Arpad BataiDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Otto CsacsovszkiDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Eniko LehoczkyDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Emma AdamDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Andras KozmaDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Nora LovasDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Andrea SiposDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Tunde KrahlingLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
,
Janos DolgosDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Peter RemenyiDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Sandor FeketeDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Tamas MassziDepartment of Hematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital, Budapest, Hungary
,
Attila TordaiLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
&
Hajnalka AndrikovicsLaboratory of Molecular Diagnostics, Hungarian National Blood Transfusion Service, Budapest, Hungary
 show all
Pages 1510-1517 | Received 13 May 2013, Accepted 24 Sep 2013, Published online: 25 Nov 2013

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Joaquin Sanchez-Garcia, Josefina Serrano, Esther Prados de La Torre, Juana Serrano-López, Clara Aparicio-Perez, E Barragán & Pau Montesinos. (2023) Identifying prognostic gene panels in acute myeloid leukemia. Expert Review of Hematology 16:4, pages 277-287.
Read now
Gail J. Roboz, Stephen A. Strickland, Mark R. Litzow, Andrew Dalovisio, Alexander E. Perl, Gaetano Bonifacio, Kelly Haines, Alysha Barbera, Das Purkayastha & Kendra Sweet. (2020) Updated safety of midostaurin plus chemotherapy in newly diagnosed FLT3 mutation–positive acute myeloid leukemia: the RADIUS-X expanded access program. Leukemia & Lymphoma 61:13, pages 3146-3153.
Read now
Mrinal M. Patnaik. (2018) The importance of FLT3 mutational analysis in acute myeloid leukemia. Leukemia & Lymphoma 59:10, pages 2273-2286.
Read now

Articles from other publishers (13)

Kun-yin Qiu, Xiong-yu Liao, Yong Liu, Ke Huang, Yang Li, Jian-pei Fang & Dun-hua Zhou. (2022) Poor outcome of pediatric patients with acute myeloid leukemia harboring high FLT3/ITD allelic ratios. Nature Communications 13:1.
Crossref
Tristan E. Knight, Holly Edwards, Soheil Meshinchi, Jeffrey W. Taub & Yubin Ge. (2022) “FLipping” the Story: FLT3-Mutated Acute Myeloid Leukemia and the Evolving Role of FLT3 Inhibitors. Cancers 14:14, pages 3398.
Crossref
Elizabeth M. Corley, Moaath K. Mustafa Ali, Hanan Alharthy, Kathryn A. F. Kline, Danielle Sewell, Jennie Y. Law, Seung Tae Lee, Sandrine Niyongere, Vu H. Duong, Maria R. Baer & Ashkan Emadi. (2022) Impact of FLT3-ITD Insertion Length on Outcomes in Acute Myeloid Leukemia: A Propensity Score-Adjusted Cohort Study. Biology 11:6, pages 916.
Crossref
Nevine F. Shafik, Amira D. Darwish, Rasha Mahmoud Allam & Ghada M. Elsayed. (2021) FLT3-ITD Allele Frequency Is an Independent Prognostic Factor for Poor Outcome in FLT3-ITD–Positive AML Patients. Clinical Lymphoma Myeloma and Leukemia 21:10, pages 676-685.
Crossref
Danyang Yuan, Xiaoyu He, Xinyin Han, Chunyan Yang, Fei Liu, Shuying Zhang, Haijing Luan, Ruilin Li, Jiayin He, Xiaohong Duan, Dongliang Wang, Qiming Zhou, Sujun Gao & Beifang Niu. (2021) Comprehensive review and evaluation of computational methods for identifying FLT3 -internal tandem duplication in acute myeloid leukaemia . Briefings in Bioinformatics 22:5.
Crossref
Caroline Engen, Monica Hellesøy, Tim Grob, Adil Al Hinai, Atle Brendehaug, Line Wergeland, Siv Lise Bedringaas, Randi Hovland, Peter J. M. Valk & Bjørn T. Gjertsen. (2021) FLT3‐ITD mutations in acute myeloid leukaemia – molecular characteristics, distribution and numerical variation. Molecular Oncology 15:9, pages 2300-2317.
Crossref
Kenichi Miyamoto & Yosuke Minami. (2020) Cutting Edge Molecular Therapy for Acute Myeloid Leukemia. International Journal of Molecular Sciences 21:14, pages 5114.
Crossref
Fang Chen, Junya Sun, Changxin Yin, Jiaying Cheng, Jinle Ni, Ling Jiang, Qiang Wang, Guopan Yu, Yongqiang Wei, Xiaoli Liu, Jing Sun, Bing Z. Carter & Xuejie Jiang. (2019) Impact of FLT3-ITD allele ratio and ITD length on therapeutic outcome in cytogenetically normal AML patients without NPM1 mutation. Bone Marrow Transplantation 55:4, pages 740-748.
Crossref
Maryam Arab, Shahrbano Rostami, Nasrin Alizad Ghandforoush, Mohsen Nikbakht, Saeed Mohammadi, Arvin Samemaleki, Kamran Alimoghaddam & Bahram Chahardouli. (2019) Comparison of Delta- PCR and Conventional Fragment Analysis for the Detection of FLT3-ITD Mutations in Paired Diagnosis-Relapse Samples of Patients with Acute Myeloid Leukemia. Journal of Advances in Medical and Biomedical Research 27:123, pages 38-44.
Crossref
Akira Shimada, Yuka Iijima-Yamashita, Akio Tawa, Daisuke Tomizawa, Miho Yamada, Shiba Norio, Tomoyuki Watanabe, Takashi Taga, Shotaro Iwamoto, Kiminori Terui, Hiroshi Moritake, Akitoshi Kinoshita, Hiroyuki Takahashi, Hideki Nakayama, Katsuyoshi Koh, Hiroaki Goto, Yoshiyuki Kosaka, Akiko Moriya Saito, Nobutaka Kiyokawa, Keizo Horibe, Yusuke Hara, Kentaro Oki, Yasuhide Hayashi, Shiro Tanaka & Souichi Adachi. (2018) Risk-stratified therapy for children with FLT3-ITD-positive acute myeloid leukemia: results from the JPLSG AML-05 study. International Journal of Hematology 107:5, pages 586-595.
Crossref
Vanessa Y.N. de Arruda, Lisa N. Matsuzaki & Maria de Lourdes Chauffaille. (2017) FMS-related tyrosine kinase 3 internal tandem duplication (FLT3-ITD): a villain among others. Revista Brasileira de Hematologia e Hemoterapia 39:3, pages 283-284.
Crossref
Caroline Engen, Line Wergeland, Jørn Skavland & Bjørn Gjertsen. (2014) Targeted Therapy of FLT3 in Treatment of AML—Current Status and Future Directions. Journal of Clinical Medicine 3:4, pages 1466-1489.
Crossref
Kun-yin Qiu, Xiong-yu Liao, Dun-hua Zhou & Jian-pei Fang. (2021) Poor Outcome of Pediatric Patients with Acute Myeloid Leukemia Harbour High FLT3/ITD Allelic Ratios. SSRN Electronic Journal.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.