Advanced search
Publication Cover
Leukemia & Lymphoma Volume 55, 2014 - Issue 12
Submit an article Journal homepage
695
Views
38
CrossRef citations to date
0
Altmetric
Review Article

Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutations in adult patients with acute myeloid leukemia: a meta-analysis

Wen-Jian LiuDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Xiao-Hong TanDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Xiu-Ping LuoDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Bao-Ping GuoDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Zhou-Ji WeiDepartment of Radiotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Qing KeDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
,
Sha HeDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China
&
Hong CenDepartment of Chemotherapy, Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of ChinaCorrespondence[email protected]
 show all
Pages 2691-2698 | Received 08 Dec 2013, Accepted 01 Feb 2014, Published online: 31 Mar 2014

Citations (38)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Bianhong Wang, Wei Guan, Na Lv, Ting Li, Fan Yu, Yuehua Huang, Yanying Wang, Lihong Li & Li Yu. (2021) Genetic features and efficacy of decitabine-based chemotherapy in elderly patients with acute myeloid leukemia. Hematology 26:1, pages 371-379.
Read now
Yun Lin, Yaping Wang, Yi Zheng, Zechuan Wang, Yanni Wang & Shaoyuan Wang. (2020) Clinical characteristics and prognostic study of adult acute myeloid leukemia patients with ASXL1 mutations. Hematology 25:1, pages 446-456.
Read now
Hsin-An Hou & Hwei-Fang Tien. (2016) Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility. Expert Review of Hematology 9:5, pages 447-469.
Read now
Angela Nebbioso, Rosaria Benedetti, Mariarosaria Conte, Concetta Iside & Lucia Altucci. (2015) Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia. Expert Opinion on Therapeutic Targets 19:9, pages 1187-1202.
Read now

Articles from other publishers (34)

Xiaoyan Xu, Hong Wang, Haohao Han, Yifang Yao, Xueqian Li, Jiaqian Qi, Chengsen Cai, Meng Zhou, Yaqiong Tang, Tingting Pan, Ziyan Zhang, Jingyi Yang, Depei Wu & Yue Han. (2023) Clinical characteristics and prognostic significance of DNA methylation regulatory gene mutations in acute myeloid leukemia. Clinical Epigenetics 15:1.
Crossref
Friedrich Stölzel, Sarah E. Fordham, Devi Nandana, Wei-Yu Lin, Helen Blair, Claire Elstob, Hayden L. Bell, Brigitte Mohr, Leo Ruhnke, Desiree Kunadt, Claudia Dill, Daniel Allsop, Rachel Piddock, Emmanouela-Niki Soura, Catherine Park, Mohd Fadly, Thahira Rahman, Abrar Alharbi, Manja Wobus, Heidi Altmann, Christoph Röllig, Lisa Wagenführ, Gail L. Jones, Tobias Menne, Graham H. Jackson, Helen J. Marr, Jude Fitzgibbon, Kenan Onel, Manja Meggendorfer, Amber Robinson, Zuzanna Bziuk, Emily Bowes, Olaf Heidenreich, Torsten Haferlach, Sara Villar, Beñat Ariceta, Rosa Ayala Diaz, Steven J. Altschuler, Lani F. Wu, Felipe Prosper, Pau Montesinos, Joaquin Martinez-Lopez, Martin Bornhäuser & James M. Allan. (2023) Biallelic TET2 mutations confer sensitivity to 5′-azacitidine in acute myeloid leukemia. JCI Insight 8:2.
Crossref
Reem Nabil, Naglaa M. Hassan, Mona S. Abdellateif, Rania M. Gawdat & Samar Sami Elshazly. (2022) The prognostic role of C-KIT, TET1 and TET2 gene expression in Acute Myeloid Leukemia. Molecular Biology Reports 50:1, pages 641-653.
Crossref
Ting Yang, Xiaobo Liu, Shaji K. Kumar, Fengyan Jin & Yun Dai. (2022) Decoding DNA methylation in epigenetics of multiple myeloma. Blood Reviews 51, pages 100872.
Crossref
Devipriya Padmakumar, Vineetha Radhakrishnan Chandraprabha, Preethi Gopinath, Akhila Raj Thampirajan Vimala Devi, Geetha Raj John Anitha, Mahitha Mohanan Sreelatha, Amritha Padmakumar & Hariharan Sreedharan. (2021) A concise review on the molecular genetics of acute myeloid leukemia. Leukemia Research 111, pages 106727.
Crossref
James Yu, Jingxin Sun, Yuan Du, Rushang Patel, Juan Carlos Varela, Shahram Mori & Chung-Che Chang. (2021) Adverse Impact of DNA Methylation Regulatory Gene Mutations on the Prognosis of AML Patients in the 2017 ELN Favorable Risk Group, Particularly Those Defined by NPM1 Mutation. Diagnostics 11:6, pages 986.
Crossref
Mateus de Oliveira Lisboa, Paulo Roberto Slud Brofman, Ana Teresa Schmid-Braz, Aline Rangel-Pozzo & Sabine Mai. (2021) Chromosomal Instability in Acute Myeloid Leukemia. Cancers 13:11, pages 2655.
Crossref
Rui Zhang, Lili Wang, Peng Chen, Xiaoning Gao, Shuhong Wang, Fei Li, Liping Dou, Chunji Gao, Yan Li & Daihong Liu. (2021) Haematologic malignancies with unfavourable gene mutations benefit from donor lymphocyte infusion with/without decitabine for prophylaxis of relapse after allogeneic HSCT: A pilot study. Cancer Medicine 10:10, pages 3165-3176.
Crossref
Emmalee R. Adelman & Maria E. Figueroa. (2021) Human hematopoiesis: aging and leukemogenic risk. Current Opinion in Hematology 28:1, pages 57-63.
Crossref
Chang-Bin Jing, Cong Fu, Nicole Prutsch, Meng Wang, Shuning He & A. Thomas Look. (2020) Synthetic lethal targeting of TET2-mutant hematopoietic stem and progenitor cells (HSPCs) with TOP1-targeted drugs and PARP1 inhibitors. Leukemia 34:11, pages 2992-3006.
Crossref
Justin S. Becker & Amir T. Fathi. (2020) Targeting IDH Mutations in AML: Wielding the Double-edged Sword of Differentiation. Current Cancer Drug Targets 20:7, pages 490-500.
Crossref
Qingyu Xu, Yan Li, Yu Jing, Na Lv, Lili Wang, Yonghui Li & Li Yu. (2019) Epigenetic modifier gene mutations‐positive AML patients with intermediate‐risk karyotypes benefit from decitabine with CAG regimen. International Journal of Cancer 146:5, pages 1457-1467.
Crossref
Pimjai Niparuck, Nittaya Limsuwanachot, Sulada Pukiat, Pichika Chantrathammachart, Budsaba Rerkamnuaychoke, Sutada Magmuang, Sithakom Phusanti, Kochawan Boonyawat, Teeraya Puavilai, Pantep Angchaisuksiri, Artit Ungkanont & Suporn Chuncharunee. (2019) Cytogenetics and FLT3-ITD mutation predict clinical outcomes in non transplant patients with acute myeloid leukemia. Experimental Hematology & Oncology 8:1.
Crossref
Ruiqi Wang, Xiaoning Gao & Li Yu. (2019) The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysis. BMC Cancer 19:1.
Crossref
Ping Zhang, Wen‐Wen Weng, Ping Chen, Yao Zhang, Jin‐Fei Ruan, Dian‐Dian Ba, Wei‐Qun Xu & Yong‐Min Tang. (2019) Low expression of TET2 gene in pediatric acute lymphoblastic leukemia is associated with poor clinical outcome . International Journal of Laboratory Hematology 41:5, pages 702-709.
Crossref
Q. Richard Lu, Lily Qian & Xianyao Zhou. (2019) Developmental origins and oncogenic pathways in malignant brain tumors. WIREs Developmental Biology 8:4.
Crossref
Yimei Feng, Xiaoping Li, Kaniel Cassady, Zhongmin Zou & Xi Zhang. (2019) TET2 Function in Hematopoietic Malignancies, Immune Regulation, and DNA Repair. Frontiers in Oncology 9.
Crossref
Ting‐Juan Zhang, Jing‐Dong Zhou, Dong‐Qin Yang, Yu‐Xin Wang, Xiang‐Mei Wen, Hong Guo, Lei Yang, Xin‐Yue Lian, Jiang Lin & Jun Qian. (2018) TET2 expression is a potential prognostic and predictive biomarker in cytogenetically normal acute myeloid leukemia . Journal of Cellular Physiology 233:8, pages 5838-5846.
Crossref
Emily F. Mason, Frank C. Kuo, Robert P. Hasserjian, Adam C. Seegmiller & Olga Pozdnyakova. (2018) A distinct immunophenotype identifies a subset of NPM1 -mutated AML with TET2 or IDH1/2 mutations and improved outcome . American Journal of Hematology 93:4, pages 504-510.
Crossref
Pillai Pallavi Madhusoodhan, William L. Carroll & Teena Bhatla. 2018. Epigenetic Mechanisms in Cancer. Epigenetic Mechanisms in Cancer 1 30 .
Peng Li & Robert S. Ohgami. 2018. Precision Molecular Pathology of Myeloid Neoplasms. Precision Molecular Pathology of Myeloid Neoplasms 47 82 .
Verónica González-Calle, Niamh Keane, Esteban Braggio & Rafael Fonseca. (2017) Precision Medicine in Myeloma: Challenges in Defining an Actionable Approach. Clinical Lymphoma Myeloma and Leukemia 17:10, pages 621-630.
Crossref
Pere Llinàs-Arias & Manel Esteller. (2017) Epigenetic inactivation of tumour suppressor coding and non-coding genes in human cancer: an update. Open Biology 7:9, pages 170152.
Crossref
Qingyu Xu, Yan Li, Na Lv, Yu Jing, Yihan Xu, Yuyan Li, Wenjun Li, Zilong Yao, Xiaosu Chen, Sai Huang, Lili Wang, Yonghui Li & Li Yu. (2017) Correlation Between Isocitrate Dehydrogenase Gene Aberrations and Prognosis of Patients with Acute Myeloid Leukemia: A Systematic Review and Meta-Analysis. Clinical Cancer Research 23:15, pages 4511-4522.
Crossref
Po-Han Lin, Huei-Ying Li, Sheng-Chih Fan, Tzu-Hang Yuan, Ming Chen, Yu-Hua Hsu, Yu-Hsuan Yang, Long-Yuan Li, Su-Peng Yeh, Li-Yuan Bai, Yu-Min Liao, Chen-Yuan Lin, Ching-Yun Hsieh, Ching-Chan Lin, Che-Hung Lin, Ming-Yu Lien, Tzu-Ting Chen, Yen-Hsuan Ni & Chang-Fang Chiu. (2017) A targeted next-generation sequencing in the molecular risk stratification of adult acute myeloid leukemia: implications for clinical practice. Cancer Medicine 6:2, pages 349-360.
Crossref
Jae-Sook Ahn, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seung-Shin Lee, Seo-Yeon Ahn, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Hee Jeong Park, Seung Hyun Choi, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim, Szardenings Michael, Mark D. Minden & Dennis Dong Hwan Kim. (2016) 5-Hydroxymethylcytosine correlates with epigenetic regulatory mutations, but may not have prognostic value in predicting survival in normal karyotype acute myeloid leukemia. Oncotarget 8:5, pages 8305-8314.
Crossref
Marcia Cristina Zago Novaretti. (2016) Rethinking the gold standard for recurrent DNA mutations detection in acute myeloid leukemia. European Journal of Haematology 96:2, pages 109-110.
Crossref
Jae-Sook Ahn, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Seun-Shin Lee, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Nan Young Kim, Seung Hyun Choi, Chul Won Jung, Jun-Ho Jang, Hee Je Kim, Joon Ho Moon, Sang Kyun Sohn, Jong-Ho Won, Sung-Hyun Kim & Dennis Dong Hwan Kim. (2016) DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation. Biology of Blood and Marrow Transplantation 22:1, pages 61-70.
Crossref
Kareem Jamani & Carolyn Owen. (2015) Update on recurrent genetic aberrations in acute myeloid leukemia. International Journal of Hematologic Oncology 4:5, pages 179-190.
Crossref
James M. Ziai & Alexa J. Siddon. (2015) Pathology Consultation on Gene Mutations in Acute Myeloid Leukemia. American Journal of Clinical Pathology 144:4, pages 539-554.
Crossref
Brian Parkin, Peter Ouillette, Mehmet Yildiz, Kamlai Saiya-Cork, Kerby Shedden & Sami N. Malek. (2015) Integrated Genomic Profiling, Therapy Response, and Survival in Adult Acute Myelogenous Leukemia. Clinical Cancer Research 21:9, pages 2045-2056.
Crossref
Xin Hu, Yun Chen & Zhizhuang Joe Zhao. 2015. Epigenetic Gene Expression and Regulation. Epigenetic Gene Expression and Regulation 379 395 .
Raymond Lo & Rosanna Weksberg. (2014) Biological and biochemical modulation of DNA methylation. Epigenomics 6:6, pages 593-602.
Crossref
Yun Huang & Anjana Rao. (2014) Connections between TET proteins and aberrant DNA modification in cancer. Trends in Genetics 30:10, pages 464-474.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.