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Leukemia & Lymphoma Volume 56, 2015 - Issue 1
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Original Article: Clinical

Aggressive mature natural killer cell neoplasms: report on a series of 12 European patients with emphasis on flow cytometry based immunophenotype and DNA content of neoplastic natural killer cells

Margarida LimaLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, PortugalCorrespondence[email protected] [email protected]
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Ana SpínolaDepartment of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal
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Sónia FonsecaLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Ana Helena SantosLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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João RodriguesUnit of Molecular Biology, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal
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Lurdes OliveiraLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Maria Luís QueirósLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Marlene SantosLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Marta GonçalvesLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Catarina LauLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Maria dos Anjos TeixeiraLaboratory of Cytometry, Department of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal;Unit for Multidisciplinary Investigation in Biomedicine, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto (UMIB/ICBAS/UP), Porto, Portugal
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Cristina GonçalvesDepartment of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal
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Cristina MarquesDepartment of Clinical Pathology, Centro Hospitalar de São João (CHSJ), Porto, Portugal
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Manuel GuerreiroDepartment of Hematology, Centro Hospitalar de São João (CHSJ), Porto, Portugal
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Manuel CunhaDepartment of Hematology, Hospital de Vila Real, Centro Hospitalar de Trás-os-Montes e Alto Douro (CHTMAD), Vila Real, Portugal
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Fernando PríncipeDepartment of Hematology, Centro Hospitalar de São João (CHSJ), Porto, Portugal
&
Jorge CoutinhoDepartment of Hematology, Hospital de Santo António (HSA), Centro Hospitalar do Porto (CHP), Porto, Portugal
 show all
Pages 103-112 | Received 04 Aug 2013, Accepted 12 Mar 2014, Published online: 06 May 2014

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Yumeng Zhang, Dasom Lee, Quinto Gesiotto & Lubomir Sokol. (2021) Aggressive natural killer cell leukemia: diagnosis, treatment recommendations, and emerging therapies. Expert Review of Hematology 14:8, pages 731-740.
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Ying Hu & Jingbo Wang. (2017) Aggressive natural killer cell leukemia: a case report. International Medical Case Reports Journal 10, pages 389-391.
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Vikram Sumbly, Mallorie Vest & Ian Landry. (2022) Aggressive Natural Killer Cell Leukemia: A Brief Overview of Its Genomic Landscape, Histological Features, and Current Management. Cureus.
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Anna Bigas, Juan José Rodriguez-Sevilla, Lluis Espinosa & Fernando Gallardo. (2022) Recent advances in T-cell lymphoid neoplasms. Experimental Hematology 106, pages 3-18.
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Siba El Hussein, L. Medeiros & Joseph Khoury. (2020) Aggressive NK Cell Leukemia: Current State of the Art. Cancers 12:10, pages 2900.
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Siba El Hussein, Keyur P. Patel, Hong Fang, Beenu Thakral, Sanam Loghavi, Rashmi Kanagal-Shamanna, Sergej Konoplev, Elias J. Jabbour, L. Jeffrey Medeiros & Joseph D. Khoury. (2020) Genomic and Immunophenotypic Landscape of Aggressive NK-Cell Leukemia. American Journal of Surgical Pathology 44:9, pages 1235-1243.
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Jian‐Chao Wang, Xue‐Qin Deng, Wei‐Ping Liu, Li‐Min Gao, Wen‐Yan Zhang, Jia‐Qi Yan, Yun‐Xia Ye, Feng Liu & Sha Zhao. (2019) Comprehensive Flow‐Cytometry‐Based Immunophenotyping Analysis for Accurate Diagnosis and Management of Extranodal NK/T Cell Lymphoma, Nasal Type. Cytometry Part B: Clinical Cytometry 98:1, pages 28-35.
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Jeffrey W. Craig & David M. Dorfman. (2017) Flow Cytometry of T cells and T-cell Neoplasms. Clinics in Laboratory Medicine 37:4, pages 725-751.
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M. M. Sales, S. I. A. C. P. Ferreira, M. R. V. Ikoma, A. F. Sandes, M. P. Beltrame, N. S. Bacal, M. C. A. Silva, M. Malvezzi, I. G. H. Lorand-Metze, A. Orfao & M. Yamamoto. (2017) Diagnosis of chronic lymphoproliferative disorders by flow cytometry using four-color combinations for immunophenotyping: A proposal of the brazilian group of flow cytometry (GBCFLUX). Cytometry Part B: Clinical Cytometry 92:5, pages 398-410.
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Juehua Gao, Amir Behdad, Peng Ji, Kristy L Wolniak, Olga Frankfurt & Yi-Hua Chen. (2017) EBV-negative aggressive NK-cell leukemia/lymphoma: a clinical and pathological study from a single institution. Modern Pathology 30:8, pages 1100-1115.
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F. E. Craig. (2017) The utility of peripheral blood smear review for identifying specimens for flow cytometric immunophenotyping. International Journal of Laboratory Hematology 39, pages 41-46.
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M. Guerreiro, F. Príncipe, M. J. Teles, S. Fonseca, A. H. Santos, E. Fonseca, P. Gomes, C. Marques & M. Lima. (2017) CD56-Negative Aggressive NK Cell Leukemia Relapsing as Multiple Cranial Nerve Palsies: Case Report and Literature Review. Case Reports in Hematology 2017, pages 1-9.
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Yi Li, Jia Wei, Xia Mao, Qingping Gao, Longlong Liu, Ping Cheng, Limei Liu, Xinhua Zhang, Ke Zhang, Jin Wang, Li Zhu, Jianfeng Zhou, Yicheng Zhang, Li Meng, Hanying Sun, Dengju Li, Mei Huang, Wei Huang, Jinniu Deng & Donghua Zhang. (2016) Flow Cytometric Immunophenotyping Is Sensitive for the Early Diagnosis of De Novo Aggressive Natural Killer Cell Leukemia (ANKL): A Multicenter Retrospective Analysis. PLOS ONE 11:8, pages e0158827.
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Li-Min Gao, Sha Zhao, Wei-Ping Liu, Wen-Yan Zhang, Gan-Di Li, Can Küçük, Xiao-Zhou Hu, Wing C. Chan, Yuan Tang, Wen-Shuang Ding, Jia-Qi Yan, Wen-Qing Yao & Jian Chao Wang. (2016) Clinicopathologic Characterization of Aggressive Natural Killer Cell Leukemia Involving Different Tissue Sites. American Journal of Surgical Pathology 40:6, pages 836-846.
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Sara Maj Hyldig Matzen, Klaus Kallenbach, Anne Regitze Reumert & Lars Munksgaard. (2015) Aggressive NK-cell leukemia in a 69 years old Caucasian woman: a case report. SpringerPlus 4:1.
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Margarida Lima. (2015) Extranodal NK/T cell lymphoma and aggressive NK cell leukaemia: evidence for their origin on CD56+bright CD16–/+dim NK cells. Pathology 47:6, pages 503-514.
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Min Shi, Natasha M. Savage, Huda Salman & William G. Morice. (2015) A case of lymphoproliferative disorder of NK ‐cells: aggressive immunophenotype but indolent behavior . Clinical Case Reports 3:9, pages 740-743.
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Margarida Lima, Magdalena Leander, Marlene Santos, Ana Helena Santos, Catarina Lau, Maria Luís Queirós, Marta Gonçalves, Sónia Fonseca, João Moura, Maria dos Anjos Teixeira & Alberto Orfao. (2015) Chemokine Receptor Expression on Normal Blood CD56 + NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population . Journal of Immunology Research 2015, pages 1-18.
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Aaron Auerbach & Nadine S. Aguilera. (2015) Epstein–Barr virus (EBV)-associated lymphoid lesions of the head and neck. Seminars in Diagnostic Pathology 32:1, pages 12-22.
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