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Original Article: Research

Cryptotanshinone acts synergistically with imatinib to induce apoptosis of human chronic myeloid leukemia cells

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Pages 730-738 | Received 05 Mar 2014, Accepted 22 May 2014, Published online: 25 Jun 2014

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Read on this site (3)

Rubin Cheng, Yilan Huang, Yun Fang, Qirui Wang, Meixiu Yan & Yuqing Ge. (2021) Cryptotanshinone enhances the efficacy of Bcr-Abl tyrosine kinase inhibitors via inhibiting STAT3 and eIF4E signalling pathways in chronic myeloid leukaemia. Pharmaceutical Biology 59:1, pages 891-901.
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Mengru Lai, Yuqing Ge, Meng Chen, Siya Sun, Jianzhen Chen & Rubin Cheng. (2020) Saikosaponin D Inhibits Proliferation and Promotes Apoptosis Through Activation of MKK4–JNK Signaling Pathway in Pancreatic Cancer Cells. OncoTargets and Therapy 13, pages 9465-9479.
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Shuhui Guo, Weiwei Luo, Lijuan Liu, Xiaocong Pang, Hong Zhu, Ailin Liu, Jinjian Lu, Dik-Lung Ma, Chung-Hang Leung, Yitao Wang & Xiuping Chen. (2016) Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. Journal of Drug Targeting 24:10, pages 934-942.
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Articles from other publishers (13)

Tong Wang, Mengmeng Zhang, Muhammad Khan, Jingjing Li, Xiao Wu, Tonghui Ma & Yongming Li. (2024) Cryptotanshinone suppresses ovarian cancer via simultaneous inhibition of glycolysis and oxidative phosphorylation. Biomedicine & Pharmacotherapy 170, pages 115956.
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Tian LI, Kunzhan CAI, Xiaohan LIU, Hongjuan CAO, Jie LIU & Lin WU. (2023) Signal transducer and activator of transcription 3 positively regulates osteoblastic differentiation in MC3T3-E1 cells. Minerva Medica 114:4.
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Dachuan Zeng, Miao Gao, Renren Zheng, Run Qin, Wei He, Suotian Liu, Wei Wei & Zhenglan Huang. (2022) The HSP90 inhibitor KW-2478 depletes the malignancy of BCR/ABL and overcomes the imatinib-resistance caused by BCR/ABL amplification. Experimental Hematology & Oncology 11:1.
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Huayao Li, Chundi Gao, Cun Liu, Lijuan Liu, Jing Zhuang, Jing Yang, Chao Zhou, Fubin Feng, Changgang Sun & Jibiao Wu. (2021) A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen. Biomedicine & Pharmacotherapy 137, pages 111332.
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Siya Sun, Lingyan Zhu, Mengru Lai, Rubin Cheng & Yuqing Ge. (2021) Tanshinone I inhibited growth of human chronic myeloid leukemia cells via JNK/ERK mediated apoptotic pathways. Brazilian Journal of Medical and Biological Research 54:8.
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Yan-Hong Wu, Yu-Rui Wu, Bo Li & Zhu-Yun Yan. (2020) Cryptotanshinone: A review of its pharmacology activities and molecular mechanisms. Fitoterapia 145, pages 104633.
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Tengjiao Song, Jiangshun Yang, Jing Zhou, Zhe Chen & Xiaofeng Yuan. (2019) A Review of the Mechanisms of Wnt7b in the Process of Malignant Tumor Invasion and Metastasis. International Journal of Pharmacology 15:5, pages 523-532.
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Thomas Efferth, Mohamed E.M. Saeed, Elhaj Mirghani, Awadh Alim, Zahir Yassin, Elfatih Saeed, Hassan E. Khalid & Salah Daak. (2017) Integration of phytochemicals and phytotherapy into cancer precision medicine. Oncotarget 8:30, pages 50284-50304.
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Jiye Wang, Guangji Zhang, Chunyan Dai, Xiufei Gao, Jianbin Wu, Li Shen, Zhe Chen & Pei Liu. (2017) Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity. Journal of International Medical Research 45:1, pages 220-230.
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Ching-Fen Wu & Thomas Efferth. 2017. Salvia Biotechnology. Salvia Biotechnology 179 207 .
Ching-Fen Wu, Ean-Jeong Seo, Sabine M. Klauck & Thomas Efferth. (2016) Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic leukemia cells. Phytomedicine 23:2, pages 174-180.
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Uddalak Bharadwaj, Moses M. Kasembeli & David J. Tweardy. 2016. STAT Inhibitors in Cancer. STAT Inhibitors in Cancer 95 161 .
YUQING GE, BO YANG, ZHE CHEN & RUBIN CHENG. (2015) Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. Molecular Medicine Reports 12:5, pages 7782-7788.
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