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Original Article: Clinical

Role of folate status and methylenetetrahydrofolate reductase genotype on the toxicity and outcome of induction chemotherapy in children with acute lymphoblastic leukemia

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Pages 1379-1384 | Received 26 Mar 2014, Accepted 15 Jul 2014, Published online: 19 Aug 2014

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Dimitri Maamari, Habib El-Khoury, Omran Saifi, Samar A Muwakkit & Nathalie K Zgheib. (2020) Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia. Pharmacogenomics and Personalized Medicine 13, pages 295-317.
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Articles from other publishers (16)

Nienke R.K. Zwart, Mira D. Franken, Wim J.E. Tissing, Floor J.E. Lubberman, Jill A. McKay, Ellen Kampman & Dieuwertje E. Kok. (2023) Folate, folic acid, and chemotherapy-induced toxicities: A systematic literature review. Critical Reviews in Oncology/Hematology 188, pages 104061.
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O. D. Gurieva, M. I. Savelyeva & T. T. Valiev. (2022) Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review). Russian Journal of Pediatric Hematology and Oncology 8:4, pages 60-70.
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Yaqing Shen, Zhujun Wang, Fen Zhou & Runming Jin. (2021) The influence of MTHFR genetic polymorphisms on methotrexate therapy in pediatric acute lymphoblastic leukemia. Open Life Sciences 16:1, pages 1203-1212.
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Hedy Maagdenberg, Natanja Oosterom, Jolanda Zanen, Donato Gemmati, Rachael E. Windsor, Sandra G. Heil, Patricia Esperón, Shakila Jabeen, Guillermo J. Ruiz-Argüelles, Oliver Zolk, Susanne Hoerning, Charlotte Sleurs, Elixabet Lopéz-Lopéz, Mónica Moreno-Galván, Marry M. van den Heuvel-Eibrink, Anke H. Maitland-van der Zee & Bruce C. Carleton. (2021) Genetic variants associated with methotrexate-induced mucositis in cancer treatment: A systematic review and meta-analysis. Critical Reviews in Oncology/Hematology 161, pages 103312.
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Volkan Köse, Özlem Arman Bilir, Abdurrahman Kara, Namık Yaşar Özbek & Hüsniye Neşe Yaralı. (2020) The impact of pretreatment serum cobalamin and folate levels on complications and peripheral blood recovery during induction chemotherapy of leukemia: a cross-sectional study. Supportive Care in Cancer 29:4, pages 2225-2230.
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Ian J. Cohen. (2021) Folinic acid over rescue of high dose methotrexate: How problematic citations conserve discredited concepts. Medical Hypotheses 146, pages 110467.
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Guillermo Gervasini & Sonia Mota-Zamorano. (2019) Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia. Current Drug Metabolism 20:4, pages 313-330.
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Sonja Pavlovic, Nikola Kotur, Biljana Stankovic, Branka Zukic, Vladimir Gasic & Lidija Dokmanovic. (2019) Pharmacogenomic and Pharmacotranscriptomic Profiling of Childhood Acute Lymphoblastic Leukemia: Paving the Way to Personalized Treatment. Genes 10:3, pages 191.
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Lei Zhong, Xia He, Yuan Zhang, Jun-Lan Chuan, Min Chen, Shao-Min Zhu & Qian Peng. (2018) Relevance of methylenetetrahydrofolate reductase gene variants C677T and A1298C with response to fluoropyrimidine-based chemotherapy in colorectal cancer: a systematic review and meta-analysis. Oncotarget 9:58, pages 31291-31301.
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Petra C. Bachour & Stephen T. Sonis. (2018) Predicting mucositis risk associated with cytotoxic cancer treatment regimens: rationale, complexity, and challenges. Current Opinion in Supportive & Palliative Care 12:2, pages 198-210.
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C Zhu, Y W Liu, S Z Wang, X L Li, X L Nie, X T Yu, L B Zhao & X L Wang. (2017) Associations between the C677T and A1298C polymorphisms of MTHFR and the toxicity of methotrexate in childhood malignancies: a meta-analysis. The Pharmacogenomics Journal 18:3, pages 450-459.
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Rachel Conyers, Subalatha Devaraja & David Elliott. (2018) Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients. Pediatric Blood & Cancer 65:4, pages e26937.
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Nirmalya Roy Moulik, Archana Kumar, Suraksha Agrawal & Abbas Ali Mahdi. (2018) Folate deficiency in north Indian children undergoing maintenance chemotherapy for acute lymphoblastic leukemia-Implications and outcome. Pediatric Blood & Cancer 65:1, pages e26730.
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Fabrice Danjou, Claudio Fozza, Magdalena Zoledziewska, Antonella Mulas, Giovanna Corda, Salvatore Contini, Fausto Dore, Antonio Galleu, Anna Angela Di Tucci, Giovanni Caocci, Eleonora Gaviano, Giancarlo Latte, Attilio Gabbas, Paolo Casula, Lucia Gemma Delogu, Giorgio La Nasa, Emanuele Angelucci, Francesco Cucca & Maurizio Longinotti. (2016) A genome-wide association study by ImmunoChip reveals potential modifiers in myelodysplastic syndromes. Experimental Hematology 44:11, pages 1034-1038.
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Vid Mlakar, Patricia Huezo-Diaz Curtis, Chakradhara Satyanarayana Uppugunduri, Maja Krajinovic & Marc Ansari. (2016) Pharmacogenomics in Pediatric Oncology: Review of Gene—Drug Associations for Clinical Use. International Journal of Molecular Sciences 17:9, pages 1502.
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Fausto Zaruma-Torres, Ismael Lares-Asseff, Aurea Lima, Aarón Reyes-Espinoza, Verónica Loera-Castañeda, Martha Sosa-Macías, Carlos Galaviz-Hernández, María C. Arias-Peláez, Miguel A. Reyes-López & Luis A. Quiñones. (2016) Genetic Polymorphisms Associated to Folate Transport as Predictors of Increased Risk for Acute Lymphoblastic Leukemia in Mexican Children. Frontiers in Pharmacology 7.
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