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Original Article: Clinical

Lack of objective response of myelodysplastic syndromes and acute myeloid leukemia to decitabine after failure of azacitidine

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Pages 1718-1722 | Received 01 Jul 2014, Accepted 14 Sep 2014, Published online: 03 Nov 2014

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Read on this site (3)

Natalie Uy, Abhay Singh, Steven D. Gore & Thomas Prebet. (2017) Hypomethylating agents (HMA) treatment for myelodysplastic syndromes: alternatives in the frontline and relapse settings. Expert Opinion on Pharmacotherapy 18:12, pages 1213-1224.
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Abdallah Abou Zahr, Carolina Bernabe Ramirez, Jocelyn Wozney, Thomas Prebet & Amer M. Zeidan. (2016) New Insights into the Pathogenesis of MDS and the rational therapeutic opportunities. Expert Review of Hematology 9:4, pages 377-388.
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Abdallah Abou Zahr, Ehab Saad Aldin, Lisa Barbarotta, Nikolai Podoltsev & Amer M Zeidan. (2015) The clinical use of DNA methyltransferase inhibitors in myelodysplastic syndromes. Expert Review of Anticancer Therapy 15:9, pages 1019-1036.
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Articles from other publishers (14)

Kristína Šimoničová, Lubos Janotka, Helena Kavcova, Zdena Sulova, Lucia Messingerova & Albert Breier. (2023) Resistance of Leukemia Cells to 5-Azacytidine: Different Responses to the Same Induction Protocol. Cancers 15:11, pages 3063.
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Hussein Awada, Carmelo Gurnari, Zhuoer Xie, Jan Philipp Bewersdorf & Amer M. Zeidan. (2023) What’s Next after Hypomethylating Agents Failure in Myeloid Neoplasms? A Rational Approach. Cancers 15:8, pages 2248.
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Amer M. Zeidan, Uma Borate, Daniel A. Pollyea, Andrew M. Brunner, Fernando Roncolato, Jacqueline S. Garcia, Robin Filshie, Olatoyosi Odenike, Anne Marie Watson, Ravitharan Krishnadasan, Ashish Bajel, Kiran Naqvi, Jiuhong Zha, Wei‐Han Cheng, Ying Zhou, David Hoffman, Jason G. Harb, Jalaja Potluri & Guillermo Garcia‐Manero. (2022) A phase 1b study of venetoclax and azacitidine combination in patients with relapsed or refractory myelodysplastic syndromes. American Journal of Hematology 98:2, pages 272-281.
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Maria R. BaerAksinija A. KoganSøren M. BentzenTian Mi, Rena G. LapidusVu H. DuongAshkan EmadiSandrine NiyongereCasey L. O'Connell, Benjamin A. YoungbloodStephen B. Baylin & Feyruz V. Rassool. (2022) Phase I Clinical Trial of DNA Methyltransferase Inhibitor Decitabine and PARP Inhibitor Talazoparib Combination Therapy in Relapsed/Refractory Acute Myeloid Leukemia. Clinical Cancer Research 28:7, pages 1313-1322.
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Kristína Šimoničová, Ľuboš Janotka, Helena Kavcová, Zdena Sulová, Albert Breier & Lucia Messingerova. (2022) Different mechanisms of drug resistance to hypomethylating agents in the treatment of myelodysplastic syndromes and acute myeloid leukemia. Drug Resistance Updates 61, pages 100805.
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Guangjie Zhao, Qian Wang, Shuang Li & Xiaoqin Wang. (2021) Resistance to Hypomethylating Agents in Myelodysplastic Syndrome and Acute Myeloid Leukemia From Clinical Data and Molecular Mechanism. Frontiers in Oncology 11.
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Julia Stomper, John Charles Rotondo, Gabriele Greve & Michael Lübbert. (2021) Hypomethylating agents (HMA) for the treatment of acute myeloid leukemia and myelodysplastic syndromes: mechanisms of resistance and novel HMA-based therapies. Leukemia 35:7, pages 1873-1889.
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Pasquale Niscola, Carmen Di Grazia, Carla Mazzone, Barbara Tolu, Paolo de Fabritiis & Emanuele Angelucci. (2019) Long-term response in refractory AML following azacitidine-failed MDS by salvage decitabine-bridged allogenic transplantation. BLOOD RESEARCH 54:4, pages 288-290.
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Jan Stratmann, Elisabeth van Kann, Christoph Rummelt, Sebastian Koschade, Christoph Röllig, Michael Lübbert, Markus Schaich, Stefani Parmentier, Martin Sebastian, Joerg Chromik, Aaron Becker von Rose, Olivier Ballo, Björn Steffen, Hubert Serve, Christian Brandts & Shabnam Shaid. (2019) Low-dose melphalan in elderly patients with relapsed or refractory acute myeloid leukemia: A well-tolerated and effective treatment after hypomethylating-agent failure. Leukemia Research 85, pages 106192.
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Richard Daifuku. 2019. Pharmacoepigenetics. Pharmacoepigenetics 425 435 .
Thomas Schroeder, Christina Rautenberg, William Krüger, Uwe Platzbecker, Gesine Bug, Juliane Steinmann, Stefan Klein, Olaf Hopfer, Kathrin Nachtkamp, Mustafa Kondakci, Stefanie Geyh, Rainer Haas, Ulrich Germing, Martin Bornhäuser & Guido Kobbe. (2017) Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI—a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group. Annals of Hematology 97:2, pages 335-342.
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Rama Nanah, Kristen McCullough, William Hogan, Kebede Begna, Mrinal Patnaik, Michelle Elliott, Mark Litzow & Aref Al-Kali. (2017) Outcome of elderly patients after failure to hypomethylating agents given as frontline therapy for acute myeloid leukemia: Single institution experience*. American Journal of Hematology 92:9, pages 866-871.
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Daniel A. Roberts & David P. Steensma. (2015) Outlook and Management of Patients with Myelodysplastic Syndromes Failed by Hypomethylating Agents. Current Hematologic Malignancy Reports 10:3, pages 318-328.
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Stéphanie Harel, Amina Cherait, Céline Berthon, Christophe Willekens, Sophie Park, Marthe Rigal, Sabine Brechignac, Sylvain Thépot, Bruno Quesnel, Claude Gardin, Lionel Adès, Pierre Fenaux & Thorsten Braun. (2015) Outcome of patients with high risk Myelodysplastic Syndrome (MDS) and advanced Chronic Myelomonocytic Leukemia (CMML) treated with decitabine after azacitidine failure. Leukemia Research 39:5, pages 501-504.
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