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Clinical Dilemma

How best to manage patients with chronic lymphocytic leuekmia with 17p deletion and/or TP53 mutation?

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Pages 587-593 | Received 15 Jan 2015, Accepted 17 Jan 2015, Published online: 17 Feb 2015

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Sanem Gökçen, E.Ümit Bağrıaçık, Handan Kayhan & Münci Yağcı. (2021) Immunomolecular evaluation of dihydroartemisinin effects on apoptosis in chronic lymphocytic leukemia cell lines. Leukemia Research 110, pages 106702.
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Bo Chu, Ning Kon, Delin Chen, Tongyuan Li, Tong Liu, Le Jiang, Shujuan Song, Omid Tavana & Wei Gu. (2019) ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nature Cell Biology 21:5, pages 579-591.
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Jeffrey Jones, Anthony Mato, Steven Coutre, John C. Byrd, Richard R. Furman, Peter Hillmen, Anders Osterborg, Constantine Tam, Stephan Stilgenbauer, William G. Wierda, Nyla A. Heerema, Karl Eckert, Fong Clow, Cathy Zhou, Alvina D. Chu, Danelle F. James & Susan M. O'Brien. (2018) Evaluation of 230 patients with relapsed/refractory deletion 17p chronic lymphocytic leukaemia treated with ibrutinib from 3 clinical trials. British Journal of Haematology 182:4, pages 504-512.
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John F. SeymourThomas J. KippsBarbara EichhorstPeter HillmenJames D’RozarioSarit AssoulineCarolyn OwenJohn GerecitanoTadeusz RobakJavier De la SernaUlrich JaegerGuillaume CartronMarco MontilloRod HumerickhouseElizabeth A. PunnooseYan LiMichelle BoyerKathryn HumphreyMehrdad MobasherArnon P. Kater. (2018) Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia. New England Journal of Medicine 378:12, pages 1107-1120.
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A Stengel, W Kern, T Haferlach, M Meggendorfer, A Fasan & C Haferlach. (2016) The impact of TP53 mutations and TP53 deletions on survival varies between AML, ALL, MDS and CLL: an analysis of 3307 cases. Leukemia 31:3, pages 705-711.
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E Montserrat & J Delgado. (2016) CLL: ibrutinib and transplantation ride together. Bone Marrow Transplantation 51:6, pages 769-770.
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