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Original Articles: Clinical

Phase I study of the anti-CD74 monoclonal antibody milatuzumab (hLL1) in patients with previously treated B-cell lymphomas

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Pages 3065-3070 | Received 17 Nov 2014, Accepted 05 Mar 2015, Published online: 12 May 2015

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Jasmine Vargas & Georgios Pantouris. (2023) Analysis of CD74 Occurrence in Oncogenic Fusion Proteins. International Journal of Molecular Sciences 24:21, pages 15981.
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Anna Woestemeier, Pasquale Scognamiglio, Yu Zhao, Jonas Wagner, Franziska Muscate, Christian Casar, Francesco Siracusa, Filippo Cortesi, Theodora Agalioti, Simone Müller, Adrian Sagebiel, Leonie Konczalla, Ramez Wahib, Karl-Frederick Karstens, Anastasios D. Giannou, Anna Duprée, Stefan Wolter, Milagros N. Wong, Anne K. Mühlig, Agata A. Bielecka, Vikas Bansal, Tianran Zhang, Oliver Mann, Victor G. Puelles, Tobias B. Huber, Ansgar W. Lohse, Jakob R. Izbicki, Noah W. Palm, Stefan Bonn, Samuel Huber & Nicola Gagliani. (2023) Multicytokine-producing CD4+ T cells characterize the livers of patients with NASH. JCI Insight 8:1.
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Benjamin Schoeps, Celina Eckfeld, Laura Flüter, Selina Keppler, Ritu Mishra, Percy Knolle, Felix Bayerl, Jan Böttcher, Chris D. Hermann, Daniel Häußler & Achim Krüger. (2021) Identification of invariant chain CD74 as a functional receptor of tissue inhibitor of metalloproteinases-1 (TIMP-1). Journal of Biological Chemistry 297:3, pages 101072.
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Daniel J Wallace, Florence Figueras, William A Wegener & David M Goldenberg. (2021) Experience with milatuzumab, an anti-CD74 antibody against immunomodulatory macrophage migration inhibitory factor (MIF) receptor, for systemic lupus erythematosus (SLE). Annals of the Rheumatic Diseases 80:7, pages 954-955.
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Walter Hanel & Narendranath Epperla. (2020) Emerging therapies in mantle cell lymphoma. Journal of Hematology & Oncology 13:1.
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Smita Y. Patel, Javier Carbone & Stephen Jolles. (2019) The Expanding Field of Secondary Antibody Deficiency: Causes, Diagnosis, and Management. Frontiers in Immunology 10.
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Shuchun Zhao, Arturo Molina, Abigail Yu, Jeff Hanson, Harry Cheung, Xiaofan Li & Yasodha Natkunam. (2019) High frequency of CD74 expression in lymphomas: implications for targeted therapy using a novel anti-CD74-drug conjugate. The Journal of Pathology: Clinical Research 5:1, pages 12-24.
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Rudranil De, Souvik Sarkar, Somnath Mazumder, Subhashis Debsharma, Asim Azhar Siddiqui, Shubhra Jyoti Saha, Chinmoy Banerjee, Shiladitya Nag, Debanjan Saha, Saikat Pramanik & Uday Bandyopadhyay. (2018) Macrophage migration inhibitory factor regulates mitochondrial dynamics and cell growth of human cancer cell lines through CD74–NF-κB signaling. Journal of Biological Chemistry 293:51, pages 19740-19760.
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Michal Haran, Vita Mirkin, Andrei Braester, Nurith Harpaz, Olga Shevetz, Marina Shtreiter, Shulamit Greenberg, Orly Mordich, Orna Amram, Inbal Binsky-Ehrenreich, Ayelet Marom, Idit Shachar, Yair Herishanu, Rosa Ruchlemer, Alain Berrebi, Liora Valinsky, Mordechai Shtalrid & Lev Shvidel. (2018) A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach . British Journal of Haematology 182:1, pages 125-128.
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Lara Valiño-Rivas, Leticia Cuarental, Osvaldo Grana, Richard Bucala, Lin Leng, Ana Sanz, Gonzalo Gomez, Alberto Ortiz & Maria Dolores Sanchez-Niño. (2018) TWEAK increases CD74 expression and sensitizes to DDT proinflammatory actions in tubular cells. PLOS ONE 13:6, pages e0199391.
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Amanda Sparkes, Patrick De Baetselier, Lea Brys, Inês Cabrito, Yann G.-J. Sterckx, Steve Schoonooghe, Serge Muyldermans, Geert Raes, Richard Bucala, Peter Vanlandschoot, Jo A. Van Ginderachte & Benoît Stijlemans. (2018) Novel half‐life extended anti‐MIF nanobodies protect against endotoxic shock. The FASEB Journal 32:6, pages 3411-3422.
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Katia Mangano, Emanuela Mazzon, Maria Sofia Basile, Roberto Di Marco, Placido Bramanti, Santa Mammana, Maria Cristina Petralia, Paolo Fagone & Ferdinando Nicoletti. (2018) Pathogenic role for macrophage migration inhibitory factor in glioblastoma and its targeting with specific inhibitors as novel tailored therapeutic approach. Oncotarget 9:25, pages 17951-17970.
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Yi Zhou, Huimei Chen, Li Liu, Xueqing Yu, Galina K. Sukhova, Min Yang, Lijun Zhang, Vasileios C. Kyttaris, George C. Tsokos, Isaac E. Stillman, Takaharu Ichimura, Joseph V. Bonventre, Peter Libby & Guo-Ping Shi. (2017) CD74 Deficiency Mitigates Systemic Lupus Erythematosus–like Autoimmunity and Pathological Findings in Mice. The Journal of Immunology 198:7, pages 2568-2577.
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Huiting Su, Ning Na, Xiaodong Zhang & Yong Zhao. (2016) The biological function and significance of CD74 in immune diseases. Inflammation Research 66:3, pages 209-216.
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Matthew Ku, Geoff Chong & Eliza A. Hawkes. (2017) Tumour cell surface antigen targeted therapies in B-cell lymphomas: Beyond rituximab. Blood Reviews 31:1, pages 23-35.
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