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Original Article

Evaluation of Residual Disease in B-Cell Chronic Lymphocytic Leukemia Patients in Clinical and Bone-Marrow Remission Using CD5-CD19 Markers and PCR Study of Gene Rearrangements

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Pages 195-204 | Received 25 Dec 1991, Published online: 01 Jul 2009

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Ciprian Tomuleasa, Cristina Selicean, Sonia Cismas, Anca Jurj, Mirela Marian, Delia Dima, Sergiu Pasca, Bobe Petrushev, Vlad Moisoiu, Wilhelm-Thomas Micu, Anna Vischer, Kanza Arifeen, Sonia Selicean, Mihnea Zdrenghea, Horia Bumbea, Alina Tanase, Ravnit Grewal, Laura Pop, Carmen Aanei & Ioana Berindan-Neagoe. (2018) Minimal residual disease in chronic lymphocytic leukemia: A consensus paper that presents the clinical impact of the presently available laboratory approaches. Critical Reviews in Clinical Laboratory Sciences 55:5, pages 329-345.
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C. Darrell Jennings & Kenneth A. Foon. (1997) Flow Cytometry: Recent Advances in Diagnosis and Monitoring of Leukemia. Cancer Investigation 15:4, pages 384-399.
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M. Keating, B. Cheson, J. G. Gribben, B. Robertson & L. Nadler. (1996) Innovative Strategies for the Treatment of CLL. Leukemia & Lymphoma 22:sup2, pages 53-64.
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R. H. Scheuermann & E. Racila. (1995) CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy. Leukemia & Lymphoma 18:5-6, pages 385-397.
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Deborah S. Richardson, Stephen A. Johnson, John A. Hopkins, Denise Howe & Malcolm J. Phillips. (1994) Absence of Minimal Residual Disease Detectable by Facs, Southern Blot or PCR in Patients with Chronic Lymphocytic Leukaemia Treated with Fludarabine. Acta Oncologica 33:6, pages 627-630.
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French Cooperative Group on Chronic Lymphocytic Leukemia. (1991) Unresolved Issues in Chronic Lymphocytic Leukemia Treatment. Leukemia & Lymphoma 5:sup1, pages 79-81.
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Silvia Heltai, Paolo Ghia & Lydia Scarfò. (2019) Relevance of Minimal Residual Disease in the Era of Targeted Agents. The Cancer Journal 25:6, pages 410-417.
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Paolo Ghia & Andy Rawstron. (2018) Minimal residual disease analysis in chronic lymphocytic leukemia: a way for achieving more personalized treatments. Leukemia 32:6, pages 1307-1316.
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Yu.V. Mirolyubova, E.A. Stadnik, V.V. Strugov, T.O. Andreeva, T.S. Nikulina, Yu.V. Virts, P.A. Butylin, A.G. Rumyantsev & A.Y. Zaritskey. (2018) Minimal Residual Disease and IGHV-Genes Mutational Status as the Main Predictors of Response to Bendamustine-Rituximab Therapy in Previously Untreated Chronic Lymphocytic Leukemia. Clinical oncohematology 11:2, pages 167-174.
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Mir Basharath Alikhan & Girish Venkataraman. 2018. Neoplastic Diseases of the Blood. Neoplastic Diseases of the Blood 79 98 .
Philip A. Thompson & William G. Wierda. (2016) Eliminating minimal residual disease as a therapeutic end point: working toward cure for patients with CLL. Blood 127:3, pages 279-286.
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Sebastian B?ttcher, Michael Hallek, Matthias Ritgen & Michael Kneba. (2013) The Role of Minimal Residual Disease Measurements in the Therapy for CLL. Hematology/Oncology Clinics of North America 27:2, pages 267-288.
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M. M. Sartor & D. J. Gottlieb. (2013) A single tube 10‐color flow cytometry assay optimizes detection of minimal residual disease in chronic lymphocytic leukemia. Cytometry Part B: Clinical Cytometry 84B:2, pages 96-103.
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A C Rawstron, S Böttcher, R Letestu, N Villamor, C Fazi, H Kartsios, R M de Tute, J Shingles, M Ritgen, C Moreno, K Lin, A R Pettitt, M Kneba, E Montserrat, F Cymbalista, M Hallek, P Hillmen & P Ghia. (2012) Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL. Leukemia 27:1, pages 142-149.
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Paolo Ghia. (2012) A look into the future: can minimal residual disease guide therapy and predict prognosis in chronic lymphocytic leukemia?. Hematology 2012:1, pages 97-104.
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Andy C Rawstron. (2011) Occult B-cell lymphoproliferative disorders. Histopathology 58:1, pages 81-89.
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Carol Moreno, Matthias Ritgen & Andy Rawstron. (2010) Is MRD eradication a desirable goal in CLL?. Best Practice & Research Clinical Haematology 23:1, pages 97-107.
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Andy C. Rawstron. (2009) Monoclonal B-cell lymphocytosis. Hematology 2009:1, pages 430-439.
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Thomas Elter, Barbara F. Eichhorst & Clemens-Martin Wendtner. (2008) Use of alemtuzumab and rituximab consolidation in CLL: Pros and cons. Current Hematologic Malignancy Reports 4:1, pages 43-46.
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Andy C. Rawstron & Peter Hillmen. (2008) Assessing minimal residual disease in chronic lymphocytic leukemia. Current Hematologic Malignancy Reports 3:1, pages 47-53.
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Hazem A. Sayala, Andy C. Rawstron & Peter Hillmen. (2007) Minimal residual disease assessment in chronic lymphocytic leukaemia. Best Practice & Research Clinical Haematology 20:3, pages 499-512.
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Tasneem Motiwala, Sarmila Majumder, Huban Kutay, David Spencer Smith, Donna S. Neuberg, David M. Lucas, John C. Byrd, Michael Grever & Samson T. Jacob. (2007) Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia. Clinical Cancer Research 13:11, pages 3174-3181.
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A C Rawstron, N Villamor, M Ritgen, S Böttcher, P Ghia, J L Zehnder, G Lozanski, D Colomer, C Moreno, M Geuna, P A S Evans, Y Natkunam, S E Coutre, E D Avery, L Z Rassenti, T J Kipps, F Caligaris-Cappio, M Kneba, J C Byrd, M J Hallek, E Montserrat & P Hillmen. (2007) International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia. Leukemia 21:5, pages 956-964.
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Michael J. Keating, Nicholas Chiorazzi, Bradley Messmer, Rajendra N. Damle, Steven L. Allen, Kanti R. Rai, Manlio Ferrarini & Thomas J. Kipps. (2003) Biology and Treatment of Chronic Lymphocytic Leukemia. Hematology 2003:1, pages 153-175.
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Karim Maloum, Laurent Sutton, Sylvie Baudet, Caroline Laurent, Patrick Bonnemye, Christian Magnac & Hélène Merle‐Béral. (2002) Novel flow‐cytometric analysis based on BCD5 + subpopulations for the evaluation of minimal residual disease in chronic lymphocytic leukaemia . British Journal of Haematology 119:4, pages 970-975.
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E Giné, F Bosch, N Villamor, M Rozman, D Colomer, A López-Guillermo, E Campo & E Montserrat. (2002) Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia/small lymphocytic lymphoma: a frequent association?. Leukemia 16:8, pages 1454-1459.
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Ranjit Thomas, Isabel Ribeiro, Patricia Shepherd, Peter Johnson, Margaret Cook, Anil Lakhani, Richard Kaczmarski, Patrick Carrington & Daniel Catovsky. (2002) Spontaneous clinical regression in chronic lymphocytic leukaemia. British Journal of Haematology 116:2, pages 341-345.
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Andy C. RawstronBen KennedyPaul A. S. EvansFaith E. DaviesStephen J. RichardsAndy P. HaynesNigel H. RussellGeoff HaleGareth J. MorganAndrew S. JackPeter Hillmen. (2001) Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood 98:1, pages 29-35.
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J Esteve, N Villamor, D Colomer, F Cervantes, E Campo, E Carreras & E Montserrat. (2001) Stem cell transplantation for chronic lymphocytic leukemia: different outcome after autologous and allogeneic transplantation and correlation with minimal residual disease status. Leukemia 15:3, pages 445-451.
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Estella Matutes & Aaron Polliack. (2001) Morphological and Immunophenotypic Features of Chronic Lymphocytic Leukemia. Reviews in Clinical and Experimental Hematology 4:1, pages 22-47.
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C. Darrell JenningsKenneth A. Foon. (1997) Recent Advances in Flow Cytometry: Application to the Diagnosis of Hematologic Malignancy. Blood 90:8, pages 2863-2892.
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Branimir Jaksic, Maura Brugiatelli, Ivo Krc, Hajna Losonczi, Jerzy Holowiecki, Ana Planinc-Peraica, Rajko Kusec, Fortunato Morabito, Pasquale Iacopino & Dieter Lutz. (1997) High dose chlorambucil versus Binet's modified cyclophosphamide, doxorubicin, vincristine, and prednisone regimen in the treatment of patients with advanced B-cell chronic lymphocytic leukemia. Cancer 79:11, pages 2107-2114.
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Stefano Molica, Maura Brugiatelli, Vincenzo Callea, Fortunato Morabito, Domenico Levato, Francesco Nobile & Antonio Alberti. (2009) Comparison of younger versus older B‐cell chronic lymphocytic leukemia patients for clinical presentation and prognosis. A retrospective study of 53 cases. European Journal of Haematology 52:4, pages 216-221.
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