Advanced search
Publication Cover
Leukemia & Lymphoma Volume 9, 1993 - Issue 6
Submit an article Journal homepage
11
Views
12
CrossRef citations to date
0
Altmetric
Original Article

Effects of the Intermolecular Toxin-Monoclonal Antibody Linkage on the In Vivo Stability, Immunogenicity and Anti-Leukemic Activity of B43 (Anti-CD19) Pokeweed Antiviral Protein Immunotoxin

Fatih M. Uckun Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
,
Dorothea E. Myers Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
,
James D. Irvin Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
,
Virginia M. Kuebelbeck Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
,
Dale Finnegan Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
,
Lisa M. Chelstrom Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
&
L. L. Houston Tumor Immunology Laboratory, Section of Cancer and Leukemia Biology, Department of Therapeutic Radiology-Radiation Oncology; Division of Hematology/Oncology/Bone Marrow Transplant Program, Department of Pediatrics; Department of Pharmacology, University of Minnesota, Minneapolis, MN; Department of Chemistry, Southwest Texas State University, San Marcos, TX; Chiron Corporation, Emeryville, CA, USA
 show all
Pages 459-476 | Received 20 Aug 1992, Published online: 01 Jul 2009

Citations (12)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Dorothea E. Myers, Xiao Jun, Dina Clementson, Randy Donelson, Andrew Sicheneder, Nathan Hoffman, Kim Bell, Mireille Sarquis, Mridula-Chandan Langlie, Nilgun Turner & Fatih M. Uckun. (1997) Large Scale Manufacturing of TXU(Anti-CD7)-Pokeweed Antiviral Protein (PAP) Immunoconjugate for Clinical Trials. Leukemia & Lymphoma 27:3-4, pages 275-302.
Read now
Roland Gunther, Lisa M. Chelstrom, Heather R. Wendorf, Elizabeth A. Schneider, Kristi Covalciuc, Bradley Johnson, Dina Clementson, James D. Irvin, Dorothea E. Myers & Fatih M. Uckun. (1996) Toxicity Profile of the Investigational New Biotherapeutic Agent, B43 (Anti-CD 19)-Pokeweed Antiviral Protein Immunotoxin. Leukemia & Lymphoma 22:1-2, pages 61-70.
Read now
Dorothea E. Myers, Yuri Yanishevski, Eric Masson, James D. Irvin, William E. Evans & Fatih M. Uckun. (1995) Favorable Pharmacodynamic Features and Superior Anti-Leukemic Activity of B43 (Anti-CD 19) Immunotoxins Containing Two Pokeweed Antiviral Protein Molecules Covalently Linked to each Monoclonal Antibody Molecule. Leukemia & Lymphoma 18:1-2, pages 93-102.
Read now
R. H. Scheuermann & E. Racila. (1995) CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy. Leukemia & Lymphoma 18:5-6, pages 385-397.
Read now

Articles from other publishers (8)

Fatih M Uckun, Larisa Rustamova, Alexei O Vassilev, Heather E Tibbles & Alexander S Petkevich. (2005) CNS activity of Pokeweed Anti-viral Protein (PAP) in mice infected with Lymphocytic Choriomeningitis Virus (LCMV). BMC Infectious Diseases 5:1.
Crossref
Anita C. Thomas & Julie H. Campbell. (2004) Conjugation of an antibody to cross-linked fibrin for targeted delivery of anti-restenotic drugs. Journal of Controlled Release 100:3, pages 357-377.
Crossref
Byung Ho Woo, Jung Tae Lee, Myung Ok Park, Kang Ro Lee, Jeung Whan Han, Eun-Seok Park, Sun Dong Yoo & Kang Choon Lee. (1999) Stability and cytotoxicity of Fab-ricin A immunotoxins prepared with water soluble long chain heterobifunctional crosslinking agents. Archives of Pharmacal Research 22:5.
Crossref
Dong Hee Na, Byung Ho Woo & Kang Choon Lee. (1999) Quantitative Analysis of Derivatized Proteins Prepared with Pyridyl Disulfide-Containing Cross-Linkers by High-Performance Liquid Chromatography. Bioconjugate Chemistry 10:2, pages 306-310.
Crossref
D. J. Flavell. 1998. Clinical Applications of Immunotoxins. Clinical Applications of Immunotoxins 57 61 .
Seth H. Pincus & Vladimir V. Tolstikov. 1995. 205 247 .
Maria-Grazia Roncarolo, Bruno Péault & Reiko NamikawaAlessandra Cesano & Daniela Santoli. 1995. Human Hematopoiesis in SCID Mice. Human Hematopoiesis in SCID Mice 171 196 .
Byung Ho Woo, Jung Tae Lee & Kang Choon Lee. (1994) Ricin A immunotoxins of IgG and Fab of anti-CALLA monoclonal antibody: Effect of water soluble long-chain SPDP on conjugate yield, immunoselectivity and cytotoxicity. Archives of Pharmacal Research 17:6, pages 452-457.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.