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Leukemia & Lymphoma Volume 18, 1995 - Issue 3-4
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Original Article

Ultrastructural Studies of the Megakaryoblastic Leukemias of Down Syndrome

Alvin Zipursky Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Departments of Paediatrics and Pathology, the University of Toronto, Toronto, Canada
,
Hilary Christensen Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Departments of Paediatrics and Pathology, the University of Toronto, Toronto, Canada
&
Etienne De Harven Department of Paediatrics, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada; Departments of Paediatrics and Pathology, the University of Toronto, Toronto, Canada
Pages 341-347 | Received 10 Aug 1994, Published online: 01 Jul 2009

Citations (18)

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J Timothy Caldwell, Yubin Ge & Jeffrey W Taub. (2014) Prognosis and management of acute myeloid leukemia in patients with Down syndrome. Expert Review of Hematology 7:6, pages 831-840.
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Articles from other publishers (17)

SD Boyd & DA Arber. 2011. Blood and Bone Marrow Pathology. Blood and Bone Marrow Pathology 273 288 .
Krysta D. Schlis & Scott A. Armstrong. 2009. Oncology of Infancy and Childhood. Oncology of Infancy and Childhood 403 416 .
Gita V. MasseyAlvin ZipurskyMyron N. ChangJohn J. DoyleSuhail NasimJeffrey W. TaubYaddanapudi RavindranathGary DahlHoward J. Weinstein. (2006) A prospective study of the natural history of transient leukemia (TL) in neonates with Down syndrome (DS): Children's Oncology Group (COG) study POG-9481. Blood 107:12, pages 4606-4613.
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David L. StachuraStella T. ChouMitchell J. Weiss. (2006) Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood 107:1, pages 87-97.
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Johann K. Hitzler & Alvin Zipursky. (2005) Origins of leukaemia in children with Down syndrome. Nature Reviews Cancer 5:1, pages 11-20.
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Yaddanapudi Ravindranath. (2005) Down syndrome and leukemia: New insights into the epidemiology, pathogenesis, and treatment. Pediatric Blood & Cancer 44:1, pages 1-7.
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Gita V. Massey. (2005) Transient leukemia in newborns with Down syndrome. Pediatric Blood & Cancer 44:1, pages 29-32.
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Suzanne McElwaine, Claire Mulligan, Jürgen Groet, Monica Spinelli, Andrea Rinaldi, Gareth Denyer, Afua Mensah, Simona Cavani, Chiara Baldo, Franca Dagna-Bricarelli, Ian Hann, Giuseppe Basso, Finbarr E. Cotter & Dean Nizetic. (2004) Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker . British Journal of Haematology 125:6, pages 729-742.
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Alvin Zipursky. (2003) Transient leukaemia – a benign form of leukaemia in newborn infants with trisomy 21. British Journal of Haematology 120:6, pages 930-938.
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Shawn E. Holt, Elizabeth J. Brown & Alvin Zipursky. (2002) Telomerase and the Benign and Malignant Megakaryoblastic Leukemias of Down Syndrome. Journal of Pediatric Hematology/Oncology 24:1, pages 14-17.
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Jeffrey W. Taub & Yaddanapudi Ravindranath. (2002) Down Syndrome and the Transient Myeloproliferative Disorder: Why Is It Transient?. Journal of Pediatric Hematology/Oncology 24:1, pages 6-8.
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Alan S. Gamis & Joanne M. Hilden. (2002) Transient Myeloproliferative Disorder, a Disorder With Too Few Data and Many Unanswered Questions: Does It Contain an Important Piece of the Puzzle to Understanding Hematopoiesis and Acute Myelogenous Leukemia?. Journal of Pediatric Hematology/Oncology 24:1, pages 2-5.
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L. Keinan Boker, Tzvia Blumstein, Siegal Sadetzki, Osnat Luxenburg, Irit Litvak, Edna Akstein & Baruch Modan. (2001) Incidence of leukemia and other cancers in Down syndrome subjects in Israel. International Journal of Cancer 93:5, pages 741-744.
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David Malkin, Elizabeth J Brown & Alvin Zipursky. (2000) The Role of p53 in Megakaryocyte Differentiation and the Megakaryocytic Leukemias of Down Syndrome. Cancer Genetics and Cytogenetics 116:1, pages 1-5.
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Zipursky Alvin, Elizabeth J. Brown, Christensen Hilary & Doyle John. (1999) Transient Myeloproliferative Disorder (Transient Leukemia) and Hematologic Manifestations of Down Syndrome. Clinics in Laboratory Medicine 19:1, pages 157-168.
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J. L. Huret & C. Léonard. (2008) Chromosome 21 and platelets: a gene dosage effect?. Clinical Genetics 51:2, pages 140-141.
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Alvin Zipursky, Elizabeth Brown, Hilary Christensen, Robert Sutherland & John Doyle. (1997) Leukemia and/or myeloproliferative syndrome in neonates with Down Syndrome. Seminars in Perinatology 21:1, pages 97-101.
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