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Original Article

Influence of Interferon-α on Cytokine Expression by the Bone Marrow Microenvironment—Impact on Treatment of Myeloproliferative Disorders

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Pages 129-134 | Received 18 Mar 1996, Published online: 01 Jul 2009

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Adrian Duek, Maya Berla & Martin H. Ellis. (2022) Recent advances in the treatment of polycythemia vera. Leukemia & Lymphoma 63:8, pages 1801-1809.
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Hans Carl Hasselbalch. (2011) A new era for IFN-α in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Expert Review of Hematology 4:6, pages 637-655.
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J. Thiele & H. M. Kvasnicka. (2001) Comparative Effects of Interferon and Hydroxyurea on Bone Marrow Fibrosis in Chronic Myelogenous Leukemia. Leukemia & Lymphoma 42:5, pages 855-862.
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F. Ravandi-Kashani, J. Cortes, H. Kantarjian & M. Talpaz. (1998) Chronic Myeloid Leukemia: Current Guidelines for Diagnosis and Management. Hematology 3:4, pages 263-276.
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Lucia Masarova, Prithviraj Bose & Srdan Verstovsek. (2019) The Rationale for Immunotherapy in Myeloproliferative Neoplasms. Current Hematologic Malignancy Reports 14:4, pages 310-327.
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Hans Carl Hasselbalch & Morten Orebo Holmström. (2018) Perspectives on interferon-alpha in the treatment of polycythemia vera and related myeloproliferative neoplasms: minimal residual disease and cure?. Seminars in Immunopathology 41:1, pages 5-19.
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Jung-Lung HsiaoWang-Sheng KoChia-Ju ShihYa-ling Chiou. (2017) The Changed Proportion of CD45RA + /CD45RO + T Cells in Chronic Hepatitis C Patients During Pegylated Interferon-α with Ribavirin Therapy . Journal of Interferon & Cytokine Research 37:7, pages 303-309.
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Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, Barbara Kroczynska, Beata Majchrzak, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Jonathan D. Licht, Darren P. Baker, Elizabeth A. Eklund, Amittha Wickrema, Amit Verma, Eleanor N. Fish & Leonidas C. Platanias. (2013) Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors. Journal of Biological Chemistry 288:33, pages 23814-23822.
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Brady L. SteinRamon V. Tiu. (2013) Biological Rationale and Clinical Use of Interferon in the Classical BCR-ABL-Negative Myeloproliferative Neoplasms. Journal of Interferon & Cytokine Research 33:4, pages 145-153.
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M Talpaz, R Hehlmann, A Quintás-Cardama, J Mercer & J Cortes. (2012) Re-emergence of interferon-α in the treatment of chronic myeloid leukemia. Leukemia 27:4, pages 803-812.
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François Guilhot, Lydia Roy, Pierre-Jean Saulnier & Joëlle Guilhot. (2009) Interferon in chronic myeloid leukaemia: past and future. Best Practice & Research Clinical Haematology 22:3, pages 315-329.
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T Ishii, Y Zhao, J Shi, S Sozer, R Hoffman & M Xu. (2007) T cells from patients with polycythemia vera elaborate growth factors which contribute to endogenous erythroid and megakaryocyte colony formation. Leukemia 21:12, pages 2433-2441.
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Lisa A. Kujawski & Moshe Talpaz. (2007) The role of interferon-alpha in the treatment of chronic myeloid leukemia. Cytokine & Growth Factor Reviews 18:5-6, pages 459-471.
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A Arizcorreta, M Márquez, C Fernández-Gutiérrez, E Pérez Guzmán, F Brun, M Rodríguez-Iglesias & J A Girón-González. (2006) T cell receptor excision circles (TRECs), CD4+, CD8+ and their CD45RO+ and CD45RA+ subpopulations in hepatitis C virus (HCV)-HIV-co-infected patients during treatment with interferon alpha plus ribavirin: analysis in a population on effective antiretroviral therapy. Clinical and Experimental Immunology 146:2, pages 270-277.
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A. Arizcorreta, F. Brun, C. Fernández-Gutiérrez, R. García Juárez, F. Guerrero, E. Pérez-Guzmán & J.A. Girón-González. (2004) Modifications of haematological series in patients co-infected with human immunodeficiency virus and hepatitis C virus during treatment with interferon and ribavirin: differences between pegylated and standard interferon. Clinical Microbiology and Infection 10:12, pages 1067-1074.
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J Giron-Michel, D Weill, G Bailly, S Legras, PC Nardeux, B Azzarone, MG Tovey & P Eid. (2002) Direct signal transduction via functional interferon-αβ receptors in CD34+ hematopoietic stem cells. Leukemia 16:6, pages 1135-1142.
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Juergen Thiele, Hans M. Kvasnicka, Annette Schmitt-Graeff, Dilek Goekce, Volker Diehl, Rudolf Zankovich & Hans E. Schaefer. (2001) Therapy-Related Changes of CD34 + Progenitor Cells in Chronic Myeloid Leukemia: A Morphometric Study on Sequential Trephine Biopsies . Journal of Hematotherapy & Stem Cell Research 10:6, pages 827-836.
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Gérard Benoit, Mathilde Roussel, Frédério Pendino, Evelyne Ségal-Bendirdjian & Michel Lanotte. (2001) Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation. Oncogene 20:49, pages 7161-7177.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt-Graeff, Gabriela Cvetanovska, Nicole Blum & Hans Eckart Schaefer. (2000) Therapy-related Changes of CD20+ and CD45RO+ Lymphocyte Subsets in Chronic Myeloid Leukemia (CML): An Immunohistochemical and Morphometric Study on Sequential Trephine Biopsies of the Bone Marrow. Modern Pathology 13:8, pages 888-896.
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IA Voutsadakis. (2000) Interferon-alpha and the pathogenesis of myeloproliferative disorders. Medical Oncology 17:4, pages 249-257.
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Claudia Wickenhauser, Beate Schmitz, Barbara Selbach, Carina Brockbals, Oliver Manske & Jürgen Thiele. (2008) Interferon α2b directly induces fibroblast proliferation and transforming growth factor β secretion of macrophages. British Journal of Haematology 109:2, pages 296-304.
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A. Solanilla, A. El Andaloussi, C. Grosset, P. Duchez, M. D. Mossalayi, F. X. Mahon, J. Reiffers, G. Marit & J. Ripoche. (2001) Differential effect of interferon α on chronic myelogenous leukaemia and normal haematopoietic progenitors in a stromal cell co‐culture context: role of the flt3 ligand. British Journal of Haematology 109:2, pages 382-387.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt‐Graeff, Marlene Spohr, Volker Diehl, Rudolf Zankovich, Norbert Niederle & Lutz‐Dietrich Leder. (2001) Effects of interferon and hydroxyurea on bone marrow fibrosis in chronic myelogenous leukaemia: a comparative retrospective multicentre histological and clinical study. British Journal of Haematology 108:1, pages 64-71.
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Juergen Thiele, Beate Schmitz, Ralf Fuchs, Hans Michael Kvasnicka, Johann Lorenzen & Robert Fischer. (1998) Detection of the bcr/abl gene in bone marrow macrophages in CML and alterations during interferon therapy—a fluorescencein situ hybridization study on trephine biopsies. The Journal of Pathology 186:3, pages 331-335.
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Csongor Kiss. (1998) Topical Topic: Interferons in pediatric oncology: End of the beginning or beginning of the end?. Medical and Pediatric Oncology 30:6, pages 364-366.
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JUERGEN THIELE, CLAUDIA WICKENHAUSER, CHRISTOPH NEUWIRTH, HANS-JOERG SCHULZE, UTA FLUCKE, HANS MICHAEL KVASNICKA, PETER BORCHMANN, RAINER KRECH & ROBERT FISCHER. (1998) Effect of IFN-α on Normal Human Hematopoiesis: An Immunohistochemical and Morphometric Study on Trephine Biopsy Specimens. Journal of Interferon & Cytokine Research 18:4, pages 247-253.
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Michael HallekP. Leif BergsagelKenneth C. Anderson. (1998) Multiple Myeloma: Increasing Evidence for a Multistep Transformation Process. Blood 91:1, pages 3-21.
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