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Original Article

The mdm2 Proto-Oncogene

Pages 227-238 | Received 08 Aug 1996, Published online: 01 Jul 2009

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Christine Wasylyk & Bohdan Wasylyk. (2000) Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAFII250 in Cell Cycle Mutant tsBN462 Cells. Molecular and Cellular Biology 20:15, pages 5554-5570.
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Zhong-Zong Pan & Andrew K. Godwin. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Yetao Jin, Shelya X. Zeng, Hunjoo Lee & Hua Lu. (2004) MDM2 Mediates p300/CREB-binding Protein-associated Factor Ubiquitination and Degradation. Journal of Biological Chemistry 279:19, pages 20035-20043.
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Dorota Dworakowska, Ewa Jassem, Jacek Jassem, Brigitte Peters, Rafał Dziadziuszko, Maciej Żylicz, Joanna Jakóbkiewicz-Banecka, Grażyna Kobierska-Gulida, Amelia Szymanowska, Jan Skokowski, Albert Roessner & Regine Schneider-Stock. (2004) MDM2 gene amplification: a new independent factor of adverse prognosis in non-small cell lung cancer (NSCLC). Lung Cancer 43:3, pages 285-295.
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A. El-Meghawry El-Kenawy, A.F. El-Kott & A.M. Khalil. (2018) Prognostic value of p53 and MDM2 Expression in Bilharziasis-Associated Squamous Cell Carcinoma of the Urinary Bladder. The International Journal of Biological Markers 18:4, pages 284-289.
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Ling Ren, Daryl Emery, Barbara Kaboord, Edith Chang & M.Walid Qoronfleh. (2003) Improved immunomatrix methods to detect protein:protein interactions. Journal of Biochemical and Biophysical Methods 57:2, pages 143-157.
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Gordon D. Strachan, Kelly L. Jordan‐Sciutto, Ravikumar Rallapalli, Rocky S. Tuan & David J. Hall. (2002) The E2F‐1 transcription factor is negatively regulated by its interaction with the MDMX protein. Journal of Cellular Biochemistry 88:3, pages 557-568.
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Lucio Lara Santos, Marta Koch Pereira, Céu Silva Costa, Teresina Pinto Amaro, Catarina Reis Lameiras, Sofía Alves Pereira, Paula Silva Lopes, Begoña Criado Alonso, Alberto Carlos Koch & Carlos Silva Lopes. (2002) The prognostic value of MDM2 overexpression in superficial urothelial bladder carcinomaValor pronóstico de la sobreexpresión de MDM2 en carcinomas uroteliales superficiales de vejiga. Revista de Oncología 4:6, pages 322-326.
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Henry Pitot & Daniel Loeb. 2002. Fundamentals of Oncology, Revised and Expanded. Fundamentals of Oncology, Revised and Expanded 643 695 .
F Sandra, N Nakamura, T Kanematsu, M Hirata & M Ohishi. (2002) The role of MDM2 in the proliferative activity of ameloblastoma. Oral Oncology 38:2, pages 153-157.
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Sonia Arora, Robin Mathew, Meera Mathur, Tushar Kant Chattopadhayay & Ranju Ralhan. (2001) Alterations in MDM2 expression in esophageal squamous cell carcinoma: Relationship with p53 status. Pathology & Oncology Research 7:3, pages 203-208.
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Corinne CapouladeLluis M. MirKarine CarlierYann LécluseCécile TétaudZohair MishalJoëlle Wiels. (2001) Apoptosis of tumoral and nontumoral lymphoid cells is induced by both mdm2 and p53 antisense oligodeoxynucleotides. Blood 97:4, pages 1043-1049.
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Gitali Ganguli, Joseph Abecassis & Bohdan Wasylyk. (2000) MDM2 induces hyperplasia and premalignant lesions when expressed in the basal layer of the epidermis. The EMBO Journal 19:19, pages 5135-5147.
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V Favaudon. (2000) Régulation du cycle cellulaire et de la mort cellulaire radio-induite. Cancer/Radiothérapie 4:5, pages 355-368.
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V. G. Gorgoulis, P. Zacharatos, A. Kotsinas, G. Mariatos, T. Liloglou, T. Vogiatzi, P. Foukas, G. Rassidakis, G. Garinis, T. Ioannides, V. Zoumpourlis, J. Bramis, P. O. Michail, P. J. Asimacopoulos, J. K. Field & Ch. Kittas. (2000) Altered Expression of the Cell Cycle Regulatory Molecules pRb, p53 and MDM2 Exert a Synergetic Effect on Tumor Growth and Chromosomal Instability in Non-small Cell Lung Carcinomas (NSCLCs). Molecular Medicine 6:3, pages 208-237.
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Jamil Momand, Hsiao-Huei Wu & Gargi Dasgupta. (2000) MDM2 — master regulator of the p53 tumor suppressor protein. Gene 242:1-2, pages 15-29.
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Nik Veldhoen, Su Metcalfe & Jo Milner. (1999) A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein. Oncogene 18:50, pages 7026-7033.
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Scott E. Seavey, Marisa Holubar, Leslie J. Saucedo & Mary Ellen Perry. (1999) The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19 ARF . Journal of Virology 73:9, pages 7590-7598.
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Christine Wasylyk, Roberto Salvi, Manuela Argentini, Christine Dureuil, Isabelle Delumeau, Joseph Abecassis, Laurent Debussche & Bohdan Wasylyk. (1999) p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53. Oncogene 18:11, pages 1921-1934.
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M Alkhalaf, G Ganguli, N Messaddeq, M Le Meur & B Wasylyk. (1999) MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice. Oncogene 18:7, pages 1419-1434.
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Emma L Arriola, Ana Rodriguez Lopez & Christine M Chresta. (1999) Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop. Oncogene 18:4, pages 1081-1091.
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Hans-Udo Kasper, Regine Schneider-Stock, Walter Mellin, Thomas Günther & Albert Roessner. (1999) P53-Protein Accumulation and MDM2-Protein Overexpression in Gastric Carcinomas. No Apparent Correlation with Survival. Pathology - Research and Practice 195:12, pages 815-820.
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Vassilis G. Gorgoulis, Panayotis Zacharatos, Athanassios Kotsinas, Triantofillos Liloglou, Aspasia Kyroudi, Marinos Veslemes, Antonios Rassidakis, Thanos D. Halazonetis, John K. Field & Christos Kittas. (1998) Alterations of the p16-pRb Pathway and the Chromosome Locus 9p21?22 in Non-Small-Cell Lung Carcinomas. The American Journal of Pathology 153:6, pages 1749-1765.
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Thierry L?veillard, Philippe Gorry, Karen Niederreither & Bohdan Wasylyk. (1998) MDM2 expression during mouse embryogenesis and the requirement of p53. Mechanisms of Development 74:1-2, pages 189-193.
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M. R. Hilleman. 1998. Genes and Environment in Cancer. Genes and Environment in Cancer 345 362 .

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