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Hua Tian, Tiao Qiang, Jinbo Wang, Li Ji & Bo Li. (2021) Simvastatin regulates the proliferation, apoptosis, migration and invasion of human acute myeloid leukemia cells via miR-19a-3p/HIF-1α axis. Bioengineered 12:2, pages 11898-11908.
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Manjili Hamidreza Kheiri, Niusha Alimohammadi & Hossein Danafar. (2019) Preparation of biocompatible copolymeric micelles as a carrier of atorvastatin and rosuvastatin for potential anticancer activity study. Pharmaceutical Development and Technology 24:3, pages 303-313.
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Ivan Krecak, Velka Gveric-Krecak, Pavle Roncevic, Sandra Basic-Kinda, Josipa Gulin, Ivana Lapic, Ksenija Fumic, Ivana Ilic, Ivana Horvat, Renata Zadro, Hrvoje Holik, Bozena Coha, Nena Peran, Igor Aurer & Nadira Durakovic. (2018) Serum chitotriosidase: a circulating biomarker in polycythemia vera. Hematology 23:10, pages 793-802.
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Herman van Besien, Antonella Sassano, Jessica K. Altman & Leonidas C. Platanias. (2013) Antileukemic properties of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. Leukemia & Lymphoma 54:12, pages 2601-2605.
Read now
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Hanna Bessler, Hertzel Salman, Michael Bergman & Meir Djaldetti. (2007) On the Factors Modulating the Effect of Statins on Malignant Cell Proliferation. Cancer Investigation 25:5, pages 279-284.
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Mark D. Minden, Jim Dimitroulakos, Dana Nohynek & Linda Z. Penn. (2001) Lovastatin Induced Control of Blast Cell Growth in an Elderly Patient with Acute Myeloblastic Leukemia. Leukemia & Lymphoma 40:5-6, pages 659-662.
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Stefano Bellosta, Nicola Fed, Franco Bernini, Rodolfo Paoletti & Alberto Corsini. (2000) Non-lipid-related effects of statins. Annals of Medicine 32:3, pages 164-176.
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Articles from other publishers (52)
Joseph Longo, Stephen J. Freedland, Linda Z. Penn & Robert J. Hamilton. (2022) Statins and prostate cancer—hype or hope? The biological perspective. Prostate Cancer and Prostatic Diseases 25:4, pages 650-656.
Crossref
Crossref
Sebastian Martewicz, Camilla Luni, Xi Zhu, Meihua Cui, Manli Hu, Siqi Qu, Damiano Buratto, Guang Yang, Eleonora Grespan & Nicola Elvassore. (2020) Nuclear Morphological Remodeling in Human Granulocytes Is Linked to Prenylation Independently from Cytoskeleton. Cells 9:11, pages 2509.
Crossref
Crossref
Joseph Longo, Jenna E. van Leeuwen, Mohamad Elbaz, Emily Branchard & Linda Z. Penn. (2020) Statins as Anticancer Agents in the Era of Precision Medicine. Clinical Cancer Research 26:22, pages 5791-5800.
Crossref
Crossref
Debora Valli, Alicja M. Gruszka & Myriam Alcalay. (2020) Has Drug Repurposing Fulfilled Its Promise in Acute Myeloid Leukaemia?. Journal of Clinical Medicine 9:6, pages 1892.
Crossref
Crossref
Abraham Pedroza-Torres, Sandra L. Romero-Córdoba, Montserrat Justo-Garrido, Iván Salido-Guadarrama, Rubén Rodríguez-Bautista, Sarita Montaño, Rodolfo Muñiz-Mendoza, Cristian Arriaga-Canon, Verónica Fragoso-Ontiveros, Rosa María Álvarez-Gómez, Greco Hernández & Luis A. Herrera. (2019) MicroRNAs in Tumor Cell Metabolism: Roles and Therapeutic Opportunities. Frontiers in Oncology 9.
Crossref
Crossref
Katarzyna Regulska, Miłosz Regulski, Bartosz Karolak, Marcin Michalak, Marek Murias & Beata Stanisz. (2019) Beyond the boundaries of cardiology: Still untapped anticancer properties of the cardiovascular system-related drugs. Pharmacological Research 147, pages 104326.
Crossref
Crossref
Ali Fatehi Hassanabad. (2019) Can Statins be Protagonists in Our Approach to Cancer Treatment?. American Journal of Clinical Oncology 42:7, pages 547-548.
Crossref
Crossref
Hamed Nosrati, Niusha Alimohammadi, Hamidreza Kheiri Manjili & Hossein Danafar. (2018) Cytotoxic Activity and Kinetic Release Study of Lovastatin-Loaded Ph-Sensitive Polymersomes. Pharmaceutical Chemistry Journal 52:8, pages 721-729.
Crossref
Crossref
Andrea Antonosante, Michele d’Angelo, Vanessa Castelli, Mariano Catanesi, Dalila Iannotta, Antonio Giordano, Rodolfo Ippoliti, Elisabetta Benedetti & Annamaria Cimini. (2018) The Involvement of PPARs in the Peculiar Energetic Metabolism of Tumor Cells. International Journal of Molecular Sciences 19:7, pages 1907.
Crossref
Crossref
Martyna Zaleska, Olga Mozenska & Jacek Bil. (2018) Statins use and cancer: an update. Future Oncology 14:15, pages 1497-1509.
Crossref
Crossref
Sergio Bordel. (2018) Constraint based modeling of metabolism allows finding metabolic cancer hallmarks and identifying personalized therapeutic windows. Oncotarget 9:28, pages 19716-19729.
Crossref
Crossref
Tulika Mishra & Gunjan Mukherjee. 2018. Fungi and their Role in Sustainable Development: Current Perspectives. Fungi and their Role in Sustainable Development: Current Perspectives
35
49
.
LIANNV QIU, JINLIN LIU, ZHENNI WANG, WEIXIAO HU, QIANG HUANG & YONGLIE ZHOU. (2015) ZGDHu-1 and fludarabine have a synergistic effect on apoptosis of chronic lymphocytic leukemia cells. Oncology Reports 34:3, pages 1239-1248.
Crossref
Crossref
Sarita R. Shah, Caroline A. Werlang, F. Kurtis Kasper & Antonios G. Mikos. (2015) Novel applications of statins for bone regeneration. National Science Review 2:1, pages 85-99.
Crossref
Crossref
F. J. Carey, M. W. Little, T. F. G. Pugh, R. Ndokera, H. Ing, A. Clark, A. Dennison, M. S. Metcalfe, R. J. Robinson & A. R. Hart. (2013) The Differential Effects of Statins on the Risk of Developing Pancreatic Cancer: A Case–Control Study in Two Centres in the United Kingdom. Digestive Diseases and Sciences 58:11, pages 3308-3312.
Crossref
Crossref
Tanja Bladt, Jens Frisvad, Peter Knudsen & Thomas Larsen. (2013) Anticancer and Antifungal Compounds from Aspergillus, Penicillium and Other Filamentous Fungi. Molecules 18:9, pages 11338-11376.
Crossref
Crossref
Lori N. Griner, Kathy L. McGraw, Joseph O. Johnson, Alan F. List & Gary W. Reuther. (2012)
JAK
2‐
V
617
F
‐mediated signalling is dependent on lipid rafts and statins inhibit
JAK
2‐
V
617
F
‐dependent cell growth
. British Journal of Haematology 160:2, pages 177-187.
Crossref
Crossref
J W Clendening & L Z Penn. (2012) Targeting tumor cell metabolism with statins. Oncogene 31:48, pages 4967-4978.
Crossref
Crossref
Claudio R. Santos & Almut Schulze. (2012) Lipid metabolism in cancer. FEBS Journal 279:15, pages 2610-2623.
Crossref
Crossref
Gayathri Subramanian, Pulkit Chaudhury, Krishnakumar Malu, Samantha Fowler, Rahul Manmode, Deepali Gotur, Monika Zwerger, David Ryan, Rita Roberti & Peter Gaines. (2012) Lamin B Receptor Regulates the Growth and Maturation of Myeloid Progenitors via its Sterol Reductase Domain: Implications for Cholesterol Biosynthesis in Regulating Myelopoiesis. The Journal of Immunology 188:1, pages 85-102.
Crossref
Crossref
Timothy Miller, Fuquan Yang, Candace E. Wise, Fanyin Meng, Sally Priester, Md Kamruzzaman Munshi, Micheleine Guerrier, David E. Dostal & Shannon S. Glaser. (2011) Simvastatin stimulates apoptosis in cholangiocarcinoma by inhibition of Rac1 activity. Digestive and Liver Disease 43:5, pages 395-403.
Crossref
Crossref
Carolyn A. Goard, Richard G. Mather, Balpreet Vinepal, James W. Clendening, Anna Martirosyan, Paul C. Boutros, Frances J. Sharom & Linda Z. Penn. (2010) Differential interactions between statins and P‐glycoprotein: Implications for exploiting statins as anticancer agents. International Journal of Cancer 127:12, pages 2936-2948.
Crossref
Crossref
Monika Podhorecka, Dorota Halicka, Piotr Klimek, Malgorzata Kowal, Sylwia Chocholska & Anna Dmoszynska. (2010) Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Annals of Hematology 89:11, pages 1115-1124.
Crossref
Crossref
James W. Clendening, Aleks Pandyra, Paul C. Boutros, Samah El Ghamrasni, Fereshteh Khosravi, Grace A. Trentin, Anna Martirosyan, Anne Hakem, Razqallah Hakem, Igor Jurisica & Linda Z. Penn. (2010) Dysregulation of the mevalonate pathway promotes transformation. Proceedings of the National Academy of Sciences 107:34, pages 15051-15056.
Crossref
Crossref
James W. Clendening, Aleksandra Pandyra, Zhihua Li, Paul C. Boutros, Anna Martirosyan, Richard Lehner, Igor Jurisica, Suzanne Trudel & Linda Z. Penn. (2010) Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma. Blood 115:23, pages 4787-4797.
Crossref
Crossref
Mizuho Nonaka, Shin Uota, Yasunori Saitoh, Mayumi Takahashi, Haruyo Sugimoto, Tohti Amet, Ayako Arai, Osamu Miura, Naoki Yamamoto & Shoji Yamaoka. (2009) Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Experimental Cell Research 315:2, pages 141-150.
Crossref
Crossref
Charles Elson & Huanbiao Mo. 2008. Tocotrienols. Tocotrienols
185
207
.
Lise Madsen, Rasmus K. Petersen, Knut R. Steffensen, Lone M. Pedersen, Philip Hallenborg, Tao Ma, Livar Frøyland, Stein Ove Døskeland, Jan-Åke Gustafsson & Karsten Kristiansen. (2008) Activation of Liver X Receptors Prevents Statin-induced Death of 3T3-L1 Preadipocytes. Journal of Biological Chemistry 283:33, pages 22723-22736.
Crossref
Crossref
Helena Gbelcová, Martin Leníček, Jaroslav Zelenka, Zdeněk Knejzlík, Gabriela Dvořáková, Marie Zadinová, Pavla Poučková, Michal Kudla, Peter Balaž, Tomáš Ruml & Libor Vítek. (2007) Differences in antitumor effects of various statins on human pancreatic cancer. International Journal of Cancer 122:6, pages 1214-1221.
Crossref
Crossref
W. Wei-Lynn Wong, James W. Clendening, Anna Martirosyan, Paul C. Boutros, Christina Bros, Fereshteh Khosravi, Igor Jurisica, A. Keith Stewart, P. Leif Bergsagel & Linda Z. Penn. (2007) Determinants of sensitivity to lovastatin-induced apoptosis in multiple myeloma. Molecular Cancer Therapeutics 6:6, pages 1886-1897.
Crossref
Crossref
Antonella Sassano, Efstratios Katsoulidis, Giovanni Antico, Jessica K. Altman, Amanda J. Redig, Saverio Minucci, Martin S. Tallman & Leonidas C. Platanias. (2007) Suppressive Effects of Statins on Acute Promyelocytic Leukemia Cells. Cancer Research 67:9, pages 4524-4532.
Crossref
Crossref
Steven M. KornblauDeborah E. Banker, Derek Stirewalt, Danny Shen, Elizabeth LemkerSrdan VerstovsekZeev EstrovStefan FaderlJorge CortesMiloslav BeranC. Ellen JacksonWenjing ChenElihu EsteyFrederick R. Appelbaum. (2006) Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 109:7, pages 2999-3006.
Crossref
Crossref
Hans Carl Hasselbalch & Caroline H. Riley. (2006) Statins in the treatment of polycythaemia vera and allied disorders: An antithrombotic and cytoreductive potential?. Leukemia Research 30:10, pages 1217-1225.
Crossref
Crossref
Katja Hindler, Charles S. Cleeland, Edgardo Rivera & Charles D. Collard. (2006) The Role of Statins in Cancer Therapy. The Oncologist 11:3, pages 306-315.
Crossref
Crossref
Kriste A. Lewis, Sarah A. Holstein & Raymond J. Hohl. (2005) Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo. Leukemia Research 29:5, pages 527-533.
Crossref
Crossref
Monica M. Bertagnolli & Stanley R. Hamilton. 2005. Cancer Chemoprevention. Cancer Chemoprevention
267
285
.
M Pallis & N Russell. (2004) Strategies for overcoming p-glycoprotein-mediated drug resistance in acute myeloblastic leukaemia. Leukemia 18:12, pages 1927-1930.
Crossref
Crossref
Deborah E. BankerSasha J. MayerHenry Y. LiCheryl L. WillmanFrederick R. AppelbaumRichard A. Zager. (2004) Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood 104:6, pages 1816-1824.
Crossref
Crossref
Naomi Gronich, Liat Drucker, Hava Shapiro, Judith Radnay, Shai Yarkoni & Michael Lishner. (2023) Simvastatin Induces Death of Multiple Myeloma Cell Lines. Journal of Investigative Medicine 52:5, pages 335-344.
Crossref
Crossref
Denise M. Boudreau, Jacqueline S. Gardner, Kathleen E. Malone, Susan R. Heckbert, David K. Blough & Janet R. Daling. (2004) The association between 3‐hydroxy‐3‐methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women. Cancer 100:11, pages 2308-2316.
Crossref
Crossref
Daphne Chapman-Shimshoni, Mona Yuklea, Judith Radnay, Hava Shapiro & Michael Lishner. (2003) Simvastatin induces apoptosis of B-CLL cells by activation of mitochondrial caspase 9. Experimental Hematology 31:9, pages 779-783.
Crossref
Crossref
M A Morgan, A Ganser & C W M Reuter. (2003) Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia. Leukemia 17:8, pages 1482-1498.
Crossref
Crossref
Ernest T. Hawk, Paul J. Limburg & Jaye L. Viner. (2002) Epidemiology and prevention of colorectal cancer. Surgical Clinics of North America 82:5, pages 905-941.
Crossref
Crossref
W W-L Wong, J Dimitroulakos, MD Minden & LZ Penn. (2002) HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16:4, pages 508-519.
Crossref
Crossref
Roland M. Schmid. (2002) HMG-CoA reductase inhibitors for the treatment of pancreatic cancer. Gastroenterology 122:2, pages 565-567.
Crossref
Crossref
Eun Jung Park, Dongho Lee, Young Geun Shin, Daniel D. Lantvit, Richard B. van Breemen, A.Douglas Kinghorn & John M. Pezzuto. (2001) Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography–electrospray mass spectrometry. Journal of Chromatography B: Biomedical Sciences and Applications 754:2, pages 327-332.
Crossref
Crossref
Michael H. Davidson. (2001) Safety Profiles for the HMG-CoA Reductase Inhibitors. Drugs 61:2, pages 197-206.
Crossref
Crossref
L Maksumova, K Ohnishi, F Muratkhodjaev, W Zhang, L Pan, A Takeshita & R Ohno. (2000) Increased sensitivity of multidrug-resistant myeloid leukemia cell lines to lovastatin. Leukemia 14:8, pages 1444-1450.
Crossref
Crossref
David J. MaronSergio FazioMacRae F. Linton. (2000) Current Perspectives on Statins. Circulation 101:2, pages 207-213.
Crossref
Crossref
Jim DimitroulakosDana NohynekKaren L. BackwayDavid W. HedleyHerman YegerMelvin H. FreedmanMark D. MindenLinda Z. Penn. (1999) Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach. Blood 93:4, pages 1308-1318.
Crossref
Crossref
Jim DimitroulakosDana NohynekKaren L. BackwayDavid W. HedleyHerman YegerMelvin H. FreedmanMark D. MindenLinda Z. Penn. (1999) Increased Sensitivity of Acute Myeloid Leukemias to Lovastatin-Induced Apoptosis: A Potential Therapeutic Approach. Blood 93:4, pages 1308-1318.
Crossref
Crossref
Robyn D. Clutterbuck, Barbara C. Millar, Ray L. Powles, Ann Newman, Daniel Catovsky, Michael Jarman & John L. Millar. (2001) Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice. British Journal of Haematology 102:2, pages 522-527.
Crossref
Crossref