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Leukemia & Lymphoma Volume 26, 1997 - Issue 1-2
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Original Article

Activity of 2-chlorodeoxyadenosine (cladribine) in 2-hour intravenous infusion in 94 previously treated patients with low grade non-hodgkin's lymphoma

T. Robak Department of Hematology, Medical University of Lód; Department of Haematology, Medical University of Lód ul, Pibianícka 62, 93-513, Lód, Poland
,
J. Gora-Tybor Department of Hematology, Medical University of Lód
,
E. Krykowski Department of Hematology, Medical University of Lód
,
J. A. Walewski Department of Lymphoproliferative Diseases, Centre of Oncology, Warsaw
,
A. Borawska Department of Lymphoproliferative Diseases, Centre of Oncology, Warsaw
,
A. Plubańska Department of Oncology, Medical University of Lód
,
P. Potemski Department of Oncology, Medical University of Lód
,
A. Hellmann Department of Hematology, Medical University of Gdańsk
,
J. M. Zaucha Department of Hematology, Medical University of Gdańsk
,
L. Konopka Intitute of Hematology and Blood Transfusion, Warsaw
,
B. Ceglarek Intitute of Hematology and Blood Transfusion, Warsaw
,
T. Durýński Intitute of Hematology and Blood Transfusion, Warsaw
,
A. Sikorska Intitute of Hematology and Blood Transfusion, Warsaw
,
K. Michalak Intitute of Hematology and Blood Transfusion, Warsaw
,
J. Urasiński Department of Hematology, Pomorian Academy of Medicine, Szczecin
,
J. Opalińska Department of Hematology, Pomorian Academy of Medicine, Szczecin
,
A. Dmoszyńska Deparmment of Hematology, University Medical School of Lublin
,
M. B. Adamczyk-Cioch Deparmment of Hematology, University Medical School of Lublin
,
Z. Kuratowska Department of Hematology, Academy of Medicine, Warsaw
,
J. Dwilewicz-Trojaczek Department of Hematology, Academy of Medicine, Warsaw
,
P. Boguradzki Department of Hematology, Academy of Medicine, Warsaw
,
M. Dere Department of Oncology, Central Regional Hospital, Toru
,
S. May Intitute of Hematology and Blood Transfusion, Warsaw
&
P. Grieb Medical Research Center, Polish Academy of Sciences, Warsaw, Poland
 show all
Pages 99-105 | Accepted 10 Sep 1996, Published online: 05 Aug 2009

Citations (23)

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Read on this site (5)

Shaohong Xu, Peng Yao, Gairong Chen & Hui Wang. (2011) A New Synthesis of 2-chloro-2′-deoxyadenosine (Cladribine), CdA). Nucleosides, Nucleotides & Nucleic Acids 30:5, pages 353-359.
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Darren S Sigal & Alan Saven. (2008) Cladribine in indolent non-Hodgkin’s lymphoma. Expert Review of Anticancer Therapy 8:4, pages 535-545.
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Tadeusz Robak, Ewa Lech-Maranda, Agnieszka Janus, Jerzy Blonski, Agnieszka Wierzbowska & Joanna Gora-Tybor. (2007) Cladribine combined with cyclophosphamide and mitoxantrone is an active salvage therapy in advanced non-Hodgkin's lymphoma. Leukemia & Lymphoma 48:6, pages 1092-1101.
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Tadeusz Robak. (2001) Cladribine in the Treatment of Chronic Lymphocytic Leukemia. Leukemia & Lymphoma 40:5-6, pages 551-564.
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Mathias J. Rummel, Kai U. Chow, Elke Jäger, Lothar Leimer, Deter K. Hossfeld, Lothar Bergmann, Hans D. Peters, Martin L. Hansmann, Annette Meyer, Dieter Hoelzer & Paris S. Mitrou. (1999) Intermittent 2-Hour-Infusion of Cladribine as First-Line Therapy or in First Relapse of Progressive Advanced Low-Grade and Mantle Cell Lymphomas. Leukemia & Lymphoma 35:1-2, pages 129-138.
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Articles from other publishers (18)

Yao Peng. (2013) A Practical Synthesis of 2-chloro-2′-deoxyadenosine (Cladribine) from 2′-deoxyadenosine. Journal of Chemical Research 37:4, pages 213-215.
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Shao Hong Xu. (2012) Efficient Syntheses of 2-Chloro-2‘-Deoxyadenosine (Cladribine) from 2-Chloroadenosine. Advanced Materials Research 535-537, pages 2425-2428.
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Darren S. Sigal, Heather J. Miller, Ethan D. Schram & Alan Saven. (2010) Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood 116:16, pages 2884-2896.
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Kensei Tobinai, Takashi Watanabe, Kazuki Tanimoto, Dai Maruyama, Masanobu Nakata, Kuniaki Itoh, Yasuo Morishima, Michinori Ogura, Noriko Usui, Masaharu Kasai, Takashi Terauchi, Shigeru Nawano, Masaki Matsusako, Yoshihiro Matsuno, Shigeo Nakamura, Shigeo Mori & Yasuo Ohashi. (2009) Phase I/II and pharmacokinetic study of cladribine with 2-h infusion in Japanese patients with relapsed indolent B-cell lymphoma mostly pretreated with rituximab. Cancer Science 100:7, pages 1344-1350.
Crossref
Tomasz Kryczka, Zygmunt Kazimierczuk, Mariola Kozłowska, Stanisław J. Chrapusta, Leena Vilpo, Juhani Vilpo, Krzysztof Stachnik, Monika Janisz & Paweł Grieb. (2007) Two novel nucleoside ester derivatives of chlorambucil as potential antileukemic prodrugs: a preliminary study. Anti-Cancer Drugs 18:3, pages 301-310.
Crossref
Kristie A. Blum, Jeffrey L. Johnson, Donna Niedzwiecki, Lawrence D. Piro, Alan Saven, Bruce A. Peterson, John C. Byrd & Bruce D. Cheson. (2006) Prolonged follow‐up after initial therapy with 2‐chlorodeoxyadenosine in patients with indolent non‐Hodgkin lymphoma. Cancer 107:12, pages 2817-2825.
Crossref
Tadeusz Robak, Piotr Smolewski, Barbara Cebula, Anna Szmigielska‐Kaplon, Krzysztof Chojnowski & Jerzy Z. Blonski. (2006) Rituximab combined with cladribine or with cladribine and cyclophosphamide in heavily pretreated patients with indolent lymphoproliferative disorders and mantle cell lymphoma. Cancer 107:7, pages 1542-1550.
Crossref
Minghong Zhong, Ireneusz Nowak & Morris J. Robins. (2006) Regiospecific and Highly Stereoselective Coupling of 6-(Substituted-imidazol-1-yl)purines with 2-Deoxy-3,5-di- O -( p -toluoyl)-α- d - e rythro -pentofuranosyl Chloride. Sodium-Salt Glycosylation in Binary Solvent Mixtures:  Improved Synthesis of Cladribine 1 . The Journal of Organic Chemistry 71:20, pages 7773-7779.
Crossref
T. Robak, A. Szmigielska-Kapłon, J.Z. Błoński, M. Kasznicki & K. Chojnowski. (2005) Activity of Cladribine Combined with Etoposide in Heavily Pretreated Patients with Indolent Lymphoid Malignancies. Chemotherapy 51:5, pages 247-251.
Crossref
Michinori Ogura, Yasuo Morishima, Yukio Kobayashi, Naokuni Uike, Susumu Sugai, Takaaki Chou, Masaharu Kasai, Ikuo Miura, Tohru Murayama, Yoshihiro Matsuno, Shigeo Nakamura, Shigeo Mori, Yasuo Ohashi, Kensei Tobinai & Members of the Cladribine Study Group. (2004) Durable Response but Prolonged Cytopenia after Cladribine Treatment in Relapsed Patients with Indolent non-Hodgkin's Lymphomas: Results of a Japanese Phase II Study. International Journal of Hematology 80:3, pages 267-277.
Crossref
T. Robak, J.Z. Blonski, J. Gora-Tybor, M. Kasznicki, L. Konopka, B. Ceglarek, M. Komarnicki, K. Lewandowski, A. Hellmann, K. Lewandowski, A. Moskwa, A. Dmoszyńska, B. Sokołowska, A. Dwilewicz-Trojaczek, A. Tomaszewska, K. Sułek & M. Całbecka. (2004) Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine. European Journal of Cancer 40:3, pages 383-389.
Crossref
Charles P. Theuer, Bryan R. Leigh, Pratik S. Multani, Roberta S. Allen & Bertrand C. Liang. 2004. 265 295 .
Gerald JägerPeter NeumeisterRuth BrezinschekThomas HinterleitnerWolfgang FiebigerMelitta PenzHans J. NeumannBrigitte MlineritschMaria DeSantisFranz QuehenbergerAndreas ChottChristine Beham-SchmidGerald HöflerWerner LinkeschMarkus Raderer. (2002) Treatment of Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue Type With Cladribine: A Phase II Study. Journal of Clinical Oncology 20:18, pages 3872-3877.
Crossref
Pier Luigi Zinzani. (2002) Non-Hodgkin's lymphoma: the evolving role of purine analogues. Best Practice & Research Clinical Haematology 15:3, pages 505-516.
Crossref
Tadeusz Robak, Joanna Góra-Tybor, Ewa Lech-Marańda, Jerzy Z. Błoński & Marek Kasznicki. (2001) Cladribine in combination with mitoxantrone and cyclophosphamide(CMC) in the treatment of heavily pre-treated patients with advanced indolent lymphoid malignancies. European Journal of Haematology 66:3, pages 188-194.
Crossref
Pierre Soubeyran, Marc Debled, Nadine Tchen, Pierre Richaud, Alain Monnereau, Françoise Bonichon & Houchingue Eghbali. (2000) Follicular lymphomas — a review of treatment modalities. Critical Reviews in Oncology/Hematology 35:1, pages 13-32.
Crossref
A. Hellmann, K. Lewandowski, J.M. Zaucha, M. Bieniaszewska, K. Hałaburda & T. Robak. (2009) Effect of a 2‐hour infusion of 2‐chlorodeoxyadenosine in the treatment of refractory or previously untreated Waldenström's macroglobulinemia. European Journal of Haematology 63:1, pages 35-41.
Crossref
T. Robak, M. Błasińska‐Morawiec, E. Krykowski, A. Hellmann, K. Lewandowski, A. Dmoszyńska, M. Adamczyk‐Cioch, M. Kazimierczak, E. Trepińska, M. Dwilewicz‐Trojaczek, Z. Kuratowska, A. B. Skotnicki, W. S. Nowak, B. Zdziarska & I. Urasiński. (2009) 2‐Chlorodeoxyadenosine (cladribine)‐related eosinophilia in patients with lymphoproliferative diseases. European Journal of Haematology 59:4, pages 216-220.
Crossref

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