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Leukemia & Lymphoma Volume 33, 1999 - Issue 3-4
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Original Article

Clinicopathological Diagnosis and Differential Criteria of Thrombocythemias in Various Myeloproliferative Disorders by Histopathology, Histochemistry and Immunostaining from Bone Marrow Biopsies

Juergen Thiele Institute of Pathology, Cologne, Germany; Institute of Pathology, University of Cologne, Joseph-Stelzmannstr. 9, D-50924, Cologne, Germany
,
Hans Michael Kvasnicka Institute of Pathology, Cologne, Germany
,
Volker Diehl First Clinic of Medicine, University of Cologne, Cologne, Germany
,
Robert Fischer Institute of Pathology, Cologne, Germany
&
Jan Jacques Michiels European Working Group on MPD, Good-heart Institute, Rotterdam, The Netherlands; Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
Pages 207-218 | Accepted 30 Jun 1998, Published online: 01 Jul 2009

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Elisa Rumi, Emanuela Sant’Antonio, Emanuela Boveri, Daniela Pietra, Chiara Cavalloni, Elisa Roncoroni, Cesare Astori & Luca Arcaini. (2018) Diagnosis and management of prefibrotic myelofibrosis. Expert Review of Hematology 11:7, pages 537-545.
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Juergen Thiele & Hans M. Kvasnicka. (2006) A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders. Leukemia & Lymphoma 47:3, pages 381-396.
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J. J. Michiels, T. Barbui, G. Finazzi, S. M. Fuchtman, J. Kutti, J. D. Rain, R. T. Silver, A. Tefferi & J. Thiele. (2000) Diagnosis and Treatment of Polycythemia Vera and Possible Future Study Designs of the PVSG. Leukemia & Lymphoma 36:3-4, pages 239-253.
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Martin Griesshammer, Bernhard Kubanek, Heimo Beneke, Hermann Heimpel, Markus Bangerter, Lothar Bergmann & Hubert Schrezenmeier. (2000) Serum Erythropoietin and Thrombopoietin Levels in Patients with Essential Thrombocythaemia. Leukemia & Lymphoma 36:5-6, pages 533-538.
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Articles from other publishers (60)

Marco Pizzi, Giorgio Alberto Croci, Marco Ruggeri, Silvia Tabano, Angelo Paolo Dei Tos, Elena Sabattini & Umberto Gianelli. (2021) The Classification of Myeloproliferative Neoplasms: Rationale, Historical Background and Future Perspectives with Focus on Unclassifiable Cases. Cancers 13:22, pages 5666.
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Ralf Knöfler, Björn S. Lange, Franziska Paul, Oliver Tiebel & Meinolf Suttorp. (2019) Bleeding signs due to acquired von Willebrand syndrome at diagnosis of chronic myeloid leukaemia in children. British Journal of Haematology 188:5, pages 701-706.
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Ayalew Tefferi. 2020. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology 1821 1835.e4 .
Jan Jacques Michiels & Hendrik De Raeve. (2019) The PVSG/WHO versus the Rotterdam European clinical, molecular and pathological diagnostic criteria for the classification of myeloproliferative disorders and myeloproliferative neoplasms (MPD/MPN): From Dameshek to Georgii, Vainchenker and Michiels 1950-2018. International Journal of Bone Marrow Research, pages 027-050.
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Tiziano Barbui, Guido Finazzi & Ayalew Tefferi. 2019. Platelets. Platelets 863 876 .
Elisa Rumi, Emanuela Boveri, Marta Bellini, Daniela Pietra, Virginia V. Ferretti, Emanuela Sant’Antonio, Chiara Cavalloni, Ilaria C. Casetti, Elisa Roncoroni, Michele Ciboddo, Pietro Benvenuti, Benedetta Landini, Elena Fugazza, Daniela Troletti, Cesare Astori & Mario Cazzola. (2017) Clinical course and outcome of essential thrombocythemia and prefibrotic myelofibrosis according to the revised WHO 2016 diagnostic criteria. Oncotarget 8:60, pages 101735-101744.
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Ayalew Tefferi. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 14 .
Samir K Turakhia, Gurunathan Murugesan, Claudiu V Cotta & Karl S Theil. (2016) Thrombocytosis and STAT5 activation in chronic myelogenous leukaemia are not associated with JAK2 V617F or calreticulin mutations . Journal of Clinical Pathology 69:8, pages 713-719.
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Giovanni Barosi. (2014) Essential thrombocythemia vs. early/prefibrotic myelofibrosis: Why does it matter. Best Practice & Research Clinical Haematology 27:2, pages 129-140.
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Gregory L. Price, Keith L. Davis, Sudeep Karve, Gerhardt Pohl & Richard A. Walgren. (2014) Survival Patterns in United States (US) Medicare Enrollees with Non-CML Myeloproliferative Neoplasms (MPN). PLoS ONE 9:3, pages e90299.
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Charlotte M. Niemeyer & Franco Locatelli. 2013. Childhood Leukemias. Childhood Leukemias 444 502 .
Giovanni Barosi, Vittorio Rosti, Elisa Bonetti, Rita Campanelli, Adriana Carolei, Paolo Catarsi, Antonina M. Isgrò, Letizia Lupo, Margherita Massa, Valentina Poletto, Gianluca Viarengo, Laura Villani & Umberto Magrini. (2012) Evidence that Prefibrotic Myelofibrosis Is Aligned along a Clinical and Biological Continuum Featuring Primary Myelofibrosis. PLoS ONE 7:4, pages e35631.
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Nanna H. Sulai & Ayalew Tefferi. (2012) Why Does My Patient Have Thrombocytosis?. Hematology/Oncology Clinics of North America 26:2, pages 285-301.
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Bridget S. Wilkins. (2010) Proplatelet production and stromal fibrosis in myeloproliferative neoplasms. Leukemia Research 34:11, pages 1417-1419.
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Jeffery M. Klco, Ravi Vij, Friederike H. Kreisel, Anjum Hassan & John L. Frater. (2010) Molecular Pathology of Myeloproliferative Neoplasms. American Journal of Clinical Pathology 133:4, pages 602-615.
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Hans Michael Kvasnicka & Juergen Thiele. (2009) Prodromal myeloproliferative neoplasms: The 2008 WHO classification. American Journal of Hematology 85:1, pages 62-69.
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Juergen Thiele. (2009) Philadelphia Chromosome–Negative Chronic Myeloproliferative Disease. American Journal of Clinical Pathology 132:2, pages 261-280.
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Hans Michael Kvasnicka & Juergen Thiele. (2009) Diagnosis of chronic myeloproliferative neoplasms with special emphasis on early stages. Diagnostic Histopathology 15:3, pages 125-133.
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Ayalew Tefferi. 2008. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology 2261 2278 .
THOMAS STAUFFER LARSEN, HANS CARL HASSELBALCH, NIELS PALLISGAARD & MICHAEL BOE MØLLER. (2007) Bone marrow histomorphology and JAK2 mutation status in essential thrombocythemia. APMIS 115:11, pages 1267-1273.
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Juergen Thiele, Attilio Orazi & Hans Kvasnicka. 2007. Myeloproliferative Disorders. Myeloproliferative Disorders 19 50 .
Victor E. Valli. 2007. Veterinary Comparative Hematopathology. Veterinary Comparative Hematopathology 425 460 .
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Ayalew Tefferi & James W Vardiman. (2007) The diagnostic interface between histology and molecular tests in myeloproliferative disorders. Current Opinion in Hematology 14:2, pages 115-122.
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J.J. Michiels, Z. Bernema, D. Van Bockstaele, H. De Raeve & W. Schroyens. (2007) Current diagnostic criteria for the chronic myeloproliferative disorders (MPD) essential thrombocythemia (ET), polycythemia vera (PV) and chronic idiopathic myelofibrosis (CIMF). Pathologie Biologie 55:2, pages 92-104.
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Jürgen Thiele & Hans M. Kvasnicka. (2007) Myelofibrosis – What’s in a Name?. Pathobiology 74:2, pages 89-96.
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Hans Michael Kvasnicka & Jürgen Thiele. (2007) Classification of Ph-Negative Chronic Myeloproliferative Disorders – Morphology as the Yardstick of Classification. Pathobiology 74:2, pages 63-71.
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Ayalew Tefferi. 2007. Platelets. Platelets 1009 1028 .
Ayalew Tefferi. 2007. Myeloproliferative Disorders. Myeloproliferative Disorders 321 348 .
A. Hochhaus, N. Niederle & B. Weidmann. 2007. Therapiekonzepte Onkologie. Therapiekonzepte Onkologie 292 317 .
J. Thiele, H.M. Kvasnicka & J. Vardiman. (2006) Bone marrow histopathology in the diagnosis of chronic myeloproliferative disorders: A forgotten pearl. Best Practice & Research Clinical Haematology 19:3, pages 413-437.
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Arsalan AhmedChung-Che(Jeff) Chang. (2006) Chronic Idiopathic Myelofibrosis: Clinicopathologic Features, Pathogenesis, and Prognosis. Archives of Pathology & Laboratory Medicine 130:8, pages 1133-1143.
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Juergen Thiele & Hans Michael Kvasnicka. (2006) Is it justified to perform a bone marrow biopsy examination in sustained erythrocytosis?. Current Hematologic Malignancy Reports 1:2, pages 87-92.
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J. Thiele & H. M. Kvasnicka. (2006) Grade of bone marrow fibrosis is associated with relevant hematological findings—a clinicopathological study on 865 patients with chronic idiopathic myelofibrosis. Annals of Hematology 85:4, pages 226-232.
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Ayalew Tefferi. (2006) Essential thrombocythemia: scientific advances and current practice. Current Opinion in Hematology 13:2, pages 93-98.
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J. Brière. (2006) Thrombocytémie essentielle. Critères du diagnostic. Stratification pronostique. Ébauche de stratégie thérapeutique. EMC - Hématologie 1:3, pages 1-19.
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Zbigniew Rudzki, Rafał Kawa, Krzysztof Okoñ, Ewa Szczygieł & Jerzy Stachura. (2005) Objective, planimetry-based assessment of megakaryocyte histological pictures in Philadelphia-chromosome-negative chronic myeloproliferative disorders: a perspective for a valuable adjunct diagnostic tool. Virchows Archiv 448:1, pages 59-67.
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Juergen Thiele, Hans Michael Kvasnicka & Attilio Orazi. (2005) Bone Marrow Histopathology in Myeloproliferative Disorders—Current Diagnostic Approach. Seminars in Hematology 42:4, pages 184-195.
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Ayalew Tefferi, Curtis A. Hanson & David J. Inwards. (2005) How to Interpret and Pursue an Abnormal Complete Blood Cell Count in Adults. Mayo Clinic Proceedings 80:7, pages 923-936.
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Yasmine Chait, Bertrand Condat, Dominique Cazals-Hatem, Pierre Rufat, Sai Atmani, Driss Chaoui, Françoise Guilmin, Jean Jacques Kiladjian, Aurélie Plessier, Marie Hélène Denninger, Nicole Casadevall, Dominique Valla & Jean B. Brière. (2005) Relevance of the criteria commonly used to diagnose myeloproliferative disorder in patients with splanchnic vein thrombosis. British Journal of Haematology 129:4, pages 553-560.
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Andreas Kreft, Guntram Büsche, Maryam Ghalibafian, Thomas Buhr, Thomas Fischer & Charles James Kirkpatrick. (2005) The Incidence of Myelofibrosis in Essential Thrombocythaemia, Polycythaemia vera and Chronic Idiopathic Myelofibrosis: A Retrospective Evaluation of Sequential Bone Marrow Biopsies. Acta Haematologica 113:2, pages 137-143.
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Tiziano Barbui, Guido Finazzi & Giovanni Barosi. 2004. Textbook of Malignant Haematology, Second Edition. Textbook of Malignant Haematology, Second Edition 735 752 .
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Tracy I George & Daniel A Arber. (2003) Pathology of the myeloproliferative diseases. Hematology/Oncology Clinics of North America 17:5, pages 1101-1127.
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Giovanni Barosi. (2003) Myelofibrosis with myeloid metaplasia. Hematology/Oncology Clinics of North America 17:5, pages 1211-1226.
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James W Vardiman. (2003) Myelodysplastic syndromes, chronic myeloproliferative diseases, and myelodysplastic/myeloproliferative diseases. Seminars in Diagnostic Pathology 20:3, pages 154-179.
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J. Thiele & H. M. Kvasnicka. (2003) Chronic myeloproliferative disorders with thrombocythemia: a comparative study of two classification systems (PVSG, WHO) on 839 patients. Annals of Hematology 82:3, pages 148-152.
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Jerry L. Spivak, Giovanni Barosi, Gianni Tognoni, Tiziano Barbui, Guido Finazzi, Roberto Marchioli & Monia Marchetti. (2003) Chronic Myeloproliferative Disorders. Hematology 2003:1, pages 200-224.
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Jan Jacques Michiels & Juergen Thiele. (2002) Clinical and Pathological Criteria for the Diagnosis of Essential Thrombocythemia, Polycythemia Vera, and Idiopathic Myelofibrosis (Agnogenic Myeloid Metaplasia). International Journal of Hematology 76:2, pages 133-145.
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Juergen Thiele, Hans Michael Kvasnicka, Annette Schmitt‐Graeff, Rudolph Zankovich & Volker Diehl. (2002) Follow‐up examinations including sequential bone marrow biopsies in essential thrombocythemia (ET): A retrospective clinicopathological study of 120 patients. American Journal of Hematology 70:4, pages 283-291.
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Marco PicardiVincenzo MartinelliRosanna CianciaErnesto SosciaRoberto MoranteAntonio SodanoGiuliana FortunatoBruno Rotoli. (2002) Measurement of spleen volume by ultrasound scanning in patients with thrombocytosis: a prospective study. Blood 99:11, pages 4228-4230.
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Y. K. MAK, C. H. CHAN, C .C. SO, M. K. CHAN & Y. C. CHU. (2002) Idiopathic myelofibrosis with extramedullary haemopoiesis involving the urinary bladder in a Chinese lady. Clinical & Laboratory Haematology 24:1, pages 55-59.
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A. Tefferi & S. Murphy. (2001) Current opinion in essential thrombocythemia: pathogenesis, diagnosis, and management. Blood Reviews 15:3, pages 121-131.
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B. Peris, E. Pastor, E. Real, E. Grau & J. M. Tenias. (2001) Extreme self-limited thrombocytosis in a young patient. Annals of Hematology 80:9, pages 565-566.
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J. Thiele, H.M. Kvasnicka, K. Muehlhausen, S. Walter, R. Zankovich & V. Diehl. (2001) Polycythemia rubra vera versus Secondary Polycythemias. A Clinicopathological Evaluation of Distinctive Features in 199 Patients. Pathology - Research and Practice 197:2, pages 77-84.
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J Thiele & H.M Kvasnicka. (2001) Clinicopathology and histochemistry on bone marrow biopsies in chronic myeloproliferative disorders – a clue to diagnosis and classification. Pathologie Biologie 49:2, pages 140-147.
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Perry J.J. van Genderen & Monique M. Troost. (2000) Polycythaemia Vera and Essential Thrombocythaemia in the Elderly. Drugs & Aging 17:2, pages 107-119.
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Giovanni Barosi. (1999) Myelofibrosis With Myeloid Metaplasia: Diagnostic Definition and Prognostic Classification for Clinical Studies and Treatment Guidelines. Journal of Clinical Oncology 17:9, pages 2954-2954.
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