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Leukemia & Lymphoma Volume 34, 1999 - Issue 1-2
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Original Article

2-Chlorodeoxyadenosine (Cladribine) in the Treatment of Elderly Patients with B-Cell Chronic Lymphocytic Leukemia

Tadeusz Robak Department of Hematology, Medical University of łódł, PolandCorrespondence[email protected]
,
Maria Błasiłska-Morawiec Department of Hematology, Medical University of łódł, Poland
,
Jerzy Z. Błołski Department of Hematology, Medical University of łódł, Poland
&
Anna Dmoszyłska Department of Hematology, Medical University of Lublin, Poland
Pages 151-156 | Accepted 20 Sep 1998, Published online: 01 Jul 2009

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Stephen P. Mulligan, Karin Karlsson, Mats Strömberg, Viggo Jønsson, Devinder Gill, Jens Hammerström, Mark Hertzberg, Roger McLennan, Bertil Uggla, John Norman, Jonas Wallvik, Gunnel Sundström, Hemming Johansson, Yvonne Brandberg, Jan Liliemark & Gunnar Juliusson. (2014) Cladribine prolongs progression-free survival and time to second treatment compared to fludarabine and high-dose chlorambucil in chronic lymphocytic leukemia. Leukemia & Lymphoma 55:12, pages 2769-2777.
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Lev Shvidel, Mordechai Shtalrid, Osnat Bairey, Naomi Rahimi-Levene, Gilles Lugassy, Ofer Shpilberg, Aaron Polliack & Alain Berrebi. (2003) Conventional Dose Fludarabine-based Regimens are Effective but have Excessive Toxicity in Elderly Patients with Refractory Chronic Lymphocytic Leukemia. Leukemia & Lymphoma 44:11, pages 1947-1950.
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Apostolia-Maria Tsimberidou, Yesid Alvarado & Francis J Giles. (2002) Evolving role of ribonucleoside reductase inhibitors in hematologic malignancies. Expert Review of Anticancer Therapy 2:4, pages 437-448.
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Vicki A Morrison. (2001) Update on prophylaxis and therapy of infection in patients with chronic lymphocytic leukemia. Expert Review of Anticancer Therapy 1:1, pages 84-90.
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Tadeusz Robak. (2001) Cladribine in the Treatment of Chronic Lymphocytic Leukemia. Leukemia & Lymphoma 40:5-6, pages 551-564.
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Alexander S.D. Spiers. (2001) Management of the Chronic Leukemias: Special Considerations in the Elderly Patient. Part I. Chronic Lymphocytic Leukemias. Hematology 6:5, pages 291-314.
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FranÇOis LefrÈRe, Olivier Hermine, Sylvie FranÇOis, GÉRard Panelatti, FranÇOise Valensi, Bernard Grosbois, Jean-Louis Misset, Bruno Varet & Xavier Troussard. (2000) Lack of Efficacy of 2-Chlorodeoxyadenoside in the Treatment of Splenic Lymphoma with Villous Lymphocytes. Leukemia & Lymphoma 40:1-2, pages 113-117.
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Articles from other publishers (21)

Talal Hilal, Juan C. Gea-Banacloche & Jose F. Leis. (2018) Chronic lymphocytic leukemia and infection risk in the era of targeted therapies: Linking mechanisms with infections. Blood Reviews 32:5, pages 387-399.
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Tadeusz Robak. (2013) Przewlekła białaczka limfocytowa u ludzi starszych. Acta Haematologica Polonica 44:2, pages 93-98.
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Rosa Visone, Angelo Veronese, Veronica Balatti & Carlo M. Croce. (2012) MiR-181b: new perspective to evaluate disease progression in chronic lymphocytic leukemia. Oncotarget 3:2, pages 195-202.
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Tamar Tadmor & Aaron Polliack. (2012) Optimal management of older patients with chronic lymphocytic leukemia: Some facts and principles guiding therapeutic choices. Blood Reviews 26:1, pages 15-23.
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Xavier C. BadouxMichael J. KeatingSijin Wen, Bang-Ning Lee, Mariela SivinaJames Reuben, William G. WierdaSusan M. O'BrienStefan FaderlSteven M. KornblauJan A. BurgerAlessandra Ferrajoli. (2011) Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. Blood 118:13, pages 3489-3498.
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Vicki A. Morrison. (2010) Infectious complications of chronic lymphocytic leukaemia: pathogenesis, spectrum of infection, preventive approaches. Best Practice & Research Clinical Haematology 23:1, pages 145-153.
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Elias Anaissie. 2008. Chronic Lymphocytic Leukemia. Chronic Lymphocytic Leukemia 261 292 .
F. Rollot-Trad, H. Lahjibi, C. Lazarovici, C. Bauer, O. Saint-Jean & M. Gisselbrecht. (2008) Hémopathies et sujets âgés : expérience d’un service de court séjour gériatrique. La Revue de Médecine Interne 29:7, pages 541-549.
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Tait D. Shanafelt, Thomas Lin, Susan M. Geyer, Clive S. Zent, Nelson Leung, Brian Kabat, Deborah Bowen, Michael R. Grever, John C. Byrd & Neil E. Kay. (2007) Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer 109:11, pages 2291-2298.
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Vicki A. Morrison. (2007) Management of Infectious Complications in Patients with Chronic Lymphocytic Leukemia. Hematology 2007:1, pages 332-338.
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Farhad Ravandi & Susan O’Brien. (2005) Immune defects in patients with chronic lymphocytic leukemia. Cancer Immunology, Immunotherapy 55:2, pages 197-209.
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Farhad Ravandi & Susan O’Brien. (2005) Infections associated with purine analogs and monoclonal antibodies. Blood Reviews 19:5, pages 253-273.
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Tadeusz Robak. (2004) The place of cladribine in the treatment of chronic lymphocytic leukemia: a 10-year experience in Poland. Annals of Hematology 84:2, pages 63-70.
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Tadeusz Robak. (2005) Therapy of Chronic Lymphocytic Leukaemia with Purine Nucleoside Analogues. Drugs & Aging 22:12, pages 983-1012.
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Chadi Nabhan, Ronald B Gartenhaus & Martin S Tallman. (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Research 28:5, pages 429-442.
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William G Wierda, Michael J Keating & Susan O??Brien. (2004) Refractory Chronic Lymphocytic Leukemia. American Journal of Cancer 3:3, pages 163-178.
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Brigitte Tranchand, Silvy Laporte, Olivier Glehen & Gilles Freyer. (2003) Pharmacology of cytotoxic agents: a helpful tool for building dose adjustment guidelines in the elderly. Critical Reviews in Oncology/Hematology 48:2, pages 199-214.
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Karin Karlsson, Mats Strömberg, Jan Liliemark, André Delannoy, S. A. N. Johnson, Anja Porwit, Eva Kimby, Gerd Lärfars, Ilse Cristiansen, Göran Nilsson, Fredrik Celsing, Gunnel Sundström, Mikaela Luthman, Ulf Tidefelt, Jonas Wallvik & Gunnar Juliusson. (2002) Oral cladribine for B-cell chronic lymphocytic leukaemia: report of a phase II trial with a 3-d, 3-weekly schedule in untreated and pretreated patients, and a long-term follow-up of 126 previously untreated patients. British Journal of Haematology 116:3, pages 538-548.
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Terry J. Hamblin. (2001) Achieving Optimal Outcomes in Chronic Lymphocytic Leukaemia. Drugs 61:5, pages 593-611.
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Thomas J. Kipps. (2000) Chronic lymphocytic leukemia. Current Opinion in Hematology 7:4, pages 223-234.
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Nelson Kalil & Bruce D. Cheson. (2000) Management of Chronic Lymphocytic Leukaemia. Drugs & Aging 16:1, pages 9-27.
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