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Journal of Drug Targeting Volume 2, 1994 - Issue 2
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Research Article

The Establishment of Polarity and Enhanced Transcytosis of Transferrin Receptors in Enterocyte-like Caco-2 Cells

Deven ShahDepartment of Pharmaceutical Sciences School of Pharmacy, University of Southern California
&
Wei-Chiang ShenDepartment of Pharmaceutical Sciences School of Pharmacy, University of Southern California
Pages 93-99 | Received 25 Mar 1993, Accepted 17 Nov 1994, Published online: 20 Oct 2008

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Mariam Khvedelidze, Tamaz Mdzinarashvili, Eka Shekiladze, Marc Schneider, Daniel Moersdorf & Ingolf Bernhardt. (2015) Structure of drug delivery DPPA and DPPC liposomes with ligands and their permeability through cells. Journal of Liposome Research 25:1, pages 20-31.
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Felicia Antohe, Geo Serban, Luminita Radulescu & Maya Simionescu. (1997) Transcytosis of Albumin in Endothelial Cells is Brefeldin A—Independent. Endothelium 5:2, pages 125-136.
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Deven Shah & Wei-Chiang Shen. (1995) The Paradox of Transferrin Receptor-mediated Drug Delivery—Intracellular Targeting or Transcellular Transport?. Journal of Drug Targeting 3:4, pages 243-245.
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Articles from other publishers (22)

Yining Xu, Neha Shrestha, Véronique Préat & Ana Beloqui. (2020) Overcoming the intestinal barrier: A look into targeting approaches for improved oral drug delivery systems. Journal of Controlled Release 322, pages 486-508.
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Chen Xie, Zhijun Wang, Yang Su, Jeffrey Wang & Wei-Chiang Shen. (2019) Discovery of an Orally Effective Factor IX-Transferrin Fusion Protein for Hemophilia B. International Journal of Molecular Sciences 21:1, pages 21.
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Gregory Russell-Jones. 2013. Engineering Polymer Systems for Improved Drug Delivery. Engineering Polymer Systems for Improved Drug Delivery 343 373 .
Noriyasu Kamei, Yoshinori Onuki, Kozo Takayama & Mariko Takeda-Morishita. (2013) Mechanistic Study of the Uptake/Permeation of Cell-Penetrating Peptides Across a Caco-2 Monolayer and Their Stimulatory Effect on Epithelial Insulin Transport. Journal of Pharmaceutical Sciences 102:11, pages 3998-4008.
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Xiaoying Chen, Jennica L. Zaro & Wei-Chiang Shen. (2013) Fusion protein linkers: Property, design and functionality. Advanced Drug Delivery Reviews 65:10, pages 1357-1369.
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Christian Langelueddecke, Eleni Roussa, Robert A. Fenton & Frank Thévenod. (2013) Expression and Function of the Lipocalin-2 (24p3/NGAL) Receptor in Rodent and Human Intestinal Epithelia. PLoS ONE 8:8, pages e71586.
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Xiaoying Chen, Jennica Zaro & Wei‐Chiang Shen. 2013. Fusion Protein Technologies for Biopharmaceuticals. Fusion Protein Technologies for Biopharmaceuticals 57 73 .
Efrat Harel, Abraham Rubinstein, Aviram Nissan, Elena Khazanov, Mirela Nadler Milbauer, Yechezkel Barenholz & Boaz Tirosh. (2011) Enhanced Transferrin Receptor Expression by Proinflammatory Cytokines in Enterocytes as a Means for Local Delivery of Drugs to Inflamed Gut Mucosa. PLoS ONE 6:9, pages e24202.
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Donald J. AbrahamPeter W. Swaan. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 447 498 .
Michelle J. Snooks, Purnima Bhat, Jason Mackenzie, Natalie A. Counihan, Nicola Vaughan & David A. Anderson. (2008) Vectorial Entry and Release of Hepatitis A Virus in Polarized Human Hepatocytes. Journal of Virology 82:17, pages 8733-8742.
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Tamara Matysiak-Budnik, Ivan Cruz Moura, Michelle Arcos-Fajardo, Corinne Lebreton, Sandrine Ménard, Céline Candalh, Karima Ben-Khalifa, Christophe Dugave, Houda Tamouza, Guillaume van Niel, Yoram Bouhnik, Dominique Lamarque, Stanislas Chaussade, Georgia Malamut, Christophe Cellier, Nadine Cerf-Bensussan, Renato C. Monteiro & Martine Heyman. (2008) Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease. The Journal of Experimental Medicine 205:1, pages 143-154.
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Ching-Jou Lim, Fariba Norouziyan & Wei-Chiang Shen. (2007) Accumulation of transferrin in Caco-2 cells: A possible mechanism of intestinal transferrin absorption. Journal of Controlled Release 122:3, pages 393-398.
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Yun Bai & Wei-Chiang Shen. (2006) Improving the Oral Efficacy of Recombinant Granulocyte Colony-Stimulating Factor and Transferrin Fusion Protein by Spacer Optimization. Pharmaceutical Research 23:9, pages 2116-2121.
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Michael Bur, Hanno Huwer, Claus-Michael Lehr, Nina Hagen, Mette Guldbrandt, Kwang-Jin Kim & Carsten Ehrhardt. (2006) Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers. European Journal of Pharmaceutical Sciences 28:3, pages 196-203.
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Ching-Jou Lim & Wei-Chiang Shen. (2005) Comparison of monomeric and oligomeric transferrin as potential carrier in oral delivery of protein drugs. Journal of Controlled Release 106:3, pages 273-286.
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Yun Bai, David K. Ann & Wei-Chiang Shen. (2005) Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proceedings of the National Academy of Sciences 102:20, pages 7292-7296.
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Amy B Foraker, Chandra M Khantwal & Peter W Swaan. (2003) Current perspectives on the cellular uptake and trafficking of riboflavin. Advanced Drug Delivery Reviews 55:11, pages 1467-1483.
Crossref
Peter W. Swaan. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery.
Cindy N. Roy, David M. Penny, John N. Feder & Caroline A. Enns. (1999) The Hereditary Hemochromatosis Protein, HFE, Specifically Regulates Transferrin-mediated Iron Uptake in HeLa Cells. Journal of Biological Chemistry 274:13, pages 9022-9028.
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Okhee Han, Mark L. Failla & J.Cecil SmithJr.Jr.. (1997) Transferrin-iron and proinflammatory cytokines influence iron status and apical iron transport efficiency of Caco-2 intestinal cell line. The Journal of Nutritional Biochemistry 8:10, pages 585-591.
Crossref
Deven Shah & Wei-chiang Shen. (1996) Transcellular Delivery of an Insulin-Transferrin Conjugate in Enterocyte-like Caco-2 Cells. Journal of Pharmaceutical Sciences 85:12, pages 1306-1311.
Crossref
Marco Tulio Núñez, Victoria Tapia & Miguel Arredondo. (1996) Intestinal Epithelia (Caco-2) Cells Acquire Iron through the Basolateral Endocytosis of Transferrin. The Journal of Nutrition 126:9, pages 2151-2158.
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