Advanced search
Publication Cover
Journal of Drug Targeting Volume 2, 1994 - Issue 2
Submit an article Journal homepage
94
Views
72
CrossRef citations to date
0
Altmetric
Research Article

Selective Targeting of Malignant Cells with Cytotoxin-Folate Conjugates

Christopher LeamonDept. of Chemistry Purdue University
&
Philip LowDept. of Chemistry Purdue University
Pages 101-112 | Received 25 Aug 1993, Accepted 18 Nov 1993, Published online: 20 Oct 2008

Citations (72)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (7)

Afaf H. Al-Nadaf, Lina A. Dahabiyeh, Sajidah Jawarneh, Sanaa Bardaweel & Nouf N. Mahmoud. (2021) Folic acid-hydrophilic polymer coated mesoporous silica nanoparticles target doxorubicin delivery. Pharmaceutical Development and Technology 26:5, pages 582-591.
Read now
George Mattheolabakis, Lara Milane, Amit Singh & Mansoor M. Amiji. (2015) Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine. Journal of Drug Targeting 23:7-8, pages 605-618.
Read now
Lifang Wu, Cui Tang & Chunhua Yin. (2010) Folate-mediated solid–liquid lipid nanoparticles for paclitaxel-coated poly(ethylene glycol). Drug Development and Industrial Pharmacy 36:4, pages 439-448.
Read now
Ram Reddy Patlolla & Venkateswarlu Vobalaboina. (2008) Folate-targeted etoposide-encapsulated lipid nanospheres. Journal of Drug Targeting 16:4, pages 269-275.
Read now
Manohar Ratnam, Hong Hao, Xuan Zheng, Hui Wang, Huiling Qi, Robert Lee & Xing Pan. (2003) Receptor induction and targeted drug delivery: a new antileukaemia strategy. Expert Opinion on Biological Therapy 3:4, pages 563-574.
Read now
Christopher Ward, Nigel Acheson & Leonard Seymour. (2000) Folic Acid Targeting of Protein Conjugates into Ascites Tumour Cells from Ovarian Cancer Patients. Journal of Drug Targeting 8:2, pages 119-123.
Read now
Christopher P. Leamon, Randolph B. Deprince & R. Wayne Hendren. (1999) Folate-mediated Drug Delivery: Effect of Alternative Conjugation Chemistry. Journal of Drug Targeting 7:3, pages 157-169.
Read now

Articles from other publishers (65)

Meysam Alizadeh-Kouzehrash & Abbas Rahmati. (2020) Solvent-free synthesis of isoindolo[2,1-c]pyrazolo[1,5-a]quinazoline and pyrazolo[5′,1′:2,3]pyrimido[6,1-a]isoindol derivatives through a one-pot three-component reaction. Molecular Diversity 25:2, pages 1123-1130.
Crossref
Piotr Gierlich, Ana I. Mata, Claire Donohoe, Rui M. M. Brito, Mathias O. Senge & Lígia C. Gomes-da-Silva. (2020) Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment. Molecules 25:22, pages 5317.
Crossref
Pallab Kumar Borah & Raj Kumar Duary. 2020. Encapsulation of Active Molecules and Their Delivery System. Encapsulation of Active Molecules and Their Delivery System 233 255 .
Saquib Ahmed M. A. Peerzade, Xiaodan Qin, Fabrice J. F. Laroche, Shajesh Palantavida, Maxim Dokukin, Berney Peng, Hui Feng & Igor Sokolov. (2019) Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish . Nanoscale 11:46, pages 22316-22327.
Crossref
Giovanni Roti, Jun Qi, Samuel Kitara, Marta Sanchez-Martin, Amy Saur Conway, Anthony C. Varca, Angela Su, Lei Wu, Andrew L. Kung, Adolfo A. Ferrando, James E. Bradner & Kimberly Stegmaier. (2018) Leukemia-specific delivery of mutant NOTCH1 targeted therapy. Journal of Experimental Medicine 215:1, pages 197-216.
Crossref
Renyong Liu, Jun Zhao, Guangmei Han, Tingting Zhao, Ruilong Zhang, Bianhua Liu, Zhengjie Liu, Cheng Zhang, Linlin Yang & Zhongping Zhang. (2017) Click-Functionalized SERS Nanoprobes with Improved Labeling Efficiency and Capability for Cancer Cell Imaging. ACS Applied Materials & Interfaces 9:44, pages 38222-38229.
Crossref
Jong-Sang Park & Joon Sig Choi. 2017. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials. Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials 623 632 .
Jeff Sparks, Tooba Anwer & Khursheed Anwer. 2017. Polymers for Biomedicine. Polymers for Biomedicine 273 295 .
Can Sarisozen & Vladimir P. Torchilin. 2016. Drug Delivery. Drug Delivery 576 622 .
Chris V. Galliford & Philip S. Low. 2016. Drug Delivery. Drug Delivery 451 474 .
Ahmad Jiblaoui, Julie Barbeau, Thomas Vivès, Patrick Cormier, Virginie Glippa, Bertrand Cosson & Thierry Benvegnu. (2016) Folate-conjugated stealth archaeosomes for the targeted delivery of novel antitumoral peptides. RSC Advances 6:79, pages 75234-75241.
Crossref
Cassandra E. Callmann, Christopher V. Barback, Matthew P. Thompson, David J. Hall, Robert F. Mattrey & Nathan C. Gianneschi. (2015) Therapeutic Enzyme-Responsive Nanoparticles for Targeted Delivery and Accumulation in Tumors. Advanced Materials 27:31, pages 4611-4615.
Crossref
Silvio Quici, Alessandro Casoni, Francesca Foschi, Lidia Armelao, Gregorio Bottaro, Roberta Seraglia, Cristina Bolzati, Nicola Salvarese, Debora Carpanese & Antonio Rosato. (2015) Folic Acid-Conjugated Europium Complexes as Luminescent Probes for Selective Targeting of Cancer Cells. Journal of Medicinal Chemistry 58:4, pages 2003-2014.
Crossref
Meghna Talekar, Srinivas Ganta, Mansoor Amiji, Stephen Jamieson, Jackie Kendall, William A. Denny & Sanjay Garg. (2013) Development of PIK-75 nanosuspension formulation with enhanced delivery efficiency and cytotoxicity for targeted anti-cancer therapy. International Journal of Pharmaceutics 450:1-2, pages 278-289.
Crossref
Yingjuan Lu & Philip S. Low. (2012) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Advanced Drug Delivery Reviews 64, pages 342-352.
Crossref
George Mattheolabakis, Basil Rigas & Panayiotis P Constantinides. (2012) Nanodelivery strategies in cancer chemotherapy: biological rationale and pharmaceutical perspectives. Nanomedicine 7:10, pages 1577-1590.
Crossref
Meghna Talekar, Srinivas Ganta, Amit Singh, Mansoor Amiji, Jackie Kendall, William A. Denny & Sanjay Garg. (2012) Phosphatidylinositol 3-kinase Inhibitor (PIK75) Containing Surface Functionalized Nanoemulsion for Enhanced Drug Delivery, Cytotoxicity and Pro-apoptotic Activity in Ovarian Cancer Cells. Pharmaceutical Research 29:10, pages 2874-2886.
Crossref
Nicole Stieger, Wilna Liebenberg, Marique E. Aucamp & Melgardt M. De Villiers. 2012. Dendrimer‐Based Drug Delivery Systems. Dendrimer‐Based Drug Delivery Systems 93 137 .
Sumanta Kumar Sahu, Swatilekha Maiti, Arindam Pramanik, Sudip Kumar Ghosh & Panchanan Pramanik. (2012) Controlling the thickness of polymeric shell on magnetic nanoparticles loaded with doxorubicin for targeted delivery and MRI contrast agent. Carbohydrate Polymers 87:4, pages 2593-2604.
Crossref
Jun Yang, Erina Vlashi & Philip Low. 2012. Water Soluble Vitamins. Water Soluble Vitamins 163 179 .
Nikhil Tyagi & Prahlad C. Ghosh. (2011) Folate receptor mediated targeted delivery of ricin entrapped into sterically stabilized liposomes to human epidermoid carcinoma (KB) cells: Effect of monensin intercalated into folate-tagged liposomes. European Journal of Pharmaceutical Sciences 43:4, pages 343-353.
Crossref
Stefano Salmaso & Fabio Sonvico. 2011. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine. Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine 251 273 .
Sumanta Kumar Sahu, Swatilekha Maiti, Tapas Kumar Maiti, Sudip K. Ghosh & Panchanan Pramanik. (2011) Folate-Decorated Succinylchitosan Nanoparticles Conjugated with Doxorubicin for Targeted Drug Delivery. Macromolecular Bioscience 11:2, pages 285-295.
Crossref
Stefano Salmaso, Sara Bersani, Anna Scomparin, Francesca Mastrotto & Paolo Caliceti. (2010) Supramolecular Bioconjugates for Protein and Small Drug Delivery. Israel Journal of Chemistry 50:2, pages 160-174.
Crossref
Yuehua Zhang, Thommey P. Thomas, Ankur Desai, Hong Zong, Pascale R. Leroueil, Istvan J. Majoros & James R. BakerJr.Jr.. (2010) Targeted Dendrimeric Anticancer Prodrug: A Methotrexate-Folic Acid-Poly(amidoamine) Conjugate and a Novel, Rapid, “One Pot” Synthetic Approach. Bioconjugate Chemistry 21:3, pages 489-495.
Crossref
Abhinav Agarwal, Abhay Asthana, Umesh Gupta & Narendra K Jain. (2008) Tumour and dendrimers: a review on drug delivery aspects. Journal of Pharmacy and Pharmacology 60:6, pages 671-688.
Crossref
Jing Zhou, Liming Yao, Chunyan Li & Fuyou Li. (2010) A versatile fabrication of upconversion nanophosphors with functional-surface tunable ligands. Journal of Materials Chemistry 20:37, pages 8078.
Crossref
Erina Vlashi, Jennifer E. Sturgis, Mini Thomas & Philip S. Low. (2009) Real Time, Noninvasive Imaging and Quantitation of the Accumulation of Ligand-Targeted Drugs into Receptor-Expressing Solid Tumors. Molecular Pharmaceutics 6:6, pages 1868-1875.
Crossref
He Hu, Liqin Xiong, Jing Zhou, Fuyou Li, Tianye Cao & Chunhui Huang. (2009) Multimodal-Luminescence Core-Shell Nanocomposites for Targeted Imaging of Tumor Cells. Chemistry - A European Journal 15:14, pages 3577-3584.
Crossref
Rakesh Kumar Tekade, Palanirajan Vijayaraj Kumar & Narendra Kumar Jain. (2008) Dendrimers in Oncology: An Expanding Horizon. Chemical Reviews 109:1, pages 49-87.
Crossref
Cristina M?ller, P. August Schubiger & Roger Schibli. (2007) Isostructural folate conjugates radiolabeled with the matched pair 99mTc/188Re: a potential strategy for diagnosis and therapy of folate receptor-positive tumors. Nuclear Medicine and Biology 34:6, pages 595-601.
Crossref
Seungpyo Hong, Pascale R. Leroueil, Istv?n J. Majoros, Bradford G. Orr, James R. BakerJr.Jr. & Mark M. Banaszak Holl. (2007) The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform. Chemistry & Biology 14:1, pages 107-115.
Crossref
Xiaobin Zhao, Natarajan Muthusamy, Robert Lee & John Byrd. 2006. Nanotechnology for Cancer Therapy. Nanotechnology for Cancer Therapy 663 675 .
Yingjuan Lu, Jun Yang & Emanuela Sega. (2006) Issues related to targeted delivery of proteins and peptides. The AAPS Journal 8:3, pages E466-E478.
Crossref
Walter A. Henne, Derek D. Doorneweerd, Joonhyung Lee, Philip S. Low & Cagri Savran. (2006) Detection of Folate Binding Protein with Enhanced Sensitivity Using a Functionalized Quartz Crystal Microbalance Sensor. Analytical Chemistry 78:14, pages 4880-4884.
Crossref
Cristina Müller, P. August Schubiger & Roger Schibli. (2006) Synthesis and in Vitro/in Vivo Evaluation of Novel 99m Tc(CO) 3 -Folates . Bioconjugate Chemistry 17:3, pages 797-806.
Crossref
Gennara Cavallaro, Licciardi Mariano, Stefano Salmaso, Paolo Caliceti & Giammona Gaetano. (2006) Folate-mediated targeting of polymeric conjugates of gemcitabine. International Journal of Pharmaceutics 307:2, pages 258-269.
Crossref
Andrew R. Hilgenbrink & Philip S. Low. (2005) Folate Receptor-Mediated Drug Targeting: From Therapeutics to Diagnostics. Journal of Pharmaceutical Sciences 94:10, pages 2135-2146.
Crossref
Dhruba J. Bharali, Derrick W. Lucey, Harishankar Jayakumar, Haridas E. Pudavar & Paras N. Prasad. (2005) Folate-Receptor-Mediated Delivery of InP Quantum Dots for Bioimaging Using Confocal and Two-Photon Microscopy. Journal of the American Chemical Society 127:32, pages 11364-11371.
Crossref
Gloria J. Kim & Shuming Nie. (2005) Targeted cancer nanotherapy. Materials Today 8:8, pages 28-33.
Crossref
Jolanta F. Kukowska-Latallo, Kimberly A. Candido, Zhengyi Cao, Shraddha S. Nigavekar, Istvan J. Majoros, Thommey P. Thomas, Lajos P. Balogh, Mohamed K. Khan & James R. BakerJr.Jr.. (2005) Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer. Cancer Research 65:12, pages 5317-5324.
Crossref
Chun-Yen Ke, Carla J. Mathias & Mark A. Green. (2005) Targeting the Tumor-Associated Folate Receptor with an 111 In−DTPA Conjugate of Pteroic Acid . Journal of the American Chemical Society 127:20, pages 7421-7426.
Crossref
Stefano Salmaso, Alessandra Semenzato, Paolo Caliceti, Johan Hoebeke, Fabio Sonvico, Catherine Dubernet & Patrick Couvreur. (2004) Specific Antitumor Targetable β-Cyclodextrin−Poly(ethylene Glycol)−Folic Acid Drug Delivery Bioconjugate. Bioconjugate Chemistry 15:5, pages 997-1004.
Crossref
Chun-Yen Ke, Carla J. Mathias & Mark A. Green. (2003) The folate receptor as a molecular target for tumor-selective radionuclide delivery. Nuclear Medicine and Biology 30:8, pages 811-817.
Crossref
Carla J. Mathias, Michael R. Lewis, David E. Reichert, Richard Laforest, Terry L. Sharp, Jason S. Lewis, Zhen-Fan Yang, David J. Waters, Paul W. Snyder, Philip S. Low, Michael J. Welch & Mark A. Green. (2003) Preparation of 66Ga- and 68Ga-labeled Ga(III)-deferoxamine-folate as potential folate-receptor-targeted PET radiopharmaceuticals. Nuclear Medicine and Biology 30:7, pages 725-731.
Crossref
Paolo Caliceti, Stefano Salmaso, Alessandra Semenzato, Tommaso Carofiglio, Roberto Fornasier, Maurizio Fermeglia, Marco Ferrone & Sabrina Pricl. (2003) Synthesis and Physicochemical Characterization of Folate−Cyclodextrin Bioconjugate for Active Drug Delivery. Bioconjugate Chemistry 14:5, pages 899-908.
Crossref
Christopher P. Leamon, Scott R. Cooper & Gregory E. Hardee. (2003) Folate-Liposome-Mediated Antisense Oligodeoxynucleotide Targeting to Cancer Cells:  Evaluation in Vitro and in Vivo. Bioconjugate Chemistry 14:4, pages 738-747.
Crossref
Christopher P. Leamon, Matthew A. Parker, Iontcho R. Vlahov, Le-Cun Xu, Joseph A. Reddy, Marilynn Vetzel & Nikki Douglas. (2002) Synthesis and Biological Evaluation of EC20:  A New Folate-Derived, 99m Tc-Based Radiopharmaceutical . Bioconjugate Chemistry 13:6, pages 1200-1210.
Crossref
Yingjuan Lu & Philip S Low. (2002) Folate-mediated delivery of macromolecular anticancer therapeutic agents. Advanced Drug Delivery Reviews 54:5, pages 675-693.
Crossref
Hans E.J. Hofland, Christophe Masson, Shaff Iginla, Irina Osetinsky, Joseph A. Reddy, Christopher P. Leamon, Daniel Scherman, Michel Bessodes & Pierre Wils. (2002) Folate-Targeted Gene Transfer in Vivo. Molecular Therapy 5:6, pages 739-744.
Crossref
Muthiah Manoharan. (2002) Oligonucleotide Conjugates as Potential Antisense Drugs with Improved Uptake, Biodistribution, Targeted Delivery, and Mechanism of Action. Antisense and Nucleic Acid Drug Development 12:2, pages 103-128.
Crossref
Gali Steinberg & Richard F. Borch. (2000) Synthesis and Evaluation of Pteroic Acid-Conjugated Nitroheterocyclic Phosphoramidates as Folate Receptor-Targeted Alkylating Agents. Journal of Medicinal Chemistry 44:1, pages 69-73.
Crossref
Christopher P. Leamon & Philip S. Low. (2001) Folate-mediated targeting: from diagnostics to drug and gene delivery. Drug Discovery Today 6:1, pages 44-51.
Crossref
Jennifer Sudimack & Robert J Lee. (2000) Targeted drug delivery via the folate receptor. Advanced Drug Delivery Reviews 41:2, pages 147-162.
Crossref
Christopher P. Leamon, Debra Weigl & R. Wayne Hendren. (1999) Folate Copolymer-Mediated Transfection of Cultured Cells. Bioconjugate Chemistry 10:6, pages 947-957.
Crossref
Karen M. Maziarz, Hugo L. Monaco, Feng Shen & Manohar Ratnam. (1999) Complete Mapping of Divergent Amino Acids Responsible for Differential Ligand Binding of Folate Receptors α and β. Journal of Biological Chemistry 274:16, pages 11086-11091.
Crossref
John F. Ross, Hui Wang, Frederick G. Behm, Prasad Mathew, Marietta Wu, Robert Booth & Manohar Ratnam. (1999) Folate receptor type ? is a neutrophilic lineage marker and is differentially expressed in myeloid leukemia. Cancer 85:2, pages 348-357.
Crossref
G. Jansen. 1999. Antifolate Drugs in Cancer Therapy. Antifolate Drugs in Cancer Therapy 293 321 .
D.M Kranz, T.C Manning, L.A Rund, B.K Cho, M.M Gruber & E.J Roy. (1998) Targeting tumor cells with bispecific antibodies and T cells. Journal of Controlled Release 53:1-3, pages 77-84.
Crossref
Susan Wang & Philip S. Low. (1998) Folate-mediated targeting of antineoplastic drugs, imaging agents, and nucleic acids to cancer cells. Journal of Controlled Release 53:1-3, pages 39-48.
Crossref
Jin Luo, Michael D. Smith, Douglas A. Lantrip, Susan Wang & P. L. Fuchs. (1997) Efficient Syntheses of Pyrofolic Acid and Pteroyl Azide, Reagents for the Production of Carboxyl-Differentiated Derivatives of Folic Acid. Journal of the American Chemical Society 119:42, pages 10004-10013.
Crossref
Feng Shen, Xuan Zheng, Jianyong Wang & Manohar Ratnam. (1997) Identification of Amino Acid Residues that Determine the Differential Ligand Specificities of Folate Receptors α and β. Biochemistry 36:20, pages 6157-6163.
Crossref
Bryan K. Cho, Edward J. Roy, Todd A. Patrick & David M. Kranz. (1997) Single-Chain Fv/Folate Conjugates Mediate Efficient Lysis of Folate-Receptor-Positive Tumor Cells. Bioconjugate Chemistry 8:3, pages 338-346.
Crossref
Lily ChuH. Steven WileyDouglas A. Lauffenburger. (1996) Endocytic Relay as a Potential Means for Enhancing Ligand Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery. Tissue Engineering 2:1, pages 17-38.
Crossref
Sandrine Cammas & Kazunori Kataoka. 1996. Solvents and Self-Organization of Polymers. Solvents and Self-Organization of Polymers 83 113 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.