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Journal of Drug Targeting Volume 2, 1994 - Issue 2
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Research Article

Biopharmaceutical Evaluation of Salicylazosulfanilic Acid as a Novel Colon-Targeted Prodrug of 5-Aminosalicylic Acid

Takehiro YamaguchiDepartment of Pharmaceutics Faculty of Pharmaceutical Sciences, Okayama University
,
Kenji SasakiDepartment of Pharmaceutical Chemistry Faculty of Pharmaceutical Sciences, Okayama University
,
Yuji KurosakiDepartment of Pharmaceutics Faculty of Pharmaceutical Sciences, Okayama University
,
Taiji NakayamaDepartment of Pharmaceutics Faculty of Pharmaceutical Sciences, Okayama University
&
Toshikiro KimuraDepartment of Pharmaceutics Faculty of Pharmaceutical Sciences, Okayama University
Pages 123-131 | Received 24 Jun 1993, Accepted 20 Oct 1993, Published online: 20 Oct 2008

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Hee Ji Lee, Hu Zhang, David A. Orlovich & J. Paul Fawcett. (2012) The influence of probiotic treatment on sulfasalazine metabolism in rat. Xenobiotica 42:8, pages 791-797.
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Yunjin Jung & Young Mi Kim. (2010) What should be considered on design of a colon-specific prodrug?. Expert Opinion on Drug Delivery 7:2, pages 245-258.
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Ken-Ichi Matsuda, Tomohiro Takaya, Fukiko Shimoji, Motoki Muraoka, Yukako Yoshikawa & Kanji Takada. (1996) Effect of food intake on the delivery of fluorescein as a model drug in colon delivery capsule after oral administration to beagle dogs. Journal of Drug Targeting 4:2, pages 59-67.
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G. Gitnick. (1996) Inflammatory Bowel Disease: a New Assessment. Scandinavian Journal of Gastroenterology 31:sup220, pages 83-86.
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Articles from other publishers (13)

Jingwei Cai, Alexis Auster, Sungjoon Cho & Zijuan Lai. (2023) Dissecting the human gut microbiome to better decipher drug liability: A once-forgotten organ takes center stage. Journal of Advanced Research.
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Marina V. Ol’khovich, Angelica V. Sharapova, Svetlana V. Blokhina & German L. Perlovich. (2016) Sulfasalazine: Dissolution and Distribution in Pharmaceutically Relevant Mediums. Journal of Chemical & Engineering Data 62:1, pages 123-128.
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Wooseong Kim, Joon Nam, Sunyoung Lee, Seongkeun Jeong & Yunjin Jung. (2016) 5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB. Molecular Pharmaceutics 13:6, pages 2126-2135.
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A. Hussain, S.H. Khalid, M.I. Qadir, A. Massud, M. Ali, I.U. Khan, M. Saleem, M.S. Iqbal, S. Asghar & H. Gul. (2011) Water uptake and drug release behaviour of methyl methacrylateco-itaconic acid [P(MMA/IA)] hydrogels cross-linked with methylene bis-acrylamide. Journal of Drug Delivery Science and Technology 21:3, pages 249-255.
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Yoshitsugu Fujioka, Yukiko Metsugi, Ken-ichi Ogawara, Kazutaka Higaki & Toshikiro Kimura. (2008) Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug. International Journal of Pharmaceutics 352:1-2, pages 36-43.
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Biljana Nigović, Šebojka Komorsky‐Lovrić & Branimir Šimunić. (2005) Electroanalytical Studies of Biologically Active Azosalicylic Acid at a Hanging Mercury Drop Electrode. Electroanalysis 17:10, pages 839-845.
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Zoran Mandi?Biljana Nigovi?Branimir ?imuni?. (2004) The mechanism and kinetics of the electrochemical cleavage of azo bond of 2-hydroxy-5-sulfophenyl-azo-benzoic acids. Electrochimica Acta 49:4, pages 607-615.
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Jun-ichi Yokoe, Norio Iwasaki, Shunji Haruta, Keitaro Kadono, Ken-ichi Ogawara, Kazutaka Higaki & Toshikiro Kimura. (2003) Analysis and prediction of absorption behavior of colon-targeted prodrug in rats by GI-transit-absorption model. Journal of Controlled Release 86:2-3, pages 305-313.
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Biljana Nigovi?Zoran Mandi?Branimir ?imuni?Ines Fistri?. (2001) Voltammetric studies of 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid as a novel prodrug of 5-aminosalicylic acid. Journal of Pharmaceutical and Biomedical Analysis 26:5-6, pages 987-994.
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Yun Jin Jung, Jeoung Soo Lee & Young Mi Kim. (2001) Colon-Specific Prodrugs of 5-Aminosalicylic Acid: Synthesis and In Vitro/In Vivo Properties of Acidic Amino Acid Derivatives of 5-Aminosalicylic Acid. Journal of Pharmaceutical Sciences 90:11, pages 1767-1775.
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Yun Jin Jung, Jeoung Soo Lee & Young Mi Kim. (2000) Synthesis and In Vitro/In Vivo Evaluation of 5‐Aminosalicyl‐Glycine as a Colon‐Specific Prodrug of 5‐Aminosalicylic Acid. Journal of Pharmaceutical Sciences 89:5, pages 594-602.
Crossref
Yun Jin Jung, Jeoung Soo Lee, Hak Hyun Kim, Yun Taek Kim & Young Mi Kim. (1998) Synthesis and properties of dextran-5-aminosalicylic acid ester as a potential colon-specific prodrug of 5-aminosalicylic acid. Archives of Pharmacal Research 21:2, pages 179-186.
Crossref
Claudia S. Leopold. (2006) Prodrugs für das Dickdarm‐Targeting. Pharmazie in unserer Zeit 26:6, pages 289-298.
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