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Research Article

Microsphere Absorption by the Nasal Mucosa of the Rat

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Pages 147-149 | Received 11 Nov 1993, Accepted 04 Dec 1994, Published online: 20 Oct 2008

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Sreenivas Pandit, Erdal Cevher, Mohammed Gulrez Zariwala, Satyanarayana Somavarapu & H. Oya Alpar. (2007) Enhancement of immune response of HBsAg loaded poly (L-lactic acid) microspheres against Hepatitis B through incorporation of alum and chitosan. Journal of Microencapsulation 24:6, pages 539-552.
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Karin Östh, Lena Strindelius, Agneta Larhed, Anders Ahlander, Godfried M. Roomans, Ingvar Sjöholm & Erik Björk. (2003) Uptake of Ovalbumin-conjugated Starch Microparticles by Pig Respiratory Nasal Mucosa In Vitro. Journal of Drug Targeting 11:1, pages 75-82.
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J. Brooking, S. S. Davis & L. Illum. (2001) Transport of Nanoparticles Across the Rat Nasal Mucosa. Journal of Drug Targeting 9:4, pages 267-279.
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A. J. Almeida & H. O. Alpar. (1996) Nasal Delivery of Vaccines. Journal of Drug Targeting 3:6, pages 455-467.
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Kamonthip Rungrojcharoenkit, Panya Sunintaboon, Damon Ellison, Louis Macareo, Panuwat Midoeng, Preamrudee Chaisuwirat, Stefan Fernandez & Sukathida Ubol. (2020) Development of an adjuvanted nanoparticle vaccine against influenza virus, an in vitro study. PLOS ONE 15:8, pages e0237218.
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Genada Sinani, Melike Sessevmez, M. Koray Gök, Saadet Özgümüş, Alper Okyar, H. Oya Alpar & Erdal Cevher. (2017) Nasal vaccination with poly(β-amino ester)-poly( d , l -lactide- co -glycolide) hybrid nanoparticles. International Journal of Pharmaceutics 529:1-2, pages 1-14.
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Aihua Yu, Haigang Wang, Jiali Wang, Fengliang Cao, Yan Gao, Jing Cui & Guangxi Zhai. (2011) Formulation Optimization and Bioavailability After Oral and Nasal Administration in Rabbits of Puerarin-Loaded Microemulsion. Journal of Pharmaceutical Sciences 100:3, pages 933-941.
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J E Eyles, I D Spiers, E D Williamson & H O Alpar. (2001) Tissue distribution of radioactivity following intranasal administration of radioactive microspheres. Journal of Pharmacy and Pharmacology 53:5, pages 601-607.
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Hiromitsu Yamamoto, Wataru Hoshina, Homare Kurashima, Hirofumi Takeuchi, Yoshiaki Kawashima, Toyokazu Yokoyama & Hiroyuki Tsujimoto. (2007) Engineering of poly(DL-lactic-co-glycolic acid) nanocomposite particles for dry powder inhalation dosage forms of insulin with the spray-fluidized bed granulating system. Advanced Powder Technology 18:2, pages 215-228.
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Maryam Amidi, Stefan G. Romeijn, J. Coos Verhoef, Hans E. Junginger, Laura Bungener, Anke Huckriede, Daan J.A. Crommelin & Wim Jiskoot. (2007) N-Trimethyl chitosan (TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: Biological properties and immunogenicity in a mouse model. Vaccine 25:1, pages 144-153.
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Yoshinori Fujimura, Takeshi Akisada, Tamotsu Harada & Ken Haruma. (2006) Uptake of microparticles into the epithelium of human nasopharyngeal lymphoid tissue. Medical Molecular Morphology 39:4, pages 181-186.
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Michael Vajdy. (2006) Current Efforts on Generation of Optimal Immune Responses against HIV through Mucosal Immunisations. Drugs in R & D 7:5, pages 267-288.
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Michael Vajdy, Indresh Srivastava, John Polo, John Donnelly, Derek O'Hagan & Manmohan Singh. (2004) Mucosal adjuvants and delivery systems for protein‐, DNA‐ and RNA‐based vaccines. Immunology & Cell Biology 82:6, pages 617-627.
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Mark A. Jepson, M.Ann Clark & Barry H. Hirst. (2004) M cell targeting by lectins: a strategy for mucosal vaccination and drug delivery. Advanced Drug Delivery Reviews 56:4, pages 511-525.
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Martin J Shephard, Daniel Todd, Brian M Adair, Alan Li Wan Po, Dermot P Mackie & Eileen M Scott. (2003) Immunogenicity of bovine parainfluenza type 3 virus proteins encapsulated in nanoparticle vaccines, following intranasal administration to mice. Research in Veterinary Science 74:2, pages 187-190.
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I Gutierro, R.M Hernández, M Igartua, A.R Gascón & J.L Pedraz. (2002) Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres. Vaccine 21:1-2, pages 67-77.
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M Christiane Schmidt, Annette Koch & Hans Merkle. 2002. Cell Culture Models of Biological Barriers. Cell Culture Models of Biological Barriers 228 252 .
J.E. Eyles, V.W. Bramwell, E.D. Williamson & H.O. Alpar. (2001) Microsphere translocation and immunopotentiation in systemic tissues following intranasal administration. Vaccine 19:32, pages 4732-4742.
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Michael Vajdy & Derek T. O?Hagan. (2001) Microparticles for intranasal immunization. Advanced Drug Delivery Reviews 51:1-3, pages 127-141.
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Jim E. Eyles, E. Diane Williamson & H. Oya Alpar. (2000) Intranasal Administration of Influenza Vaccines. BioDrugs 13:1, pages 35-59.
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J.E Eyles, E.D Williamson, I.D Spiers, A.J Stagg, S.M Jones & H.O Alpar. (2000) Generation of protective immune responses to plague by mucosal administration of microsphere coencapsulated recombinant subunits. Journal of Controlled Release 63:1-2, pages 191-200.
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Jim E Eyles, E.Diane Williamson & H.Oya Alpar. (1999) Immunological responses to nasal delivery of free and encapsulated tetanus toxoid: studies on the effect of vehicle volume. International Journal of Pharmaceutics 189:1, pages 75-79.
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Jim E. Eyles, Ian D. Spiers, E. Diane Williamson & H. Oya Alpar. (1998) Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal and intra-muscular administration of microsphere co-encapsulated Yersinia pestis sub-unit vaccines. Vaccine 16:20, pages 2000-2009.
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Jim E. Eyles, Gregory J.E. Sharp, E. Diane Williamson, Ian D. Spiers & H. Oya Alpar. (1998) Intra nasal administration of poly-lactic acid microsphere co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse. Vaccine 16:7, pages 698-707.
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Maureen D Donovan & Ye Huang. (1998) Large molecule and particulate uptake in the nasal cavity: the effect of size on nasal absorption. Advanced Drug Delivery Reviews 29:1-2, pages 147-155.
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