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Journal of Drug Targeting Volume 2, 1994 - Issue 2
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Research Article

Epithelial cell permeability of a series of peptidic HIV protease inhibitors: Aminoterminal substituent effects

Robert ConradiDrug Delivery Systems Research, Upjohn Laboratories The Upjohn Company
,
Allen HilgersDrug Delivery Systems Research, Upjohn Laboratories The Upjohn Company
,
Philip BurtonDrug Delivery Systems Research, Upjohn Laboratories The Upjohn Company
&
Jackson HesterMedicinal Chemistry Research, Upjohn Laboratories The Upjohn Company
Pages 167-171 | Received 03 Nov 1993, Accepted 27 Dec 1993, Published online: 20 Oct 2008

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Cindy Q. Xia, Johnny J. Yang, Shijun Ren & Eric J. Lien. (1998) QSAR Analysis of Polyamine Transport Inhibitors in L1210 Cells. Journal of Drug Targeting 6:1, pages 65-77.
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Articles from other publishers (17)

Stephen M. Carl, Dea Herrera‐Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, Stephanie Mowery & Gregory T. Knipp. 2022. Drug Transporters. Drug Transporters 115 142 .
Christof Hannesschlaeger, Andreas Horner & Peter Pohl. (2019) Intrinsic Membrane Permeability to Small Molecules. Chemical Reviews 119:9, pages 5922-5953.
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Hitesh V. Motwani, Maria De Rosa, Luke R. Odell, Anders Hallberg & Mats Larhed. (2015) Aspartic protease inhibitors containing tertiary alcohol transition-state mimics. European Journal of Medicinal Chemistry 90, pages 462-490.
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Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson & Gregory T. Knipp. 2014. Drug Transporters. Drug Transporters 67 90 .
Lucia Lazorova, Ina Hubatsch, Jenny K. Ekegren, Johan Gising, Daisuke Nakai, Noha M. Zaki, Christel A.S. Bergström, Ulf Norinder, Mats Larhed & Per Artursson. (2011) Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors. Journal of Pharmaceutical Sciences 100:9, pages 3763-3772.
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Alessandra Pagliara, Marianne Reist, Sandrine Geinoz, Pierre-Alain Carrupt & Bernard Testa. (1999) Evaluation and Prediction of Drug Permeation. Journal of Pharmacy and Pharmacology 51:12, pages 1339-1357.
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Stefan Balaz. (2009) Modeling Kinetics of Subcellular Disposition of Chemicals. Chemical Reviews 109:5, pages 1793-1899.
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Anna‐Lena Ungell & Per Artursson. 2008. Drug Bioavailability. Drug Bioavailability 133 159 .
Niclas C. Tan, Peng Yu, Yong-Uk Kwon & Thomas Kodadek. (2008) High-throughput evaluation of relative cell permeability between peptoids and peptides. Bioorganic & Medicinal Chemistry 16:11, pages 5853-5861.
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Jenny K. Ekegren, Nina Ginman, Åsa Johansson, Hans Wallberg, Mats Larhed, Bertil Samuelsson, Torsten Unge & Anders Hallberg. (2006) Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold. Journal of Medicinal Chemistry 49:5, pages 1828-1832.
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Thomas J. Raub. (2005) P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design. Molecular Pharmaceutics 3:1, pages 3-25.
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Giovanni M. Pauletti. 1999. Advances in Amino Acid Mimetics and Peptidomimetics Volume 2. Advances in Amino Acid Mimetics and Peptidomimetics Volume 2 89 123 .
Gert Fricker & Jürgen Drewe. (1998) Current Concepts in Intestinal Peptide Absorption. Journal of Peptide Science 2:4, pages 195-211.
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Moo J. Cho & Rudy Juliano. (1996) Macromolecular versus smallmolecule therapeutics: drug discovery, development and clinical considerations. Trends in Biotechnology 14:5, pages 153-158.
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R. A. Conradi, P. S. Burton & R. T. Borchardt. 1996. Lipophilicity in Drug Action and Toxicology. Lipophilicity in Drug Action and Toxicology 233 252 .
Han van De Waterbeemd, Gian Camenisch, Gerd Folkers & Oleg A. Raevsky. (2006) Estimation of Caco‐2 Cell Permeability using Calculated Molecular Descriptors. Quantitative Structure-Activity Relationships 15:6, pages 480-490.
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Dale J. Kempf. (1995) Progress in the discovery of orally bioavailable inhibitors of HIV protease. Perspectives in Drug Discovery and Design 2:3, pages 427-436.
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