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Research Article

Evaluation of dextran-flufenamic acid ester as a polymeric colon-specific prodrug of flufenamic acid, an anti-inflammatory drug, for chronotherapy

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Pages 336-343 | Received 01 Feb 2010, Accepted 31 May 2010, Published online: 08 Jul 2010

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Zhuo-Yue Li, Yi-Fan Yin, Yang Guo, Hui Li, Mei-Qi Xu, Man Liu, Jing-Ru Wang, Zhen-Han Feng, Xiao-Chuan Duan, Shuang Zhang, Shuai-Qiang Zhang, Guang-Xue Wang, Ai Liao, Shu-Min Wang & Xuan Zhang. (2020) Enhancing Anti-Tumor Activity of Sorafenib Mesoporous Silica Nanomatrix in Metastatic Breast Tumor and Hepatocellular Carcinoma via the Co-Administration with Flufenamic Acid. International Journal of Nanomedicine 15, pages 1809-1821.
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Wooseong Kim, Yejin Yang, Dohoon Kim, Seongkeun Jeong, Jin-Wook Yoo, Jeong-Hyun Yoon & Yunjin Jung. (2017) Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes. Drug Design, Development and Therapy 11, pages 419-429.
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M. A. Hussain, K. Abbas, I. Jantan & S. N. A. Bukhari. (2017) Polysaccharide-based materials in macromolecular prodrug design and development. International Materials Reviews 62:2, pages 78-98.
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Joon Nam, Wooseong Kim, Sunyoung Lee, Seongkeun Jeong, Jin-Wook Yoo, Min-Soo Kim & Yunjin Jung. (2016) Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis. Journal of Drug Targeting 24:5, pages 468-474.
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Mayur M Patel. (2015) Colon: a gateway for chronotherapeutic drug delivery systems. Expert Opinion on Drug Delivery 12:9, pages 1389-1395.
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Jaleh Varshosaz. (2012) Dextran conjugates in drug delivery. Expert Opinion on Drug Delivery 9:5, pages 509-523.
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Articles from other publishers (9)

Bhavana B. Bhat, Chetan H. Mehta, Akhil Suresh, Varalakshmi Velagacherla & Usha Y. Nayak. (2023) Controlled Release Technologies for Chronotherapy: Current Status and Future Perspectives. Current Pharmaceutical Design 29:14, pages 1069-1091.
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Satheesh Vilas & Sivasudha Thilagar. (2021) Formulation and optimisation of lamivudine‐loaded Eudragit ® S 100 polymer‐coated pectin microspheres for colon‐specific delivery . IET Nanobiotechnology 15:1, pages 90-99.
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Mehwish Abid, Muhammad Naveed, Iqra Azeem, Amir Faisal, Muhammad Faizan Nazar & Basit Yameen. (2020) Colon specific enzyme responsive oligoester crosslinked dextran nanoparticles for controlled release of 5-fluorouracil. International Journal of Pharmaceutics 586, pages 119605.
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Robert C. Waters & Günther Hochhaus. (2019) Characterization of a dextran-budesonide prodrug for inhalation therapy. European Journal of Pharmaceutical Sciences 129, pages 58-67.
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Chityal Ganesh Kumar, Yedla Poornachandra & Sujitha Pombala. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 1 61 .
Y. Yang, Y. Zhao, A. Yu, D. Sun & L.X. Yu. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 331 354 .
Jaya Preethi Peesa, Prasanna Raju Yalavarthi, Arun Rasheed & Venkata Basaveswara Rao Mandava. (2016) A perspective review on role of novel NSAID prodrugs in the management of acute inflammation. Journal of Acute Disease 5:5, pages 364-381.
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Jie Zhou, Yuan Lu Cui & Yun Qi. (2014) A Preliminary Study of Crosslinked Alginate-Chitosan Microspheres for Delivery System. Advanced Materials Research 887-888, pages 520-523.
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Raj Kumar Shukla & Akanksha Tiwari. (2012) Carbohydrate polymers: Applications and recent advances in delivering drugs to the colon. Carbohydrate Polymers 88:2, pages 399-416.
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