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Research Article

The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides

Pages 675-680 | Received 12 May 2010, Accepted 11 Oct 2010, Published online: 09 Dec 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Randall Kenien, Wei-Chiang Shen & Jennica L. Zaro. (2012) Vesicle-to-cytosol transport of disulfide-linked cargo mediated by an amphipathic cell-penetrating peptide. Journal of Drug Targeting 20:9, pages 793-800.
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Randall Kenien, Jennica L. Zaro & Wei-Chiang Shen. (2012) MAP-mediated nuclear delivery of a cargo protein. Journal of Drug Targeting 20:4, pages 329-337.
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Articles from other publishers (21)

Kendra Ramirez-Acosta, Ivan A Rosales-Fuerte, J Eduardo Perez-Sanchez, Alfredo Nuñez-Rivera, Josue Juarez & Ruben D Cadena-Nava. (2022) Design and selection of peptides to block the SARS-CoV-2 receptor binding domain by molecular docking. Beilstein Journal of Nanotechnology 13, pages 699-711.
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Hannah C. Hymel, Alireza Rahnama, Olivia M. Sanchez, Dong Liu, Ted J. Gauthier & Adam T. Melvin. (2022) How Cargo Identity Alters the Uptake of Cell-Penetrating Peptide (CPP)/Cargo Complexes: A Study on the Effect of Net Cargo Charge and Length. Cells 11:7, pages 1195.
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Xianzhou Huang, Chunqing Ou, Yaqian Shu, Yan Wang, Songlin Gong, Rui Luo, Shouchun Chen, Qinjie Wu & Changyang Gong. (2021) A self-sustained nanoplatform reverses TRAIL-resistance of pancreatic cancer through coactivating of exogenous and endogenous apoptotic pathway. Biomaterials 272, pages 120795.
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Ammar Yasir Abdulrahman, Ahmad S. Khazali, Teow Chong Teoh, Hussin A. Rothan & Rohana Yusof. (2019) Novel Peptides Inhibit Zika NS2B-NS3 Serine Protease and Virus Replication in Human Hepatic Cell Line. International Journal of Peptide Research and Therapeutics 25:4, pages 1659-1668.
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Sam van Dun, Jurgen Schill, Lech-Gustav Milroy & Luc Brunsveld. (2018) Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers. Chemistry - A European Journal 24:61, pages 16445-16451.
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Marcel Grogg, Donald Hilvert, Marc-Olivier Ebert, Albert K. Beck, Dieter Seebach, Felix Kurth, Petra S. Dittrich, Christof Sparr, Sergio Wittlin, Matthias Rottmann & Pascal Mäser. (2018) Cell Penetration, Herbicidal Activity, and in-vivo -Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin . Helvetica Chimica Acta 101:10, pages e1800112.
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S.A. Bode & D.W.P.M. Löwik. (2017) Constrained cell penetrating peptides. Drug Discovery Today: Technologies 26, pages 33-42.
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Long Chen, Qiang Zhang, Xiushuang Yuan, Yimeng Cao, Yanyan Yuan, Huiwei Yin, Xiufang Ding, Zhentai Zhu & Shi-Zhong Luo. (2017) How charge distribution influences the function of membrane-active peptides: Lytic or cell-penetrating?. The International Journal of Biochemistry & Cell Biology 83, pages 71-75.
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Hui Jing, Wen Cheng, Shouqiang Li, Bolin Wu, Xiaoping Leng, Shouping Xu & Jiawei Tian. (2016) Novel cell-penetrating peptide-loaded nanobubbles synergized with ultrasound irradiation enhance EGFR siRNA delivery for triple negative Breast cancer therapy. Colloids and Surfaces B: Biointerfaces 146, pages 387-395.
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Jennica L. Zaro & Wei-Chiang Shen. (2015) Cationic and amphipathic cell-penetrating peptides (CPPs): Their structures and in vivo studies in drug delivery. Frontiers of Chemical Science and Engineering 9:4, pages 407-427.
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Vivek K Sharma & Jonathan K Watts. (2015) Oligonucleotide therapeutics: chemistry, delivery and clinical progress. Future Medicinal Chemistry 7:16, pages 2221-2242.
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Charlotte D’Souza, Sónia Troeira Henriques, Conan K. Wang & David J. Craik. (2014) Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry 88, pages 10-18.
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Chunmeng Sun, Wei-Chiang Shen, Jiasheng Tu & Jennica L. Zaro. (2014) Interaction between Cell-Penetrating Peptides and Acid-Sensitive Anionic Oligopeptides as a Model for the Design of Targeted Drug Carriers. Molecular Pharmaceutics 11:5, pages 1583-1590.
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Ammar Ouahab, Nihad Cheraga, Vitus Onoja, Yan Shen & Jiasheng Tu. (2014) Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: In vitro study. International Journal of Pharmaceutics 466:1-2, pages 233-245.
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Likun Fei, Li-Peng Yap, Peter S. Conti, Wei-Chiang Shen & Jennica L. Zaro. (2014) Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide. Biomaterials 35:13, pages 4082-4087.
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Soo Hyeon Lee, Bastien Castagner & Jean-Christophe Leroux. (2013) Is there a future for cell-penetrating peptides in oligonucleotide delivery?. European Journal of Pharmaceutics and Biopharmaceutics 85:1, pages 5-11.
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Shixian Huang, Kun Shao, Yuyang Kuang, Yang Liu, Jianfeng Li, Sai An, Yubo Guo, Haojun Ma, Xi He & Chen Jiang. (2013) Tumor targeting and microenvironment-responsive nanoparticles for gene delivery. Biomaterials 34:21, pages 5294-5302.
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Yi Hu, Chunxia Qiao, Ming Lv, Jiannan Feng, Ming Yu, Beifen Shen, Qiuping Zhang & Yan Li. (2012) Arg9 facilitates the translocation and downstream signal inhibition of an anti-HER2 single chain antibody. BMC Research Notes 5:1.
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Ruth DuncanSimon C. W. Richardson. (2012) Endocytosis and Intracellular Trafficking as Gateways for Nanomedicine Delivery: Opportunities and Challenges. Molecular Pharmaceutics 9:9, pages 2380-2402.
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Jennica L. Zaro, Likun Fei & Wei-Chiang Shen. (2012) Recombinant peptide constructs for targeted cell penetrating peptide-mediated delivery. Journal of Controlled Release 158:3, pages 357-361.
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Robert H. Mo, Jennica L. Zaro & Wei-Chiang Shen. (2011) Comparison of Cationic and Amphipathic Cell Penetrating Peptides for siRNA Delivery and Efficacy. Molecular Pharmaceutics 9:2, pages 299-309.
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