467
Views
71
CrossRef citations to date
0
Altmetric
Research Article

Microbubble-mediated ultrasonic techniques for improved chemotherapeutic delivery in cancer

, , &
Pages 43-54 | Received 10 Jun 2011, Accepted 07 Sep 2011, Published online: 10 Oct 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Tingting Luo, Luhua Bai, Yi Zhang, Leidan Huang, Hui Li, Shunji Gao, Xiaoxiao Dong, Ningshan Li & Zheng Liu. (2022) Optimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors. Drug Delivery 29:1, pages 2796-2804.
Read now
Inoru Yokoe, Daiki Omata, Johan Unga, Ryo Suzuki, Kazuo Maruyama, Yoshiharu Okamoto & Tomohiro Osaki. (2021) Lipid bubbles combined with low-intensity ultrasound enhance the intratumoral accumulation and antitumor effect of pegylated liposomal doxorubicin in vivo. Drug Delivery 28:1, pages 530-541.
Read now
Fernando Mérida, Carlos Rinaldi, Eduardo J Juan & Madeline Torres-Lugo. (2020) In vitro Ultrasonic Potentiation of 2-Phenylethynesulfonamide/Magnetic Fluid Hyperthermia Combination Treatments for Ovarian Cancer. International Journal of Nanomedicine 15, pages 419-432.
Read now
Fangfang Shi, Fang Yang, Xiangfeng He, Ying Zhang, Songyan Wu, Miao Li, Yunxia Zhang, Wu Di, Jun Dou & Ning Gu. (2016) Inhibitory effect of epirubicin-loaded lipid microbubbles with conjugated anti-ABCG2 antibody combined with therapeutic ultrasound on multiple myeloma cancer stem cells. Journal of Drug Targeting 24:1, pages 34-46.
Read now
Shuang Yang, Pan Wang, Xiaobing Wang, Kun Zhang, Xing Zhang & Quanhong Liu. (2013) Efficacy of combined therapy with paclitaxel and low-level ultrasound in human chronic myelogenous leukemia cell line K562. Journal of Drug Targeting 21:9, pages 874-884.
Read now

Articles from other publishers (66)

Ryan Margolis, Lokesh Basavarajappa, Junjie Li, Girgis Obaid & Kenneth Hoyt. (2023) Image-guided focused ultrasound-mediated molecular delivery to breast cancer in an animal model. Physics in Medicine & Biology 68:15, pages 155012.
Crossref
S. I. Kaykanat & A. K. Uguz. (2023) The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery. Biomicrofluidics 17:2.
Crossref
Louis Lo, Oro Uchenunu, Roberto J. Botelho, Costin N. Antonescu & Raffi Karshafian. (2023) AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment. iScience 26:2, pages 105883.
Crossref
Arzu ESEN, Mustafa KAYMAZ & Şeydanur KARADAĞ. (2022) KÖPEKLERDE MEME TÜMÖRÜ OLGULARINDA GÜNCEL KEMOTERAPÖTİK YAKLAŞIM: MİKROBALONCUKLARCURRENT CHEMOTHERAPEUTIC APPROACH IN DOG MAMMARY TUMOR CASES: MICROBUBBLES. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni 13:3, pages 132-142.
Crossref
Tana Yang, Yixuan Zhang, Tan Wang, Mo Li, Ying Zhang, Dan Zhao, Libin Xu & Xiaobing Wang. (2022) Low-frequency ultrasound irradiation increases paclitaxel-induced sarcoma cells apoptosis and facilitates the transmembrane delivery of drugs. Frontiers in Pharmacology 13.
Crossref
Ryan Margolis, Junjie Li, Menitte Eroy, Dara Chanthavisay, Girgis Obaid & Kenneth Hoyt. (2022) Improved treatment of head and neck cancer using 3-D focused ultrasound-mediated cetuximab drug delivery. Improved treatment of head and neck cancer using 3-D focused ultrasound-mediated cetuximab drug delivery.
Liguang Zhou, Jing Liu, Wen Meng, Huawei Zhang & Bo Chen. (2022) Evaluation of Silibinin-Loaded Microbubbles Combined with Ultrasound in Ovarian Cancer Cells: Cytotoxicity and Mechanisms. Anti-Cancer Agents in Medicinal Chemistry 22:7, pages 1320-1327.
Crossref
Shirui Lu, Pengxuan Zhao, Youbin Deng & Yani Liu. (2022) Mechanistic Insights and Therapeutic Delivery through Micro/Nanobubble-Assisted Ultrasound. Pharmaceutics 14:3, pages 480.
Crossref
Spiros Kotopoulis, Mihaela Popa, Mireia Mayoral Safont, Elisa Murvold, Ragnhild Haugse, Anika Langer, Georg Dimcevski, Christina Lam, Tormod Bjånes, Odd Helge Gilja & Emmet Mc Cormack. (2022) SonoVue® vs. Sonazoid™ vs. Optison™: Which Bubble Is Best for Low-Intensity Sonoporation of Pancreatic Ductal Adenocarcinoma?. Pharmaceutics 14:1, pages 98.
Crossref
Binwei Lin, Huan Du, Jinjia Fan, Dan Huang, Feng Gao, Jie Li, Yu Zhang, Gang Feng, Tangzhi Dai & Xiaobo Du. (2021) Radioimmunotherapy Combined With Low-Intensity Ultrasound and Microbubbles: A Potential Novel Strategy for Treatment of Solid Tumors. Frontiers in Oncology 11.
Crossref
Haizhui Xia, Decao Yang, Wei He, Xuehua Zhu, Ye Yan, Zenan Liu, Tong Liu, Jianling Yang, Shi Tan, Jie Jiang, Xiaofei Hou, Huile Gao, Ling Ni & Jian Lu. (2021) Ultrasound-mediated microbubbles cavitation enhanced chemotherapy of advanced prostate cancer by increasing the permeability of blood-prostate barrier. Translational Oncology 14:10, pages 101177.
Crossref
Ryan Margolis, Lokesh Basavarajappa, Junjie Li & Kenneth Hoyt. (2021) Ultrasound Image-Guided Drug Delivery using a Spherically Focused Phased Array Transducer. Ultrasound Image-Guided Drug Delivery using a Spherically Focused Phased Array Transducer.
Lokesh Basavarajappa, Junjie Li, Haowei Tai, Jane Song, Kevin J. Parker & Kenneth Hoyt. (2021) Early Detection of Liver Steatosis using Multiparametric Ultrasound Imaging. Early Detection of Liver Steatosis using Multiparametric Ultrasound Imaging.
Lokesh Basavarajappa, Girdhari Rijal & Kenneth Hoyt. (2021) Multifocused Ultrasound Therapy for Controlled Microvascular Permeabilization and Improved Drug Delivery. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 68:4, pages 961-968.
Crossref
Xi Xiang, Houqing Pang, Tian Ma, Fangxue Du, Ling Li, Jianbo Huang, Lang Ma & Li Qiu. (2021) Ultrasound targeted microbubble destruction combined with Fe-MOF based bio-/enzyme-mimics nanoparticles for treating of cancer. Journal of Nanobiotechnology 19:1.
Crossref
Ragnhild Haugse, Anika Langer, Elisa Thodesen Murvold, Daniela Elena Costea, Bjørn Tore Gjertsen, Odd Helge Gilja, Spiros Kotopoulis, Gorka Ruiz de Garibay & Emmet McCormack. (2020) Low-Intensity Sonoporation-Induced Intracellular Signalling of Pancreatic Cancer Cells, Fibroblasts and Endothelial Cells. Pharmaceutics 12:11, pages 1058.
Crossref
Sayan Mullick Chowdhury, Lotfi Abou-Elkacem, Taehwa Lee, Jeremy Dahl & Amelie M. Lutz. (2020) Ultrasound and microbubble mediated therapeutic delivery: Underlying mechanisms and future outlook. Journal of Controlled Release 326, pages 75-90.
Crossref
Anca Onaciu, Ancuta Jurj, Cristian Moldovan & Ioana Berindan-Neagoe. 2020. Engineered Nanomaterials - Health and Safety. Engineered Nanomaterials - Health and Safety.
Zhi Yong Shen, Bei Qi Shen, Ai Jun Shen & Xin Hua Zhu. (2020) Cavitation-Enhanced Delivery of the Nanomaterial Graphene Oxide-Doxorubicin to Hepatic Tumors in Nude Mice Using 20 kHz Low-Frequency Ultrasound and Microbubbles. Journal of Nanomaterials 2020, pages 1-13.
Crossref
Mei Liu, Redmond‐Craig Anderson, Xiaoli Lan, Peter S. Conti & Kai Chen. (2019) Recent advances in the development of nanoparticles for multimodality imaging and therapy of cancer. Medicinal Research Reviews 40:3, pages 909-930.
Crossref
Tantawi, MD Mohamed, Liu, MD Ji-Bin & R Eisenbrey, PhD John. (2020) Recent Advances in Microbubble-Augmented Cancer Therapy. ADVANCED ULTRASOUND IN DIAGNOSIS AND THERAPY 4:3, pages 155.
Crossref
J. Yu, Y. Zhao, C. Liu, B. Hu, M. Zhao, Y. Ma & J. Jiang. (2019) Synergistic anti-tumor effect of paclitaxel and miR-34a combined with ultrasound microbubbles on cervical cancer in vivo and in vitro. Clinical and Translational Oncology 22:1, pages 60-69.
Crossref
Farnaz Fekri, John Abousawan, Stephen Bautista, Laura Orofiamma, Roya M. Dayam, Costin N. Antonescu & Raffi Karshafian. (2019) Targeted enhancement of flotillin-dependent endocytosis augments cellular uptake and impact of cytotoxic drugs. Scientific Reports 9:1.
Crossref
Lokesh Basavarajappa, Girdhari Rijal & Kenneth Hoyt. (2019) Image-guided focused ultrasound therapy system and method for improved anticancer drug delivery. Image-guided focused ultrasound therapy system and method for improved anticancer drug delivery.
Silke Roovers, Tim Segers, Guillaume Lajoinie, Joke Deprez, Michel Versluis, Stefaan C. De Smedt & Ine Lentacker. (2019) The Role of Ultrasound-Driven Microbubble Dynamics in Drug Delivery: From Microbubble Fundamentals to Clinical Translation. Langmuir 35:31, pages 10173-10191.
Crossref
Ketabat, Pundir, Mohabatpour, Lobanova, Koutsopoulos, Hadjiiski, Chen, Papagerakis & Papagerakis. (2019) Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives. Pharmaceutics 11:7, pages 302.
Crossref
Valeria Carina, Viviana Costa, Maria Sartori, Daniele Bellavia, Angela De Luca, Lavinia Raimondi, Milena Fini & Gianluca Giavaresi. (2019) Adjuvant Biophysical Therapies in Osteosarcoma. Cancers 11:3, pages 348.
Crossref
Junru Wu. (2018) Acoustic Streaming and Its Applications. Fluids 3:4, pages 108.
Crossref
Fangfang Shi, Miao Li, Jing Wang, Di Wu, Meng Pan, Mei Guo & Jun Dou. (2018) Induction of multiple myeloma cancer stem cell apoptosis using conjugated anti-ABCG2 antibody with epirubicin-loaded microbubbles. Stem Cell Research & Therapy 9:1.
Crossref
Fangyuan Xiong, Sabnis Nirupama, Shashank R Sirsi, Andras Lacko & Kenneth Hoyt. (2017) Ultrasound-stimulated drug delivery of reconstituted high-density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake. Ultrasound-stimulated drug delivery of reconstituted high-density lipoprotein nanoparticles: Effects of drug concentration on tumor uptake.
Ran Peng, Yang Luo, Zhangyong Li, Wei Wang & Yu Pang. (2017) Design of an ultrasonic physiotherapy system with pulse wave feedback control. Technology and Health Care 25, pages 305-315.
Crossref
Sayan Mullick Chowdhury, Taehwa Lee & Jürgen K. Willmann. (2017) Ultrasound-guided drug delivery in cancer. Ultrasonography 36:3, pages 171-184.
Crossref
Jun Chen, Sithira Ratnayaka, Aaron Alford, Veronika Kozlovskaya, Fei Liu, Bing Xue, Kenneth Hoyt & Eugenia Kharlampieva. (2017) Theranostic Multilayer Capsules for Ultrasound Imaging and Guided Drug Delivery. ACS Nano 11:3, pages 3135-3146.
Crossref
Kenneth Hoyt, Shashank Sirsi & Robert Mattrey. (2016) Quantification in molecular ultrasound imaging using compartmental modeling. Quantification in molecular ultrasound imaging using compartmental modeling.
Jinfeng Xu, Xinxin Zeng, Yingying Liu, Hui Luo, Zhanghong Wei, Huiyu Liu, Yuli Zhou, Hairong Zheng, Jie Zhou, Guanghong Tan & Fei Yan. (2016) A novel dual-targeted ultrasound contrast agent provides improvement of gene delivery efficiency in vitro. Tumor Biology 37:7, pages 8609-8619.
Crossref
Yu Yang, Wenkun Bai, Yini Chen, Shuliang Nan, Yanduan Lin, Tao Ying & Bing Hu. (2016) Low-frequency ultrasound-mediated microvessel disruption combined with docetaxel to treat prostate carcinoma xenografts in nude mice: A novel type of chemoembolization. Oncology Letters.
Crossref
Jie Hu, Yujin Zong, Jun Li, Xiaodong Zhou, Jun Zhang, Ting Zhu, Mingke Jiao, Haili Su & Bin Bo. (2016) In Vitro and In Vivo Evaluation of Targeted Sunitinib‐Loaded Polymer Microbubbles Against Proliferation of Renal Cell Carcinoma. Journal of Ultrasound in Medicine 35:3, pages 589-597.
Crossref
Lun Wu, Wen‑Bo Zhou, Feng Shen, Wei Liu, Hong‑Wei Wu, Shi‑Ji Zhou & Sheng‑Wei Li. (2016) Connexin32‑mediated antitumor effects of suicide gene therapy against hepatocellular carcinoma: In�vitro and in�vivo anticancer activity. Molecular Medicine Reports.
Crossref
Jiale Qin, Tzu-Yin Wang & Jürgen K. Willmann. 2016. Therapeutic Ultrasound. Therapeutic Ultrasound 263 291 .
YU YANG, WENKUN BAI, YINI CHEN, YANDUAN LIN & BING HU. (2015) Optimization of low-frequency low-intensity ultrasound-mediated microvessel disruption on prostate cancer xenografts in nude mice using an orthogonal experimental design. Oncology Letters 10:5, pages 2999-3007.
Crossref
CAIFENG WAN, FENGHUA LI & HONGLI LI. (2015) Gene therapy for ocular diseases meditated by ultrasound and microbubbles (Review). Molecular Medicine Reports 12:4, pages 4803-4814.
Crossref
Andrew K.W. Wood & Chandra M. Sehgal. (2015) A Review of Low-Intensity Ultrasound for Cancer Therapy. Ultrasound in Medicine & Biology 41:4, pages 905-928.
Crossref
Anna G. Sorace & Kenneth Hoyt. (2014) Imaging the microvascular response to ultrasound-stimulated therapy in a preclinical animal model of breast cancer. Imaging the microvascular response to ultrasound-stimulated therapy in a preclinical animal model of breast cancer.
Jason M. Warram, Esther de Boer, Anna G. Sorace, Thomas K. Chung, Hyunki Kim, Rick G. Pleijhuis, Gooitzen M. van Dam & Eben L. Rosenthal. (2014) Antibody-based imaging strategies for cancer. Cancer and Metastasis Reviews 33:2-3, pages 809-822.
Crossref
Marshall Mahoney, Anna Sorace, Jason Warram, Sharon Samuel & Kenneth Hoyt. (2014) Volumetric Contrast‐Enhanced Ultrasound Imaging of Renal Perfusion. Journal of Ultrasound in Medicine 33:8, pages 1427-1437.
Crossref
Anna G. Sorace, Melissa Korb, Jason M. Warram, Heidi Umphrey, Kurt R. Zinn, Eben Rosenthal & Kenneth Hoyt. (2014) Ultrasound-Stimulated Drug Delivery for Treatment of Residual Disease after Incomplete Resection of Head and Neck Cancer. Ultrasound in Medicine & Biology 40:4, pages 755-764.
Crossref
Reshu Saini & Kenneth Hoyt. (2014) Recent developments in dynamic contrast-enhanced ultrasound imaging of tumor angiogenesis. Imaging in Medicine 6:1, pages 41-52.
Crossref
Sana S. Dastgheyb & John R. Eisenbrey. 2014. Handbook of Polymer Applications in Medicine and Medical Devices. Handbook of Polymer Applications in Medicine and Medical Devices 253 277 .
Noboru Sasaki, Nobuki Kudo, Kensuke Nakamura, Sue Yee Lim, Masahiro Murakami, W. R. Bandula Kumara, Yu Tamura, Hiroshi Ohta, Masahiro Yamasaki & Mitsuyoshi Takiguchi. (2013) Ultrasound image-guided therapy enhances antitumor effect of cisplatin. Journal of Medical Ultrasonics 41:1, pages 11-21.
Crossref
Christina Kalli, Wey Chyi Teoh & Edward Leen. 2014. Anticancer Genes. Anticancer Genes 231 254 .
Anna G. Sorace, Jason M. Warram, Marshall Mahoney, Kurt R. Zinn & Kenneth Hoyt. (2013) Enhancement of Adenovirus Delivery after Ultrasound-Stimulated Therapy in a Cancer Model. Ultrasound in Medicine & Biology 39:12, pages 2374-2381.
Crossref
Matthieu Lepetit-Coiffé, Anna Yudina, Christel Poujol, Philippe Lourenco de Oliveira, Franck Couillaud & Chrit T. W. Moonen. (2013) Quantitative Evaluation of Ultrasound-Mediated Cellular Uptake of a Fluorescent Model Drug. Molecular Imaging and Biology 15:5, pages 523-533.
Crossref
Margarita Todorova, Vlad Agache, Omid Mortazavi, Branson Chen, Raffi Karshafian, Kullervo Hynynen, Shan Man, Robert S. Kerbel & David E. Goertz. (2013) Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles. International Journal of Cancer 132:12, pages 2956-2966.
Crossref
Jason CastleMatthew ButtsAndrew HealeyKevin KentMichael MarinoSteven B. Feinstein. (2013) Ultrasound-mediated targeted drug delivery: recent success and remaining challenges. American Journal of Physiology-Heart and Circulatory Physiology 304:3, pages H350-H357.
Crossref
Anna G. Sorace, Reshu Saini, Eben Rosenthal, Jason M. Warram, Kurt R. Zinn & Kenneth Hoyt. (2013) Optical fluorescent imaging to monitor temporal effects of microbubble-mediated ultrasound therapy. IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 60:2, pages 281-289.
Crossref
Hong Chen & Joo Hwang. (2013) Ultrasound-targeted microbubble destruction for chemotherapeutic drug delivery to solid tumors. Journal of Therapeutic Ultrasound 1:1, pages 10.
Crossref
M.A. Wheatley & M. Cochran. (2013) Ultrasound contrast agents. Journal of Drug Delivery Science and Technology 23:1, pages 57-72.
Crossref
David E. Goertz, Margarita Todorova, Omid Mortazavi, Vlad Agache, Branson Chen, Raffi Karshafian & Kullervo Hynynen. (2012) Antitumor Effects of Combining Docetaxel (Taxotere) with the Antivascular Action of Ultrasound Stimulated Microbubbles. PLoS ONE 7:12, pages e52307.
Crossref
Hong Chen, Andrew A. Brayman, Andrew P. Evan & Thomas J. Matula. (2012) Preliminary Observations on the Spatial Correlation Between Short-Burst Microbubble Oscillations and Vascular Bioeffects. Ultrasound in Medicine & Biology 38:12, pages 2151-2162.
Crossref
Azza A. Al-Mahrouki, Raffi Karshafian, Anoja Giles & Gregory J. Czarnota. (2012) Bioeffects of Ultrasound-Stimulated Microbubbles on Endothelial Cells: Gene Expression Changes Associated with Radiation Enhancement In Vitro. Ultrasound in Medicine & Biology 38:11, pages 1958-1969.
Crossref
Anna G. Sorace, Reshu Saini, Marshall Mahoney & Kenneth Hoyt. (2012) Molecular Ultrasound Imaging Using a Targeted Contrast Agent for Assessing Early Tumor Response to Antiangiogenic Therapy. Journal of Ultrasound in Medicine 31:10, pages 1543-1550.
Crossref
Anna G. Sorace, Joseph Knowles, Cara Heath, Eben Rosenthal & Kenneth Hoyt. (2012) Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer. Ultrasound therapy amplifies chemotherapeutic effectiveness in head and neck cancer.
Anna G. Sorace, Reshu Saini, Marshall J. Mahoney & Kenneth Hoyt. (2012) Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells. Targeted molecular ultrasound therapy improves chemotherapeutic drug delivery in cancer cells.
Zhen Zhang, Jiang Chen, Lufeng Chen, Xianli Yang, Hongshan Zhong, Xun Qi, Yonghua Bi & Ke Xu. (2012) Low frequency and intensity ultrasound induces apoptosis of brain glioma in rats mediated by caspase-3, Bcl-2, and survivin. Brain Research 1473, pages 25-34.
Crossref
J M Warram, A G Sorace, R Saini, A V Borovjagin, K Hoyt & K R Zinn. (2012) Systemic delivery of a breast cancer-detecting adenovirus using targeted microbubbles. Cancer Gene Therapy 19:8, pages 545-552.
Crossref
Cara H. Heath, Anna Sorace, Joseph Knowles, Eben Rosenthal & Kenneth Hoyt. (2012) Microbubble Therapy Enhances Anti‐tumor Properties of Cisplatin and Cetuximab In Vitro and In Vivo. Otolaryngology–Head and Neck Surgery 146:6, pages 938-945.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.