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Research Article

Characterization and optimization of bilosomes for oral vaccine delivery

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Pages 291-299 | Received 11 Aug 2012, Accepted 05 Nov 2012, Published online: 05 Apr 2013

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Read on this site (8)

Matteo Aroffu, Maria Letizia Manca, José Luis Pedraz & Maria Manconi. (2023) Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements. Expert Opinion on Drug Delivery 0:0, pages 1-21.
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Nabil K Alruwaili, Ameeduzzafar Zafar, Omar Awad Alsaidan, Mohd Yasir, Ehab M. Mostafa, Sultan F. Alnomasy, Alenazy Rawaf, Ali Alquraini & Fadhel A. Alomar. (2022) Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study. Drug Delivery 29:1, pages 3035-3050.
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Sadek Ahmed, Mohamed Aly Kassem & Sinar Sayed. (2020) Bilosomes as Promising Nanovesicular Carriers for Improved Transdermal Delivery: Construction, in vitro Optimization, ex vivo Permeation and in vivo Evaluation. International Journal of Nanomedicine 15, pages 9783-9798.
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Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey & Ibrahim Elsayed. (2020) Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency. Drug Delivery 27:1, pages 996-1009.
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Poonam Parashar, Preeti Rana, Monika Dwivedi & Shubhini A Saraf. (2019) Dextrose modified bilosomes for peroral delivery: improved therapeutic potential and stability of silymarin in diethylnitrosamine-induced hepatic carcinoma in rats. Journal of Liposome Research 29:3, pages 251-263.
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Azza Abdelmageed Matloub, Alaa Hamed Salama, Hadeer Ahmed Aglan, Mona Mahmoud AbouSamra, Sahar Salah Mohamed ElSouda & Hanaa Hamdy Ahmed. (2018) Exploiting bilosomes for delivering bioactive polysaccharide isolated from Enteromorpha intestinalis for hacking hepatocellular carcinoma. Drug Development and Industrial Pharmacy 44:4, pages 523-534.
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Yosra SR Elnaggar. (2015) Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine. International Journal of Nanomedicine 10, pages 3955-3971.
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Nirmal Marasini, Mariusz Skwarczynski & Istvan Toth. (2014) Oral delivery of nanoparticle-based vaccines. Expert Review of Vaccines 13:11, pages 1361-1376.
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Jitinder S. Wilkhu, Sarah E. McNeil, David E. Anderson, Marc Kirchmeier & Yvonne Perrie. (2017) Development of a solid dosage platform for the oral delivery of bilayer vesicles. European Journal of Pharmaceutical Sciences 108, pages 71-77.
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Julia E. Vela Ramirez, Lindsey A. Sharpe & Nicholas A. Peppas. (2017) Current state and challenges in developing oral vaccines. Advanced Drug Delivery Reviews 114, pages 116-131.
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Sayali Karandikar, Amit Mirani, Vishal Waybhase, Vandana B. Patravale & Sandeep Patankar. 2017. Nanostructures for Oral Medicine. Nanostructures for Oral Medicine 263 293 .
Nily Dan. 2017. Nanostructures for Drug Delivery. Nanostructures for Drug Delivery 63 105 .
N. Marasini, K.A. Ghaffar, M. Skwarczynski & I. Toth. 2017. Micro and Nanotechnology in Vaccine Development. Micro and Nanotechnology in Vaccine Development 221 239 .
Anshuman Shukla, Vijay Mishra & Prashant Kesharwani. (2016) Bilosomes in the context of oral immunization: development, challenges and opportunities. Drug Discovery Today 21:6, pages 888-899.
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Md Nurunnabi, Zehedina Khatun, Vishnu Revuri, Md Nafiujjaman, Seungbin Cha, Sungpil Cho, Kang Moo Huh & Yong-kyu Lee. (2016) Design and strategies for bile acid mediated therapy and imaging. RSC Advances 6:78, pages 73986-74002.
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Nishi Mody, Rajeev Sharma, Udita Agrawal & Suresh P Vyas. (2015) Nanocarriers: a versatile approach for mucosal vaccine delivery. Therapeutic Delivery 6:2, pages 231-245.
Crossref
Jitinder S. Wilkhu & Yvonne Perrie. 2015. Subunit Vaccine Delivery. Subunit Vaccine Delivery 95 123 .
Jitinder S. Wilkhu, Sarah E. McNeil, David E. Anderson & Yvonne Perrie. (2013) Consideration of the efficacy of non-ionic vesicles in the targeted delivery of oral vaccines. Drug Delivery and Translational Research 4:3, pages 233-245.
Crossref
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Crossref
Jitinder S. Wilkhu, Defang Ouyang, Marc J. Kirchmeier, David E. Anderson & Yvonne Perrie. (2014) Investigating the role of cholesterol in the formation of non-ionic surfactant based bilayer vesicles: Thermal analysis and molecular dynamics. International Journal of Pharmaceutics 461:1-2, pages 331-341.
Crossref

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