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Journal of Drug Targeting Volume 23, 2015 - Issue 7-8: Special issue in honour of Professor Robert Langer: JDT Lifetime Achievement Award winner 2015
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Review Article

Targeted polymeric nanoparticles for cancer gene therapy

Jayoung KimDepartment of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA,
,
David R. WilsonDepartment of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA,
,
Camila G. ZamboniDepartment of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ;Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA, ;Instituto do Câncer do Estado de São Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil,
&
Jordan J. GreenDepartment of Biomedical Engineering and the Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, ;Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA, and ;Department of Neurosurgery and ;Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence[email protected]
Pages 627-641 | Received 01 Apr 2015, Accepted 02 May 2015, Published online: 10 Jun 2015

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M. Gover Antoniraj, Mahesh Ayyavu, Linda Jeeva Kumari Henry, Goutham Nageshwar Rao, Subramanian Natesan, D. Sathish Sundar & Ruckmani Kandasamy. (2018) Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery. Drug Development and Industrial Pharmacy 44:3, pages 365-376.
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Bahman Khalvati, Fatemeh Sheikhsaran, Sedigheh Sharifzadeh, Tahereh Kalantari, Abbas Behzad Behbahani, Akram Jamshidzadeh & Ali Dehshahri. (2017) Delivery of plasmid encoding interleukin-12 gene into hepatocytes by conjugated polyethylenimine-based nanoparticles. Artificial Cells, Nanomedicine, and Biotechnology 45:5, pages 1036-1044.
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Sofía Mirón-Barroso, Joana Correia, Adam Frampton, Mark Lythgoe, James Clark, Laura Tookman, Silvia Ottaviani, Leandro Castellano, Alexandra Porter, Theoni Georgiou & Jonathan Krell. (2022) Polymeric Carriers for Delivery of RNA Cancer Therapeutics. Non-Coding RNA 8:4, pages 58.
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Sajid Iqbal, Alessandro F. Martins, Muhammad Sohail, Jingjing Zhao, Qi Deng, Muhan Li & Zhongxi Zhao. (2022) Synthesis and Characterization of Poly (β-amino Ester) and Applied PEGylated and Non-PEGylated Poly (β-amino ester)/Plasmid DNA Nanoparticles for Efficient Gene Delivery. Frontiers in Pharmacology 13.
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Athirah Bakhtiar, Qing Xin Liew, Khuen Yen Ng & Ezharul Hoque Chowdhury. (2022) Active targeting via ligand-anchored pH-responsive strontium nanoparticles for efficient nucleic acid delivery into breast cancer cells. Journal of Pharmaceutical Investigation 52:2, pages 243-257.
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Alazne Moreno-Lanceta, Mireia Medrano-Bosch, Elazer R. Edelman & Pedro Melgar-Lesmes. 2022. Pharmaceutical Nanobiotechnology for Targeted Therapy. Pharmaceutical Nanobiotechnology for Targeted Therapy 561 608 .
Fitsum Feleke Sahle. 2022. Macrophage Targeted Delivery Systems. Macrophage Targeted Delivery Systems 145 167 .
. 2021. Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II). Nanomaterials: Evolution and Advancement towards Therapeutic Drug Delivery (Part II) 194 245 .
Muhammad Sohail, Wenna Guo, Zhiyong Li, Hui Xu, Feng Zhao, Daquan Chen & Fenghua Fu. (2021) Nanocarrier-based Drug Delivery System for Cancer Therapeutics: A Review of the Last Decade. Current Medicinal Chemistry 28:19, pages 3753-3772.
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Hannah J. Vaughan, Camila G. Zamboni, Nicholas P. Radant, Pranshu Bhardwaj, Esther Revai Lechtich, Laboni F. Hassan, Khalid Shah & Jordan J. Green. (2021) Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer. Molecular Therapy - Oncolytics 21, pages 377-388.
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Adip G. Bhargav, Sujan K. Mondal, Cesar A. Garcia, Jordan J. Green & Alfredo Quiñones‐Hinojosa. (2020) Nanomedicine Revisited: Next Generation Therapies for Brain Cancer. Advanced Therapeutics 3:10, pages 2000118.
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Polina Perepelkina & Susanna Sologova. (2020) Suicide gene therapy for caner: HSVtkGV and possible delivery systems. Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology):3, pages 43-50.
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Shahin Shams & Eduardo A. Silva. 2020. Engineering Strategies for Regenerative Medicine. Engineering Strategies for Regenerative Medicine 107 148 .
Shiv Kumar Prajapati, Ankit Jain, Aakanchha Jain & Sourabh Jain. (2019) Biodegradable polymers and constructs: A novel approach in drug delivery. European Polymer Journal 120, pages 109191.
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Rúben Faria, Ângela Sousa, Ana R. Neves, João A. Queiroz & Diana Costa. (2019) Methotrexate-plasmid DNA polyplexes for cancer therapy: Characterization, cancer cell targeting ability and tuned in vitro transfection. Journal of Molecular Liquids 292, pages 111391.
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Caitlin L. Maikawa, Alex Sevit, Binhong Lin, Rachel J. Wallstrom, Joseph L. Mann, Anthony C. Yu, Robert M. Waymouth & Eric A. Appel. (2019) Block copolymer composition drives function of self‐assembled nanoparticles for delivery of small‐molecule cargo. Journal of Polymer Science Part A: Polymer Chemistry 57:12, pages 1322-1332.
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Diana Rita Barata Costa, Fani Pereira de Sousa & João António de Sampaio Rodrigues Queiroz. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 297 327 .
Arunachalam Muthuraman, Seema Mehdi & Narahari Rishitha. 2019. Nanoparticles in Pharmacotherapy. Nanoparticles in Pharmacotherapy 73 112 .
Cynthia Kassab, Brittany Parker Kerrigan, Hillary Caruso, Sanaalarab Al Enazy & Amy B. Heimberger. 2019. Nervous System Drug Delivery. Nervous System Drug Delivery 297 334 .
Shima Asfia, Mahsa Mohammadian & Hasan Kouchakzadeh. 2019. Nanomaterials for Advanced Biological Applications. Nanomaterials for Advanced Biological Applications 55 84 .
Guimiao Lin, Li Li, Nishtha Panwar, Jie Wang, Swee Chuan Tjin, Xiaomei Wang & Ken-Tye Yong. (2018) Non-viral gene therapy using multifunctional nanoparticles: Status, challenges, and opportunities. Coordination Chemistry Reviews 374, pages 133-152.
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Shengxian Li, Xiangru Feng, Jixue Wang, Liang He, Chunxi Wang, Jianxun Ding & Xuesi Chen. (2018) Polymer nanoparticles as adjuvants in cancer immunotherapy. Nano Research 11:11, pages 5769-5786.
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Eduardo De los Reyes-Berbel, Rafael Salto-Gonzalez, Mariano Ortega-Muñoz, Francisco Jose Reche-Perez, Ana Belen Jodar-Reyes, Fernando Hernandez-Mateo, Maria Dolores Giron-Gonzalez & Francisco Santoyo-Gonzalez. (2018) PEI-NIR Heptamethine Cyanine Nanotheranostics for Tumor Targeted Gene Delivery. Bioconjugate Chemistry 29:8, pages 2561-2575.
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Jayoung Kim, James G. Shamul, Sagar R. Shah, Alyssa Shin, Ben J. Lee, Alfredo Quinones-Hinojosa & Jordan J. Green. (2018) Verteporfin-Loaded Poly(ethylene glycol)-Poly(beta-amino ester)-Poly(ethylene glycol) Triblock Micelles for Cancer Therapy. Biomacromolecules 19:8, pages 3361-3370.
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Mauro Almeida, Mariana Magalhães, Francisco Veiga & Ana Figueiras. (2017) Poloxamers, poloxamines and polymeric micelles: Definition, structure and therapeutic applications in cancer. Journal of Polymer Research 25:1.
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Jorge Roacho‑Perez, Hugo Gallardo‑Blanco, Margarita Sanchez‑Dominguez, Perla Garcia‑Casillas, Christian Chapa‑Gonzalez & Celia Sanchez‑Dominguez. (2017) Nanoparticles for death‑induced gene therapy in cancer (Review). Molecular Medicine Reports.
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Jayoung Kim, Adam C. Mirando, Aleksander S. Popel & Jordan J. Green. (2017) Gene delivery nanoparticles to modulate angiogenesis. Advanced Drug Delivery Reviews 119, pages 20-43.
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Yanping Sun, Zhen Yang, Chunxi Wang, Tianzhi Yang, Cuifang Cai, Xiaoyun Zhao, Li Yang & Pingtian Ding. (2017) Exploring the role of peptides in polymer-based gene delivery. Acta Biomaterialia 60, pages 23-37.
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David R. Wilson, Denis Routkevitch, Yuan Rui, Arman Mosenia, Karl J. Wahlin, Alfredo Quinones-Hinojosa, Donald J. Zack & Jordan J. Green. (2017) A Triple-Fluorophore-Labeled Nucleic Acid pH Nanosensor to Investigate Non-viral Gene Delivery. Molecular Therapy 25:7, pages 1697-1709.
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Vasundhara Shukla, Manu Dalela, Manika Vij, Ralph Weichselbaum, Surender Kharbanda, Munia Ganguli, Donald Kufe & Harpal Singh. (2017) Systemic delivery of the tumor necrosis factor gene to tumors by a novel dual DNA-nanocomplex in a nanoparticle system. Nanomedicine: Nanotechnology, Biology and Medicine 13:5, pages 1833-1839.
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David R. Wilson, Arman Mosenia, Mark P. Suprenant, Rahul Upadhya, Denis Routkevitch, Randall A. Meyer, Alfredo Quinones‐Hinojosa & Jordan J. Green. (2017) Continuous microfluidic assembly of biodegradable poly(beta‐amino ester)/DNA nanoparticles for enhanced gene delivery. Journal of Biomedical Materials Research Part A 105:6, pages 1813-1825.
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Narsireddy Amreddy, Anish Babu, Ranganayaki Muralidharan, Anupama Munshi & Rajagopal Ramesh. (2017) Polymeric Nanoparticle-Mediated Gene Delivery for Lung Cancer Treatment. Topics in Current Chemistry 375:2.
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Cian M. McCrudden, John W. McBride, Joanne McCaffrey, Ahlam A. Ali, Nicholas J. Dunne, Vicky L. Kett, Jonathan A. Coulter, Tracy Robson & Helen O. McCarthy. (2017) Systemic RALA/iNOS Nanoparticles: A Potent Gene Therapy for Metastatic Breast Cancer Coupled as a Biomarker of Treatment. Molecular Therapy - Nucleic Acids 6, pages 249-258.
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David R. Wilson & Jordan J. Green. 2017. Biomedical Nanotechnology. Biomedical Nanotechnology 31 46 .
Jayoung Kim, Yechan Kang, Stephany Y. Tzeng & Jordan J. Green. (2016) Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy. Acta Biomaterialia 41, pages 293-301.
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Thomas Carter, Paul Mulholland & Kerry Chester. (2016) Antibody-targeted nanoparticles for cancer treatment. Immunotherapy 8:8, pages 941-958.
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Stephany Y. Tzeng, David R. Wilson, Sarah K. Hansen, Alfredo Quiñones‐Hinojosa & Jordan J. Green. (2016) Polymeric nanoparticle‐based delivery of TRAIL DNA for cancer‐specific killing. Bioengineering & Translational Medicine 1:2, pages 149-159.
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