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Pinar Calis, Lucia Vojtech, Florian Hladik & Michael G. Gravett. (2022) A review of ex vivo placental perfusion models: an underutilized but promising method to study maternal-fetal interactions. The Journal of Maternal-Fetal & Neonatal Medicine 35:25, pages 8823-8835.
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Fumi Furuhashi, Hiroaki Tanaka, Shintaro Maki, Makoto Tsuji, Shoichi Magawa, Michiko K. Kaneda, Masafumi Nii, Kayo Tanaka, Toru Ogura, Yuki Nishimura, Masayuki Endoh, Tadashi Kimura, Tomomi Kotani, Akihiko Sekizawa & Tomoaki Ikeda. (2021) Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial. The Journal of Maternal-Fetal & Neonatal Medicine 34:22, pages 3709-3715.
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Annie G. Cox, Sarah A. Marshall, Kirsten R. Palmer & Euan M. Wallace. (2019) Current and emerging pharmacotherapy for emergency management of preeclampsia. Expert Opinion on Pharmacotherapy 20:6, pages 701-712.
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Francesca M. Russo, Paola Mian, Elke H. Krekels, Kristel Van Calsteren, Dick Tibboel, Jan Deprest & Karel Allegaert. (2019) Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit. Xenobiotica 49:1, pages 98-105.
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Mohamed Adel El-Sayed, Said Abdel-Aty Saleh, Mohammad Ahmed Maher & Asmaa Mohamed Khidre. (2018) Utero-placental perfusion Doppler indices in growth restricted fetuses: effect of sildenafil citrate. The Journal of Maternal-Fetal & Neonatal Medicine 31:8, pages 1045-1050.
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Breno José Acauan Filho, Bartira Ercilia Pinheiro da Costa, Patrícia Barcelos Ogando, Matias Costa Vieira, Ivan Carlos Antonello & Carlos Eduardo Poli-de-Figueiredo. (2016) Serum nitrate and NOx levels in preeclampsia are higher than in normal pregnancy. Hypertension in Pregnancy 35:2, pages 226-233.
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Charlotte J Oyston, Joanna L Stanley & Philip N Baker. (2015) Potential targets for the treatment of preeclampsia. Expert Opinion on Therapeutic Targets 19:11, pages 1517-1530.
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Jennifer M Sasser, Sydney R Murphy & Joey P Granger. (2015) Emerging drugs for preeclampsia – the endothelium as a target. Expert Opinion on Emerging Drugs 20:4, pages 527-530.
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Edibe Karasu, Nurten Kayacan, Gulay Sadan & Bora Dinc. (2012) Endothelial Dysfunction in the Human Umbilical Artery due to Preeclampsia Can Be Prevented by Sildenafil. Clinical and Experimental Hypertension 34:2, pages 79-85.
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Thomas R. Everett, Ian B. Wilkinson & Christoph C. Lees. (2012) Drug development in preeclampsia: a ‘no go’ area?. The Journal of Maternal-Fetal & Neonatal Medicine 25:1, pages 50-52.
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Robert A Kloner, Gary Comstock, Laurence A Levine, Steven Tiger & Vera J Stecher. (2011) Investigational noncardiovascular uses of phosphodiesterase-5 inhibitors. Expert Opinion on Pharmacotherapy 12:15, pages 2297-2313.
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Rebekah A. Samangaya, Mark Wareing, Laurence Skillern & Philip N. Baker. (2011) Phosphodiesterase Inhibitor Effect on Small Artery Function in Preeclampsia. Hypertension in Pregnancy 30:2, pages 144-152.
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John Downing. (2010) Sildenafil for the Treatment of Preeclampsia. Hypertension in Pregnancy 29:2, pages 248-250.
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Articles from other publishers (111)
Anouk Pels, Wessel Ganzevoort, Louise C Kenny, Philip N Baker, Peter von Dadelszen, Christian Gluud, Chirag T Kariya, Aleid G Leemhuis, Katie M Groom, Andrew N Sharp, Laura A Magee, Janus C Jakobsen, Ben Willem J Mol & Aris T Papageorghiou. (2023) Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy. Cochrane Database of Systematic Reviews 2023:7.
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Yenlik Rakhanova, Wassim Y. Almawi, Gulzhanat Aimagambetova & Dieter Riethmacher. (2023) The effects of sildenafil citrate on intrauterine growth restriction: a systematic review and meta-analysis. BMC Pregnancy and Childbirth 23:1.
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Eera Fatima Bangi, Muhammad Hamza Yousuf, Shubekshya Upadhyay, Pranjal Jain & Rohit Jain. (2023) Comprehensive Review of Hypertensive Disorders Related to Pregnancy. Southern Medical Journal 116:6, pages 482-489.
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Sapna Ramdin, Sooraj Baijnath, Thajasvarie Naicker & Nalini Govender. (2023) The Clinical Value of Rodent Models in Understanding Preeclampsia Development and Progression. Current Hypertension Reports 25:6, pages 77-89.
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Julia Macente, Nina Nauwelaerts, Francesca M. Russo, Jan Deprest, Karel Allegaert, Bart Lammens, Rodolfo Hernandes Bonan, Jessica M. Turner, Sailesh Kumar, Andrea Diniz, Frederico S. Martins & Pieter Annaert. (2023) PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia. Frontiers in Pharmacology 14.
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Manu Vatish, Veronica R. Powys & Ana Sofia Cerdeira. (2023) Novel therapeutic and diagnostic approaches for preeclampsia. Current Opinion in Nephrology & Hypertension 32:2, pages 124-133.
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Peter von Dadelszen, François Audibert, Emmanuel Bujold, Jeffrey N. Bone, Ash Sandhu, Jing Li, Chirag Kariya, Youkee Chung, Tang Lee, Kelvin Au, M. Amanda Skoll, Marianne Vidler, Laura A. Magee, Bruno Piedboeuf, Philip N. Baker, Sayrin Lalji & Kenneth I. Lim. (2022) Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations. BMC Research Notes 15:1.
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Crossref
Jessica M. Turner, Francesca Russo, Jan Deprest, Ben W. Mol & Sailesh Kumar. (2022) Phosphodiesterase‐5 inhibitors in pregnancy: Systematic review and meta‐analysis of maternal and perinatal safety and clinical outcomes. BJOG: An International Journal of Obstetrics & Gynaecology 129:11, pages 1817-1831.
Crossref
Crossref
Felix Rafael De Bie, David Basurto, Sailesh Kumar, Jan Deprest & Francesca Maria Russo. (2022) Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations. International Journal of Environmental Research and Public Health 19:18, pages 11207.
Crossref
Crossref
Jonathan D. Reiss, Alan L. Chang, Jonathan A. Mayo, Katherine Bianco, Henry C. Lee, David K. Stevenson, Gary M. Shaw, Nima Aghaeepour & Karl G. Sylvester. (2021) Newborn screen metabolic panels reflect the impact of common disorders of pregnancy. Pediatric Research 92:2, pages 490-497.
Crossref
Crossref
H. van Hove, L. Mathiesen, J.J.M. Freriksen, K. Vähäkangas, A. Colbers, P. Brownbill & R. Greupink. (2022) Placental transfer and vascular effects of pharmaceutical drugs in the human placenta ex vivo: A review. Placenta 122, pages 29-45.
Crossref
Crossref
Jeffrey N. Bone, Akshdeep Sandhu, Edgardo D. AbalosAsma Khalil, Joel Singer, Sarina Prasad, Shazmeen OmarMarianne Vidler, Peter von Dadelszen & Laura A. Magee. (2022) Oral Antihypertensives for Nonsevere Pregnancy Hypertension: Systematic Review, Network Meta- and Trial Sequential Analyses. Hypertension 79:3, pages 614-628.
Crossref
Crossref
Maria-Grazia Lazzaroni, Francesca Crisafulli, Liala Moschetti, Paolo Semeraro, Ana-Rita Cunha, Agna Neto, Andrea Lojacono, Francesca Ramazzotto, Cristina Zanardini, Sonia Zatti, Paolo Airò, Angela Tincani, Franco Franceschini & Laura Andreoli. (2022) Reproductive Issues and Pregnancy Implications in Systemic Sclerosis. Clinical Reviews in Allergy & Immunology 64:3, pages 321-342.
Crossref
Crossref
Jessica Liauw, Katie Groom, Wessel Ganzevoort, Christian Gluud, Christopher J. D. McKinlay, Andrew Sharp, Laura Mackay, Chirag Kariya, Ken Lim, Peter von Dadelszen, Jacqueline Limpens, Janus C. Jakobsen, Francois Audibert, Zarko Alfirevic, Philip Baker, Emmanuel Bujold, Youkee Chung, Christine Cornforth, Wessel Ganzevoort, Sanne J. Gordijn, Katie Groom, Christian Gluud, Janus C. Jakobsen, Edward D. Johnstone, Chirag Kariya, Louise Kenny, Tang Lee, Larry Li, Jessica Liauw, Ken Lim, Laura Magee, Laura Mackay, Lesley McCowan, Chris McKinlay, Ben W. Mol, Wes Onland, Aris Papageorghiou, Anouk Pels, Andrew Sharp & Peter von Dadelszen. (2021) Short-term outcomes of phosphodiesterase type 5 inhibitors for fetal growth restriction: a study protocol for a systematic review with individual participant data meta-analysis, aggregate meta-analysis, and trial sequential analysis. Systematic Reviews 10:1.
Crossref
Crossref
Carolyn E. Cesta, Silvia Segovia Chacón, Anders Engeland, Anne Broe, Per Damkier, Kari Furu, Helle Kieler & Pär Karlsson. (2021) Use of sildenafil and other phosphodiesterase type 5 inhibitors among pregnant women in Scandinavia. Acta Obstetricia et Gynecologica Scandinavica 100:11, pages 2111-2118.
Crossref
Crossref
Felix R. De Bie, Francesca M. Russo, Pieter Van Brantegem, Barbara E. Coons, James K. Moon, Zexuan Yang, Chengcheng Pang, Janaina C. Senra, Camilla Omann, Pieter Annaert, Karel Allegaert, Marcus G. Davey, Alan W. Flake & Jan Deprest. (2021) Pharmacokinetics and pharmacodynamics of sildenafil in fetal lambs on extracorporeal support. Biomedicine & Pharmacotherapy 143, pages 112161.
Crossref
Crossref
Ana C. Palei, Joey P. Granger & Frank T. Spradley. (2021) Placental Ischemia Says “NO” to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia. International Journal of Molecular Sciences 22:20, pages 11261.
Crossref
Crossref
Christopher A. Waker, Melissa R. Kaufman & Thomas L. Brown. (2021) Current State of Preeclampsia Mouse Models: Approaches, Relevance, and Standardization. Frontiers in Physiology 12.
Crossref
Crossref
Kathleen Marulanda, Nick D. Tsihlis, Sean E. McLean & Melina R. Kibbe. (2020) Emerging antenatal therapies for congenital diaphragmatic hernia-induced pulmonary hypertension in preclinical models. Pediatric Research 89:7, pages 1641-1649.
Crossref
Crossref
Anshu AnshuDr.Dr., Usha KumariDr.Dr. & Debarshi JanaDr.Dr.. (2021) USE OF SLIDENAFIL CITRATE IN CASES OF INTRAUTERINE GROWTH RESTRICTION AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR. INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH, pages 23-24.
Crossref
Crossref
Felix Rafael De Bie, Dyuti Sharma, Damien Lannoy, Karel Allegaert, Laurent Storme, Jan Deprest & Francesca Maria Russo. (2021) Transplacental Transfer and Fetal Pharmacodynamics of Sildenafil in the Pregnant Sheep Model. Fetal Diagnosis and Therapy 48:6, pages 411-420.
Crossref
Crossref
Maryam Damghanian, Farnaz Farnam & Roghieh Kharaghani. (2020) The Effects of Sildenafil on Fetal Doppler Indices: A Systematic Review and Meta-Analysis. Journal of Advances in Medical and Biomedical Research 28:131, pages 307-315.
Crossref
Crossref
Kathryn L. GatfordPrabha H. AndraweeraClaire T. RobertsAlison S. Care. (2020) Animal Models of Preeclampsia. Hypertension 75:6, pages 1363-1381.
Crossref
Crossref
Hannah R. Turbeville & Jennifer M. Sasser. (2020) Preeclampsia beyond pregnancy: long-term consequences for mother and child. American Journal of Physiology-Renal Physiology 318:6, pages F1315-F1326.
Crossref
Crossref
. (2020) Gestational Hypertension and Preeclampsia. Obstetrics & Gynecology 135:6, pages e237-e260.
Crossref
Crossref
Anouk Pels, Jan Derks, Ayten Elvan-Taspinar, Joris van Drongelen, Marjon de Boer, Hans Duvekot, Judith van Laar, Jim van Eyck, Salwan Al-Nasiry, Marieke Sueters, Marinka Post, Wes Onland, Aleid van Wassenaer-Leemhuis, Christiana Naaktgeboren, Janus C. Jakobsen, Christian Gluud, Ruben G. Duijnhoven, Titia Lely, Sanne Gordijn & Wessel Ganzevoort. (2020) Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction. JAMA Network Open 3:6, pages e205323.
Crossref
Crossref
L. J. Renshall, E. C. Cottrell, E. Cowley, C. P. Sibley, P. N. Baker, E. B. Thorstensen, S. L. Greenwood, M. Wareing & M. R. Dilworth. (2020)
Antenatal sildenafil citrate treatment increases offspring blood pressure in the placental-specific
Igf2
knockout mouse model of FGR
. American Journal of Physiology-Heart and Circulatory Physiology 318:2, pages H252-H263.
Crossref
Crossref
A. Khalil, A. Sharp, C. Cornforth, R. Jackson, H. Mousa, S. Stock, J. Harrold, M. A. Turner, L. C. Kenny, P. N. Baker, E. D. Johnstone, P. Von Dadelszen, L. Magee, A. T. Papageorghiou & Z. Alfirevic. (2020) Effect of sildenafil on maternal hemodynamics in pregnancies complicated by severe early‐onset fetal growth restriction: planned subgroup analysis from a multicenter randomized placebo‐controlled double‐blind trial. Ultrasound in Obstetrics & Gynecology 55:2, pages 198-209.
Crossref
Crossref
Leena Alanne, Amarnath Bhide, Jonna Hoffren, Juulia Lantto, Heikki Huhta, Merja Kokki, Mervi Haapsamo, Ganesh Acharya & Juha Räsänen. (2020) Effects of nifedipine and sildenafil on placental hemodynamics and gas exchange during fetal hypoxemia in a chronic sheep model. Placenta 90, pages 103-108.
Crossref
Crossref
Undurti N. DasUndurti N. Das. 2020. Molecular Biochemical Aspects of Cancer. Molecular Biochemical Aspects of Cancer
41
65
.
Anouk Pels, Janus C. Jakobsen, Wessel Ganzevoort, Christiana A. Naaktgeboren, Wes Onland, Aleid G. van Wassenaer-Leemhuis & Christian Gluud. (2019) Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restriction. Trials 20:1.
Crossref
Crossref
Noémie Simon-Tillaux, Edouard Lecarpentier, Vassilis Tsatsaris & Alexandre Hertig. (2019) Sildenafil for the treatment of preeclampsia, an update: should we still be enthusiastic?. Nephrology Dialysis Transplantation 34:11, pages 1819-1826.
Crossref
Crossref
Jan Deprest, Anne Debeer, Lennart Van der Veeken, Karel Allegaert, Liesbeth Lewi & Luc De Catte. 2019. Fetal Therapy. Fetal Therapy
503
511
.
Katarzyna M. Maksym & Anna L. David. 2019. Fetal Therapy. Fetal Therapy
287
301
.
Laura E. Coats, Gwendolyn K. Davis, Ashley D. Newsome, Norma B. Ojeda & Barbara T. Alexander. (2019) Low Birth Weight, Blood Pressure and Renal Susceptibility. Current Hypertension Reports 21:8.
Crossref
Crossref
Raquel Domingues da Silva Ferreira, Romulo Negrini, Wanderley Marques Bernardo, Ricardo Simões & Sebastião Piato. (2019) The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis. PLOS ONE 14:7, pages e0219732.
Crossref
Crossref
Emilie Hitzerd, Michelle Broekhuizen, Katrina M. Mirabito Colafella, Marija Glisic, René de Vries, Birgit C.P. Koch, Michiel A. de Raaf, Daphne Merkus, Sam Schoenmakers, Irwin K.M. Reiss, A.H. Jan Danser & Sinno H.P. Simons. (2019) Placental effects and transfer of sildenafil in healthy and preeclamptic conditions. EBioMedicine 45, pages 447-455.
Crossref
Crossref
David Basurto, Francesca Maria Russo, Lennart Van der Veeken, Johannes Van der Merwe, Stuart Hooper, Alexandra Benachi, Felix De Bie, Olga Gomez & Jan Deprest. (2019) Prenatal diagnosis and management of congenital diaphragmatic hernia. Best Practice & Research Clinical Obstetrics & Gynaecology 58, pages 93-106.
Crossref
Crossref
Shintaro Maki, Hiroaki Tanaka, Makoto Tsuji, Fumi Furuhashi, Shoichi Magawa, Michiko K. Kaneda, Masafumi Nii, Kayo Tanaka, Eiji Kondo, Satoshi Tamaru, Toru Ogura, Yuki Nishimura, Masayuki Endoh, Tadashi Kimura, Tomomi Kotani, Akihiko Sekizawa & Tomoaki Ikeda. (2019) Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial. Journal of Clinical Medicine 8:6, pages 856.
Crossref
Crossref
Emilie Hitzerd, Michelle Broekhuizen, Rugina I. Neuman, Katrina M. Mirabito Colafella, Daphne Merkus, Sam Schoenmakers, Sinno H.P. Simons, Irwin K.M. Reiss & A.H. Jan Danser. (2019) Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia. Current Pharmaceutical Design 25:5, pages 505-527.
Crossref
Crossref
Francesca M. Russo, Felix De Bie, Ryan Hodges, Alan Flake & Jan Deprest. (2019) Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: From Bench to Bedside. Current Pharmaceutical Design 25:5, pages 601-608.
Crossref
Crossref
Sarah A. Marshall, Annie G. Cox, Laura J. Parry & Euan M. Wallace. (2019) Targeting the vascular dysfunction: Potential treatments for preeclampsia. Microcirculation 26:4, pages e12522.
Crossref
Crossref
KM Groom, LM McCowan, LK Mackay, AC Lee, G Gardener, J Unterscheider, R Sekar, JE Dickinson, P Muller, RA Reid, D Watson, A Welsh, J Marlow, SP Walker, J Hyett, J Morris, PR Stone & PN Baker. (2019) STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early‐onset fetal growth restriction. BJOG: An International Journal of Obstetrics & Gynaecology.
Crossref
Crossref
N. V. Kosovtsova, N. V. Bashmakova, E. O. Okulova, M. V. Pavlichenko & T. V. Markova. (2019) Prenatal non-surgical treatments for pulmonary hypoplasia in congenital diaphragmatic hernia. Rossiiskii vestnik akushera-ginekologa 19:1, pages 46.
Crossref
Crossref
. (2019) ACOG. Obstetrics & Gynecology 133:1, pages 1-1.
Crossref
Crossref
Francesca Maria Russo, Alexandra Benachi, Tim Van Mieghem, Jan De Hoon, Kristel Van Calsteren, Pieter Annaert, Jean-Marc Tréluyer, Karel Allegaert & Jan Deprest. (2018) Antenatal sildenafil administration to prevent pulmonary hypertension in congenital diaphragmatic hernia (SToP-PH): study protocol for a phase I/IIb placenta transfer and safety study. Trials 19:1.
Crossref
Crossref
Francesca M. Russo, Sigrid Conings, Karel Allegaert, Tim Van Mieghem, Jaan Toelen, Kristel Van Calsteren, Pieter Annaert & Jan Deprest. (2018) Sildenafil crosses the placenta at therapeutic levels in a dually perfused human cotyledon model. American Journal of Obstetrics and Gynecology 219:6, pages 619.e1-619.e10.
Crossref
Crossref
Anne Brandolt Larré, Fernando Sontag, Débora Montenegro Pasin, Nathália Paludo, Rayssa Ruszkowski do Amaral, Bartira Ercília Pinheiro da Costa & Carlos Eduardo Poli-de-Figueiredo. (2018) Phosphodiesterase Inhibition in the Treatment of Preeclampsia: What Is New?. Current Hypertension Reports 20:10.
Crossref
Crossref
Edgardo Abalos, Lelia Duley, D Wilhelm Steyn & Celina Gialdini. (2018) Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. Cochrane Database of Systematic Reviews 2018:10.
Crossref
Crossref
Mohammed Maged, Alaa Wageh, Maher Shams & Abdlgawad Elmetwally. (2018) Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial. Taiwanese Journal of Obstetrics and Gynecology 57:4, pages 483-486.
Crossref
Crossref
Robert B. WaltonLuckey C. ReedSarah M. EstradaStacey S. SchmiedeckeDiana L. Villazana-KretzerPeter G. NapolitanoNicholas Ieronimakis. (2018) Evaluation of Sildenafil and Tadalafil for Reversing Constriction of Fetal Arteries in a Human Placenta Perfusion Model. Hypertension 72:1, pages 167-176.
Crossref
Crossref
Fiona C. Brownfoot, Stephen Tong, Natalie J. Hannan, Ping Cannon, Vi Nguyen & Tu'uhevaha J. Kaitu'u-Lino. (2018) Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia. Pregnancy Hypertension 13, pages 1-6.
Crossref
Crossref
JMN Duffy, M Hirsch, L Pealing, M Showell, KS Khan, S Ziebland, RJ McManus, Janneke Hooft, Chris Gale, Mark Brown, William Grobman, Ray Fitzpatrick, S. Ananth Karumanchi, Nuala Lucas, Laura Magee, Ben Mol, Michael Stark, Shakila Thangaratinam, Mathew Wilson, Peter Dadelszen & Paula Williamson. (2017) Inadequate safety reporting in pre‐eclampsia trials: a systematic evaluation. BJOG: An International Journal of Obstetrics & Gynaecology 125:7, pages 795-803.
Crossref
Crossref
Aamod Nawathe & Anna L. David. (2018) Prophylaxis and treatment of foetal growth restriction. Best Practice & Research Clinical Obstetrics & Gynaecology 49, pages 66-78.
Crossref
Crossref
Katie M. Groom & Anna L. David. (2018) The role of aspirin, heparin, and other interventions in the prevention and treatment of fetal growth restriction. American Journal of Obstetrics and Gynecology 218:2, pages S829-S840.
Crossref
Crossref
Andrew Sharp, Christine Cornforth, Richard Jackson, Jane Harrold, Mark A Turner, Louise C Kenny, Philip N Baker, Edward D Johnstone, Asma Khalil, Peter von Dadelszen, Aris T Papageorghiou, Zarko Alfirevic, Umber Agarwal, Elaine Willis, Silvia Mammarella, Geraldine Masson, Joe Aquilina, Elena Greco, Sally Higgins, Dimuthu Vinayagam, Louise Shaw, Louise Stephens, David Howe, Abby Rand, Shalini Patni, Tommy Mousa, Asma Rabab, Helen Russell, Therese Hannon, Andrea Fenn, Mark Kilby, Tara Selman, Anna David, Rebecca Spencer, Kelly Cohen, Andrew Breeze, Alastair McKelvey, Lawrence Impey, Christos Loannou, Sarah Stock, Liona Poon, Dharmintra Pasupathy, Louise Webster & George Bugg. (2018) Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial. The Lancet Child & Adolescent Health 2:2, pages 93-102.
Crossref
Crossref
Andrea Dall’Asta, Valentina Brunelli, Federico Prefumo, Tiziana Frusca & Christoph C Lees. (2017) Early onset fetal growth restriction. Maternal Health, Neonatology and Perinatology 3:1.
Crossref
Crossref
A. Pels, L. C. Kenny, Z. Alfirevic, P. N. Baker, Peter von Dadelszen, C. Gluud, C. T. Kariya, B. W. Mol, A. T. Papageorghiou, A. G. van Wassenaer-Leemhuis, W. Ganzevoort & K. M. Groom. (2017) STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials. BMC Pregnancy and Childbirth 17:1.
Crossref
Crossref
Francesca Maria Russo, Paolo De Coppi, Karel Allegaert, Jaan Toelen, Lennart van der Veeken, George Attilakos, Mary Patrice Eastwood, Anna Louise David & Jan Deprest. (2017) Current and future antenatal management of isolated congenital diaphragmatic hernia. Seminars in Fetal and Neonatal Medicine 22:6, pages 383-390.
Crossref
Crossref
Ines Barone, Cinzia Giordano, Daniela Bonofiglio, Sebastiano Andò & Stefania Catalano. (2017) Phosphodiesterase type 5 and cancers: progress and challenges. Oncotarget 8:58, pages 99179-99202.
Crossref
Crossref
Nina D. PaauwFieke TerstappenWessel GanzevoortJaap A. JolesHendrik GremmelsA. Titia Lely. (2017) Sildenafil During Pregnancy. Hypertension 70:5, pages 998-1006.
Crossref
Crossref
JMN Duffy, M Hirsch, A Kawsar, C Gale, L Pealing, MN Plana, M Showell, PR Williamson, KS Khan, S Ziebland & RJ McManus. (2017) Outcome reporting across randomised controlled trials evaluating therapeutic interventions for pre-eclampsia. BJOG: An International Journal of Obstetrics & Gynaecology 124:12, pages 1829-1839.
Crossref
Crossref
Spencer C Cushen & Styliani Goulopoulou. (2017) New Models of Pregnancy-Associated Hypertension. American Journal of Hypertension 30:11, pages 1053-1062.
Crossref
Crossref
Anne Brandolt Larré, Aline Parisotto, Bruna Fagundes Rockenbach, Débora Montenegro Pasin, Cláudia Capellari, Daniele Cristovão Escouto, Bartira Ercília Pinheiro da Costa & Carlos Eduardo Poli-de-Figueiredo. (2017) Phosphodiesterases and preeclampsia. Medical Hypotheses 108, pages 94-100.
Crossref
Crossref
James A. LambertMatthew A. CarlisleAdam LamSaurabh AggarwalStephen DoranChangchun RenWayne E. BradleyLouis Dell’ItaliaNamasivayam AmbalavananDavid A. FordRakesh P. PatelTamas JillingSadis Matalon. (2017) Mechanisms and Treatment of Halogen Inhalation–Induced Pulmonary and Systemic Injuries in Pregnant Mice. Hypertension 70:2, pages 390-400.
Crossref
Crossref
Hiroaki Tanaka, Michiko Kubo, Masafumi Nii, Sintarou Maki, Takashi Umekawa & Tomoaki Ikeda. (2017) Treatment using tadalafil for severe pre‐eclampsia with fetal growth restriction. Journal of Obstetrics and Gynaecology Research 43:7, pages 1205-1208.
Crossref
Crossref
Frances J Kellie. (2017) Vasodilators for treating intrauterine growth restriction. Cochrane Database of Systematic Reviews.
Crossref
Crossref
Marcelo R Luizon, Ana CT Palei, Ricardo C Cavalli & Valeria C Sandrim. (2017) Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives. Pharmacogenomics 18:6, pages 571-583.
Crossref
Crossref
Rachel D. Williamson, Cathal McCarthy, Fergus P. McCarthy & Louise C. Kenny. (2017) Oxidative stress in pre-eclampsia; have we been looking in the wrong place?. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 8, pages 1-5.
Crossref
Crossref
Nozomi Itani, Katie L. Skeffington, Christian Beck & Dino A. Giussani. (2017) Sildenafil therapy for fetal cardiovascular dysfunction during hypoxic development: studies in the chick embryo. The Journal of Physiology 595:5, pages 1563-1573.
Crossref
Crossref
SARA ORNAGHI & MICHAEL J. PAIDAS. (2017) Novel Therapy for the Treatment of Early-Onset Preeclampsia. Clinical Obstetrics & Gynecology 60:1, pages 169-182.
Crossref
Crossref
Michiko Kubo, Takashi Umekawa, Yuka Maekawa, Hiroaki Tanaka, Masafumi Nii, Nao Murabayashi, Kazuhiro Osato, Yuki Kamimoto & Tomoaki Ikeda. (2017) Retrospective study of tadalafil for fetal growth restriction: Impact on maternal and perinatal outcomes. Journal of Obstetrics and Gynaecology Research 43:2, pages 291-297.
Crossref
Crossref
Nerolen Soobryan, Saravanakumar Murugesan, Wendy Phoswa, Prem Gathiram, Jagidesa Moodley & Irene Mackraj. (2017) The effects of sildenafil citrate on uterine angiogenic status and serum inflammatory markers in an L-NAME rat model of pre-eclampsia. European Journal of Pharmacology 795, pages 101-107.
Crossref
Crossref
Liam Dunn, Vicki Flenady & Sailesh Kumar. (2016) Reducing the risk of fetal distress with sildenafil study (RIDSTRESS): a double-blind randomised control trial. Journal of Translational Medicine 14:1.
Crossref
Crossref
Juncao Chen, Xiaoyuan Gong, Pingyang Chen, Kaiju Luo & Xiuquan Zhang. (2016) Effect of L-arginine and sildenafil citrate on intrauterine growth restriction fetuses: a meta-analysis. BMC Pregnancy and Childbirth 16:1.
Crossref
Crossref
Daphne S. MousHeleen M. KoolMarjon J. Buscop-van KempenAnton H. KoningOleh DzyubachykRene M. H. WijnenDick TibboelRobbert J. Rottier. (2016) Clinically relevant timing of antenatal sildenafil treatment reduces pulmonary vascular remodeling in congenital diaphragmatic hernia. American Journal of Physiology-Lung Cellular and Molecular Physiology 311:4, pages L734-L742.
Crossref
Crossref
Charlotte OystonJoanna L. StanleyMark H. OliverFrank H. BloomfieldPhilip N. Baker. (2016) Maternal Administration of Sildenafil Citrate Alters Fetal and Placental Growth and Fetal–Placental Vascular Resistance in the Growth-Restricted Ovine Fetus. Hypertension 68:3, pages 760-767.
Crossref
Crossref
Caitriona Monaghan & Baskaran Thilaganathan. (2016) Fetal Growth Restriction (FGR): How the Differences Between Early and Late FGR Impact on Clinical Management?. Journal of Fetal Medicine 3:3, pages 101-107.
Crossref
Crossref
Alberto Trapani, Luis Flavio Gonçalves, Thamyris Finger Trapani, Simone Vieira, Marilen Pires & Maria Marlene de Souza Pires. (2016) Perinatal and Hemodynamic Evaluation of Sildenafil Citrate for Preeclampsia Treatment. Obstetrics & Gynecology 128:2, pages 253-259.
Crossref
Crossref
A. TrapaniJrJr, L. F. Gonçalves, T. F. Trapani, M. J. Franco, R. N. Galluzzo & M. M. S. Pires. (2016) Comparison between transdermal nitroglycerin and sildenafil citrate in intrauterine growth restriction: effects on uterine, umbilical and fetal middle cerebral artery pulsatility indices. Ultrasound in Obstetrics & Gynecology 48:1, pages 61-65.
Crossref
Crossref
Suzanne D. Burke, Zsuzsanna K. Zsengellér, Eliyahu V. Khankin, Agnes S. Lo, Augustine Rajakumar, Jennifer J. DuPont, Amy McCurley, Mary E. Moss, Dongsheng Zhang, Christopher D. Clark, Alice Wang, Ellen W. Seely, Peter M. Kang, Isaac E. Stillman, Iris Z. Jaffe & S. Ananth Karumanchi. (2016) Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. Journal of Clinical Investigation 126:7, pages 2561-2574.
Crossref
Crossref
Angela MakrisKristen R. YeungShirlene M. LimNeroli SunderlandScott HeffernanJohn F. ThompsonJim IliopoulosMurray C. KillingsworthJim YongBei XuRobert F. OgleRavi ThadhaniS. Ananth KarumanchiAnnemarie Hennessy. (2016) Placental Growth Factor Reduces Blood Pressure in a Uteroplacental Ischemia Model of Preeclampsia in Nonhuman Primates. Hypertension 67:6, pages 1263-1272.
Crossref
Crossref
Ellen E. GillisJennifer N. MooneyMichael R. GarrettJoey P. GrangerJennifer M. Sasser. (2016) Sildenafil Treatment Ameliorates the Maternal Syndrome of Preeclampsia and Rescues Fetal Growth in the Dahl Salt–Sensitive Rat. Hypertension 67:3, pages 647-653.
Crossref
Crossref
Lena Erlandsson, Åsa Nääv, Annemarie Hennessy, Daniel Vaiman, Magnus Gram, Bo Åkerström & Stefan R. Hansson. (2016) Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities. American Journal of Reproductive Immunology 75:3, pages 402-410.
Crossref
Crossref
Andrew N Sharp & Zarko Alfirevic. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.
Aiko Kakigano, Takuji Tomimatsu, Kazuya Mimura, Tomoko Kanayama, Satoko Fujita, Kenji Minato, Keiichi Kumasawa, Yukiko Taniguchi, Takeshi Kanagawa, Masayuki Endo, Tomoaki Ishihara, Takushi Namba, Tohru Mizushima & Tadashi Kimura. (2015) Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening: Phosphodiesterase-5 Inhibitor Vardenafil Restores Endothelial Dysfunction via Induction of Placental Growth Factor. Reproductive Sciences 22:10, pages 1272-1280.
Crossref
Crossref
Elizabeth Cottrell & Colin Sibley. (2015) From Pre-Clinical Studies to Clinical Trials: Generation of Novel Therapies for Pregnancy Complications. International Journal of Molecular Sciences 16:12, pages 12907-12924.
Crossref
Crossref
Jay M. Bolnick, Brian A. Kilburn, Alan D. Bolnick, Michael P. Diamond, Manvinder Singh, Michael Hertz, Jing Dai & D. Randall Armant. (2015) Sildenafil stimulates human trophoblast invasion through nitric oxide and guanosine 3′,5′-cyclic monophosphate signaling. Fertility and Sterility 103:6, pages 1587-1595.e2.
Crossref
Crossref
Fernanda Sales Luiz Vianna, Lavinia Schüler-Faccini & Corinna Weber-Schöndorfer. 2015. Drugs During Pregnancy and Lactation. Drugs During Pregnancy and Lactation
193
223
.
Wessel Ganzevoort, Zarko Alfirevic, Peter von Dadelszen, Louise Kenny, Aris Papageorghiou, Aleid van Wassenaer-Leemhuis, Christian Gluud, Ben Willem Mol & Philip N Baker. (2014) STRIDER: Sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction – a protocol for a systematic review with individual participant data and aggregate data meta-analysis and trial sequential analysis. Systematic Reviews 3:1.
Crossref
Crossref
Cerine Jeanty, Shaun M. Kunisaki & Tippi C. MacKenzie. (2014) Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia. Seminars in Fetal and Neonatal Medicine 19:6, pages 349-356.
Crossref
Crossref
Eric M. George. (2014) New Approaches for Managing Preeclampsia: Clues From Clinical and Basic Research. Clinical Therapeutics 36:12, pages 1873-1881.
Crossref
Crossref
Tamanrit Johal, Christoph C. Lees, Thomas R. Everett & Ian B. Wilkinson. (2014) The nitric oxide pathway and possible therapeutic options in pre-eclampsia. British Journal of Clinical Pharmacology 78:2, pages 244-257.
Crossref
Crossref
R. N. Spencer, D. J. Carr & A. L. David. (2014) Treatment of poor placentation and the prevention of associated adverse outcomes - what does the future hold?. Prenatal Diagnosis 34:7, pages 677-684.
Crossref
Crossref
Christine Fenton, Sebastian R. Hobson, Euan M. Wallace & Rebecca Lim. (2014) Future therapies for pre-eclampsia: beyond treading water. Australian and New Zealand Journal of Obstetrics and Gynaecology 54:1, pages 3-8.
Crossref
Crossref
Jae Hyeok JeongHwi Gon KimOok Hwan Choi. (2014) Sildenafil Inhibits Advanced Glycation End Products-induced sFlt-1 Release Through Upregulation of Heme Oxygenase-1. Journal of Menopausal Medicine 20:2, pages 57.
Crossref
Crossref
Eveline H. Shue, Samuel C. Schecter, Wenhui Gong, Mozziyar Etemadi, Michael Johengen, Corey Iqbal, S. Christopher Derderian, Peter Oishi, Jeffrey R. Fineman & Doug Miniati. (2014) Antenatal maternally-administered phosphodiesterase type 5 inhibitors normalize eNOS expression in the fetal lamb model of congenital diaphragmatic hernia. Journal of Pediatric Surgery 49:1, pages 39-45.
Crossref
Crossref
John W. Downing, Curtis L. Baysinger, Raymond F. Johnson & Ray L. Paschall. (2013) Review: Potential druggable targets for the treatment of early onset preeclampsia. Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health 3:4, pages 203-210.
Crossref
Crossref
Eric M. George, Ana C. Palei, Edward A. Dent & Joey P. Granger. (2013) Sildenafil attenuates placental ischemia-induced hypertension. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 305:4, pages R397-R403.
Crossref
Crossref
Lelia Duley, Shireen Meher & Leanne Jones. (2013) Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database of Systematic Reviews.
Crossref
Crossref
V Mehta, K N Abi-Nader, D M Peebles, E Benjamin, V Wigley, B Torondel, E Filippi, S W Shaw, M Boyd, J Martin, I Zachary & A L David. (2011) Long-term increase in uterine blood flow is achieved by local overexpression of VEGF-A165 in the uterine arteries of pregnant sheep. Gene Therapy 19:9, pages 925-935.
Crossref
Crossref
Joanna L. StanleyIrene J. AnderssonRajan PoudelChristian F. Rueda-ClausenColin P. SibleySandra T. DavidgePhilip N. Baker. (2012)
Sildenafil Citrate Rescues Fetal Growth in the Catechol-
O
-Methyl Transferase Knockout Mouse Model
. Hypertension 59:5, pages 1021-1028.
Crossref
Crossref
. 2012. Arzneimittel in Schwangerschaft und Stillzeit. Arzneimittel in Schwangerschaft und Stillzeit
33
574
.
Eric M. George & Joey P. Granger. 2012. Muscle. Muscle
1329
1337
.
Eric M. George & Joey P. Granger. (2011) Mechanisms and Potential Therapies for Preeclampsia. Current Hypertension Reports 13:4, pages 269-275.
Crossref
Crossref
F.P. McCarthy, J.C. Kingdom, L.C. Kenny & S.K. Walsh. (2011) Animal models of preeclampsia; uses and limitations. Placenta 32:6, pages 413-419.
Crossref
Crossref
P von Dadelszen, S Dwinnell, LA Magee, BC Carleton, A Gruslin, B Lee, KI Lim, RM Liston, SP Miller, D Rurak, RL Sherlock, MA Skoll, MM Wareing & PN Baker. (2011) Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. BJOG: An International Journal of Obstetrics & Gynaecology 118:5, pages 624-628.
Crossref
Crossref
C. Randall Lane & Terence K. Trow. (2011) Pregnancy and Pulmonary Hypertension. Clinics in Chest Medicine 32:1, pages 165-174.
Crossref
Crossref
Jennifer M. Sasser & Chris Baylis. (2010) Effects of sildenafil on maternal hemodynamics and fetal growth in normal rat pregnancy. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298:2, pages R433-R438.
Crossref
Crossref
Shireen Meher & Lelia Duley. (2007) Nitric oxide for preventing pre-eclampsia and its complications. Cochrane Database of Systematic Reviews 2010:2.
Crossref
Crossref
Lelia Duley, David J Henderson-Smart & Shireen Meher. 1996. Cochrane Database of Systematic Reviews. Cochrane Database of Systematic Reviews.