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Clinical and Experimental Hypertension Volume 34, 2012 - Issue 8
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Research Article

Effect of Amiloride and Spironolactone on Renal Tubular Function, Ambulatory Blood Pressure, and Pulse Wave Velocity in Healthy Participants in a Double-Blinded, Randomized, Placebo-Controlled, Crossover Trial

Solveig Klok MatthesenDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, DenmarkCorrespondence[email protected]
,
Thomas LarsenDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
,
Thomas Guldager LauridsenDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
,
Henrik VaseDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
,
Pia Holland GjørupDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
,
Karen Marie NykjærDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
,
Søren NielsenThe Water and Salt Research Center, Institute of Anatomy, University of Aarhus Denmark, Aarhus, Denmark
&
Erling Bjerregaard PedersenDepartment of Medical Research, Holstebro Hospital and University of Aarhus, Holstebro, Denmark;Department of Medicine, Holstebro Hospital and University of Aarhus, Holstebro, Denmark
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Pages 588-600 | Received 21 Feb 2012, Accepted 26 Mar 2012, Published online: 16 May 2012

Citations (13)

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Frank H. Mose, Thomas Larsen, Janni M. Jensen, Annebirthe B. Hansen, Jesper N. Bech & Erling B. Pedersen. (2014) Effect of atorvastatin on renal NO availability and tubular function in patients with stage II-III chronic kidney disease and type 2 diabetes. Scandinavian Journal of Clinical and Laboratory Investigation 74:1, pages 8-19.
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Articles from other publishers (12)

M. H. Malmberg, F. H. Mose, E. B. Pedersen & J. N. Bech. (2020) A Comparison of Urine Dilution Ability between Adult Dominant Polycystic Kidney Disease, Other Chronic Kidney Diseases, and Healthy Control Subjects: A Case-Control Study. International Journal of Nephrology 2020, pages 1-12.
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M. H. Malmberg, F. H. Mose, E. B. Pedersen & J. N. Bech. (2020) Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study. BMC Nephrology 21:1.
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Qianhui Sun & Peter Sever. (2020) Amiloride: A review. Journal of the Renin-Angiotensin-Aldosterone System 21:4, pages 147032032097589.
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Safa Al Therwani, My Emma Sofie Malmberg, Jeppe Bakkestroem Rosenbaek, Jesper Noergaard Bech & Erling Bjerregaard Pedersen. (2017) Effect of tolvaptan on renal handling of water and sodium, GFR and central hemodynamics in autosomal dominant polycystic kidney disease during inhibition of the nitric oxide system: a randomized, placebo-controlled, double blind, crossover study. BMC Nephrology 18:1.
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Safa Al Therwani, Jeppe Bakkestrøm Rosenbæk, Frank Holden Mose, Jesper Nørgaard Bech & Erling Bjerregaard Pedersen. (2017) Effect of tolvaptan on renal water and sodium excretion and blood pressure during nitric oxide inhibition: a dose-response study in healthy subjects. BMC Nephrology 18:1.
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Jeppe Bakkestroem Rosenbaek, Safa Al Therwani, Janni Majgaard Jensen, Frank Holden Mose, Christine Wandall-Frostholm, Erling Bjerregaard Pedersen & Jesper Noergaard Bech. (2017) Effect of sodium nitrite on renal function and sodium and water excretion and brachial and central blood pressure in healthy subjects: a dose-response study. American Journal of Physiology-Renal Physiology 313:2, pages F378-F387.
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Niels Frederik Breum Jakobsen, Esben Laugesen, Lars Rolighed, Peter H Nissen, Per Løgstrup Poulsen, Erling Bjerregaard Pedersen, Leif Mosekilde & Lars Rejnmark. (2016) The cardiovascular system in familial hypocalciuric hypercalcemia: a cross-sectional study on physiological effects of inactivating variants in the calcium-sensing receptor gene. European Journal of Endocrinology 175:4, pages 299-309.
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Xiaohua HuangEvert Dorhout MeesPieter Vos, Shereen Hamza & Branko Braam. (2016) Everything we always wanted to know about furosemide but were afraid to ask. American Journal of Physiology-Renal Physiology 310:10, pages F958-F971.
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Frank H. Mose, Janni M. Jensen, Safa Therwani, Jesper Mortensen, Annebirthe B. Hansen, Jesper N. Bech & Erling B. Pedersen. (2015) Effect of nebivolol on renal nitric oxide availability and tubular function in patients with essential hypertension. British Journal of Clinical Pharmacology 80:3, pages 425-435.
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Safa Al Therwani, Frank Holden Mose, Janni Majgaard Jensen, Jesper Nørgaard Bech & Erling Bjerregaard Pedersen. (2014) Effect of vasopressin antagonism on renal handling of sodium and water and central and brachial blood pressure during inhibition of the nitric oxide system in healthy subjects. BMC Nephrology 15:1.
Crossref
Frank Holden Mose, Thomas Larsen, Janni Majgaard Jensen, Annebirthe Bo Hansen, Jesper Nørgaard Bech & Erling Bjerregaard Pedersen. (2014) Effects of atorvastatin on systemic and renal NO dependency in patients with non-diabetic stage II-III chronic kidney disease. British Journal of Clinical Pharmacology 78:4, pages 789-799.
Crossref
Thomas Larsen, Frank H Mose, Jesper N Bech & Erling B Pedersen. (2013) Effect of paricalcitol on renin and albuminuria in non-diabetic stage III-IV chronic kidney disease: a randomized placebo-controlled trial. BMC Nephrology 14:1.
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