445
Views
70
CrossRef citations to date
0
Altmetric
Research Article

The role of hypothiocyanous acid (HOSCN) in biological systems

Pages 1147-1158 | Received 18 Jun 2009, Published online: 12 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jörg Flemmig, Jana Gau, Denise Schlorke & Jürgen Arnhold. (2016) Lactoperoxidase as a potential drug target. Expert Opinion on Therapeutic Targets 20:4, pages 447-461.
Read now
P. E. Morgan, R. P. Laura, R. A. Maki, W. F. Reynolds & M. J. Davies. (2015) Thiocyanate supplementation decreases atherosclerotic plaque in mice expressing human myeloperoxidase. Free Radical Research 49:6, pages 743-749.
Read now
P. E. Nedoboy, P. E. Morgan, T. J. Mocatta, A. M. Richards, C. C. Winterbourn & M. J. Davies. (2014) High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction. Free Radical Research 48:10, pages 1256-1266.
Read now
David I. Pattison, Michael J. Davies & Clare L. Hawkins. (2012) Reactions and reactivity of myeloperoxidase-derived oxidants: Differential biological effects of hypochlorous and hypothiocyanous acids. Free Radical Research 46:8, pages 975-995.
Read now
Vihas T. Vasu, Sharon J. de Cruz, Jessica S. Houghton, Keri A. Hayakawa, Brian M. Morrissey, Carroll E. Cross & Jason P. Eiserich. (2011) Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase. Free Radical Research 45:2, pages 165-176.
Read now

Articles from other publishers (65)

Xing Zhang, Shuqi Xu, Christine Y. Chuang, Brian J. Day, Clare L. Hawkins & Michael J. Davies. (2024) Selenocyanate (SeCN−) acts as an efficient competitive substrate for myeloperoxidase and decreases biological damage induced by hypochlorous acid. Redox Biochemistry and Chemistry 7, pages 100018.
Crossref
Stephanie M. Bozonet, Nicholas J. Magon, Abigail J. Schwartfeger, Andreas Konigstorfer, Sarah G. Heath, Margreet C.M. Vissers, Vanessa K. Morris, Christoph Göbl, James M. Murphy, Guy S. Salvesen & Mark B. Hampton. (2023) Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis. Journal of Biological Chemistry 299:6, pages 104792.
Crossref
Shuqi Xu, Christine Y. Chuang, Ernst Malle, Luke F. Gamon, Clare L. Hawkins & Michael J. Davies. (2022) Influence of plasma halide, pseudohalide and nitrite ions on myeloperoxidase-mediated protein and extracellular matrix damage. Free Radical Biology and Medicine 188, pages 162-174.
Crossref
V. V. Salmin, A. V. Morgun, R. Ya. Olovyannikova, V. A. Kutyakov, E. V. Lychkovskaya, E. B. Brusina & A. B. Salmina. (2022) Atmospheric Reactive Oxygen Species and Some Aspects of the Antiviral Protection at the Respiratory Epithelium. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 16:2, pages 79-90.
Crossref
Jürgen Arnhold & Ernst Malle. (2022) Halogenation Activity of Mammalian Heme Peroxidases. Antioxidants 11:5, pages 890.
Crossref
Ari Zeida & Rafael Radi. 2022. Redox Chemistry and Biology of Thiols. Redox Chemistry and Biology of Thiols 99 113 .
Jürgen Arnhold. (2021) Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces. Antioxidants 10:11, pages 1805.
Crossref
Lyudmila V. Bel'skaya & Elena A. Sarf. (2021) Biochemical composition and characteristics of salivary FTIR spectra: Correlation analysis. Journal of Molecular Liquids 341, pages 117380.
Crossref
V.V. Salmin, A.V. Morgun, R.Ya. Olovyannikova, V.A. Kutyakov, E.V. Lychkovskaya, E.B. Brusina & A.B. Salmina. (2021) Atmospheric reactive oxygen species and some aspects of the antiviral protection of the respiratory epithelium. Biomeditsinskaya Khimiya 67:5, pages 383-393.
Crossref
Sinead T. Morrin, Rachael H. Buck, Michael Farrow & Rita M. Hickey. (2021) Milk-derived anti-infectives and their potential to combat bacterial and viral infection. Journal of Functional Foods 81, pages 104442.
Crossref
Saad S. Al-Shehri. (2021) Reactive oxygen and nitrogen species and innate immune response. Biochimie 181, pages 52-64.
Crossref
Agnes Ulfig & Lars I. Leichert. (2020) The effects of neutrophil-generated hypochlorous acid and other hypohalous acids on host and pathogens. Cellular and Molecular Life Sciences 78:2, pages 385-414.
Crossref
Lilit Tonoyan, Diego Montagner, Ruairi Friel & Vincent O'Flaherty. (2020) Antimicrobials offered from nature: Peroxidase-catalyzed systems and their mimics. Biochemical Pharmacology 182, pages 114281.
Crossref
Jürgen Arnhold. (2020) The Dual Role of Myeloperoxidase in Immune Response. International Journal of Molecular Sciences 21:21, pages 8057.
Crossref
Yuyang Liu, Thomas Burton, Benjamin Saul Rayner, Patrick T. San Gabriel, Han Shi, Mary El Kazzi, XiaoSuo Wang, Joanne M. Dennis, Gulfam Ahmad, Angie L. Schroder, Antony Gao, Paul Kenneth Witting & Belal Chami. (2020) The role of sodium thiocyanate supplementation during dextran sodium sulphate-stimulated experimental colitis. Archives of Biochemistry and Biophysics 692, pages 108490.
Crossref
Adam Sikora, Jacek Zielonka, Karolina Dębowska, Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Radosław Podsiadły, Angelika Artelska, Karolina Pierzchała & Balaraman Kalyanaraman. (2020) Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology. Frontiers in Chemistry 8.
Crossref
T. I. Shlapakova, R. K. Kostin & E. E. Tyagunova. (2020) Reactive Oxygen Species: Participation in Cellular Processes and Progression of Pathology. Russian Journal of Bioorganic Chemistry 46:5, pages 657-674.
Crossref
Boushra Bathish, Martina Paumann-Page, Louise N. Paton, Anthony J. Kettle & Christine C. Winterbourn. (2020) Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Journal of Biological Chemistry 295:36, pages 12697-12705.
Crossref
Aicha Benabdelkrim, Ala Eddine Tourchi, Dalila Hammoutène, Saida Ben Yaghlane, Hassan H. Abdallah, Roberto Linguerri & Majdi Hochlaf. (2020) Characterization of the simplest sulfenyl thiocyanate: isomers, spectroscopy and implications of astrophysical and biological relevance. Physical Chemistry Chemical Physics 22:30, pages 17052-17061.
Crossref
Jürgen Arnhold. 2020. Cell and Tissue Destruction. Cell and Tissue Destruction 23 54 .
Marcin Magacz, Karolina Kędziora, Jacek Sapa & Wirginia Krzyściak. (2019) The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products. International Journal of Molecular Sciences 20:6, pages 1443.
Crossref
Belal Chami, Nathan J.J. Martin, Joanne M. Dennis & Paul K. Witting. (2018) Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease. Archives of Biochemistry and Biophysics 645, pages 61-71.
Crossref
Harald Below, Romy Baguhl, Wiebke Geßner, Axel Kramer, Elke Below, Heike Kahlert & Alexander Welk. (2018) Specific and robust ion chromatographic determination of hypothiocyanite in saliva samples. Analytical and Bioanalytical Chemistry 410:11, pages 2739-2749.
Crossref
Jana Gau, Jürgen Arnhold & Jörg Flemmig. (2018) Reactivation of peroxidase activity in human saliva samples by polyphenols. Archives of Oral Biology 85, pages 70-78.
Crossref
Ajoe John Kattoor, Naga Venkata K Pothineni, Deepak Palagiri & Jawahar L. Mehta. (2017) Oxidative Stress in Atherosclerosis. Current Atherosclerosis Reports 19:11.
Crossref
Farzaneh Sarrami, Li-Juan Yu & Amir Karton. (2017) Computational design of bio-inspired carnosine-based HOBr antioxidants. Journal of Computer-Aided Molecular Design 31:10, pages 905-913.
Crossref
Jana Gau, Martine Prévost, Pierre Van Antwerpen, Menyhárt-Botond Sarosi, Steffen Rodewald, Jürgen Arnhold & Jörg Flemmig. (2017) Tannins and Tannin-Related Derivatives Enhance the (Pseudo-)Halogenating Activity of Lactoperoxidase. Journal of Natural Products 80:5, pages 1328-1338.
Crossref
Esmail M. El-Fakharany, Vladimir N. Uversky & Elrashdy M. Redwan. (2016) Comparative Analysis of the Antiviral Activity of Camel, Bovine, and Human Lactoperoxidases Against Herpes Simplex Virus Type 1. Applied Biochemistry and Biotechnology 182:1, pages 294-310.
Crossref
Martina Paumann-Page, Romy-Sophie Katz, Marzia Bellei, Irene Schwartz, Eva Edenhofer, Benjamin Sevcnikar, Monika Soudi, Stefan Hofbauer, Gianantonio Battistuzzi, Paul G. Furtmüller & Christian Obinger. (2017) Pre-steady-state Kinetics Reveal the Substrate Specificity and Mechanism of Halide Oxidation of Truncated Human Peroxidasin 1. Journal of Biological Chemistry 292:11, pages 4583-4592.
Crossref
Karla Cervantes Gracia, Daniel Llanas-Cornejo & Holger Husi. (2017) CVD and Oxidative Stress. Journal of Clinical Medicine 6:2, pages 22.
Crossref
Kenji Izuhara, Shoichi Suzuki, Masahiro Ogawa, Satoshi Nunomura, Yasuhiro Nanri, Yasutaka Mitamura & Tomohito Yoshihara. (2017) The Significance of Hypothiocyanite Production via the Pendrin/DUOX/Peroxidase Pathway in the Pathogenesis of Asthma. Oxidative Medicine and Cellular Longevity 2017, pages 1-7.
Crossref
Françoise Bafort, Olivier Parisi, Jean-Paul Perraudin & Mohammed Haïssam Jijakli. (2017) The Lactoperoxidase System: a Natural Biochemical Biocontrol Agent for Pre- and Postharvest Applications. Journal of Phytopathology 165:1, pages 22-34.
Crossref
Kenji Izuhara, Shoichi Suzuki, Charity Nofziger, Masahiro Ogawa, Shoichiro Ohta, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Nicoletta Pedemonte, Luis J. V. Galietta & Markus Paulmichl. 2017. The Role of Pendrin in Health and Disease. The Role of Pendrin in Health and Disease 141 154 .
Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, Satoshi Nunomura, Yasuhiro Nanri, Hiroshi Shiraishi, Yasutaka Mitamura, Tomohito Yoshihara, James J. Lee & Kenji Izuhara. (2016) Induction of Airway Allergic Inflammation by Hypothiocyanite via Epithelial Cells. Journal of Biological Chemistry 291:53, pages 27219-27227.
Crossref
Shoichi Suzuki, Masahiro Ogawa, Shoichiro Ohta, Kazuhiko Arima, Satoshi Nunomura, Yasuhiro Nanri, Yasutaka Mitamura, Tomohito Yoshihara, Yutaka Nakamura, Kohei Yamauchi, Kazuyuki Chibana, Yoshiki Ishii, James J. Lee, Yasuaki Aratani, Shigeru Kakuta, Sachiko Kubo, Yoichiro Iwakura, Hiroki Yoshida & Kenji Izuhara. (2016) The potential for repositioning antithyroid agents as antiasthma drugs. Journal of Allergy and Clinical Immunology 138:5, pages 1458-1461.e8.
Crossref
Denise Schlorke, Jörg Flemmig, Jana Gau, Paul G. Furtmüller, Christian Obinger & Jürgen Arnhold. (2016) New insights into thiocyanate oxidation by human myeloperoxidase. Journal of Inorganic Biochemistry 162, pages 117-126.
Crossref
Dragana Odobasic, A. Richard Kitching & Stephen R. Holdsworth. (2016) Neutrophil-Mediated Regulation of Innate and Adaptive Immunity: The Role of Myeloperoxidase. Journal of Immunology Research 2016, pages 1-11.
Crossref
Denise Schlorke, Jörg Flemmig, Claudia Birkemeyer & Jürgen Arnhold. (2016) Formation of cyanogen iodide by lactoperoxidase. Journal of Inorganic Biochemistry 154, pages 35-41.
Crossref
Anthony J. Kettle & Christine C. Winterbourn. 2015. Heme Peroxidases. Heme Peroxidases 272 308 .
Elrashdy M. Redwan, Hussein A. Almehdar, Esmail M. EL-Fakharany, Abdul-Wahab K. Baig & Vladimir N. Uversky. (2015) Potential antiviral activities of camel, bovine, and human lactoperoxidases against hepatitis C virus genotype 4. RSC Advances 5:74, pages 60441-60452.
Crossref
F. Bafort, O. Parisi, J.-P. Perraudin & M. H. Jijakli. (2014) Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review. Enzyme Research 2014, pages 1-13.
Crossref
Benjamin S. Rayner, Dominic T. Love & Clare L. Hawkins. (2014) Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells. Free Radical Biology and Medicine 71, pages 240-255.
Crossref
Anthony J. Kettle, Amelia M. Albrett, Anna L. Chapman, Nina Dickerhof, Louisa V. Forbes, Irada Khalilova & Rufus Turner. (2014) Measuring chlorine bleach in biology and medicine. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:2, pages 781-793.
Crossref
Michael T. Ashby. 2014. Systems Biology of Free Radicals and Antioxidants. Systems Biology of Free Radicals and Antioxidants 3873 3897 .
Dragana OdobasicA. Richard Kitching, Yuan YangKim M. O’SullivanRuth C. M. MuljadiKristy L. EdgttonDiana S. Y. TanShaun A. Summers, Eric F. MorandStephen R. Holdsworth. (2013) Neutrophil myeloperoxidase regulates T-cell−driven tissue inflammation in mice by inhibiting dendritic cell function. Blood 121:20, pages 4195-4204.
Crossref
József Kalmár, Gábor Lente & István Fábián. (2013) Detailed Kinetics and Mechanism of the Oxidation of Thiocyanate Ion (SCN – ) by Peroxomonosulfate Ion (HSO 5 – ). Formation and Subsequent Oxidation of Hypothiocyanite Ion (OSCN – ) . Inorganic Chemistry 52:4, pages 2150-2156.
Crossref
Debabrata Chatterjee, Barnali Paul & Rupa Mukherjee. (2013) Oxidation of thiocyanate with H2O2 catalyzed by [RuIII(edta)(H2O)]−. Dalton Transactions 42:27, pages 10056.
Crossref
Mauro Lo Conte & Kate S. Carroll. 2013. Oxidative Stress and Redox Regulation. Oxidative Stress and Redox Regulation 1 42 .
Joshua D. Chandler & Brian J. Day. (2012) THIOCYANATE: A potentially useful therapeutic agent with host defense and antioxidant properties. Biochemical Pharmacology 84:11, pages 1381-1387.
Crossref
Virender K. Sharma. 2012. Oxidation of Amino Acids, Peptides, and Proteins. Oxidation of Amino Acids, Peptides, and Proteins 78 121 .
Jihan Talib, David I. Pattison, Jason A. Harmer, David S. Celermajer & Michael J. Davies. (2012) High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine. Free Radical Biology and Medicine 53:1, pages 20-29.
Crossref
Rainer Bischoff & Hartmut Schlüter. (2012) Amino acids: Chemistry, functionality and selected non-enzymatic post-translational modifications. Journal of Proteomics 75:8, pages 2275-2296.
Crossref
Tessa J. Barrett, David I. Pattison, Stephen E. Leonard, Kate S. Carroll, Michael J. Davies & Clare L. Hawkins. (2012) Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates. Free Radical Biology and Medicine 52:6, pages 1075-1085.
Crossref
Naomi L. Cook, Helena M. Viola, Victor S. Sharov, Livia C. Hool, Christian Schöneich & Michael J. Davies. (2012) Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells. Free Radical Biology and Medicine 52:5, pages 951-961.
Crossref
Tessa J. Barrett & Clare L. Hawkins. (2011) Hypothiocyanous Acid: Benign or Deadly?. Chemical Research in Toxicology 25:2, pages 263-273.
Crossref
Noriyuki Akahoshi, Itsuko Ishizaki, Masayuki Naya, Toshihiko Maekawa, Shougo Yamazoe, Tadashi Horiuchi, Mayumi Kajimura, Yoshiharu Ohashi, Makoto Suematsu & Isao Ishii. (2011) TOF-SIMS imaging of halide/thiocyanate anions and hydrogen sulfide in mouse kidney sections using silver-deposited plates. Analytical and Bioanalytical Chemistry 402:5, pages 1859-1864.
Crossref
Michael J. Davies. 2012. Encyclopedia of Radicals in Chemistry, Biology and Materials. Encyclopedia of Radicals in Chemistry, Biology and Materials.
Ojia Skaff, David I. Pattison, Philip E. Morgan, Rushad Bachana, Vimal K. Jain, K. Indira Priyadarsini & Michael J. Davies. (2011) Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage. Biochemical Journal 441:1, pages 305-316.
Crossref
Michael T. Ashby. 2012. Inorganic/Bioinorganic Reaction Mechanisms. Inorganic/Bioinorganic Reaction Mechanisms 263 303 .
József Kalmár, Kelemu L. Woldegiorgis, Bernadett Biri & Michael T. Ashby. (2011) Mechanism of Decomposition of the Human Defense Factor Hypothiocyanite Near Physiological pH. Journal of the American Chemical Society 133:49, pages 19911-19921.
Crossref
Philip E. Morgan, David I. Pattison, Jihan Talib, Fiona A. Summers, Jason A. Harmer, David S. Celermajer, Clare L. Hawkins & Michael J. Davies. (2011) High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. Free Radical Biology and Medicine 51:9, pages 1815-1822.
Crossref
Imad Al Ghouleh, Nicholas K.H. Khoo, Ulla G. Knaus, Kathy K. Griendling, Rhian M. Touyz, Victor J. Thannickal, Aaron Barchowsky, William M. Nauseef, Eric E. Kelley, Phillip M. Bauer, Victor Darley-Usmar, Sruti Shiva, Eugenia Cifuentes-Pagano, Bruce A. Freeman, Mark T. Gladwin & Patrick J. Pagano. (2011) Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling. Free Radical Biology and Medicine 51:7, pages 1271-1288.
Crossref
David I. Pattison, Robert J. O’Reilly, Ojia Skaff, Leo Radom, Robert F. Anderson & Michael J. Davies. (2011) One-Electron Reduction of N -Chlorinated and N -Brominated Species Is a Source of Radicals and Bromine Atom Formation . Chemical Research in Toxicology 24:3, pages 371-382.
Crossref
Amanda E. Lane, Joanne T. M. Tan, Clare L. Hawkins, Alison K. Heather & Michael J. Davies. (2010) The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochemical Journal 430:1, pages 161-169.
Crossref
Michael J. Davies. (2010) Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. Journal of Clinical Biochemistry and Nutrition 48:1, pages 8-19.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.