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Research Article

Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats

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Pages 668-678 | Received 30 Jan 2010, Published online: 07 Apr 2010

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Muaz Belviranli, Hakkı Gökbel, Nilsel Okudan & Sadık Büyükbaş. (2012) Oxidative stress and anti-oxidant status in diabetic rat liver: Effect of plant polyphenols. Archives of Physiology and Biochemistry 118:5, pages 237-243.
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Articles from other publishers (29)

Fahad A. Al-Abbasi & Imran Kazmi. (2022) Therapeutic role of kaempferol and myricetin in streptozotocin-induced diabetes synergistically via modulation in pancreatic amylase, glycogen storage and insulin secretion. Molecular and Cellular Biochemistry 478:9, pages 1927-1937.
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Chun-Sik Bae, Youngchan Lee & Taeho Ahn. (2023) Therapeutic treatments for diabetes mellitus-induced liver injury by regulating oxidative stress and inflammation. Applied Microscopy 53:1.
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Xinxin LIU, Chuan HE & Tomoyuki KOYAMA. (2023) D-Pinitol Ameliorated Osteoporosis via Elevating D-<i>chiro</i>-Inositol Level in Ovariectomized Mice. Journal of Nutritional Science and Vitaminology 69:3, pages 220-228.
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Xinxin Liu & Tomoyuki Koyama. (2023) D-Pinitol Improved Glucose Metabolism and Inhibited Bone Loss in Mice with Diabetic Osteoporosis. Molecules 28:9, pages 3870.
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Sara Arefhosseini, Neda Roshanravan, Samira Asghari, Helda Tutunchi & Mehrangiz Ebrahimi-Mameghani. (2023) Expression of inflammatory genes, WBC-derived inflammatory biomarkers and liver function indices: Effects of myo-inositol supplementation in obese patients with NAFLD. Journal of Functional Foods 104, pages 105524.
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Anandakumar Pandi, Vanitha Manickam Kalappan & Naveenkumar Chandrashekar. (2022) Effects of d-pinitol on diabetes mellitus: an updated review. Bulletin of the National Research Centre 46:1.
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Anandakumar Pandi, Kamaraj Sattu, Vanitha M. Kalappan, Vanita Lal, Seshadri R. Varikasuvu, Anirban Ganguly & Jitender Prasad. (2022) Pharmacological effects of D‐Pinitol – A comprehensive review . Journal of Food Biochemistry 46:10.
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Dina Medina‐Vera, Juan Antonio Navarro, Patricia Rivera, Cristina Rosell‐Valle, Alfonso Gutiérrez‐Adán, Carlos Sanjuan, Antonio Jesús López‐Gambero, Rubén Tovar, Juan Suárez, Francisco Javier Pavón, Elena Baixeras, Juan Decara & Fernando Rodríguez de Fonseca. (2022) d ‐Pinitol promotes tau dephosphorylation through a cyclin‐dependent kinase 5 regulation mechanism: A new potential approach for tauopathies? . British Journal of Pharmacology 179:19, pages 4655-4672.
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Abdullatif Azab. (2022) D-Pinitol—Active Natural Product from Carob with Notable Insulin Regulation. Nutrients 14:7, pages 1453.
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Xiao‐li Li, Fei Yu, Chun‐li Fu, Xin Yu, Mei Xu & Mei Cheng. (2021) Phosphoproteomics analysis of diabetic cardiomyopathy in aging‐accelerated mice and effects of D‐pinitol. PROTEOMICS – Clinical Applications 16:1, pages 2100019.
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Liping Hu, Rui Zhang, Jianhua Wu, Chao Feng & Li Kong. (2021) Sequoyitol Alleviates High Glucose-Induced Inflammation, Oxidative Stress and Apoptosis of Retina Epithelial Cells. Journal of Biomaterials and Tissue Engineering 11:5, pages 1003-1009.
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Marina Sánchez-Hidalgo, Antonio J. León-González, Marina Gálvez-Peralta, Nuria H. González-Mauraza & Carmen Martin-Cordero. (2020) d-Pinitol: a cyclitol with versatile biological and pharmacological activities. Phytochemistry Reviews 20:1, pages 211-224.
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Arianna Pani, Riccardo Giossi, Danilo Menichelli, Veronica Andrea Fittipaldo, Francesca Agnelli, Elvira Inglese, Alessandra Romandini, Rossana Roncato, Basilio Pintaudi, Francesco Del Sole & Francesco Scaglione. (2020) Inositol and Non-Alcoholic Fatty Liver Disease: A Systematic Review on Deficiencies and Supplementation. Nutrients 12:11, pages 3379.
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Xiangmei Yao, Keqian Shi, Yanmei Yang, Xuezhong Gu, Weiwei Tan, Qi Wang, Xiaoli Gao, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan & Song Jin. (2020) D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway. Saudi Journal of Biological Sciences 27:8, pages 2134-2138.
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Juan A. Navarro, Juan Decara, Dina Medina-Vera, Rubén Tovar, Juan Suarez, Javier Pavón, Antonia Serrano, Margarita Vida, Alfonso Gutierrez-Adan, Carlos Sanjuan, Elena Baixeras & Fernando Rodríguez de Fonseca. (2020) D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats. Nutrients 12:7, pages 2030.
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JOEL A. DA SILVA JÚNIOR, AMANDA C.V.F. DA SILVA, LETÍCIA S. FIGUEIREDO, THIAGO R. ARAUJO, ISRAELLE N. FREITAS, EVERARDO M. CARNEIRO, ELANE S. RIBEIRO & ROSANE A. RIBEIRO. (2020) D-Pinitol Increases Insulin Secretion and Regulates Hepatic Lipid Metabolism in Msg-Obese Mice. Anais da Academia Brasileira de Ciências 92:4.
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Eunok Lee, Yeni Lim, Sung Won Kwon & Oran Kwon. (2019) Pinitol consumption improves liver health status by reducing oxidative stress and fatty acid accumulation in subjects with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial. The Journal of Nutritional Biochemistry 68, pages 33-41.
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Sandra López-Domènech, Celia Bañuls, Aranzazu M. de Marañón, Zaida Abab-Jiménez, Carlos Morillas, Segundo Ángel Gómez-Abril, Susana Rovira-Llopis, Víctor Manuel Víctor, Antonio Hernández-Mijares & Milagros Rocha. (2018) Pinitol alleviates systemic inflammatory cytokines in human obesity by a mechanism involving unfolded protein response and sirtuin 1. Clinical Nutrition 37:6, pages 2036-2044.
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Eun Koh, Soojeong Kim, Minyoung Kim, Yu Hong, Seok Shin, Cheol Park, Yoon Chang, Sungjin Chung & Ho‑Shik Kim. (2018) D‑Pinitol alleviates cyclosporine A‑induced renal tubulointerstitial fibrosis via activating Sirt1 and Nrf2 antioxidant pathways. International Journal of Molecular Medicine.
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José Ignacio López-Sánchez, Diego A. Moreno & Cristina García-Viguer. (2018) D-pinitol, a highly valuable product from carob pods: Health-promoting effects and metabolic pathways of this natural super-food ingredient and its derivatives. AIMS Agriculture and Food 3:1, pages 41-63.
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Celia Bañuls, Susana Rovira-Llopis, Sandra López-Doménech, Silvia Veses, Víctor M. Víctor, Milagros Rocha & Antonio Hernández-Mijares. (2016) Effect of consumption of a carob pod inositol-enriched beverage on insulin sensitivity and inflammation in middle-aged prediabetic subjects. Food & Function 7:10, pages 4379-4387.
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Antonio Hernández-Mijares, Celia Bañuls, Susana Rovira-Llopis, Ángeles Álvarez, Samuel Orden, Olalla Rubio-Puchol, Víctor M. Víctor & Milagros Rocha. (2015) Chronic consumption of an inositol-enriched beverage ameliorates endothelial dysfunction and oxidative stress in type 2 diabetes. Journal of Functional Foods 18, pages 598-607.
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Prasetyastuti .Mochammad Willy Prat Anthony, Nuha Aulia Rahman, Ngadikun .Sunarti .. (2014) Hypoglycemic and Antioxidative Effects of Pomegranate (Punica granatum L.) Juice in Streptozotocin Induced Diabetic Rats. Pakistan Journal of Nutrition 13:10, pages 567-572.
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Xian-Wei LiYan LiuWei HaoJie-Ren Yang. (2014) Sequoyitol ameliorates diabetic nephropathy in diabetic rats induced with a high-fat diet and a low dose of streptozotocin. Canadian Journal of Physiology and Pharmacology 92:5, pages 405-417.
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Aparajita Dey & J. Lakshmanan. (2013) The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver. Food & Function 4:8, pages 1148.
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Jungeun Yu, Seunga Choi, Eui-Soon Park, Bongjin Shin, Jiyeon Yu, Seoung Hoon Lee, Masamichi Takami, Jong Soon Kang, Hyungun Meong & Jaerang Rho. (2012) D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. Journal of Clinical Immunology 32:6, pages 1360-1371.
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Hong Shen, Mengle Shao, Kae Won Cho, Suqing Wang, Zheng Chen, Liang Sheng, Ting Wang, Yong Liu & Liangyou Rui. (2012) Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and β-cells. American Journal of Physiology-Endocrinology and Metabolism 302:8, pages E932-E940.
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Fenglin Li, Hong Tang, Furen Xiao, Jingli Gong, Yong Peng & Xiangle Meng. (2011) Protective Effect of Salidroside from Rhodiolae Radix on Diabetes-Induced Oxidative Stress in Mice. Molecules 16:12, pages 9912-9924.
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Selvaraj Sivakumar, Periyasamy Palsamy & Sorimuthu Pillai Subramanian. (2010) Impact of d-pinitol on the attenuation of proinflammatory cytokines, hyperglycemia-mediated oxidative stress and protection of kidney tissue ultrastructure in streptozotocin-induced diabetic rats. Chemico-Biological Interactions 188:1, pages 237-245.
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