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Research Article

Kolaviron protects apoptotic cell death in PC12 cells exposed to Atrazine

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Pages 1061-1073 | Received 25 Feb 2011, Accepted 22 May 2011, Published online: 05 Jul 2011

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Sunny O. Abarikwu, Rex-Clovis C. Njoku, Ifeoma G. John, Benjamin A. Amadi, Chidimma J. Mgbudom-Okah & Chigozie L. Onuah. (2022) Antioxidant and anti-inflammatory protective effects of rutin and kolaviron against busulfan-induced testicular injuries in rats. Systems Biology in Reproductive Medicine 68:2, pages 151-161.
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Sunny O. Abarikwu, Queen C. Duru, Rex-Clovis C. Njoku, Benjamin A. Amadi, Aseme Tamunoibuomie & Enebimoere Keboh. (2017) Effects of co-exposure to atrazine and ethanol on the oxidative damage of kidney and liver in Wistar rats. Renal Failure 39:1, pages 588-596.
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Olatunde Owoeye, Isaac A. Adedara, Oluwafemi S. Bakare, Oluwatobi A. Adeyemo, Christa Egun & Ebenezer O. Farombi. (2014) Kolaviron and vitamin E ameliorate hematotoxicity and oxidative stress in brains of prepubertal rats treated with an anticonvulsant phenytoin. Toxicology Mechanisms and Methods 24:5, pages 353-361.
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Isaac A. Adedara, Premendu P. Mathur & Ebenezer O. Farombi. (2013) Kolaviron prevents ethylene glycol monoethyl ether-induced testicular apoptosis via down-regulation of stress proteins, Fas/Fas-L and caspases expressions in rats. Toxicology Mechanisms and Methods 23:9, pages 689-696.
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Articles from other publishers (35)

Chidimma J. Mgbudom‐Okah, Sunny O. Abarikwu, Matthew O. Wegwu & Ralf Henkel. (2023) Testosterone restores TM3 and TM4 cell viability, reduces reactive oxygen species generation, and protects against atrazine‐induced stereological changes in rat testes. Journal of Biochemical and Molecular Toxicology.
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Jan Tauchen, Adela Frankova, Anna Manourova, Irena Valterova, Bohdan Lojka & Olga Leuner. (2023) Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant. Phytochemistry Reviews.
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Edesiri P. Tesi, Benneth Ben‐Azu, Oyovwi O. Mega, Joseph Mordi, Obed O. Knowledge, Egbuchua D. Awele, Rume A. Rotu, Victor Emojevwe, Olusegun G. Adebayo & Okubo Aya‐Ebi Eneni. (2022) Kolaviron, a flavonoid‐rich extract ameliorates busulfan‐induced chemo‐brain and testicular damage in male rats through inhibition of oxidative stress, inflammatory, and apoptotic pathways. Journal of Food Biochemistry 46:4.
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Marina Cetkovic-Cvrlje, Shana Rogan & Emily Barbaro. (2022) Garcinia kola treatment exhibits immunomodulatory properties while not affecting type 1 diabetes development in an experimental mouse model . International Journal of Immunopathology and Pharmacology 36, pages 205873842110698.
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Samarpita Banerjee, Champa Keeya Tudu, Samapika Nandy, Devendra K. Pandey, Mimosa Ghorai, Mahipal S. Shekhawat, Arabinda Ghosh, Potshangbam Nongdam, Abdel R. Al-Tawaha, Ercan Bursal, Gaber E-S Batiha, Suchhanda Ghosh, Vinay Kumar & Abhijit Dey. 2022. Herbal Medicines. Herbal Medicines 37 69 .
Johnson Olaleye Oladele, Oluwaseun Titilope Oladele, Oyedotun M. Oyeleke & Adenike T. Oladiji. 2021. Contemporary Developments and Perspectives in International Health Security - Volume 2. Contemporary Developments and Perspectives in International Health Security - Volume 2.
Veronica F. Salau, Ochuko L. Erukainure, Vishal Bharuth, Collins U. Ibeji, Tosin A. Olasehinde & Md. Shahidul Islam. (2021) Kolaviron stimulates glucose uptake with concomitant modulation of metabolic activities implicated in neurodegeneration in isolated rat brain, without perturbation of tissue ultrastructural morphology. Neuroscience Research 169, pages 57-68.
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Sunny O. Abarikwu, Guilherme M.J. Costa, Nathalia de Lima e Martins Lara, Samyra M.S.N. Lacerda & Luiz R. de França. (2021) Atrazine impairs testicular function in BalB/c mice by affecting Leydig cells. Toxicology 455, pages 152761.
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Ochuko L. Erukainure, Veronica F. Salau, Chika I. Chukwuma & Md. Shahidul Islam. (2021) Kolaviron: A Biflavonoid with Numerous Health Benefits. Current Pharmaceutical Design 27:4, pages 490-504.
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Oladele OlaleyeJohnsonJohnson, Oladele TitilopeOluwaseunOluwaseun & Oyeleke MosesOyedotunOyedotun. (2021) Possible health benefits of polyphenols in neurological disorders associated with COVID-19. Acta Facultatis Medicae Naissensis 38:3, pages 193-209.
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Etah Etah Nkanu, Ujong Peter Ujong, Gabriel Ujong Otu & Amaku Etetim. (2019) Impact of kolaviron(a biflavonoid) on lipid peroxidation, thromboxane and cyclooxygenase activity in dexamethasone treated ats. Scientific African 6, pages e00162.
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Ebenezer O. Farombi, Ifeoluwa O. Awogbindin, Temitope H. Farombi, Johnson O. Oladele, Edirin R. Izomoh, Oladimeji B. Aladelokun, Ibukunoluwa O. Ezekiel, Oluwabunmi I. Adebambo & Victoria O. Abah. (2019) Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson’s disease. NeuroToxicology 73, pages 132-141.
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Olubukola Benedicta Ojo, Zainab Abiola Amoo, Ibrahim Olabayode Saliu, M. Tolulope Olaleye, Ebenezer O. Farombi & Afolabi Clement Akinmoladun. (2019) Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia/reperfusion injury. Biomedicine & Pharmacotherapy 111, pages 859-872.
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Afolabi Clement Akinmoladun, Temitope Hannah Farombi & Ebenezer Olatunde Farombi. 2019. Encyclopedia of Food Chemistry. Encyclopedia of Food Chemistry 370 386 .
Ana Marija Marjanović Čermak, Ivan Pavičić & Davor Želježić. (2018) Redox imbalance caused by pesticides: a review of OPENTOX-related research. Archives of Industrial Hygiene and Toxicology 69:2, pages 126-134.
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Bao Yuan, Shuang Liang, Yong-Xun Jin, Ming-Jun Zhang, Jia-Bao Zhang & Nam-Hyung Kim. (2017) Toxic effects of atrazine on porcine oocytes and possible mechanisms of action. PLOS ONE 12:6, pages e0179861.
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S. O. Abarikwu, Q. C. Duru, O. V. Chinonso & R.-C. Njoku. (2016) Antioxidant enzymes activity, lipid peroxidation, oxidative damage in the testis and epididymis, and steroidogenesis in rats after co-exposure to atrazine and ethanol. Andrologia 48:5, pages 548-557.
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Wei Hu, Pang-hu Zhou, Ting Rao, Xiao-bin Zhang, Wei Wang & Li-jun Zhang. (2015) Adrenomedullin attenuates interleukin-1β-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway. Experimental Cell Research 339:2, pages 220-230.
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Isaac A. Adedara, Olatunde Owoeye, Motunrayo A. Aiyegbusi, Joshua O. Dagunduro, Yetunde M. Daramola & Ebenezer O. Farombi. (2015) Kolaviron protects against benzo[a]pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats. Environmental Toxicology and Pharmacology 40:2, pages 459-470.
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Peixin Huang, John Yang, Jie Ning, Michael Wang & Qisheng Song. (2015) Atrazine Triggers DNA Damage Response and Induces DNA Double-Strand Breaks in MCF-10A Cells. International Journal of Molecular Sciences 16:12, pages 14353-14368.
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Xiao-Yao Song, Jia-Nan Li, Yan-Ping Wu, Bo Zhang & Bai-Xiang Li. (2015) Atrazine Causes Autophagy- and Apoptosis-Related Neurodegenerative Effects in Dopaminergic Neurons in the Rat Nigrostriatal Dopaminergic System. International Journal of Molecular Sciences 16:12, pages 13490-13506.
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Afolabi C. Akinmoladun, Bolanle L. Akinrinola, M. Tolulope Olaleye & Ebenezer O. Farombi. (2015) Kolaviron, a Garcinia kola Biflavonoid Complex, Protects Against Ischemia/Reperfusion Injury: Pertinent Mechanistic Insights from Biochemical and Physical Evaluations in Rat Brain. Neurochemical Research 40:4, pages 777-787.
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Abhijit Dey & Jitendra Nath De. (2015) Neuroprotective therapeutics from botanicals and phytochemicals against Huntington's disease and related neurodegenerative disorders. Journal of Herbal Medicine 5:1, pages 1-19.
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Sunny O. Abarikwu. (2014) Anti-inflammatory effects of kolaviron modulate the expressions of inflammatory marker genes, inhibit transcription factors ERK1/2, p-JNK, NF-κB, and activate Akt expressions in the 93RS2 Sertoli cell lines. Molecular and Cellular Biochemistry 401:1-2, pages 197-208.
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Sunny O. Abarikwu & Ebenezer O. Farombi. (2015) Atrazine induces apoptosis of SH-SY5Y human neuroblastoma cells via the regulation of Bax/Bcl-2 ratio and caspase-3-dependent pathway. Pesticide Biochemistry and Physiology 118, pages 90-98.
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Cheng-Shi Jiang, Yan Fu, Li Zhang, Jing-Xu Gong, Zhen-Zhong Wang, Wei Xiao, Hai-Yan Zhang & Yue-Wei Guo. (2015) Synthesis and biological evaluation of novel marine-derived indole-based 1,2,4-oxadiazoles derivatives as multifunctional neuroprotective agents. Bioorganic & Medicinal Chemistry Letters 25:2, pages 216-220.
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Dinesh Babu Jestadi, Alugoju Phaniendra, Undru Babji, Bhavatharini Shanmuganathan & Latha Periyasamy. (2014) Effects of Atrazine on Reproductive Health of Nondiabetic and Diabetic Male Rats. International Scholarly Research Notices 2014, pages 1-7.
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Sunny O. Abarikwu, Oghenetega F. Akiri, Mojisola A. Durojaiye & Adenike F. Alabi. (2014) Combined administration of curcumin and gallic acid inhibits gallic acid-induced suppression of steroidogenesis, sperm output, antioxidant defenses and inflammatory responsive genes. The Journal of Steroid Biochemistry and Molecular Biology 143, pages 49-60.
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Sunny O. Abarikwu. (2014) Kolaviron, a natural flavonoid from the seeds of Garcinia kola, reduces LPS-induced inflammation in macrophages by combined inhibition of IL-6 secretion, and inflammatory transcription factors, ERK1/2, NF-κB, p38, Akt, p-c-JUN and JNK. Biochimica et Biophysica Acta (BBA) - General Subjects 1840:7, pages 2373-2381.
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Eun Ju Jeong, Lim Hwang, Mina Lee, Ki Yong Lee, Mi-Jeong Ahn & Sang Hyun Sung. (2014) Neuroprotective biflavonoids of Chamaecyparis obtusa leaves against glutamate-induced oxidative stress in HT22 hippocampal cells. Food and Chemical Toxicology 64, pages 397-402.
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Zhoumeng Lin, Celia A. Dodd & Nikolay M. Filipov. (2013) Differentiation state-dependent effects of in vitro exposure to atrazine or its metabolite diaminochlorotriazine in a dopaminergic cell line. Life Sciences 92:1, pages 81-90.
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Sunny O. Abarikwu, Aditya B. Pant & Ebenezer O. Farombi. (2012) Quercetin decreases steroidogenic enzyme activity, NF-κB expression, and oxidative stress in cultured Leydig cells exposed to atrazine. Molecular and Cellular Biochemistry 373:1-2, pages 19-28.
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Sunny O. Abarikwu, Aditya B. Pant & Ebenezer O. Farombi. (2012) Dietary Antioxidant, Quercetin, Protects Sertoli‐Germ Cell Coculture from Atrazine‐Induced Oxidative Damage. Journal of Biochemical and Molecular Toxicology 26:11, pages 477-485.
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Sunny O. Abarikwu, Ebenezer O. Farombi & Aditya B. Pant. (2012) Kolaviron Biflavanoids of Garcinia Kola Seeds Protect Atrazine-Induced Cytotoxicity in Primary Cultures of Rat Leydig Cells. International Journal of Toxicology 31:4, pages 407-415.
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Sunny O. Abarikwu, Aditya B. Pant & Ebenezer O. Farombi. (2011) 4‐Hydroxynonenal Induces Mitochondrial‐Mediated Apoptosis and Oxidative Stress in SH‐SY5Y Human Neuronal Cells. Basic & Clinical Pharmacology & Toxicology 110:5, pages 441-448.
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