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Research Article

Ascorbic acid and N-acetyl cysteine prevent uncoupling of nitric oxide synthase and increase tolerance to ischemia/reperfusion injury in diabetic rat heart

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Pages 1173-1183 | Received 19 May 2011, Accepted 11 Jul 2011, Published online: 10 Aug 2011

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Saptarshi Kar, Bhagyesh Bhandar & Mahendra Kavdia. (2012) Impact of SOD in eNOS uncoupling: a two-edged sword between hydrogen peroxide and peroxynitrite. Free Radical Research 46:12, pages 1496-1513.
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Wang-Soo Lee & Jaetaek Kim. (2021) Application of Animal Models in Diabetic Cardiomyopathy. Diabetes & Metabolism Journal 45:2, pages 129-145.
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Yi Tan, Zhiguo Zhang, Chao Zheng, Kupper A. Wintergerst, Bradley B. Keller & Lu Cai. (2020) Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nature Reviews Cardiology 17:9, pages 585-607.
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Nina Kaludercic & Fabio Di Lisa. (2020) Mitochondrial ROS Formation in the Pathogenesis of Diabetic Cardiomyopathy. Frontiers in Cardiovascular Medicine 7.
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Angelique M. E. Spoelstra-de Man, Paul W. G. Elbers & Heleen M. Oudemans-van Straaten. (2018) Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Critical Care 22:1.
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Phiwayinkosi V. Dludla, Stephanie C. Dias, Nnini Obonye, Rabia Johnson, Johan Louw & Bongani B. Nkambule. (2018) A Systematic Review on the Protective Effect of N-Acetyl Cysteine Against Diabetes-Associated Cardiovascular Complications. American Journal of Cardiovascular Drugs 18:4, pages 283-298.
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Christopher S. Rabender, Ninu Bruno, Asim Alam, Gobalakrishnan Sundaresan, Jamal Zweit & Ross B. Mikkelsen. (2018) Sepiapterin Enhances Tumor Radio- and Chemosensitivities by Promoting Vascular Normalization. Journal of Pharmacology and Experimental Therapeutics 365:3, pages 536-543.
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A. M. E. Spoelstra-de Man, P. W. G. Elbers & H. M. Oudemans‐van Straaten. 2018. Annual Update in Intensive Care and Emergency Medicine 2018. Annual Update in Intensive Care and Emergency Medicine 2018 125 139 .
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L.G.M. Wijermars, A.F. Schaapherder, S. Kostidis, R.C.I. Wüst & J.H. Lindeman. (2016) Succinate Accumulation and Ischemia–Reperfusion Injury: Of Mice but Not Men, a Study in Renal Ischemia–Reperfusion. American Journal of Transplantation 16:9, pages 2741-2746.
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Anne Lejay, Fei Fang, Rohan John, Julie A.D. Van, Meredith Barr, Fabien Thaveau, Nabil Chakfe, Bernard Geny & James W. Scholey. (2016) Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus. Journal of Molecular and Cellular Cardiology 91, pages 11-22.
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Nuno R. Ferreira, C.F. Lourenço, Rui M. Barbosa & João Laranjinha. (2015) Coupling of ascorbate and nitric oxide dynamics in vivo in the rat hippocampus upon glutamatergic neuronal stimulation: A novel functional interplay. Brain Research Bulletin 114, pages 13-19.
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Zoltán V. Varga, Zoltán Giricz, Lucas Liaudet, György Haskó, Peter Ferdinandy & Pál Pacher. (2015) Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:2, pages 232-242.
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Amlan Das, Bhavani Gopalakrishnan, Lawrence J Druhan, Tse-Yao Wang, Francesco De Pascali, Antal Rockenbauer, Ira Racoma, Saradhadevi Varadharaj, Jay L Zweier, Arturo J Cardounel & Frederick A Villamena. (2014) Reversal of SIN-1-induced eNOS dysfunction by the spin trap, DMPO, in bovine aortic endothelial cells via eNOS phosphorylation. British Journal of Pharmacology 171:9, pages 2321-2334.
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Alan Mortensen & Jens Lykkesfeldt. (2014) Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies. Nitric Oxide 36, pages 51-57.
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Hong Li, Yunfei Bian, Nana Zhang, Jia Guo, Cheng Wang, Wayne Bond Lau & Chuanshi Xiao. (2013) Intermedin protects against myocardial ischemia-reperfusion injury in diabetic rats. Cardiovascular Diabetology 12:1.
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Alan Mortensen, Stine Hasselholt, Pernille Tveden-Nyborg & Jens Lykkesfeldt. (2013) Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo. Nutrition Research 33:10, pages 859-867.
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David M Ansley & Baohua Wang. (2013) Oxidative stress and myocardial injury in the diabetic heart. The Journal of Pathology 229:2, pages 232-241.
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Mengyu Gao & Junping Kou. (2012) Response to correspondence: “The link between inhibition of nitric oxide metabolite production and reduction of LPS induced lung injury,” by Dr. Michael Eisenhut. International Immunopharmacology 14:2, pages 233.
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Shu-Fen Liou, Jong-Hau Hsu, Jyh-Chong Liang, Hung-Jen Ke, Ing-Jun Chen, Jiunn-Ren Wu & Jwu-Lai Yeh. (2011) San-Huang-Xie-Xin-Tang protects cardiomyocytes against hypoxia/reoxygenation injury via inhibition of oxidative stress-induced apoptosis. Journal of Natural Medicines 66:2, pages 311-320.
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