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Free Radical Research Volume 45, 2011 - Issue 11-12
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Research Article

A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse

Miho EmotoCenter for Medical Education, Sapporo Medical University, Sapporo, Hokkaido, Japan
,
Fumiya MitoDepartment of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
,
Toshihide YamasakiDepartment of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
,
Ken-Ichi YamadaDepartment of Bio-functional Science, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
,
Hideo Sato-AkabaDepartment of Systems Innovation, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, Japan
,
Hiroshi HirataDivision of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Hokkaido, Japan
&
Hirotada FujiiCenter for Medical Education, Sapporo Medical University, Sapporo, Hokkaido, JapanCorrespondence[email protected]
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Pages 1325-1332 | Received 30 May 2011, Accepted 25 Aug 2011, Published online: 26 Sep 2011

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Hideo Sato-Akaba, Miho C. Emoto, Ken-ichi Yamada, Hisashi Koshino & Hirotada G. Fujii. (2021) Three-dimensional electron paramagnetic resonance imaging of mice using ascorbic acid sensitive nitroxide imaging probes . Free Radical Research 55:9-10, pages 950-957.
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Fuminori Hyodo, Shinji Ito, Hinako Eto, Abdelazim Elsayed Elhelaly, Masaharu Murata, Tomohiko Akahoshi, Hideo Utsumi & Masayuki Matuso. (2021) Free radical imaging of endogenous redox molecules using dynamic nuclear polarization magnetic resonance imaging. Free Radical Research 55:4, pages 343-351.
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Articles from other publishers (22)

S. Yu. Trakhinina, A. I. Taratayko, Yu. I. Glazachev & I. A. Kirilyuk. (2023) Sterically shielded pyrrolidine nitroxides with 3-(4,5-dicarboxy-1H-1,2,3-triazol-1-yl)propyl substituent. Russian Chemical Bulletin 72:7, pages 1569-1575.
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Aleksandra Rančić, Nikola Babić, Maylis Orio & Fabienne Peyrot. (2023) Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes. Antioxidants 12:2, pages 402.
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Andrey I. Taratayko, Yurii I. Glazachev, Ilia V. Eltsov, Elena I. Chernyak & Igor A. Kirilyuk. (2022) 3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains. Molecules 27:6, pages 1922.
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Miho C. Emoto, Hideo Sato-Akaba, Naoya Hamaue, Katsuya Kawanishi, Hisashi Koshino, Shun Shimohama & Hirotada G. Fujii. (2021) Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer’s disease by in vivo electron paramagnetic resonance imaging. Free Radical Biology and Medicine 172, pages 9-18.
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Victor I. Ovcharenko & Olga V. Kuznetsova. (2020) New method for the synthesis of heterospin metal complexes with nitroxides. Russian Chemical Reviews 89:11, pages 1261-1273.
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Nikola Babić, Maylis Orio & Fabienne Peyrot. (2020) Unexpected rapid aerobic transformation of 2,2,6,6-tetraethyl-4-oxo(piperidin-1-yloxyl) radical by cytochrome P450 in the presence of NADPH: Evidence against a simple reduction of the nitroxide moiety to the hydroxylamine. Free Radical Biology and Medicine 156, pages 144-156.
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Nikola Babić & Fabienne Peyrot. (2019) New synthetic route to 2,2,6,6-tetraethylpiperidin-4-one: A key-intermediate towards tetraethyl nitroxides. Tetrahedron Letters 60:44, pages 151207.
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Michal Gonet, Boris Epel, Howard J. Halpern & Martyna Elas. (2019) Merging Preclinical EPR Tomography with other Imaging Techniques. Cell Biochemistry and Biophysics 77:3, pages 187-196.
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Sébastien Combes, Khoa Truong Tran, Mehmet Menaf Ayhan, Hakim Karoui, Antal Rockenbauer, Alain Tonetto, Valérie Monnier, Laurence Charles, Roselyne Rosas, Stéphane Viel, Didier Siri, Paul Tordo, Sylvain Clair, Ruibing Wang, David Bardelang & Olivier Ouari. (2019) Triangular Regulation of Cucurbit[8]uril 1:1 Complexes. Journal of the American Chemical Society 141:14, pages 5897-5907.
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Nikola Babić & Fabienne Peyrot. (2019) Molecular Probes for Evaluation of Oxidative Stress by In Vivo EPR Spectroscopy and Imaging: State-of-the-Art and Limitations. Magnetochemistry 5:1, pages 13.
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Miho C. Emoto, Kota Sasaki, Koya Maeda, Hirotada G. Fujii & Shingo Sato. (2018) Synthesis and Evaluation as a Blood–Brain Barrier-Permeable Probe of 7-<i>N</i>-(PROXYL-3-yl-methyl)theophylline. Chemical and Pharmaceutical Bulletin 66:9, pages 887-891.
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Xiaolei Wang, Miho Emoto, Yusuke Miyake, Kaori Itto, Shu Xu, Hirotada Fujii, Hiroshi Hirata & Hirokazu Arimoto. (2016) Novel blood–brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging. Bioorganic & Medicinal Chemistry Letters 26:20, pages 4947-4949.
Crossref
Fuminori Hyodo, Shinji Ito, Hinako Eto, Tomoko Nakaji, Keiji Yasukawa, Ryoma Kobayashi & Hideo Utsumi. (2016) Development of Redox Metabolic Imaging Using Endogenous Molecules生体内分子・医薬品を用いた新たな代謝イメージング法の開発. YAKUGAKU ZASSHI 136:8, pages 1107-1114.
Crossref
Kota Sasaki, Tomohiro Ito, Hirotada G. Fujii & Shingo Sato. (2016) Synthesis and Reduction Kinetics of Five Ibuprofen–Nitroxides for Ascorbic Acid and Methyl Radicals. CHEMICAL & PHARMACEUTICAL BULLETIN Chemical and Pharmaceutical Bulletin 64:10, pages 1509-1513.
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P. Roser, M. J. Schmidt, M. Drescher & D. Summerer. (2016) Site-directed spin labeling of proteins for distance measurements in vitro and in cells. Organic & Biomolecular Chemistry 14:24, pages 5468-5476.
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David Bardelang, Gilles Casano, Florent Poulhès, Hakim Karoui, Jessica Filippini, Antal Rockenbauer, Roselyne Rosas, Valérie Monnier, Didier Siri, Anouk Gaudel-Siri, Olivier Ouari & Paul Tordo. (2014) Spin Exchange Monitoring of the Strong Positive Homotropic Allosteric Binding of a Tetraradical by a Synthetic Receptor in Water. Journal of the American Chemical Society 136:50, pages 17570-17577.
Crossref
Miho C. Emoto, Hideo Sato-Akaba, Hiroshi Hirata & Hirotada G. Fujii. (2014) Dynamic changes in the distribution and time course of blood–brain barrier-permeative nitroxides in the mouse head with EPR imaging: visualization of blood flow in a mouse model of ischemia. Free Radical Biology and Medicine 74, pages 222-228.
Crossref
Xiaolei Wang, Miho Emoto, Atsushi Sugimoto, Yusuke Miyake, Kaori Itto, Mitsuo Amasaka, Shu Xu, Hiroshi Hirata, Hirotada Fujii & Hirokazu Arimoto. (2014) Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging. Tetrahedron Letters 55:13, pages 2146-2149.
Crossref
Miho C. Emoto, Ken-ichi Yamada, Mayumi Yamato & Hirotada G. Fujii. (2013) Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents. Neuroscience Letters 546, pages 11-15.
Crossref
Hirotada G. Fujii, Hideo Sato-Akaba, Miho C. Emoto, Kouichi Itoh, Yasuhiro Ishihara & Hiroshi Hirata. (2013) Noninvasive mapping of the redox status in septic mouse by in vivo electron paramagnetic resonance imaging. Magnetic Resonance Imaging 31:1, pages 130-138.
Crossref
Joseph T. Paletta, Maren Pink, Bridget Foley, Suchada Rajca & Andrzej Rajca. (2012) Synthesis and Reduction Kinetics of Sterically Shielded Pyrrolidine Nitroxides. Organic Letters 14:20, pages 5322-5325.
Crossref
Hyo-Yang Ahn, Kathryn E. Fairfull-Smith, Benjamin J. Morrow, Vanessa Lussini, Bosung Kim, Mykhailo V. Bondar, Steven E. Bottle & Kevin D. Belfield. (2012) Two-Photon Fluorescence Microscopy Imaging of Cellular Oxidative Stress Using Profluorescent Nitroxides. Journal of the American Chemical Society 134:10, pages 4721-4730.
Crossref

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