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Free Radical Research Volume 46, 2012 - Issue 6
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Research Article

Doxorubicin-induced neurotoxicity is attenuated by a 43-kD protein from the leaves of Cajanus indicus L. via NF-κB and mitochondria dependent pathways

Sankhadeep PalDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, India
,
Manisha AhirDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, India
&
Parames C. SilDivision of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Kolkata, IndiaCorrespondence[email protected] [email protected]
Pages 785-798 | Received 30 Dec 2011, Accepted 20 Mar 2012, Published online: 10 Apr 2012

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Kaviyarasi Renu, Lakshmi Prasanna Pureti, Balachandar Vellingiri & Abilash Valsala Gopalakrishnan. (2022) Toxic effects and molecular mechanism of doxorubicin on different organs – an update. Toxin Reviews 41:2, pages 650-674.
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Amir Abbas Farshid, Esmaeal Tamaddonfard & Sima Najafi. (2015) Effects of histidine and n-acetylcysteine on experimental lesions induced by doxorubicin in sciatic nerve of rats. Drug and Chemical Toxicology 38:4, pages 436-441.
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Articles from other publishers (30)

Dehua Liao, Danggang Shangguan, Yi Wu, Yun Chen, Ni Liu, Jingyi Tang, Dunwu Yao & Yingrui Shi. (2023) Curcumin protects against doxorubicin induced oxidative stress by regulating the Keap1-Nrf2-ARE and autophagy signaling pathways. Psychopharmacology 240:5, pages 1179-1190.
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Yan Gao, Jingyao Dong, Mengmeng Chen, Taiwei Wang, Zhaoyun Yang, Kang He, Yuewei Li, Kai Wang, Jian Jiang & Shuang Zhang. (2022) Protective effect of low-dose radiation on doxorubicin-induced brain injury in mice. Archives of Biochemistry and Biophysics 729, pages 109390.
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Chandrakala Aluganti NarasimhuluDinender K. Singla. (2022) Doxorubicin-induced apoptosis enhances monocyte infiltration and adverse cardiac remodeling in diabetic animals. Canadian Journal of Physiology and Pharmacology 100:5, pages 441-452.
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Nilsel Okudan, Muaz Belviranlı & Tuğba Sezer. (2022) Potential Protective Effect of Coenzyme Q10 on Doxorubicin-Induced Neurotoxicity and Behavioral Disturbances in Rats. Neurochemical Research 47:5, pages 1280-1289.
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Alaa Emam Ali, Doaa Mokhtar Elsherbiny, Samar S. Azab & Ebtehal El-Demerdash. (2022) The diuretic amiloride attenuates doxorubicin-induced chemobrain in rats: Behavioral and mechanistic study. NeuroToxicology 88, pages 1-13.
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Ghadha Ibrahim Fouad & Kawkab A. Ahmed. (2021) Neuroprotective Potential of Berberine Against Doxorubicin-Induced Toxicity in Rat’s Brain. Neurochemical Research 46:12, pages 3247-3263.
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Emin Kaymak, Ali Tuğrul Akin, Emel Öztürk, Derya Karabulut, Nurhan Kuloğlu & Birkan Yakan. (2021) Thymoquinone has a neuroprotective effect against inflammation, oxidative stress, and endoplasmic reticulum stress in the brain cortex, medulla, and hippocampus due to doxorubicin. Journal of Biochemical and Molecular Toxicology 35:11.
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Satyanarayana R. Pondugula, Mohammed Majrashi, Mohammed Almaghrabi, Sindhu Ramesh, Kodye L. Abbott, Manoj Govindarajulu, Kristina Gill, Eddie Fahoury, Natasha Narayanan, Darshini Desai, Jun Ren, Rishi Nadar, Trey McElroy, Timothy Moore, Muhammed Majeed, Nagabhushanam Kalyanam & Muralikrishnan Dhanasekaran. (2021) Oroxylum Indicum ameliorates chemotherapy induced cognitive impairment. PLOS ONE 16:6, pages e0252522.
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Salvatore AntonucciMoises Di SanteFederica TonoloLaura PontarolloValeria ScalconPetra AlanovaRoberta MenabòAndrea CarpiAlberto BindoliMaria Pia RigobelloMarco GiorgioNina KaludercicFabio Di Lisa. (2021) The Determining Role of Mitochondrial Reactive Oxygen Species Generation and Monoamine Oxidase Activity in Doxorubicin-Induced Cardiotoxicity. Antioxidants & Redox Signaling 34:7, pages 531-550.
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Salvatore Antonucci, Fabio Di Lisa & Nina Kaludercic. (2021) Mitochondrial reactive oxygen species in physiology and disease. Cell Calcium 94, pages 102344.
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Claudia Pellacani & Georgios Eleftheriou. (2020) Neurotoxicity of antineoplastic drugs: Mechanisms, susceptibility, and neuroprotective strategies. Advances in Medical Sciences 65:2, pages 265-285.
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Sukanya Saha, Sushweta Mahalanobish, Sayanta Dutta & Parames C. Sil. (2019) Mangiferin ameliorates collateral neuropathy in t BHP induced apoptotic nephropathy by inflammation mediated kidney to brain crosstalk . Food & Function 10:9, pages 5981-5999.
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Javad Motaharinia, Yunes Panahi, George E. Barreto, Fatemeh Beiraghdar & Amirhossein Sahebkar. (2019) Efficacy of curcumin on prevention of drug‐induced nephrotoxicity: A review of animal studies. BioFactors 45:5, pages 690-702.
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Sara Emad El-Agamy, Amal Kamal Abdel-Aziz, Ahmed Esmat & Samar S. Azab. (2019) Chemotherapy and cognition: comprehensive review on doxorubicin-induced chemobrain. Cancer Chemotherapy and Pharmacology 84:1, pages 1-14.
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Hua Li, Xuhui Li, Wei Luo & Xiaolong Zhu. (2019) (Z)-7,4′-Dimethoxy-6-hydroxy-aurone-4-O-β-glucopyranoside exerts neuroprotective effects in vitro and anxiolytic activity in vivo. NeuroReport 30:4, pages 280-287.
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Jennifer D. CohenYasuhiro Tanaka. (2018) Comparative Sensitivity of Human-Induced Pluripotent Stem Cell-Derived Neuronal Subtypes to Chemically Induced Neurodegeneration. Applied In Vitro Toxicology 4:4, pages 347-364.
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Dehua Liao, Daxiong Xiang, Ruili Dang, Pengfei Xu, Jiemin Wang, Wenxiu Han, Yingzhou Fu, Dunwu Yao, Lizhi Cao & Pei Jiang. (2018) Neuroprotective Effects of dl-3-n-Butylphthalide against Doxorubicin-Induced Neuroinflammation, Oxidative Stress, Endoplasmic Reticulum Stress, and Behavioral Changes. Oxidative Medicine and Cellular Longevity 2018, pages 1-13.
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Daniela Almeida, Rita Pinho, Verónica Correia, Jorge Soares, Maria Bastos, Félix Carvalho, João Capela & Vera Costa. (2018) Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A ‘Chemobrain’ In Vitro Study. Pharmaceuticals 11:2, pages 41.
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Pritam Sadhukhan, Sukanya Saha, Sayanta Dutta, Sushweta Mahalanobish & Parames C. Sil. (2018) Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer’s disease. Pharmacological Research 129, pages 100-114.
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Mohammad Mohajeri & Amirhossein Sahebkar. (2018) Protective effects of curcumin against doxorubicin-induced toxicity and resistance: A review. Critical Reviews in Oncology/Hematology 122, pages 30-51.
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Asmaa F. Khafaga & Yasser S. El-Sayed. (2017) All-trans-retinoic acid ameliorates doxorubicin-induced cardiotoxicity: in vivo potential involvement of oxidative stress, inflammation, and apoptosis via caspase-3 and p53 down-expression. Naunyn-Schmiedeberg's Archives of Pharmacology 391:1, pages 59-70.
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Abhijit Dey, Raktim Bhattacharya, Anuradha Mukherjee & Devendra Kumar Pandey. (2017) Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions. Biotechnology Advances 35:2, pages 178-216.
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Marzena Szwed, Audrey Laroche-Clary, Jacques Robert & Zofia Jozwiak. (2015) Efficacy of doxorubicin-transferrin conjugate in apoptosis induction in human leukemia cells through reactive oxygen species generation. Cellular Oncology 39:2, pages 107-118.
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Liang Yang, Cheng Luo, Cong Chen, Xun Wang, Wen Shi & Jiankang Liu. (2016) All-trans retinoic acid protects against doxorubicin-induced cardiotoxicity by activating the ERK2 signalling pathway. British Journal of Pharmacology 173:2, pages 357-371.
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I. Marques-Aleixo, E. Santos-Alves, M.M. Balça, P.I. Moreira, P.J. Oliveira, J. Magalhães & A. Ascensão. (2016) Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling. Mitochondrion 26, pages 43-57.
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Sankhadeep Pal, Abhijit Sarkar, Pabitra Bikash Pal & Parames C. Sil. (2015) Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways. Biochimie 112, pages 20-34.
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Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos & Félix Carvalho. (2015) In vitro models for neurotoxicology research. Toxicology Research 4:4, pages 801-842.
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Jyotirmoy Ghosh & Parames C. Sil. 2015. 457 483 .
Pabitra Bikash Pal, Krishnendu Sinha & Parames C. Sil. (2014) Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats. PLoS ONE 9:9, pages e107220.
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Kahkashan Rashid, Krishnendu Sinha & Parames C. Sil. (2013) An update on oxidative stress-mediated organ pathophysiology. Food and Chemical Toxicology 62, pages 584-600.
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