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Research Article

DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16

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Pages 316-324 | Received 06 Aug 2012, Accepted 03 Feb 2013, Published online: 08 Mar 2013

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Jia Xu, Youming Guo, Tianzhuo Sui, Qifei Wang, Yue Zhang, Ruining Zhang, Mingyang Wang, Shuwen Guan & Liping Wang. (2017) Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans. Free Radical Research 51:5, pages 529-544.
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Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou & Ying-Xiu Li. (2022) Planococcus maritimu ML1206 Strain Enhances Stress Resistance and Extends the Lifespan in Caenorhabditis elegans via FOXO/DAF-16. Marine Drugs 21:1, pages 1.
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Kai Wang, Yuting Liang, Yu Su & Liping Wang. (2020) DhHP-6 ameliorates hepatic oxidative stress and insulin resistance in type 2 diabetes mellitus through the PI3K/AKT and AMPK pathway. Biochemical Journal 477:12, pages 2363-2381.
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Jiaqing Yan, Zhengqiang Li, Min Liu, Xiaoli Sun, Li Ma, Zhi Wang, Zijian Zhao, Xuri Huang & Long Yuan. (2020) Activity adaptability of a DhHP-6 peroxidase-mimic in wide pH and temperature ranges and solvent media. Catalysis Science & Technology 10:6, pages 1848-1857.
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Kai Wang, Yu Su, Yuting Liang, Yanhui Song & Liping Wang. (2019) Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences 20:6, pages 1517.
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Jia Xu, Ye Yuan, Ruining Zhang, Yanhui Song, Tianzhuo Sui, Jiaqi Wang, Chonghan Wang, Yujia Chen, Shuwen Guan & Liping Wang. (2019) A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation. Bioorganic Chemistry 82, pages 332-339.
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Yike Su, Xinshu Guan, Bing Wang, Tianyang Gao, Mingyang Wang, Zhonglin Wei, Liping Wang & Xinhua Guo. (2018) Characteristic b2-CO2 ions formed by an N-terminal deuterohemin containing histidine peptide under low-energy collision-induced dissociation. International Journal of Mass Spectrometry 434, pages 246-250.
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Jia Xu, Kai Wang, Ye Yuan, Hui Li, Ruining Zhang, Shuwen Guan & Liping Wang. (2018) A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice. International Journal of Molecular Sciences 19:11, pages 3304.
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Ai-Jun Ding, Shan-Qing Zheng, Xiao-Bing Huang, Ti-Kun Xing, Gui-Sheng Wu, Hua-Ying Sun, Shu-Hua Qi & Huai-Rong Luo. (2017) Current Perspective in the Discovery of Anti-aging Agents from Natural Products. Natural Products and Bioprospecting 7:5, pages 335-404.
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Wei Jiang, Xinghuo Wang, Jiawen Chen, Ying Liu, Haobo Han, Yi Ding, Quanshun Li & Jun Tang. (2017) Deuterohemin-Peptide Enzyme Mimic-Embedded Metal-Organic Frameworks through Biomimetic Mineralization with Efficient ATRP Catalytic Activity. ACS Applied Materials & Interfaces 9:32, pages 26948-26957.
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Yingshi Ji, Xin Yan, Yang Hu, Huan Xue, Jianfeng Sun, Huaqiu Chen, Jiayu Zhang, Liping Wang, Baigong Xue & Li Sun. (2017) DhHP-6 attenuates cerebral ischemia-reperfusion injury in rats through the inhibition of apoptosis. Molecular Medicine Reports 16:5, pages 7229-7236.
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Zijian Zhao, Ji Zhang, Mingyang Wang, Zhi Wang, Liping Wang, Li Ma, Xuri Huang & Zhengqiang Li. (2016) Structure advantage and peroxidase activity enhancement of deuterohemin-peptide–inorganic hybrid flowers. RSC Advances 6:106, pages 104265-104272.
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Hang Zhou, Wei Jiang, Ni An, Qiuping Zhang, Shidong Xiang, Liping Wang & Jun Tang. (2015) Enzyme mimetic-catalyzed ATRP and its application in block copolymer synthesis combined with enzymatic ring-opening polymerization. RSC Advances 5:53, pages 42728-42735.
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Liyan Lei, Guangji Zhang, Pengfei Li, Yuan Zhang, Youming Guo, Wenqi Zhang, Wenbo Zhang, Bing Hu & Liping Wang. (2014) Deuterohemin-AlaHisLys mitigates the symptoms of rats with non-insulin dependent diabetes mellitus by scavenging reactive oxygen species and activating the PI3-K/AKT signal transduction pathway. Chemico-Biological Interactions 220, pages 64-74.
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